Page last updated: 2024-10-27

flumazenil and Epilepsy, Absence

flumazenil has been researched along with Epilepsy, Absence in 4 studies

Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.

Epilepsy, Absence: A seizure disorder usually occurring in childhood characterized by rhythmic electrical brain discharges of generalized onset. Clinical features include a sudden cessation of ongoing activity usually without loss of postural tone. Rhythmic blinking of the eyelids or lip smacking frequently accompanies the SEIZURES. The usual duration is 5-10 seconds, and multiple episodes may occur daily. Juvenile absence epilepsy is characterized by the juvenile onset of absence seizures and an increased incidence of myoclonus and tonic-clonic seizures. (Menkes, Textbook of Child Neurology, 5th ed, p736)

Research Excerpts

ExcerptRelevanceReference
"Five patients with idiopathic generalized epilepsy (IGE) were studied at rest and during absence seizures with [11C]flumazenil and positron emission tomography (PET)."1.29Benzodiazepine-GABAA receptor binding during absence seizures. ( Brooks, DJ; Cunningham, VJ; Duncan, JS; Fish, DR; Lammertsma, AA; Prevett, MC, 1995)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19901 (25.00)18.7374
1990's2 (50.00)18.2507
2000's1 (25.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nassiri-Asl, M1
Shariati-Rad, S1
Zamansoltani, F1
Marescaux, C1
Micheletti, G1
Vergnes, M1
Depaulis, A1
Rumbach, L1
Warter, JM1
Prevett, MC2
Lammertsma, AA2
Brooks, DJ2
Cunningham, VJ1
Fish, DR2
Duncan, JS2
Bartenstein, PA1
Patsalos, PN1

Other Studies

4 other studies available for flumazenil and Epilepsy, Absence

ArticleYear
Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors.
    BMC complementary and alternative medicine, 2007, Aug-08, Volume: 7

    Topics: Animals; Anticonvulsants; Antidotes; Convulsants; Diazepam; Disease Models, Animal; Dose-Response Re

2007
Biphasic effects of Ro 15-1788 on spontaneous petit mal-like seizures in rats.
    European journal of pharmacology, 1984, Jul-13, Volume: 102, Issue:2

    Topics: Animals; Anticonvulsants; Benzodiazepinones; Convulsants; Diazepam; Dose-Response Relationship, Drug

1984
Benzodiazepine-GABAA receptor binding during absence seizures.
    Epilepsia, 1995, Volume: 36, Issue:6

    Topics: Adolescent; Adult; Age of Onset; Brain; Carbon Radioisotopes; Cerebrovascular Circulation; Child; Ep

1995
Benzodiazepine-GABAA receptors in idiopathic generalized epilepsy measured with [11C]flumazenil and positron emission tomography.
    Epilepsia, 1995, Volume: 36, Issue:2

    Topics: Adolescent; Adult; Brain; Carbon Radioisotopes; Cerebral Cortex; Epilepsy, Absence; Female; Flumazen

1995