flumazenil has been researched along with Epilepsy, Temporal Lobe in 57 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Epilepsy, Temporal Lobe: A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the TEMPORAL LOBE, most commonly from its mesial aspect. A wide variety of psychic phenomena may be associated, including illusions, hallucinations, dyscognitive states, and affective experiences. The majority of complex partial seizures (see EPILEPSY, COMPLEX PARTIAL) originate from the temporal lobes. Temporal lobe seizures may be classified by etiology as cryptogenic, familial, or symptomatic. (From Adams et al., Principles of Neurology, 6th ed, p321).
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have previously shown that an imaging marker, increased periventricular [(11)C]flumazenil ([(11)C]FMZ) binding, is associated with failure to become seizure free (SF) after surgery for temporal lobe epilepsy (TLE) with hippocampal sclerosis (HS)." | 7.81 | Advanced [(18)F]FDG and [(11)C]flumazenil PET analysis for individual outcome prediction after temporal lobe epilepsy surgery for hippocampal sclerosis. ( Costes, N; Gray, KR; Hammers, A; Mauguiere, F; Ryvlin, P; Yankam Njiwa, J, 2015) |
| "Twelve adult patients considered for epilepsy surgery with medically intractable temporal lobe epilepsy (TLE; n = 7), extratemporal lobe epilepsy (ETE; n = 2), and TLE+ETE (n = 3) were prospectively examined with DWI interictally (serving as baseline) and 10 min after application of 1 mg flumazenil i." | 7.72 | Presurgical evaluation of epilepsy by brain diffusion: MR-detected effects of flumazenil on the epileptogenic focus. ( de Greiff, A; Diener, HC; Dörfler, A; Hufnagel, A; Konermann, S; Leonhardt, G; Ludwig, T; Marks, S; Weber, J; Wiedemayer, H, 2003) |
| "By using [11C]flumazenil-positron emission tomography ([11C]FMZ-PET), we have previously shown that reductions of central benzodiazepine receptors (cBZRs) are restricted to the hippocampus in mesial temporal lobe epilepsy (mTLE) caused by unilateral hippocampal sclerosis (HS)." | 7.70 | In vivo [11C]flumazenil-PET correlates with ex vivo [3H]flumazenil autoradiography in hippocampal sclerosis. ( Baird, VH; Bowery, NG; Brooks, DJ; Cunningham, VJ; Duncan, JS; Hand, KS; Koepp, MJ; Labbé, C; Richardson, MP; Van Paesschen, W, 1998) |
| "Using statistical parametric mapping and [11C]flumazenil (FMZ) PET we have previously shown reduction of central benzodiazepine receptor (cBZR) binding restricted to the hippocampus in mesial temporal lobe epilepsy due to unilateral hippocampal sclerosis." | 7.69 | Regional hippocampal [11C]flumazenil PET in temporal lobe epilepsy with unilateral and bilateral hippocampal sclerosis. ( Brooks, DJ; Cunningham, VJ; Duncan, JS; Koepp, MJ; Labbé, C; Richardson, MP; Van Paesschen, W, 1997) |
| "We have previously shown that an imaging marker, increased periventricular [(11)C]flumazenil ([(11)C]FMZ) binding, is associated with failure to become seizure free (SF) after surgery for temporal lobe epilepsy (TLE) with hippocampal sclerosis (HS)." | 3.81 | Advanced [(18)F]FDG and [(11)C]flumazenil PET analysis for individual outcome prediction after temporal lobe epilepsy surgery for hippocampal sclerosis. ( Costes, N; Gray, KR; Hammers, A; Mauguiere, F; Ryvlin, P; Yankam Njiwa, J, 2015) |
