Page last updated: 2024-10-27

flumazenil and Glioma

flumazenil has been researched along with Glioma in 6 studies

Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.

Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Research Excerpts

ExcerptRelevanceReference
" This study aimed to determine whether the exacerbated upper limb motor-sensory deficits are mediated through benzodiazepine sites by demonstrating reversibility by flumazenil in patients with gliomas in eloquent areas."7.91Midazolam Sedation Induces Upper Limb Coordination Deficits That Are Reversed by Flumazenil in Patients with Eloquent Area Gliomas. ( Gelb, AW; Han, R; Hui, X; Lin, N; Zhang, K, 2019)
" This study aimed to determine whether the exacerbated upper limb motor-sensory deficits are mediated through benzodiazepine sites by demonstrating reversibility by flumazenil in patients with gliomas in eloquent areas."3.91Midazolam Sedation Induces Upper Limb Coordination Deficits That Are Reversed by Flumazenil in Patients with Eloquent Area Gliomas. ( Gelb, AW; Han, R; Hui, X; Lin, N; Zhang, K, 2019)
"The effects of several benzodiazepines (diazepam, clonazepam, Ro 15-1788 and Ro 5-4864) on cell proliferation of 2 human gliomas were estimated in vitro by means of [3H]-thymidine uptake assay."3.67Inhibition of cell proliferation of human gliomas by benzodiazepines in vitro. ( Kunert-Radek, J; Pawlikowski, M; Radek, A; Stepien, H, 1988)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19902 (33.33)18.7374
1990's1 (16.67)18.2507
2000's1 (16.67)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lin, N1
Han, R1
Hui, X1
Zhang, K1
Gelb, AW1
Vlisides, PE1
Mashour, GA1
Ishizawa, Y1
Furuya, K1
Yamagishi, S1
Dohi, S1
Selleri, S1
Bruni, F1
Costagli, C1
Costanzo, A1
Guerrini, G1
Ciciani, G1
Costa, B1
Martini, C1
Ferrarese, C1
Appollonio, I1
Frigo, M1
Gaini, SM1
Piolti, R1
Frattola, L1
Pawlikowski, M1
Kunert-Radek, J1
Radek, A1
Stepien, H1

Other Studies

6 other studies available for flumazenil and Glioma

ArticleYear
Midazolam Sedation Induces Upper Limb Coordination Deficits That Are Reversed by Flumazenil in Patients with Eloquent Area Gliomas.
    Anesthesiology, 2019, Volume: 131, Issue:1

    Topics: Adult; Brain Neoplasms; Female; Flumazenil; GABA Modulators; Glioma; Humans; Hypnotics and Sedatives

2019
Pharmacologic Unmasking of Neurologic Deficits: A Stress Test for the Brain.
    Anesthesiology, 2019, Volume: 131, Issue:1

    Topics: Brain; Exercise Test; Flumazenil; Glioma; Humans; Midazolam; Upper Extremity

2019
Non-GABAergic effects of midazolam, diazepam and flumazenil on voltage-dependent ion currents in NG108-15 cells.
    Neuroreport, 1997, Jul-28, Volume: 8, Issue:11

    Topics: Animals; Calcium Channels; Diazepam; Dose-Response Relationship, Drug; Flumazenil; gamma-Aminobutyri

1997
2-Arylpyrazolo[1,5-a]pyrimidin-3-yl acetamides. New potent and selective peripheral benzodiazepine receptor ligands.
    Bioorganic & medicinal chemistry, 2001, Volume: 9, Issue:10

    Topics: Acetamides; Animals; Benzodiazepinones; Binding Sites; Cerebral Cortex; Clonazepam; Flumazenil; Glio

2001
Benzodiazepine receptors and diazepam-binding inhibitor in human cerebral tumors.
    Annals of neurology, 1989, Volume: 26, Issue:4

    Topics: Adolescent; Adult; Aged; Astrocytoma; Brain; Brain Neoplasms; Diazepam Binding Inhibitor; Female; Fl

1989
Inhibition of cell proliferation of human gliomas by benzodiazepines in vitro.
    Acta neurologica Scandinavica, 1988, Volume: 77, Issue:3

    Topics: Astrocytoma; Benzodiazepines; Benzodiazepinones; Cell Division; Clonazepam; Diazepam; Female; Flumaz

1988