flumazenil has been researched along with Drug Overdose in 82 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate cost effectiveness of administration of flumazenil to patients presenting with suspected acute drug overdose." | 9.09 | Flumazenil in drug overdose: randomized, placebo-controlled study to assess cost effectiveness. ( Barnett, R; Boothe, P; Finegan, BA; Grace, M; Latozek, K; Legatt, D; Neal, C, 1999) |
| "The use of flumazenil, a benzodiazepine antagonist, was studied in two patients with coma of unknown etiology." | 9.06 | The diagnostic utility of flumazenil (a benzodiazepine antagonist) in coma of unknown etiology. ( Burkhart, KK; Kulig, KW, 1990) |
| "Flumazenil is a valuable and safe differential diagnostic tool in unclear cases of multiple drug poisoning." | 9.06 | Diagnostic utility of flumazenil in coma with suspected poisoning: a double blind, randomised controlled study. ( Baehrendtz, S; Gustafsson, LL; Höjer, J; Matell, G, 1990) |
| "Comatose patients with clinical or ECG criteria thought to contraindicate the use of flumazenil have a reasonably high risk of seizures after administration of this drug." | 7.69 | Empiric use of flumazenil in comatose patients: limited applicability of criteria to define low risk. ( Baud, FJ; Gueye, PN; Hoffman, JR; Taboulet, P; Vicaut, E, 1996) |
| "Anterograde amnesia, possibly accompanied by acute brain syndrome, is a potential side-effect of certain benzodiazepines, particularly triazolam." | 7.68 | Anterograde amnesia in triazolam overdose despite flumazenil treatment: a case report. ( Deng, JF; Hung, DZ; Tsai, WJ, 1992) |
| "The Glasgow coma scale and a sedation-level scoring system were checked prior to and at 1, 5, and 30 minutes after the dose eliciting response or on completion of the full dose of flumazenil." | 5.29 | Diagnostic and therapeutic utility of flumazenil in comatose patients with drug overdose. ( Chern, TL; Deng, JF; Hu, SC; Lee, CH, 1993) |
| "The use of flumazenil, a benzodiazepine antagonist, was studied in two patients with coma of unknown etiology." | 5.06 | The diagnostic utility of flumazenil (a benzodiazepine antagonist) in coma of unknown etiology. ( Burkhart, KK; Kulig, KW, 1990) |
| "Flumazenil is a valuable and safe differential diagnostic tool in unclear cases of multiple drug poisoning." | 5.06 | Diagnostic utility of flumazenil in coma with suspected poisoning: a double blind, randomised controlled study. ( Baehrendtz, S; Gustafsson, LL; Höjer, J; Matell, G, 1990) |
| " Flumazenil is an effective antidote but there is a risk of seizures, particularly in those who have co-ingested tricyclic antidepressants." | 3.78 | Flumazenil use in benzodiazepine overdose in the UK: a retrospective survey of NPIS data. ( Cooper, G; Dyas, J; Routledge, PA; Thompson, JP; Veiraiah, A, 2012) |
| "Included patient were those aged 12 years or younger who received flumazenil, who had evidence of clinical poisoning as defined by an altered mental status, and who were reported to the California Poison Control System for the period 1999 to 2008." | 3.78 | Flumazenil administration in poisoned pediatric patients. ( Cantrell, FL; Clark, RF; Kreshak, AA; Tomaszewski, CA, 2012) |
| "Flumazenil is a central antagonist of the sedative effects of benzodiazepines." | 3.77 | Topics in clinical pharmacology: flumazenil, a benzodiazepine antagonist. ( Longmire, AW; Seger, DL, 1993) |
| "Comatose patients with clinical or ECG criteria thought to contraindicate the use of flumazenil have a reasonably high risk of seizures after administration of this drug." | 3.69 | Empiric use of flumazenil in comatose patients: limited applicability of criteria to define low risk. ( Baud, FJ; Gueye, PN; Hoffman, JR; Taboulet, P; Vicaut, E, 1996) |
