Page last updated: 2024-10-27

flumazenil and Epilepsy, Tonic-Clonic

flumazenil has been researched along with Epilepsy, Tonic-Clonic in 5 studies

Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.

Epilepsy, Tonic-Clonic: A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). (From Adams et al., Principles of Neurology, 6th ed, p329)

Research Excerpts

ExcerptRelevanceReference
"The influence of flumazenil on seizures induced by pentylenetetrazol (PTZ) was studied in rats aged 7, 12, 18, 25, and 90 days."3.68Anticonvulsant activity of flumazenil in rats during ontogenetic development. ( Kubová, H; Mares, P; Rathouská, J; Vorlícek, J, 1993)
"Physical dependence was produced in the rat by exposure to continuous release of diazepam from silastic capsule implants (recrystallized diazepam) or by dosing through a gastric fistula."1.29Precipitated abstinence in the diazepam-dependent rat. ( Martin, WR; Sloan, JW; Wala, EP, 1993)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19901 (20.00)18.7374
1990's3 (60.00)18.2507
2000's1 (20.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nassiri-Asl, M1
Shariati-Rad, S1
Zamansoltani, F1
Scollo-Lavizzari, G1
Martin, WR1
Sloan, JW1
Wala, EP1
Rathouská, J1
Kubová, H1
Mares, P1
Vorlícek, J1
Mordel, A1
Winkler, E1
Almog, S1
Tirosh, M1
Ezra, D1

Other Studies

5 other studies available for flumazenil and Epilepsy, Tonic-Clonic

ArticleYear
Anticonvulsive effects of intracerebroventricular administration of rutin in rats.
    Progress in neuro-psychopharmacology & biological psychiatry, 2008, May-15, Volume: 32, Issue:4

    Topics: Animals; Anticonvulsants; Brain; Convulsants; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clon

2008
The anticonvulsant effect of the benzodiazepine antagonist, Ro 15-1788: an EEG study in 4 cases.
    European neurology, 1984, Volume: 23, Issue:1

    Topics: Action Potentials; Adult; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Drug Interactions; El

1984
Precipitated abstinence in the diazepam-dependent rat.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 46, Issue:3

    Topics: Animals; Behavior, Animal; Brain; Diazepam; Drug Implants; Epilepsy, Tonic-Clonic; Female; Flumazeni

1993
Anticonvulsant activity of flumazenil in rats during ontogenetic development.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 44, Issue:3

    Topics: Aging; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; Female; F

1993
Seizures after flumazenil administration in a case of combined benzodiazepine and tricyclic antidepressant overdose.
    Critical care medicine, 1992, Volume: 20, Issue:12

    Topics: Adult; Clonazepam; Diazepam; Drug Overdose; Epilepsy, Tonic-Clonic; Female; Flumazenil; Humans; Imip

1992