| "The objective of this investigation was to characterize quantitatively the time-dependent changes in midazolam (MDL) efficacy in the silent period after induction of status epilepticus (SE) in rats." | 3.74 | Decreased Efficacy of GABAA-receptor modulation by midazolam in the kainate model of temporal lobe epilepsy. ( Danhof, M; Gunput, RA; Liefaard, LC; Voskuyl, RA, 2007) |
| "Twelve adult patients considered for epilepsy surgery with medically intractable temporal lobe epilepsy (TLE; n = 7), extratemporal lobe epilepsy (ETE; n = 2), and TLE+ETE (n = 3) were prospectively examined with DWI interictally (serving as baseline) and 10 min after application of 1 mg flumazenil i." | 3.72 | Presurgical evaluation of epilepsy by brain diffusion: MR-detected effects of flumazenil on the epileptogenic focus. ( de Greiff, A; Diener, HC; Dörfler, A; Hufnagel, A; Konermann, S; Leonhardt, G; Ludwig, T; Marks, S; Weber, J; Wiedemayer, H, 2003) |
| "By using [11C]flumazenil-positron emission tomography ([11C]FMZ-PET), we have previously shown that reductions of central benzodiazepine receptors (cBZRs) are restricted to the hippocampus in mesial temporal lobe epilepsy (mTLE) caused by unilateral hippocampal sclerosis (HS)." | 3.70 | In vivo [11C]flumazenil-PET correlates with ex vivo [3H]flumazenil autoradiography in hippocampal sclerosis. ( Baird, VH; Bowery, NG; Brooks, DJ; Cunningham, VJ; Duncan, JS; Hand, KS; Koepp, MJ; Labbé, C; Richardson, MP; Van Paesschen, W, 1998) |
| "In 4 patients whose seizures were generated by mesial temporal lobe structures, BZ receptor density was measured with [11C]flumazenil PET before, and 1 year after the epilepsy surgery and cessation of seizures." | 3.70 | Regional increases in [11C]flumazenil binding after epilepsy surgery. ( Blomqvist, G; Gulyas, B; Halldin, C; Litton, JE; Savic, I, 1998) |
| "Using statistical parametric mapping and 11C-flumazenil (FMZ) PET we have previously shown reduction of central benzodiazepine receptor (cBZR) binding restricted to the hippocampus in mesial temporal lobe epilepsy (mTLE) due to hippocampal sclerosis (HS)." | 3.69 | 11C-flumazenil PET, volumetric MRI, and quantitative pathology in mesial temporal lobe epilepsy. ( Ashburner, J; Brooks, DJ; Cunningham, VJ; Duncan, JS; Koepp, MJ; Labbé, C; Revesz, T; Richardson, MP; Van Paesschen, W, 1997) |
| " Binding of [11C]-flumazenil to this complex in vivo is reduced in hippocampal sclerosis (HS)." | 3.69 | Central benzodiazepine receptor autoradiography in hippocampal sclerosis. ( Baird, VH; Bowery, NG; Duncan, JS; Hand, KS; Harkness, WF; Koepp, MJ; Revesz, T; Thom, M; Van Paesschen, W, 1997) |
| "Using statistical parametric mapping and [11C]flumazenil (FMZ) PET we have previously shown reduction of central benzodiazepine receptor (cBZR) binding restricted to the hippocampus in mesial temporal lobe epilepsy due to unilateral hippocampal sclerosis." | 3.69 | Regional hippocampal [11C]flumazenil PET in temporal lobe epilepsy with unilateral and bilateral hippocampal sclerosis. ( Brooks, DJ; Cunningham, VJ; Duncan, JS; Koepp, MJ; Labbé, C; Richardson, MP; Van Paesschen, W, 1997) |