| " When sedation with benzodiazepines is carried out, the specific antagonist, flumazenil should always be available for use in emergencies such as accidental oversedation, iatrogenic overdose or paradoxical reactions." | 3.69 | Use of inhalational and intravenous sedation in dentistry. ( Rodrigo, MR, 1997) |
| "To report a fatal case of refractory status epilepticus precipitated by flumazenil use in a mixed benzodiazepine-tricyclic antidepressant overdose." | 3.69 | Fatal seizures after flumazenil administration in a patient with mixed overdose. ( DiSalvo, RP; Haverkos, GP; Imhoff, TE, 1994) |
| "Anterograde amnesia, possibly accompanied by acute brain syndrome, is a potential side-effect of certain benzodiazepines, particularly triazolam." | 3.68 | Anterograde amnesia in triazolam overdose despite flumazenil treatment: a case report. ( Deng, JF; Hung, DZ; Tsai, WJ, 1992) |
| "Administration of flumazenil is safe in benzodiazepine-poisoned patients with appropriate indications." | 3.01 | Protective effect of flumazenil infusion in severe acute benzodiazepine toxicity: a pilot randomized trial. ( Ebrahimi, S; Hassanian-Moghaddam, H; Razavizadeh, AS; Zamani, N; Ziaeefar, P, 2021) |
| "1 mg/minute) to avoid complications or withhold the administration with development of first signs of adverse effects." | 2.82 | Strategies for the treatment of acute benzodiazepine toxicity in a clinical setting: the role of antidotes. ( Hassanian-Moghaddam, H; Zamani, N, 2022) |
| "Flumazenil was not given in 55 cases." | 2.68 | Emergency department use of flumazenil prior to poison center consultation. ( Aks, S; Burda, T; Fischbein, C; Leikin, JB; Woods, K, 1997) |
| "Flumazenil acts as an antidote for pharmacological and toxic effects due to benzodiazepines." | 2.67 | Efficacy of flumazenil in acute alcohol intoxication: double blind placebo-controlled evaluation. ( Askenasi, R; Lheureux, P, 1991) |
| " Serious adverse events (SAEs) including seizures and cardiac arrhythmias have been reported in patients treated with flumazenil, and the clinical advantage of flumazenil treatment has been questioned." | 2.53 | Adverse Events Associated with Flumazenil Treatment for the Management of Suspected Benzodiazepine Intoxication--A Systematic Review with Meta-Analyses of Randomised Trials. ( Graudal, N; Jürgens, G; Ladekarl, MB; Penninga, EI, 2016) |
| "Flumazenil has been reported to reverse sedation from all three Z-drugs." | 2.49 | The clinical and forensic toxicology of Z-drugs. ( Gunja, N, 2013) |
| "Flumazenil is a specific and competitive antagonist at the central benzodiazepine receptor, reversing all effects of benzodiazepine agonists without tranquillising or anticonvulsant actions." | 2.40 | A risk-benefit assessment of flumazenil in the management of benzodiazepine overdose. ( Flaishon, R; Rudick, V; Sorkine, P; Szold, O; Weinbroum, AA, 1997) |
| "Flumazenil is a benzodiazepine receptor antagonist used to reverse sedation and respiratory depression induced by benzodiazepines." | 2.39 | Seizure after flumazenil administration in a pediatric patient. ( McDuffee, AT; Tobias, JD, 1995) |
| "Flumazenil has been studied for a variety of indications, including as an antidote to benzodiazepine overdose and for awakening of comatose patients, reversal of sedation after surgery and in critically ill patients, and management of hepatic encephalopathy." | 2.38 | Flumazenil: a benzodiazepine antagonist. ( Hoffman, EJ; Warren, EW, 1993) |
| "Drug overdose is therefore a medical emergency necessitating close observation and support of vital functions." | 2.38 | The use of flumazenil in the management of acute drug poisoning--a review. ( Geller, E; Halpern, P; Weinbroum, A, 1991) |
