flumazenil has been researched along with Dystonia in 3 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Dystonia: An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often affects the large axial muscles of the trunk and limb girdles. Conditions which feature persistent or recurrent episodes of dystonia as a primary manifestation of disease are referred to as DYSTONIC DISORDERS. (Adams et al., Principles of Neurology, 6th ed, p77)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The underlying mechanisms of idiopathic dystonias are poorly understood." | 1.31 | Effects of striatal injections of GABA(A) receptor agonists and antagonists in a genetic animal model of paroxysmal dystonia. ( Hamann, M; Richter, A, 2002) |
| "Because dystonia in mutant dtsz hamsters is transient and disappears after approximately 60-70 days of age, [3H]flumazenil binding was studied at the age of maximum severity of dystonia (30-40 days) and after disappearance of the disease, to examine which neurochemical changes were related to dystonia." | 1.29 | Regionally selective and age-dependent alterations in benzodiazepine receptor binding in the genetically dystonic hamster. ( Löscher, W; Möhler, H; Pratt, GD; Richter, A, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pratt, GD | 1 |
| Richter, A | 2 |
| Möhler, H | 1 |
| Löscher, W | 1 |
| Hamann, M | 1 |
| Stolarek, IH | 1 |
| Ford, MJ | 1 |
3 other studies available for flumazenil and Dystonia
| Article | Year |
|---|---|
Regionally selective and age-dependent alterations in benzodiazepine receptor binding in the genetically dystonic hamster.
Topics: Aging; Animals; Binding Sites; Brain; Cerebellum; Corpus Striatum; Cricetinae; Disease Models, Anima | 1995 |
Effects of striatal injections of GABA(A) receptor agonists and antagonists in a genetic animal model of paroxysmal dystonia.
Topics: Animals; Bicuculline; Binding Sites; Corpus Striatum; Cricetinae; Dystonia; Female; Flumazenil; Flur | 2002 |
Acute dystonia induced by midazolam and abolished by flumazenil.
Topics: Acute Disease; Adolescent; Dystonia; Flumazenil; Humans; Male; Midazolam | 1990 |