flumazenil has been researched along with Epilepsies, Partial in 37 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Epilepsies, Partial: Conditions characterized by recurrent paroxysmal neuronal discharges which arise from a focal region of the brain. Partial seizures are divided into simple and complex, depending on whether consciousness is unaltered (simple partial seizure) or disturbed (complex partial seizure). Both types may feature a wide variety of motor, sensory, and autonomic symptoms. Partial seizures may be classified by associated clinical features or anatomic location of the seizure focus. A secondary generalized seizure refers to a partial seizure that spreads to involve the brain diffusely. (From Adams et al., Principles of Neurology, 6th ed, pp317)
| Excerpt | Relevance | Reference |
|---|---|---|
| "When flumazenil (3 mg) was administered immediately after intravenous diazepam (10 mg), the reduction in interictal epileptic activity was not significantly different from that produced by diazepam alone." | 2.67 | The effect of intravenous flumazenil on interictal electroencephalographic epileptic activity: results of a placebo-controlled study. ( Hart, YM; Meinardi, H; Nutt, DJ; Sander, JW; Shorvon, SD, 1991) |
| "Most PET receptor studies in idiopathic generalized epilepsy conducted to date include only small numbers of patients and should be interpreted with caution." | 2.42 | Flumazenil positron emission tomography and other ligands for functional imaging. ( Hammers, A, 2004) |
| "We observed an early-onset partial epilepsy syndrome with seizure semiology strongly suggestive of temporal lobe epilepsy (TLE), with mild intellectual deficit co-occurring in a large proportion of the patients." | 1.35 | Partial epilepsy syndrome in a Gypsy family linked to 5q31.3-q32. ( Angelicheva, D; Azmanov, DN; Bojinova, V; Brown, M; Carter, K; Guergueltcheva, V; Jablensky, A; Kalaydjieva, L; Kaneva, R; Mihaylova, V; Morar, B; Radionova, M; Sander, JW; Smith, SJ; Stevens, JM; Tournev, I; Zlatareva, D, 2009) |
| "Fourteen patients had unilateral frontal lobe epilepsy, five occipital lobe epilepsy (OLE), six parietal lobe epilepsy (PLE) and 19 neocortical epilepsy that was not clearly lobar." | 1.32 | Grey and white matter flumazenil binding in neocortical epilepsy with normal MRI. A PET study of 44 patients. ( Brooks, DJ; Duncan, JS; Hammers, A; Hurlemann, R; Koepp, MJ; Richardson, MP, 2003) |
| "Flumazenil, 1 mg, was injected intravenously in 67 patients undergoing presurgical monitoring for epilepsy surgery, 49 of whom had been treated with benzodiazepines (BZDs) before flumazenil was given." | 1.31 | Induction of partial epileptic seizures by flumazenil. ( Elger, CE; Schulze-Bonhage, A, 2000) |
| "Flumazenil binding was decreased in some MCDs with increased grey matter volume and increased in some adjacent or overlying areas of normal-appearing cortex, suggesting functional abnormalities beyond MRI- detectable structural changes." | 1.31 | Central benzodiazepine receptors in malformations of cortical development: A quantitative study. ( Brooks, DJ; Cunningham, VJ; Duncan, JS; Hammers, A; Koepp, MJ; Labbé, C; Richardson, MP, 2001) |