| "When flumazenil (3 mg) was administered immediately after intravenous diazepam (10 mg), the reduction in interictal epileptic activity was not significantly different from that produced by diazepam alone." | 2.67 | The effect of intravenous flumazenil on interictal electroencephalographic epileptic activity: results of a placebo-controlled study. ( Hart, YM; Meinardi, H; Nutt, DJ; Sander, JW; Shorvon, SD, 1991) |
| "We observed an early-onset partial epilepsy syndrome with seizure semiology strongly suggestive of temporal lobe epilepsy (TLE), with mild intellectual deficit co-occurring in a large proportion of the patients." | 1.35 | Partial epilepsy syndrome in a Gypsy family linked to 5q31.3-q32. ( Angelicheva, D; Azmanov, DN; Bojinova, V; Brown, M; Carter, K; Guergueltcheva, V; Jablensky, A; Kalaydjieva, L; Kaneva, R; Mihaylova, V; Morar, B; Radionova, M; Sander, JW; Smith, SJ; Stevens, JM; Tournev, I; Zlatareva, D, 2009) |
| "Unilateral mesial temporal lobe epilepsy is associated with insular hypometabolism and benzodiazepine receptor loss." | 1.31 | Insular cortex involvement in mesiotemporal lobe epilepsy: a positron emission tomography study. ( Baulac, M; Bouilleret, V; Dupont, S; Samson, Y; Semah, F; Spelle, L, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.75) | 18.7374 |
| 1990's | 24 (42.11) | 18.2507 |
| 2000's | 23 (40.35) | 29.6817 |
| 2010's | 8 (14.04) | 24.3611 |
| 2020's | 1 (1.75) | 2.80 |
| Authors | Studies |
|---|---|
| Avendaño-Estrada, A | 1 |
| Velasco, F | 1 |
| Velasco, AL | 1 |
| Cuellar-Herrera, M | 1 |
| Saucedo-Alvarado, PE | 1 |
| Marquez-Franco, R | 1 |
| Rivera-Bravo, B | 1 |
| Ávila-Rodríguez, MA | 1 |
| Niu, N | 1 |
| Xing, H | 1 |
| Wu, M | 1 |
| Ma, Y | 1 |
| Liu, Y | 1 |
| Ba, J | 1 |
| Zhu, S | 1 |
| Li, F | 1 |
| Huo, L | 1 |
| Fujitani, S | 1 |
| Matsuda, K | 4 |
| Nakamura, F | 2 |
| Baba, K | 2 |
| Usui, N | 2 |
| Tottori, T | 2 |
| Mihara, T | 3 |
| Terada, K | 3 |
| Usui, K | 2 |
| Inoue, Y | 2 |
| Kajita, Y | 1 |
| Wakabayashi, T | 1 |
| Vivash, L | 2 |
| Gregoire, MC | 3 |
| Lau, EW | 1 |
| Ware, RE | 1 |
| Binns, D | 2 |
| Roselt, P | 2 |
| Bouilleret, V | 3 |
| Myers, DE | 2 |
| Cook, MJ | 1 |
| Hicks, RJ | 2 |
| O'Brien, TJ | 2 |
| Berard, A | 1 |
| Wimberley, C | 1 |
| Katsifis, A | 1 |
| Dedeurwaerdere, S | 1 |
| Yankam Njiwa, J | 1 |
| Gray, KR | 1 |
| Costes, N | 1 |
| Mauguiere, F | 5 |
| Ryvlin, P | 5 |
| Hammers, A | 6 |
| Stanišić, M | 1 |
| Coello, C | 1 |
| Ivanović, J | 1 |
| Egge, A | 1 |
| Danfors, T | 1 |
| Hald, J | 1 |
| Heminghyt, E | 1 |
| Mikkelsen, MM | 1 |
| Krossnes, BK | 1 |
| Pripp, AH | 1 |
| Larsson, PG | 1 |
| Hosomi, K | 1 |
| Kishima, H | 1 |
| Oshino, S | 1 |
| Hirata, M | 1 |
| Tani, N | 1 |
| Maruo, T | 1 |
| Khoo, HM | 1 |
| Shimosegawa, E | 1 |
| Hatazawa, J | 1 |
| Kato, A | 1 |
| Yoshimine, T | 1 |
| Sata, Y | 1 |
| Aihara, M | 1 |
| Yagi, K | 1 |
| Yonekura, Y | 2 |
| Koepp, MJ | 9 |
| Hurlemann, R | 1 |
| Thom, M | 3 |
| Richardson, MP | 4 |
| Brooks, DJ | 8 |
| Duncan, JS | 9 |
| Coste, S | 1 |
| Hermier, M | 1 |
| Konermann, S | 1 |
| Marks, S | 1 |
| Ludwig, T | 1 |
| Weber, J | 1 |
| de Greiff, A | 1 |
| Dörfler, A | 1 |
| Leonhardt, G | 1 |