| "Flumazenil is a recently discovered pharmacologic antagonist of the CNS effects of benzodiazepines." | 2.38 | Flumazenil: a new benzodiazepine antagonist. ( Bayer, MJ; Bosse, GM; Hoffman, JR; Votey, SR, 1991) |
| "Opiate abuse is often associated with benzodiazepine abuse." | 2.38 | [Drug emergencies]. ( Monotti, R, 1993) |
| "The incidence of coma was significantly higher, and the length of hospital stay significantly longer in elderly." | 1.43 | Benzodiazepine poisoning in elderly. ( Djordjević, S; Ercegović, GV; Segrt, Z; Stosić, JJ; Vukcević, NP, 2016) |
| " Considering the long half-life of diazepam and its metabolites, concomitant use of theophylline may reduce the need for repeated dosing of flumazenil in patients with acute diazepam poisoning." | 1.43 | Determination of flumazenil in serum by liquid chromatography-mass spectrometry: Application to kinetics study in acute diazepam overdose. ( Djordjević, S; Jović-Stosić, J; Kilibarda, V; Perković-Vukcević, N; Segrt, Z, 2016) |
| "A 27-year-old man, presented with deep coma, bilateral pinpoint unreactive pupils, acute respiratory failure and hypotension, complicated by hypoxic ischemic changes in the central nervous system." | 1.43 | Flubromazolam--A new life-threatening designer benzodiazepine. ( Panieński, P; Sommerfeld, K; Teżyk, A; Żaba, C; Zielińska-Psuja, B; Łukasik-Głębocka, M, 2016) |
| " Ongoing monitoring of this particular adverse event will be required with a sustained patient safety message to health services to maintain awareness of the issue and reduction in the number of midazolam-related errors." | 1.42 | Reducing risk of overdose with midazolam injection in adults: an evaluation of change in clinical practice to improve patient safety in England. ( Flood, C; Lamont, T; Mansaray, M; Marsh, R; Matthew, L; Patel, B, 2015) |
| "The objective of the study is to assess adverse events and clinical outcomes of flumazenil administration in known and suspected BZD overdose in an ED at a tertiary academic medical center." | 1.42 | Lack of adverse effects from flumazenil administration: an ED observational study. ( Cumpston, K; Nguyen, TT; Rose, SR; Troendle, M; Wills, BK, 2015) |
| "A 10-year-old boy with trisomy 21 presented to the emergency department 1 hour after he was found sedate with several zolpidem 5-mg tablets in his mouth." | 1.39 | Pediatric zolpidem ingestion demonstrating zero-order kinetics treated with flumazenil. ( Carstairs, SD; Negus, E; Thornton, SL, 2013) |
| "Buprenorphine is a partial opioid agonist with a "ceiling effect" for respiratory depression." | 1.36 | Prospective comparative assessment of buprenorphine overdose with heroin and methadone: clinical characteristics and response to antidotal treatment. ( Baud, FJ; Buisine, A; Chevillard, L; Jacobs, F; Mégarbane, B; Résière, D; Vicaut, E, 2010) |
| "She developed generalized seizures shortly after the administration of flumazenil." | 1.35 | [Seizure triggered by benzodiazepine receptor antagonist]. ( Pedersen, LM; Petersen, M; Søndergaard, I, 2009) |
| "Flumazenil was administered as escalating bolus doses followed by a continuous infusion." | 1.31 | Mechanism of respiratory insufficiency in pure or mixed drug-induced coma involving benzodiazepines. ( Baud, FJ; Borron, SW; Gueye, PN; Harf, A; Lofaso, F; Mellerio, F; Vicaut, E, 2002) |
| "The Glasgow coma scale and a sedation-level scoring system were checked prior to and at 1, 5, and 30 minutes after the dose eliciting response or on completion of the full dose of flumazenil." | 1.29 | Diagnostic and therapeutic utility of flumazenil in comatose patients with drug overdose. ( Chern, TL; Deng, JF; Hu, SC; Lee, CH, 1993) |
| "Only one anorectic patient became comatose after ingestion of 0." | 1.29 | [Acute overdose of Zolpidem (Stilnox)]. ( Meier-Abt, PJ; Radovanovic, D; Wyss, PA, 1996) |