| "Seventeen patients with unilateral partial epilepsy were subjected to 99mTc-hexamethylpropylene amine oxime (HMPAO) SPECT, and early and delayed IMZ SPECT." | 1.30 | Asymmetries of benzodiazepine receptor binding potential in the inferior medial temporal lobe and cerebellum detected with 123I-iomazenil SPECT in comparison with 99mTc-HMPAO SPECT in patients with partial epilepsy. ( Ichikawa, A; Kuji, I; Sumiya, H; Tonami, N; Tsuji, S, 1998) |
| "All patients had partial epilepsy and normal magnetic resonance imaging (MRI) of the brain." | 1.29 | Cortical benzodiazepine receptor changes are related to frequency of partial seizures: a positron emission tomography study. ( Savic, I; Svanborg, E; Thorell, JO, 1996) |
| "A patient with focal epilepsy due to a localized abnormality in cortical differentiation is presented who showed a marked focal decrease in Bz receptor binding and a normal 99mTc-HMPAO SPECT." | 1.28 | [Cortical dysplasia as an epileptogenic focus: reduced binding of 123I-iomezanil with barely perceptible 99mTc-HMPAO SPECT]. ( Bartenstein, P; Lehmenkühler, C; Schuierer, G; Sciuk, J, 1992) |
| "Ten patients with partial epilepsy and five healthy controls had positron emission tomography (PET) of the brain after intravenous administration of the 11C-labelled benzodiazepine (BZ) receptor ligand 'Ro-15 1788'." | 1.27 | In-vivo demonstration of reduced benzodiazepine receptor binding in human epileptic foci. ( Pauli, S; Persson, A; Roland, P; Savic, I; Sedvall, G; Widén, L, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (5.41) | 18.7374 |
| 1990's | 19 (51.35) | 18.2507 |
| 2000's | 14 (37.84) | 29.6817 |
| 2010's | 2 (5.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ikemoto, S | 1 |
| Hamano, SI | 1 |
| Hirata, Y | 1 |
| Matsuura, R | 1 |
| Kikuchi, K | 1 |
| Komoto, D | 1 |
| Iida, K | 1 |
| Higaki, T | 1 |
| Kaichi, Y | 1 |
| Takauchi, K | 1 |
| Arihiro, K | 1 |
| Kakita, A | 1 |
| Hirokawa, Y | 1 |
| Awai, K | 1 |
| Juhász, C | 2 |
| Asano, E | 1 |
| Shah, A | 2 |
| Chugani, DC | 2 |
| Batista, CE | 1 |
| Muzik, O | 2 |
| Sood, S | 1 |
| Chugani, HT | 2 |
| Goethals, I | 1 |
| Van de Wiele, C | 1 |
| Boon, P | 1 |
| Dierckx, R | 1 |
| Hammers, A | 3 |
| Koepp, MJ | 5 |
| Richardson, MP | 4 |
| Hurlemann, R | 1 |
| Brooks, DJ | 4 |
| Duncan, JS | 5 |
| Ryvlin, P | 3 |
| Mauguière, F | 3 |
| Bouvard, S | 2 |
| Costes, N | 1 |
| Bonnefoi, F | 1 |
| Lavenne, F | 1 |
| Delforge, J | 1 |
| Morimoto, K | 1 |
| Tamagami, H | 1 |
| Matsuda, K | 1 |
| Hirashima, Y | 1 |
| Morimoto, M | 1 |
| Nishimura, A | 1 |
| Osamura, T | 1 |
| Sugimoto, T | 1 |
| Kuki, I | 1 |
| Kawawaki, H | 1 |
| Oba, S | 1 |
| Okazaki, S | 1 |
| Ikeda, H | 1 |
| Tomiwa, K | 1 |
| Bartenstein, P | 2 |
| Koepp, M | 1 |
| Venz, S | 2 |
| Cordes, M | 4 |
| Straub, HB | 1 |
| Hierholzer, J | 2 |
| Schröder, R | 1 |
| Richter, W | 2 |
| Schmitz, B | 3 |
| Meencke, H | 1 |
| Felix, R | 2 |
| Siekmann, R | 1 |
| Keske, U | 1 |
| Eichstädt, H | 2 |
| Verhoeff, NP | 1 |
| Busemann Sokole, E | 1 |
| Hengst, D | 1 |
| Stubbs, JB | 1 |