| Wiedemayer, H | 1 |
| Diener, HC | 1 |
| Hufnagel, A | 1 |
| Leroy, C | 1 |
| Poisbeau, P | 1 |
| Keller, AF | 1 |
| Nehlig, A | 1 |
| Shuke, N | 1 |
| Hashizume, K | 1 |
| Kiriyama, K | 1 |
| Okizaki, A | 1 |
| Yamamoto, W | 1 |
| Zhao, C | 1 |
| Nakai, H | 1 |
| Tanaka, T | 1 |
| Aburano, T | 1 |
| Padma, MV | 1 |
| Simkins, R | 1 |
| White, P | 1 |
| Satter, M | 1 |
| Christian, BT | 1 |
| Dunigan, K | 1 |
| Lee, C | 1 |
| Jacobs, M | 1 |
| Mukherjee, J | 1 |
| Mantil, JC | 1 |
| Morimoto, K | 2 |
| Tamagami, H | 1 |
| Kaneko, K | 1 |
| Sasaki, M | 1 |
| Morioka, T | 1 |
| Koga, H | 1 |
| Abe, K | 1 |
| Sawamoto, H | 1 |
| Ohya, N | 1 |
| Yoshiura, T | 1 |
| Mihara, F | 1 |
| Honda, H | 1 |
| Liefaard, LC | 1 |
| Gunput, RA | 1 |
| Danhof, M | 1 |
| Voskuyl, RA | 1 |
| Panagoda, P | 1 |
| Heckemann, RA | 1 |
| Kelsch, W | 1 |
| Turkheimer, FE | 1 |
| Umeoka, S | 1 |
| Fujiwara, T | 1 |
| Robertson, HA | 1 |
| Bartenstein, P | 2 |
| Koepp, M | 1 |
| Burdette, DE | 1 |
| Sakurai, SY | 1 |
| Henry, TR | 3 |
| Ross, DA | 2 |
| Pennell, PB | 2 |
| Frey, KA | 2 |
| Sackellares, JC | 2 |
| Albin, RL | 1 |
| Staedt, J | 1 |
| Stoppe, G | 1 |
| Kögler, A | 1 |
| Steinhoff, BJ | 1 |
| Gilman, S | 1 |
| Koeppe, RA | 1 |
| Brunberg, JA | 1 |
| Berent, S | 1 |
| Young, AB | 1 |
| Kuhl, DE | 1 |
| Savic, I | 2 |
| Thorell, JO | 1 |
| Tanaka, F | 1 |
| Ikeda, A | 1 |
| Mikuni, N | 1 |
| Nishizawa, S | 1 |
| Ishizu, K | 1 |
| Okazawa, H | 1 |
| Hattori, N | 1 |
| Shibasaki, H | 1 |
| Konishi, J | 1 |
| Onishi, Y | 1 |
| Debets, RM | 1 |
| Sadzot, B | 1 |
| van Isselt, JW | 2 |
| Brekelmans, GJ | 1 |
| Meiners, LC | 1 |
| van Huffelen, AO | 1 |
| Franck, G | 2 |
| van Veelen, CW | 2 |
| Labbé, C | 5 |
| Cunningham, VJ | 4 |
| Ashburner, J | 1 |
| Van Paesschen, W | 4 |
| Revesz, T | 2 |
| Hand, KS | 2 |
| Baird, VH | 2 |
| Harkness, WF | 1 |
| Bowery, NG | 2 |
| Szelies, B | 1 |
| Weber-Luxenburger, G | 1 |
| Pawlik, G | 1 |
| Kessler, J | 1 |
| Holthoff, V | 1 |
| Mielke, R | 1 |
| Herholz, K | 1 |
| Bauer, B | 1 |
| Wienhard, K | 1 |
| Heiss, WD | 1 |
| Venz, S | 1 |
| Hierholzer, J | 1 |
| Cordes, M | 1 |
| Straub, HB | 1 |
| Keske, U | 1 |
| Meencke, HJ | 1 |
| Eichstädt, H | 1 |
| Felix, R | 1 |
| Blomqvist, G | 1 |
| Halldin, C | 1 |
| Litton, JE | 1 |
| Gulyas, B | 1 |
| Bouvard, S | 2 |
| Le Bars, D | 2 |
| De Lamérie, G | 1 |
| Kahane, P | 1 |
| Froment, JC | 1 |
| Juhász, C | 2 |
| Nagy, F | 1 |
| Watson, C | 2 |
| da Silva, EA | 1 |
| Muzik, O | 2 |
| Chugani, DC | 2 |
| Shah, J | 2 |
| Chugani, HT | 2 |
| Woermann, FG | 1 |
| Shah, A | 1 |
| Lamusuo, S | 1 |
| Pitkänen, A | 1 |
| Jutila, L | 1 |
| Ylinen, A | 1 |
| Partanen, K | 1 |
| Kälviäinen, R | 1 |
| Ruottinen, HM | 1 |
| Oikonen, V | 1 |
| Någren, K | 1 |
| Lehikoinen, P | 1 |
| Vapalahti, M | 1 |
| Vainio, P | 1 |
| Rinne, JO | 1 |
| Matheja, P | 1 |
| Lüdemann, P | 1 |
| Kuwert, T | 1 |
| Weckesser, M | 1 |
| Kellinghaus, C | 1 |
| Weitemeyer, L | 1 |
| Diehl, B | 1 |
| Schuierer, G | 1 |
| Ringelstein, EB | 1 |
| Schober, O | 2 |
| Dupont, S | 1 |
| Spelle, L | 1 |
| Baulac, M | 1 |
| Samson, Y | 1 |
| Semah, F | 1 |
| Munkácsy, C | 1 |
| Clemens, B | 1 |
| Ménes, A | 1 |
| Mikecz, P | 1 |
| Trón, L | 1 |