| "Midazolam has limited influence on the cardiac toxic effects of amitriptyline." | 1.28 | Flumazenil in mixed benzodiazepine/tricyclic antidepressant overdose: a placebo-controlled study in the dog. ( Askenasi, R; Leduc, D; Lheureux, P; Vranckx, M, 1992) |
| "Flumazenil is a competitive benzodiazepine antagonist." | 1.28 | Complete heart block after flumazenil. ( Clarke, F; Herd, B, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 47 (57.32) | 18.2507 |
| 2000's | 12 (14.63) | 29.6817 |
| 2010's | 20 (24.39) | 24.3611 |
| 2020's | 3 (3.66) | 2.80 |
| Authors | Studies |
|---|---|
| Zamani, N | 3 |
| Hassanian-Moghaddam, H | 2 |
| Razavizadeh, AS | 1 |
| Ziaeefar, P | 1 |
| Ebrahimi, S | 1 |
| Schult, RF | 1 |
| Omar, D | 1 |
| Wiegand, TJ | 1 |
| Gordetsky, RM | 1 |
| Acquisto, NM | 1 |
| Cimolai, N | 1 |
| Gunja, N | 1 |
| Thornton, SL | 1 |
| Negus, E | 1 |
| Carstairs, SD | 1 |
| Kyong, YY | 1 |
| Park, JT | 1 |
| Choi, KH | 1 |
| Flood, C | 1 |
| Matthew, L | 1 |
| Marsh, R | 1 |
| Patel, B | 1 |
| Mansaray, M | 1 |
| Lamont, T | 1 |
| Sencion Martinez, GL | 1 |
| Samillán, K | 1 |
| Espinosa, JL | 1 |
| Rodriguez Puyol, D | 1 |
| Martinez Miguel, P | 1 |
| Villa, P | 1 |
| Penninga, EI | 1 |
| Graudal, N | 1 |
| Ladekarl, MB | 1 |
| Jürgens, G | 1 |
| Nguyen, TT | 1 |
| Troendle, M | 1 |
| Cumpston, K | 1 |
| Rose, SR | 1 |
| Wills, BK | 1 |
| Sivilotti, ML | 1 |
| Łukasik-Głębocka, M | 1 |
| Sommerfeld, K | 1 |
| Teżyk, A | 1 |
| Zielińska-Psuja, B | 1 |
| Panieński, P | 1 |
| Żaba, C | 1 |
| Djordjević, S | 2 |
| Jović-Stosić, J | 1 |
| Kilibarda, V | 1 |
| Segrt, Z | 2 |
| Perković-Vukcević, N | 1 |
| Yonel, Z | 1 |
| Asuni, A | 1 |
| Taneja, P | 1 |
| Vukcević, NP | 1 |
| Ercegović, GV | 1 |
| Stosić, JJ | 1 |
| Yagi, K | 1 |
| An, H | 1 |
| Godwin, J | 1 |
| Yang, CC | 1 |
| Deng, JF | 3 |
| Pedersen, LM | 1 |
| Petersen, M | 1 |
| Søndergaard, I | 1 |
| Mégarbane, B | 1 |
| Buisine, A | 1 |
| Jacobs, F | 1 |
| Résière, D | 1 |
| Chevillard, L | 1 |
| Vicaut, E | 3 |
| Baud, FJ | 3 |
| Weaver, JM | 1 |
| Veiraiah, A | 1 |
| Dyas, J | 1 |
| Cooper, G | 1 |
| Routledge, PA | 1 |
| Thompson, JP | 1 |
| Wilson, KE | 1 |
| Thorpe, RJ | 1 |
| McCabe, JF | 1 |
| Girdler, NM | 1 |
| Kreshak, AA | 1 |
| Tomaszewski, CA | 1 |
| Clark, RF | 1 |
| Cantrell, FL | 1 |
| Rodenberg, H | 1 |
| Siddiqi, M | 1 |
| Jennings, CA | 1 |
| Bartlett, D | 1 |
| Tote, S | 1 |
| Mulleague, L | 1 |
| Carai, MA | 1 |
| Colombo, G | 1 |
| Gessa, GL | 1 |
| Thomson, JS | 1 |
| Donald, C | 1 |
| Lewin, K | 1 |
| Carvalho, C | 1 |
| Walker, DA | 1 |
| McDuffee, AT | 1 |
| Tobias, JD | 1 |
| Haverkos, GP | 1 |
| DiSalvo, RP | 1 |
| Imhoff, TE | 1 |
| Weinberg, AD | 1 |
| Pals, JK | 1 |
| Marinelli, FC | 1 |
| Thibault, GE | 1 |
| Birnbaumer, DM | 1 |
| Isaacs, SM | 1 |
| Longmire, AW | 1 |
| Seger, DL | 1 |
| Sugarman, JM | 1 |
| Paul, RI | 1 |
| Klarlund, R | 1 |
| Metzger, E | 1 |
| Spivey, WH | 1 |
| Roberts, JR | 1 |
| Derlet, RW | 1 |
| Hoffman, EJ | 1 |
| Warren, EW | 1 |
| Krenzelok, EP | 2 |
| Krisanda, TJ | 1 |
| Chern, TL | 2 |
| Hu, SC | 1 |
| Lee, CH | 1 |
| Stahl, MM | 1 |
| Saldeen, P | 1 |
| Vinge, E | 1 |
| Monotti, R | 1 |
| Gueye, PN | 2 |
| Hoffman, JR | 2 |
| Taboulet, P | 1 |
| Wyss, PA | 1 |
| Radovanovic, D | 1 |
| Meier-Abt, PJ | 1 |
| Perry, HE | 1 |
| Shannon, MW | 1 |
| Kwan, A | 1 |
| Burda, T | 1 |
| Leikin, JB | 1 |
| Fischbein, C | 1 |
| Woods, K | 1 |
| Aks, S | 1 |
| Weinbroum, AA | 1 |
| Flaishon, R | 1 |
| Sorkine, P | 1 |
| Szold, O | 1 |
| Rudick, V | 1 |
| Goldfrank, LR | 1 |
| Rodrigo, MR | 1 |
| Roberge, RJ | 1 |
| Atchley, B | 1 |
| Ryan, K | 1 |
| Shepherd, G | 1 |
| Barnett, R | 1 |
| Grace, M | 1 |