| van Royen, EA | 1 |
| Savic, I | 3 |
| Svanborg, E | 1 |
| Thorell, JO | 2 |
| Fish, DR | 1 |
| Mielke, R | 1 |
| Weber-Luxenburger, G | 1 |
| Kessler, J | 1 |
| Szelies, B | 1 |
| Heiss, WD | 1 |
| Decoo, D | 1 |
| Destée, A | 1 |
| Bo, P | 1 |
| Soragna, D | 1 |
| Marchioni, E | 1 |
| Albergati, A | 1 |
| Candeloro, E | 1 |
| Savoldi, F | 1 |
| Kuji, I | 1 |
| Sumiya, H | 1 |
| Tsuji, S | 1 |
| Ichikawa, A | 1 |
| Tonami, N | 1 |
| Le Bars, D | 1 |
| De Lamérie, G | 1 |
| Grégoire, MC | 1 |
| Kahane, P | 1 |
| Froment, JC | 1 |
| Koutroumanidis, M | 1 |
| Binnie, CD | 1 |
| Panayiotopoulos, CP | 1 |
| Schulze-Bonhage, A | 1 |
| Elger, CE | 1 |
| Shah, J | 1 |
| Watson, C | 1 |
| Canady, A | 1 |
| Labbé, C | 1 |
| Cunningham, VJ | 1 |
| Lehmenkühler, C | 1 |
| Sciuk, J | 1 |
| Schuierer, G | 1 |
| Olsen, RW | 1 |
| Bureau, M | 1 |
| Houser, CR | 1 |
| Delgado-Escueta, AV | 1 |
| Richards, JG | 1 |
| Möhler, H | 1 |
| Hart, YM | 1 |
| Meinardi, H | 1 |
| Sander, JW | 2 |
| Nutt, DJ | 1 |
| Shorvon, SD | 1 |
| Schubiger, PA | 2 |
| Hasler, PH | 2 |
| Beer-Wohlfahrt, H | 1 |
| Bekier, A | 1 |
| Oettli, R | 1 |
| Ferstl, F | 1 |
| Deisenhammer, E | 1 |
| De Roo, M | 1 |
| Moser, E | 1 |
| Ferstl, FJ | 1 |
| Cordes, I | 1 |
| Henkes, H | 1 |
| Christe, W | 1 |
| Barzen, G | 1 |
| Persson, A | 1 |
| Roland, P | 1 |
| Pauli, S | 1 |
| Sedvall, G | 1 |
| Widén, L | 1 |
| Angelicheva, D | 1 |
| Tournev, I | 1 |
| Guergueltcheva, V | 1 |
| Mihaylova, V | 1 |
| Azmanov, DN | 1 |
| Morar, B | 1 |
| Radionova, M | 1 |
| Smith, SJ | 1 |
| Zlatareva, D | 1 |
| Stevens, JM | 1 |
| Kaneva, R | 1 |
| Bojinova, V | 1 |
| Carter, K | 1 |
| Brown, M | 1 |
| Jablensky, A | 1 |
| Kalaydjieva, L | 1 |
| Kardos, M | 1 |
| Nagy, I | 1 |
| Schultz, K | 1 |
| Kiss, I | 1 |
| Gastonyi, V | 1 |
7 reviews available for flumazenil and Epilepsies, Partial
| Article | Year |
|---|---|
Is central benzodiazepine receptor imaging useful for the identification of epileptogenic foci in localization-related epilepsies?
Topics: Brain; Epilepsies, Partial; Flumazenil; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Humans; Iodi | 2003 |
Flumazenil positron emission tomography and other ligands for functional imaging.
Topics: Brain; Epilepsies, Partial; Epilepsy, Generalized; Flumazenil; GABA Modulators; Humans; Ligands; Neu | 2004 |
[Functional neuroimaging in adults].
Topics: Adult; Anterior Temporal Lobectomy; Anticonvulsants; Carbon Radioisotopes; Combined Modality Therapy | 2004 |
[Benzodiazepine receptor imaging with positron emission tomography and single photon emission tomography].
Topics: Brain; Brain Damage, Chronic; Brain Mapping; Cerebral Cortex; Epilepsies, Partial; Epilepsy, Tempora | 1995 |
PET studies in epilepsy.
Topics: Brain; Carbon Radioisotopes; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Fentanyl; Flumaze | 1997 |
Positron emission tomography in partial epilepsies: the clinical point of view.
Topics: Brain; Carbon Radioisotopes; Cerebrovascular Circulation; Electroencephalography; Epilepsies, Partia | 1998 |
PET: central benzodiazepine neuroreceptor mapping in localization-related epilepsies.