| Sikula, J | 1 |
| Kollár, J | 1 |
| Emri, M | 1 |
| Johnson, EW | 1 |
| de Lanerolle, NC | 1 |
| Kim, JH | 1 |
| Sundaresan, S | 1 |
| Spencer, DD | 1 |
| Mattson, RH | 1 |
| Zoghbi, SS | 1 |
| Baldwin, RM | 1 |
| Hoffer, PB | 1 |
| Seibyl, JP | 1 |
| Haldemann, RC | 1 |
| Bicik, I | 1 |
| Pfeiffer, A | 1 |
| Wieser, HG | 1 |
| Hasler, PH | 1 |
| Schubiger, P | 1 |
| von Schulthess, GK | 1 |
| Ludolph, A | 1 |
| Lottes, G | 1 |
| Scheidhauer, K | 1 |
| Sciuk, J | 1 |
| Beer, HF | 1 |
| Hart, YM | 1 |
| Meinardi, H | 1 |
| Sander, JW | 3 |
| Nutt, DJ | 1 |
| Shorvon, SD | 1 |
| van Huffelen, AC | 1 |
| van Rijk, PP | 1 |
| van Bentum, AM | 1 |
| Dive, D | 1 |
| Maquet, P | 1 |
| Velis, DN | 1 |
| van Emde Boas, W | 1 |
| Angelicheva, D | 2 |
| Tournev, I | 2 |
| Guergueltcheva, V | 1 |
| Mihaylova, V | 1 |
| Azmanov, DN | 2 |
| Morar, B | 2 |
| Radionova, M | 2 |
| Smith, SJ | 1 |
| Zlatareva, D | 2 |
| Stevens, JM | 1 |
| Kaneva, R | 2 |
| Bojinova, V | 1 |
| Carter, K | 1 |
| Brown, M | 1 |
| Jablensky, A | 1 |
| Kalaydjieva, L | 2 |
| Zhelyazkova, S | 1 |
7 reviews available for flumazenil and Epilepsy, Temporal Lobe
| Article | Year |
|---|---|
Performance of PET imaging for the localization of epileptogenic zone in patients with epilepsy: a meta-analysis.
Topics: Epilepsy; Epilepsy, Temporal Lobe; Flumazenil; Fluorodeoxyglucose F18; Humans; Magnetic Resonance Im | 2021 |
[Functional neuroimaging in adults].
Topics: Adult; Anterior Temporal Lobectomy; Anticonvulsants; Carbon Radioisotopes; Combined Modality Therapy | 2004 |
[Benzodiazepine receptor imaging with positron emission tomography and single photon emission tomography].
Topics: Brain; Brain Damage, Chronic; Brain Mapping; Cerebral Cortex; Epilepsies, Partial; Epilepsy, Tempora | 1995 |
Functional neuroimaging with positron emission tomography.
Topics: Anticonvulsants; Brain; Cerebrovascular Circulation; Deoxyglucose; Epilepsy; Epilepsy, Temporal Lobe | 1996 |
[Benzodiazepine receptor imaging in the brain: recent developments and clinical validity].
Topics: Brain; Carbon Radioisotopes; Epilepsy, Temporal Lobe; Flumazenil; Humans; Iodine Radioisotopes; Pani | 1999 |
Relationship between EEG and positron emission tomography abnormalities in clinical epilepsy.
Topics: Biomarkers; Brain Diseases; Brain Diseases, Metabolic; Electroencephalography; Epilepsy; Epilepsy, T | 2000 |
PET: cholinergic neuroreceptor mapping.
Topics: Benzilates; Brain; Calcium Channel Blockers; Epilepsy, Temporal Lobe; Flumazenil; GABA Modulators; H | 2000 |
5 trials available for flumazenil and Epilepsy, Temporal Lobe
| Article | Year |
|---|---|
18F-flumazenil: a γ-aminobutyric acid A-specific PET radiotracer for the localization of drug-resistant temporal lobe epilepsy.
Topics: Adolescent; Adult; Aged; Aminobutyrates; Case-Control Studies; Drug Resistance; Epilepsy, Temporal L | 2013 |
Pre-surgical identification of epileptogenic areas in temporal lobe epilepsy by 123I-iomazenil SPECT: a comparison with IMP SPECT and FDG PET.
Topics: Adolescent; Adult; Epilepsy, Temporal Lobe; Female; Flumazenil; Fluorodeoxyglucose F18; Humans; Iodi | 2006 |
11C-flumazenil PET in patients with refractory temporal lobe epilepsy and normal MRI.