| Boothe, P | 1 |
| Latozek, K | 1 |
| Neal, C | 1 |
| Legatt, D | 1 |
| Finegan, BA | 1 |
| Singh, PK | 1 |
| Richell-Herren, K | 1 |
| James, M | 1 |
| Vijayalakshmi, G | 1 |
| Das, DG | 1 |
| Buylaert, WA | 1 |
| Lofaso, F | 1 |
| Borron, SW | 1 |
| Mellerio, F | 1 |
| Harf, A | 1 |
| Hung, DZ | 1 |
| Tsai, WJ | 1 |
| Pietilä, K | 1 |
| Valve, K | 1 |
| Bruguerolle, B | 1 |
| Emperaire, N | 1 |
| Mordel, A | 1 |
| Winkler, E | 1 |
| Almog, S | 1 |
| Tirosh, M | 1 |
| Ezra, D | 1 |
| Lheureux, P | 4 |
| Vranckx, M | 2 |
| Leduc, D | 2 |
| Askenasi, R | 4 |
| Herd, B | 1 |
| Clarke, F | 1 |
| Weinbroum, A | 1 |
| Halpern, P | 1 |
| Geller, E | 2 |
| Höjer, J | 2 |
| Baehrendtz, S | 2 |
| Magnusson, A | 1 |
| Gustafsson, LL | 2 |
| Crome, P | 1 |
| Schaller, MD | 1 |
| Marchant, B | 1 |
| Ectors, M | 1 |
| Scollo-Lavizzari, G | 2 |
| Matell, G | 1 |
| Votey, SR | 1 |
| Bosse, GM | 1 |
| Bayer, MJ | 1 |
| Vrankx, M | 1 |
| Passeron, D | 1 |
| Biboulet, P | 1 |
| Beauvoir, C | 1 |
| Burkhart, KK | 1 |
| Kulig, KW | 1 |
| Ritz, R | 1 |
| Zuber, M | 1 |
| Elsasser, S | 1 |
| Karavokiros, KA | 1 |
| Tsipis, GB | 1 |
| Lopez, A | 1 |
| Rebollo, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Flumazenil on Hypoactive Delirium in the ICU: A Double-Blind, Placebo-Controlled Pilot Study[NCT02899156] | Phase 4 | 22 participants (Actual) | Interventional | 2016-03-31 | Terminated (stopped due to A planned interim analysis led to the trial being stopped early based on the observed size effect and power analysis.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
average duration of time patient was randomized to each infusion up to 72 hours (NCT02899156)
Timeframe: up to 72 hours after the start of the infusion
| Intervention | hours (Mean) |
|---|---|
| Flumazenil Group | 54.8 |
| Placebo Group | 58.2 |
average maximum rate (ml/hr) during the 72 hours after study infusion (NCT02899156)
Timeframe: up to 72 hours after the start of the infusion
| Intervention | milliliters per hour (Mean) |
|---|---|
| Flumazenil Group | 5 |
| Placebo Group | 5.2 |
length of time that the patient was admitted to an intensive care unit service during the hospital stay (NCT02899156)
Timeframe: duration of admission to the intensive care unit
| Intervention | days (Mean) |
|---|---|
| Flumazenil Group | 7.8 |
| Placebo Group | 7 |
Defined by the number of days in the 14-day period after randomization that the patient was alive and not delirious (i.e. CAM-ICU negative). Zero delirium-free days will be observed for patients that die within the 14-day period. (NCT02899156)
Timeframe: up to 14 days after randomization
| Intervention | days (Median) |
|---|---|
| Flumazenil Group | 12.7 |
| Placebo Group | 9.2 |
number of days within the first 28 days after enrollment that the patient was free from needing mechanical ventilation (NCT02899156)
Timeframe: up to 28 days after randomization
| Intervention | days (Mean) |
|---|---|
| Flumazenil Group | 23.6 |
| Placebo Group | 24.9 |
defined by the proportion of patients who were delirium free at 14 days after randomization (NCT02899156)
Timeframe: up to 14 days after randomization
| Intervention | Participants (Count of Participants) |
|---|---|
| Flumazenil Group | 9 |
| Placebo Group | 7 |
number of times that a RASS score of + 2 to +4 occurred that did not resolve with decreasing study infusion (NCT02899156)
Timeframe: up to 72 hours after the start of the infusion
| Intervention | Participants (Count of Participants) |
|---|---|
| Flumazenil Group | 0 |
| Placebo Group | 0 |
20 reviews available for flumazenil and Drug Overdose
| Article | Year |
|---|---|
Strategies for the treatment of acute benzodiazepine toxicity in a clinical setting: the role of antidotes.