Topics: Cerebral Cortex; Epilepsies, Partial; Flumazenil; GABA Modulators; Hippocampus; Humans; Receptors, G | 2000 |
5 trials available for flumazenil and Epilepsies, Partial
| Article | Year |
|---|---|
[Preoperative evaluation of drug resistant focal epilepsies with 123I-iomazenil SPECT. Comparison with vidio/EEG monitoring and postoperative results].
Topics: Adolescent; Adult; Brain; Child; Electroencephalography; Epilepsies, Partial; Female; Flumazenil; Fo | 1994 |
11C-flumazenil PET in neocortical epilepsy.
Topics: Adolescent; Adult; Brain Mapping; Carbon Isotopes; Epilepsies, Partial; Epilepsy, Frontal Lobe; Fema | 1998 |
The effect of intravenous flumazenil on interictal electroencephalographic epileptic activity: results of a placebo-controlled study.
Topics: Adult; Anticonvulsants; Brain; Diazepam; Dose-Response Relationship, Drug; Drug Therapy, Combination | 1991 |
Evaluation of a multicentre study with Iomazenil--a benzodiazepine receptor ligand.
Topics: Adult; Alzheimer Disease; Brain Chemistry; Epilepsies, Partial; Evaluation Studies as Topic; Female; | 1991 |
123-I-iomazenil-SPECT in patients with focal epilepsies--a comparative study with 99mTc-HMPAO-SPECT, CT and MR.
Topics: Adult; Epilepsies, Partial; Female; Flumazenil; Humans; Iodine Radioisotopes; Magnetic Resonance Ima | 1991 |
25 other studies available for flumazenil and Epilepsies, Partial
| Article | Year |
|---|---|
Maturational Changes of Gamma-Aminobutyric Acid A Receptors Measured With Benzodiazepine Binding of Iodine 123 Iomazenil Single-Photon Emission Computed Tomography.
Topics: Adolescent; Brain; Brain Mapping; Child; Child, Preschool; Epilepsies, Partial; Female; Flumazenil; | 2018 |
Diagnostic Performance of Positron Emission Tomography for the Presurgical Evaluation of Patients with Non-lesional Intractable Partial Epilepsy: Comparison among 18F-FDG, 11C-Flumazenil, and 11C-Flumazenil Binding Potential Imaging Using Statistical Imag
Topics: Adolescent; Adult; Brain; Brain Mapping; Brain Waves; Carbon Radioisotopes; Case-Control Studies; Da | 2015 |
Focal decreases of cortical GABAA receptor binding remote from the primary seizure focus: what do they indicate?
Topics: Adolescent; Carbon Radioisotopes; Cerebral Cortex; Child; Child, Preschool; Dominance, Cerebral; Ele | 2009 |
Grey and white matter flumazenil binding in neocortical epilepsy with normal MRI. A PET study of 44 patients.
Topics: Adolescent; Adult; Artifacts; Epilepsies, Partial; Epilepsy, Frontal Lobe; False Negative Reactions; | 2003 |
Seizure-related short-term plasticity of benzodiazepine receptors in partial epilepsy: a [11C]flumazenil-PET study.
Topics: Adolescent; Adult; Carbon Radioisotopes; Drug Resistance; Electroencephalography; Epilepsies, Partia | 2005 |
Central-type benzodiazepine receptors and epileptogenesis: basic mechanisms and clinical validity.
Topics: Adult; Amygdala; Animals; Autoradiography; Cerebral Cortex; Dentate Gyrus; Disease Models, Animal; E | 2005 |
Alternative psychosis and dysgraphia accompanied by forced normalization in a girl with occipital lobe epilepsy.
Topics: Agraphia; Anticonvulsants; Carbamazepine; Child; Electroencephalography; Epilepsies, Partial; Female | 2008 |
[123I iomazenil SPECT and identification of the epileptogenic tubers in patients with tuberous sclerosis].
Topics: Adolescent; Adult; Cerebral Cortex; Child; Child, Preschool; Epilepsies, Partial; Female; Flumazenil | 2008 |
[123I-iomazenil- and 99mTc-HMPAO in the diagnosis of focal epilepsies: a comparison of untreated and treated patients].
Topics: Adolescent; Adult; Epilepsies, Partial; Female; Flumazenil; Humans; Iodine Radioisotopes; Male; Midd | 1994 |
Dosimetry of iodine-123 iomazenil in humans.