Topics: Adult; Carbon Radioisotopes; Epilepsy, Temporal Lobe; Female; Flumazenil; GABA Modulators; Hippocamp | 2000 |
[11 C]Flumazenil binding in the medial temporal lobe in patients with temporal lobe epilepsy: correlation with hippocampal MR volumetry, T2 relaxometry, and neuropathology.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Epilepsy, Temporal Lobe; Female; Flumazenil; GA | 2000 |
The effect of intravenous flumazenil on interictal electroencephalographic epileptic activity: results of a placebo-controlled study.
Topics: Adult; Anticonvulsants; Brain; Diazepam; Dose-Response Relationship, Drug; Drug Therapy, Combination | 1991 |
45 other studies available for flumazenil and Epilepsy, Temporal Lobe
| Article | Year |
|---|---|
Quantitative Analysis of [18F]FFMZ and [18F]FDG PET Studies in the Localization of Seizure Onset Zone in Drug-Resistant Temporal Lobe Epilepsy.
Topics: Adolescent; Adult; Brain Mapping; Drug Resistant Epilepsy; Epilepsy, Temporal Lobe; Female; Flumazen | 2019 |
Statistical parametric mapping of interictal 123I-iomazenil SPECT in temporal lobe epilepsy surgery.
Topics: Adolescent; Adult; Brain Mapping; Drug Resistance; Epilepsy, Temporal Lobe; Female; Flumazenil; Func | 2013 |
In vivo measurement of hippocampal GABAA/cBZR density with [18F]-flumazenil PET for the study of disease progression in an animal model of temporal lobe epilepsy.
Topics: Animals; Disease Progression; Epilepsy, Temporal Lobe; Flumazenil; Hippocampus; Male; Models, Animal | 2014 |
Advanced [(18)F]FDG and [(11)C]flumazenil PET analysis for individual outcome prediction after temporal lobe epilepsy surgery for hippocampal sclerosis.
Topics: Adult; Carbon Radioisotopes; Epilepsy, Temporal Lobe; Female; Flumazenil; Fluorodeoxyglucose F18; Hi | 2015 |
Seizure outcomes in relation to the extent of resection of the perifocal fluorodeoxyglucose and flumazenil PET abnormalities in anteromedial temporal lobectomy.
Topics: Adolescent; Adult; Anterior Temporal Lobectomy; Child; Epilepsy, Temporal Lobe; Female; Flumazenil; | 2015 |
Altered extrafocal iomazenil activity in mesial temporal lobe epilepsy.
Topics: Adult; Epilepsy, Temporal Lobe; Female; Flumazenil; Follow-Up Studies; Functional Laterality; Humans | 2013 |
Quantitative analysis of benzodiazepine receptor in temporal lobe epilepsy: [(125)I]iomazenil autoradiographic study of surgically resected specimens.
Topics: Adolescent; Adult; Autoradiography; Benzodiazepines; Cell Count; Child; Child, Preschool; Epilepsy, | 2002 |
Abnormalities of grey and white matter [11C]flumazenil binding in temporal lobe epilepsy with normal MRI.
Topics: Adolescent; Adult; Brain; Carbon Radioisotopes; Epilepsy, Temporal Lobe; Female; Flumazenil; Humans; | 2002 |
Temporal pole MRI abnormalities in temporal lobe epilepsy.
Topics: Atrophy; Epilepsy, Temporal Lobe; Flumazenil; GABA Modulators; Humans; Magnetic Resonance Imaging; T | 2002 |
Presurgical evaluation of epilepsy by brain diffusion: MR-detected effects of flumazenil on the epileptogenic focus.
Topics: Adult; Brain Mapping; Cerebral Cortex; Diffusion Magnetic Resonance Imaging; Epilepsy; Epilepsy, Tem | 2003 |
Pharmacological plasticity of GABA(A) receptors at dentate gyrus synapses in a rat model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Diazepam; Disease Models, Animal; Electric Conductivity; Ep | 2004 |
Correct localization of epileptogenic focus with I-123 iomazenil cerebral benzodiazepine receptor imaging: a case report of temporal lobe epilepsy with discordant ictal cerebral blood flow SPECT.
Topics: Adult; Brain Mapping; Cerebrovascular Circulation; Epilepsy, Temporal Lobe; Female; Flumazenil; Huma | 2004 |
Clinical utility of 11C-flumazenil positron emission tomography in intractable temporal lobe epilepsy.