Topics: Antidotes; Benzodiazepines; Drug Overdose; Flumazenil; Humans | 2022 |
The clinical and forensic toxicology of Z-drugs.
Topics: Acetamides; Azabicyclo Compounds; Coma; Drug Overdose; Flumazenil; GABA Modulators; GABA-A Receptor | 2013 |
Adverse Events Associated with Flumazenil Treatment for the Management of Suspected Benzodiazepine Intoxication--A Systematic Review with Meta-Analyses of Randomised Trials.
Topics: Antidotes; Benzodiazepines; Drug Overdose; Flumazenil; Humans; Randomized Controlled Trials as Topic | 2016 |
Flumazenil, naloxone and the 'coma cocktail'.
Topics: Analgesics, Opioid; Antidotes; Benzodiazepines; Coma; Drug Overdose; Flumazenil; Humans; Naloxone | 2016 |
Defining Over-Sedation: Literature Review and National Survey of Dental Hospitals Within the United Kingdom.
Topics: Antidotes; Conscious Sedation; Consensus; Drug Overdose; Flumazenil; Humans; Hypnotics and Sedatives | 2016 |
[Flumazenil].
Topics: Antidotes; Benzodiazepines; Drug Overdose; Flumazenil; GABA-A Receptor Antagonists; Humans | 2014 |
The coma cocktail: indications, contraindications, adverse effects, proper dose, and proper route.
Topics: Adult; Antidotes; Child; Coma; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Ov | 2004 |
Seizure after flumazenil administration in a pediatric patient.
Topics: Adolescent; Antidepressive Agents, Tricyclic; Child; Child, Preschool; Drug Overdose; Female; Flumaz | 1995 |
Topics in clinical pharmacology: flumazenil, a benzodiazepine antagonist.
Topics: Anesthesia, General; Animals; Anti-Anxiety Agents; Benzodiazepines; Drug Interactions; Drug Overdose | 1993 |
Flumazenil: a review.
Topics: Adult; Benzodiazepines; Child; Drug Overdose; Flumazenil; Humans | 1994 |
Flumazenil: a benzodiazepine antagonist.
Topics: Anesthesia; Benzodiazepines; Drug Interactions; Drug Overdose; Flumazenil; Hepatic Encephalopathy; H | 1993 |
Flumazenil: an antidote for benzodiazepine toxicity.
Topics: Benzodiazepines; Drug Overdose; Flumazenil; Humans | 1993 |
[Drug emergencies].
Topics: Acute Disease; Cocaine; Combined Modality Therapy; Critical Care; Drug Overdose; Flumazenil; Humans; | 1993 |
Diagnosis and management of opioid- and benzodiazepine-induced comatose overdose in children.
Topics: Adolescent; Antidotes; Benzodiazepines; Child; Child, Preschool; Coma; Drug Overdose; Flumazenil; Hu | 1996 |
A risk-benefit assessment of flumazenil in the management of benzodiazepine overdose.
Topics: Anti-Anxiety Agents; Antidotes; Drug Interactions; Drug Overdose; Female; Flumazenil; GABA Modulator | 1997 |
Coma induced by intoxication.
Topics: Accidental Falls; Alcohol-Induced Disorders, Nervous System; Alcoholic Intoxication; Antidotes; Brai | 2000 |
The use of flumazenil in the management of acute drug poisoning--a review.
Topics: Anti-Anxiety Agents; Drug Overdose; Flumazenil; Humans | 1991 |
Risks and benefits of therapy with flumazenil (Anexate) in mixed drug intoxications.
Topics: Antidepressive Agents, Tricyclic; Benzodiazepines; Coma; Drug Interactions; Drug Overdose; Flumazeni | 1991 |
Flumazenil: a new benzodiazepine antagonist.
Topics: Animals; Benzodiazepines; Drug Overdose; Flumazenil; Humans | 1991 |
Flumazenil: a benzodiazepine antagonist.
Topics: Anesthesia, General; Benzodiazepines; Cerebrovascular Circulation; Drug Overdose; Flumazenil; Half-L | 1990 |
11 trials available for flumazenil and Drug Overdose
| Article | Year |
|---|---|
Protective effect of flumazenil infusion in severe acute benzodiazepine toxicity: a pilot randomized trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidotes; Benzodiazepines; Drug Overdose; Female; Fluma | 2021 |
Topics in clinical pharmacology: flumazenil, a benzodiazepine antagonist.
