flumazenil has been researched along with Essential Tremor in 3 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Essential Tremor: A relatively common disorder characterized by a fairly specific pattern of tremors which are most prominent in the upper extremities and neck, inducing titubations of the head. The tremor is usually mild, but when severe may be disabling. An autosomal dominant pattern of inheritance may occur in some families (i.e., familial tremor). (Mov Disord 1988;13(1):5-10)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Using (11)C-flumazenil and PET, we calculated the distribution volume, an index of availability of benzodiazepine receptor sites of the GABA(A) complex, in a group of 8 patients with bilateral essential tremor, as compared with 11 healthy controls." | 7.76 | GABAergic dysfunction in essential tremor: an 11C-flumazenil PET study. ( Boecker, H; Brooks, DJ; Ceballos-Baumann, AO; Liedtke, C; Miederer, I; Miederer, M; Sprenger, T; Wagner, KJ; Weindl, A, 2010) |
| " Only non-impairing doses were used to evaluate for anti-tremor efficacy in the harmaline model, which was assessed in wildtype and α6 subunit knockout littermates." | 4.31 | Search for Novel Therapies for Essential Tremor Based on Positive Modulation of α6-Containing GABA ( Ernst, M; Handforth, A; Singh, RP; Treven, M, 2023) |
| "We measured the tremor clinical rating scale score and acquired DASB and Flumazenil PET scans in 10 patients who presented with essential tremor at different stages of clinical severity." | 3.78 | Gaba and serotonin molecular neuroimaging in essential tremor: a clinical correlation study. ( Figueiras, FP; Gironell, A; Gispert, JD; Herance, JR; Pagonabarraga, J; Pascual-Sedano, B; Trampal, C, 2012) |
| "Using (11)C-flumazenil and PET, we calculated the distribution volume, an index of availability of benzodiazepine receptor sites of the GABA(A) complex, in a group of 8 patients with bilateral essential tremor, as compared with 11 healthy controls." | 3.76 | GABAergic dysfunction in essential tremor: an 11C-flumazenil PET study. ( Boecker, H; Brooks, DJ; Ceballos-Baumann, AO; Liedtke, C; Miederer, I; Miederer, M; Sprenger, T; Wagner, KJ; Weindl, A, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Handforth, A | 1 |
| Singh, RP | 1 |
| Treven, M | 1 |
| Ernst, M | 1 |
| Boecker, H | 1 |
| Weindl, A | 1 |
| Brooks, DJ | 1 |
| Ceballos-Baumann, AO | 1 |
| Liedtke, C | 1 |
| Miederer, M | 1 |
| Sprenger, T | 1 |
| Wagner, KJ | 1 |
| Miederer, I | 1 |
| Gironell, A | 1 |
| Figueiras, FP | 1 |
| Pagonabarraga, J | 1 |
| Herance, JR | 1 |
| Pascual-Sedano, B | 1 |
| Trampal, C | 1 |
| Gispert, JD | 1 |
3 other studies available for flumazenil and Essential Tremor
| Article | Year |
|---|---|
Search for Novel Therapies for Essential Tremor Based on Positive Modulation of α6-Containing GABA
Topics: Animals; Essential Tremor; Flumazenil; gamma-Aminobutyric Acid; Harmaline; Humans; Ketamine; Mice; M | 2023 |
GABAergic dysfunction in essential tremor: an 11C-flumazenil PET study.
Topics: Aged; Brain; Cerebellum; Essential Tremor; Female; Flumazenil; GABA Modulators; gamma-Aminobutyric A | 2010 |
Gaba and serotonin molecular neuroimaging in essential tremor: a clinical correlation study.
Topics: Aged; Cerebellum; Essential Tremor; Female; Flumazenil; gamma-Aminobutyric Acid; Humans; Image Proce | 2012 |