Topics: Adult; Electrophysiology; Epilepsy, Temporal Lobe; Female; Flumazenil; Fluorodeoxyglucose F18; Funct | 2004 |
Periventricular white matter flumazenil binding and postoperative outcome in hippocampal sclerosis.
Topics: Adult; Brain; Cerebral Ventricles; Epilepsy, Temporal Lobe; Female; Flumazenil; Hippocampus; Humans; | 2005 |
Central-type benzodiazepine receptors and epileptogenesis: basic mechanisms and clinical validity.
Topics: Adult; Amygdala; Animals; Autoradiography; Cerebral Cortex; Dentate Gyrus; Disease Models, Animal; E | 2005 |
Decreased Efficacy of GABAA-receptor modulation by midazolam in the kainate model of temporal lobe epilepsy.
Topics: Animals; Autoradiography; Beta Rhythm; Disease Models, Animal; Electroencephalography; Epilepsy, Tem | 2007 |
[11C]Flumazenil PET in temporal lobe epilepsy: do we need an arterial input function or kinetic modeling?
Topics: Adult; Carbon Isotopes; Cerebrovascular Circulation; Epilepsy, Temporal Lobe; Female; Flumazenil; GA | 2008 |
Usefulness of 123I-iomazenil single-photon emission computed tomography in discriminating between mesial and lateral temporal lobe epilepsy in patients in whom magnetic resonance imaging demonstrates normal findings.
Topics: Adult; Electroencephalography; Epilepsy, Temporal Lobe; Female; Flumazenil; Humans; Iodine Radioisot | 2007 |
Evidence for distinct benzodiazepine receptors for anticonvulsant and sedative actions: implications for the treatment of temporal lobe epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Benzodiazepinones; Diazepam; Epilepsy, Temporal Lobe; Flumazenil | 1983 |
Temporal lobe central benzodiazepine binding in unilateral mesial temporal lobe epilepsy.
Topics: Adult; Analysis of Variance; Autoradiography; Epilepsy, Temporal Lobe; Female; Flumazenil; Flunitraz | 1995 |
Changes of central benzodiazepine receptor density in the course of anticonvulsant treatment in temporal lobe epilepsy.
Topics: Adult; Brain Mapping; Carbamazepine; Epilepsy, Temporal Lobe; Female; Flumazenil; Humans; Image Proc | 1995 |
In vivo cerebral metabolism and central benzodiazepine-receptor binding in temporal lobe epilepsy.
Topics: Adult; Brain; Carbon Radioisotopes; Cerebral Cortex; Deoxyglucose; Electroencephalography; Epilepsy, | 1993 |
Localized cerebellar reductions in benzodiazepine receptor density in human partial epilepsy.
Topics: Adult; Cerebellum; Deoxyglucose; Epilepsies, Partial; Epilepsy, Frontal Lobe; Epilepsy, Temporal Lob | 1996 |
Presurgical identification of epileptic foci with iodine-123 iomazenil SPET: comparison with brain perfusion SPET and FDG PET.
Topics: Adult; Brain; Deoxyglucose; Electroencephalography; Epilepsy, Frontal Lobe; Epilepsy, Temporal Lobe; | 1997 |
Is 11C-flumazenil PET superior to 18FDG PET and 123I-iomazenil SPECT in presurgical evaluation of temporal lobe epilepsy?
Topics: Adolescent; Adult; Carbon Radioisotopes; Deoxyglucose; Electroencephalography; Epilepsy, Temporal Lo | 1997 |
11C-flumazenil PET, volumetric MRI, and quantitative pathology in mesial temporal lobe epilepsy.
Topics: Adult; Brain Diseases; Carbon Radioisotopes; Epilepsy, Temporal Lobe; Female; Flumazenil; Hippocampu | 1997 |
Central benzodiazepine receptor autoradiography in hippocampal sclerosis.
Topics: Adult; Autoradiography; Epilepsy, Temporal Lobe; Flumazenil; GABA-A Receptor Antagonists; Hippocampu | 1997 |
MRI-guided flumazenil- and FDG-PET in temporal lobe epilepsy.
Topics: Adult; Blood Glucose; Brain Mapping; Epilepsy, Temporal Lobe; Female; Flumazenil; Fluorodeoxyglucose | 1996 |
Regional hippocampal [11C]flumazenil PET in temporal lobe epilepsy with unilateral and bilateral hippocampal sclerosis.