Topics: Anesthesia, General; Animals; Anti-Anxiety Agents; Benzodiazepines; Drug Interactions; Drug Overdose | 1993 |
A clinical trial of escalating doses of flumazenil for reversal of suspected benzodiazepine overdose in the emergency department.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Benzodiazepines; Dose-Response Relationship, Drug; Doubl | 1993 |
Emergency department use of flumazenil prior to poison center consultation.
Topics: Antidotes; Benzodiazepines; Contraindications; Drug Overdose; Flumazenil; Humans; Hypnotics and Seda | 1997 |
Flumazenil in drug overdose: randomized, placebo-controlled study to assess cost effectiveness.
Topics: Adolescent; Adult; Alberta; Antidotes; Cost-Benefit Analysis; Double-Blind Method; Drug Overdose; Fe | 1999 |
Efficacy of flumazenil in acute alcohol intoxication: double blind placebo-controlled evaluation.
Topics: Adolescent; Adult; Aged; Alcoholic Intoxication; Benzodiazepines; Coma; Double-Blind Method; Drug Ov | 1991 |
A placebo-controlled trial of flumazenil given by continuous infusion in severe benzodiazepine overdosage.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; Double-Blind Method; Drug Overdose; | 1991 |
Diagnostic utility of flumazenil in coma with suspected poisoning: a double blind, randomised controlled study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; Antidepressive Agents; Coma; Double | 1990 |
The diagnostic utility of flumazenil (a benzodiazepine antagonist) in coma of unknown etiology.
Topics: Adult; Alprazolam; Carbon Monoxide Poisoning; Clinical Trials as Topic; Coma; Double-Blind Method; D | 1990 |
Use of flumazenil in intoxicated patients with coma. A double-blind placebo-controlled study in ICU.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Benzodiazepines; Clinical Trials as Topic; Double-Blind | 1990 |
Flumazenil: a benzodiazepine antagonist.
Topics: Anesthesia, General; Benzodiazepines; Cerebrovascular Circulation; Drug Overdose; Flumazenil; Half-L | 1990 |
53 other studies available for flumazenil and Drug Overdose
| Article | Year |
|---|---|
Experience with lower dose flumazenil at an academic medical center.
Topics: Academic Medical Centers; Antidotes; Benzodiazepines; Dose-Response Relationship, Drug; Drug Overdos | 2021 |
Zopiclone overdose and flumazenil rescue.
Topics: Azabicyclo Compounds; Benzodiazepines; Drug Overdose; Flumazenil; Humans; Piperazines | 2017 |
Pediatric zolpidem ingestion demonstrating zero-order kinetics treated with flumazenil.
Topics: Antidotes; Central Nervous System Depressants; Child; Coma; Down Syndrome; Drug Overdose; Emergencie | 2013 |
Serial monitoring of sedation scores in benzodiazepine overdose.
Topics: Aged; Anticonvulsants; Antidotes; Clonazepam; Drug Overdose; Female; Flumazenil; Humans; Monitoring, | 2014 |
Reducing risk of overdose with midazolam injection in adults: an evaluation of change in clinical practice to improve patient safety in England.
Topics: Antidotes; Dose-Response Relationship, Drug; Drug Overdose; England; Flumazenil; Health Knowledge, A | 2015 |
[Hemoperfusion with activated charcoal on valproic acid poisoning. A case report].
Topics: Benzodiazepines; Charcoal; Combined Modality Therapy; Depressive Disorder; Drug Overdose; Female; Fl | 2015 |
Lack of adverse effects from flumazenil administration: an ED observational study.
Topics: Adult; Aged; Aged, 80 and over; Antidotes; Benzodiazepines; Drug Overdose; Emergency Service, Hospit | 2015 |
Flubromazolam--A new life-threatening designer benzodiazepine.
Topics: Adult; Antidotes; Benzodiazepines; Coma; Combined Modality Therapy; Designer Drugs; Drug Overdose; F | 2016 |
Determination of flumazenil in serum by liquid chromatography-mass spectrometry: Application to kinetics study in acute diazepam overdose.
Topics: Aminophylline; Antidotes; Chromatography, Liquid; Diazepam; Dimensional Measurement Accuracy; Dose-R | 2016 |
Benzodiazepine poisoning in elderly.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antidotes; Benzodiazepines; Bromazepam; Coh | 2016 |
Flumazenil in benzodiazepine overdose.
Topics: Antidotes; Benzodiazepines; Drug Overdose; Flumazenil; Humans | 2016 |
Utility of flumazenil in zopiclone overdose.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidotes; Azabicyclo Compounds; Drug Overdose; Female; | 2008 |
[Seizure triggered by benzodiazepine receptor antagonist].