Topics: Adult; Epilepsies, Partial; Flumazenil; Humans; Iodine Radioisotopes; Male; Middle Aged; Radiometry; | 1993 |
Cortical benzodiazepine receptor changes are related to frequency of partial seizures: a positron emission tomography study.
Topics: Adult; Carbon Radioisotopes; Cerebral Cortex; Electroencephalography; Epilepsies, Partial; Female; F | 1996 |
Benzodiazepine receptors in focal epilepsy with cortical dysgenesis: an 11C-flumazenil PET study.
Topics: Adult; Aged; Carbon Radioisotopes; Cerebral Cortex; Epilepsies, Partial; Female; Flumazenil; gamma-A | 1996 |
Localized cerebellar reductions in benzodiazepine receptor density in human partial epilepsy.
Topics: Adult; Cerebellum; Deoxyglucose; Epilepsies, Partial; Epilepsy, Frontal Lobe; Epilepsy, Temporal Lob | 1996 |
Widespread functional deficits in perception-related networks demonstrated by PET in a case with simple visual seizures.
Topics: Adult; Carbon Radioisotopes; Deoxyglucose; Electroencephalography; Epilepsies, Partial; Female; Flum | 1997 |
The effects of flumazenil on focal, electroinduced after-discharge in rabbits.
Topics: Amygdala; Animals; Anticonvulsants; Benzodiazepines; Brain; Electric Stimulation; Electroencephalogr | 1998 |
Asymmetries of benzodiazepine receptor binding potential in the inferior medial temporal lobe and cerebellum detected with 123I-iomazenil SPECT in comparison with 99mTc-HMPAO SPECT in patients with partial epilepsy.
Topics: Adult; Cerebellum; Epilepsies, Partial; Female; Flumazenil; Humans; Iodine Radioisotopes; Male; Midd | 1998 |
Clinical utility of flumazenil-PET versus [18F]fluorodeoxyglucose-PET and MRI in refractory partial epilepsy. A prospective study in 100 patients.
Topics: Brain; Electroencephalography; Epilepsies, Partial; Epilepsy, Frontal Lobe; Epilepsy, Temporal Lobe; | 1998 |
Induction of partial epileptic seizures by flumazenil.
Topics: Anticonvulsants; Benzodiazepines; Electrodes, Implanted; Electroencephalography; Epilepsies, Partial | 2000 |
Relationship of flumazenil and glucose PET abnormalities to neocortical epilepsy surgery outcome.
Topics: Adolescent; Adult; Brain Mapping; Child; Child, Preschool; Electroencephalography; Epilepsies, Parti | 2001 |
Central benzodiazepine receptors in malformations of cortical development: A quantitative study.
Topics: Adolescent; Adult; Carbon Radioisotopes; Central Nervous System; Cerebral Cortex; Child; Child, Pres | 2001 |
[Cortical dysplasia as an epileptogenic focus: reduced binding of 123I-iomezanil with barely perceptible 99mTc-HMPAO SPECT].
Topics: Cerebral Cortex; Epilepsies, Partial; Female; Flumazenil; Humans; Iodine Radioisotopes; Middle Aged; | 1992 |
GABA/benzodiazepine receptors in human focal epilepsy.
Topics: Amygdala; Autoradiography; Brain Mapping; Dominance, Cerebral; Electroencephalography; Epilepsies, P | 1992 |
In-vivo demonstration of reduced benzodiazepine receptor binding in human epileptic foci.
Topics: Adult; Analysis of Variance; Carbon Radioisotopes; Cerebral Cortex; Epilepsies, Partial; Female; Flu | 1988 |
Partial epilepsy syndrome in a Gypsy family linked to 5q31.3-q32.
Topics: Adolescent; Adult; Child; Chromosomes, Human, Pair 5; Electroencephalography; Epilepsies, Partial; E | 2009 |
[Congenital type I antithrombin III deficiency with serious complications in a 7-year-old girl].
Topics: Acenocoumarol; Antithrombin III Deficiency; Ataxia; Blood Coagulation Disorders; Child; Epilepsies, | 1989 |