Topics: Adolescent; Adult; Carbon Radioisotopes; Child; Child, Preschool; Electroencephalography; Epilepsy, | 1997 |
Quantitative estimation of I-123-Iomazenil receptor binding in temporal lobe epilepsies using two SPECT acquisitions--comparison with the regional cerebral blood flow and a compartment model.
Topics: Adult; Brain; Cerebrovascular Circulation; Electroencephalography; Epilepsy, Temporal Lobe; Female; | 1998 |
In vivo [11C]flumazenil-PET correlates with ex vivo [3H]flumazenil autoradiography in hippocampal sclerosis.
Topics: Adult; Autoradiography; Carbon Radioisotopes; Electroencephalography; Epilepsy, Temporal Lobe; Femal | 1998 |
Regional increases in [11C]flumazenil binding after epilepsy surgery.
Topics: Adult; Carbon Radioisotopes; Cerebral Cortex; Confidence Intervals; Epilepsy, Temporal Lobe; Female; | 1998 |
Clinical utility of flumazenil-PET versus [18F]fluorodeoxyglucose-PET and MRI in refractory partial epilepsy. A prospective study in 100 patients.
Topics: Brain; Electroencephalography; Epilepsies, Partial; Epilepsy, Frontal Lobe; Epilepsy, Temporal Lobe; | 1998 |
Transient and falsely lateralizing flumazenil-PET asymmetries in temporal lobe epilepsy.
Topics: Adult; Epilepsy, Temporal Lobe; Flumazenil; Hippocampus; Humans; Reference Values; Time Factors; Tom | 1999 |
Glucose and [11C]flumazenil positron emission tomography abnormalities of thalamic nuclei in temporal lobe epilepsy.
Topics: Adolescent; Adult; Amygdala; Blood Glucose; Brain Mapping; Dominance, Cerebral; Electroencephalograp | 1999 |
Neocortical abnormalities of [11C]-flumazenil PET in mesial temporal lobe epilepsy.
Topics: Adult; Carbon Radioisotopes; Epilepsy, Temporal Lobe; Female; Flumazenil; Humans; Male; Middle Aged; | 2001 |
Disturbed benzodiazepine receptor function at the onset of temporal lobe epilepsy--lomanzenil-binding in de-novo TLE.
Topics: Adolescent; Adult; Binding Sites; Disease Progression; Epilepsy, Temporal Lobe; Female; Flumazenil; | 2001 |
Insular cortex involvement in mesiotemporal lobe epilepsy: a positron emission tomography study.
Topics: Adolescent; Adult; Carbon Radioisotopes; Cerebral Cortex; Epilepsy, Temporal Lobe; Female; Flumazeni | 2002 |
[Effect of flumazenil on the regional cerebral blood flow measured by [15O]-butanol PET scan and transcranial Doppler ultrasonography].
Topics: Adult; Anti-Anxiety Agents; Brain; Butanols; Cerebrovascular Circulation; Epilepsy, Temporal Lobe; F | 2002 |
"Central" and "peripheral" benzodiazepine receptors: opposite changes in human epileptogenic tissue.
Topics: Adult; Autoradiography; Epilepsy, Temporal Lobe; Female; Flumazenil; Hippocampus; Humans; Male; Rece | 1992 |
123I-iomazenil: a quantitative study of the central benzodiazepine receptor distribution.
Topics: Adult; Aged; Amygdala; Epilepsy, Temporal Lobe; Female; Flumazenil; Hippocampus; Humans; Iodine Radi | 1992 |
Benzodiazepine receptors and cerebral blood flow in partial epilepsy.
Topics: Adult; Brain; Cerebrovascular Circulation; Epilepsy, Temporal Lobe; Female; Flumazenil; Humans; Iodi | 1991 |
Identification of the side of epileptic focus with 123I-Iomazenil SPECT. A comparison with 18FDG-PET and ictal EEG findings in patients with medically intractable complex partial seizures.
Topics: Adult; Blood Glucose; Deoxyglucose; Dominance, Cerebral; Electroencephalography; Epilepsy, Temporal | 1990 |
Partial epilepsy syndrome in a Gypsy family linked to 5q31.3-q32.
Topics: Adolescent; Adult; Child; Chromosomes, Human, Pair 5; Electroencephalography; Epilepsies, Partial; E | 2009 |
Focal epilepsy of probable temporal lobe origin in a Gypsy family showing linkage to a novel locus on 7p21.3.
Topics: Adolescent; Adult; Age of Onset; Child; Chromosome Mapping; Chromosomes, Human, Pair 7; Electroencep | 2011 |