Topics: Aged; Antidepressive Agents, Tricyclic; Antidotes; Drug Overdose; Female; Flumazenil; Humans; Seizur | 2009 |
Prospective comparative assessment of buprenorphine overdose with heroin and methadone: clinical characteristics and response to antidotal treatment.
Topics: Adult; Antidotes; Buprenorphine; Drug Overdose; Female; Flumazenil; Heroin; Heroin Dependence; Human | 2010 |
The fallacy of a lifesaving sublingual injection of flumazenil.
Topics: Anesthesia Recovery Period; Antidotes; Benzodiazepines; Conscious Sedation; Drug Overdose; Flumazeni | 2011 |
Flumazenil use in benzodiazepine overdose in the UK: a retrospective survey of NPIS data.
Topics: Adult; Antidotes; Benzodiazepines; Drug Overdose; Female; Flumazenil; Humans; Incidence; Male; Middl | 2012 |
Complications associated with intravenous midazolam sedation in anxious dental patients.
Topics: Adolescent; Adult; Aged; Anesthesia, Dental; Anesthetics, Intravenous; Child; Clinical Audit; Consci | 2011 |
Flumazenil administration in poisoned pediatric patients.
Topics: Antidotes; California; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Overdose; Fem | 2012 |
The new toy.
Topics: Anti-Anxiety Agents; Antidotes; Benzodiazepines; Drug Overdose; Emergency Medical Services; Emergenc | 2003 |
A near-fatal overdose of carisoprodol (SOMA): case report.
Topics: Adult; Antidotes; Carisoprodol; Charcoal; Chlordiazepoxide; Clindamycin; Drug Overdose; Drug Therapy | 2004 |
The role of flumazenil in self harm with benzodiazepines: to give or not to give?
Topics: Antidotes; Benzodiazepines; Contraindications; Drug Overdose; Flumazenil; GABA Modulators; Humans; S | 2005 |
Resuscitative effect of a gamma-aminobutyric acid B receptor antagonist on gamma-hydroxybutyric acid mortality in mice.
Topics: Animals; Benzocycloheptenes; Bicuculline; Drug Overdose; Flumazenil; GABA Antagonists; gamma-Aminobu | 2005 |
Use of Flumazenil in benzodiazepine overdose.
Topics: Antidotes; Benzodiazepines; Drug Overdose; Flumazenil; Humans; Practice Guidelines as Topic | 2006 |
Coma cocktail: a role for flumazenil?
Topics: Antidotes; Benzodiazepines; Coma; Drug Overdose; Evidence-Based Medicine; Flumazenil; Humans | 2007 |
Fatal seizures after flumazenil administration in a patient with mixed overdose.
Topics: Acute Kidney Injury; Adult; Antidepressive Agents, Tricyclic; Benzodiazepines; Charcoal; Drug Overdo | 1994 |
Oxazepam overdose associated with ethanol ingestion: treatment with a benzodiazepine antagonist.
Topics: Alcohol Drinking; Benzodiazepines; Drug Interactions; Drug Overdose; Flumazenil; Humans; Male; Middl | 1994 |
Flumazenil--when is its use appropriate?
Topics: Anti-Anxiety Agents; Conscious Sedation; Drug Overdose; Flumazenil; Humans | 1993 |
Flumazenil: an antidotal anecdote.
Topics: Aged; Drug Overdose; Female; Flumazenil; Humans; Lorazepam | 1994 |
Judicious use of flumazenil.
Topics: Benzodiazepines; Coma; Drug Overdose; Flumazenil; Humans; Risk Factors | 1993 |
Diagnostic and therapeutic utility of flumazenil in comatose patients with drug overdose.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Benzodiazepines; Coma; Drug Overdose; Emergencies; Femal | 1993 |
Reversal of fetal benzodiazepine intoxication using flumazenil.
Topics: Adult; Cardiotocography; Diazepam; Drug Overdose; Female; Fetal Diseases; Flumazenil; Gastric Lavage | 1993 |
Empiric use of flumazenil in comatose patients: limited applicability of criteria to define low risk.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidotes; Coma; Drug Overdose; Female; Flumazenil; Huma | 1996 |
[Acute overdose of Zolpidem (Stilnox)].
Topics: Adolescent; Adult; Aged; Antidotes; Coma; Drug Overdose; Female; Flumazenil; Humans; Hypnotics and S | 1996 |
Flumazenil-induced seizure accompanying benzodiazepine and baclofen intoxication.
Topics: Adult; Antidotes; Baclofen; Benzodiazepines; Drug Interactions; Drug Overdose; Female; Flumazenil; H | 1996 |
Flumazenil: a pharmacologic antidote with limited medical toxicology utility, or ... an antidote in search of an overdose.
Topics: Antidotes; Benzodiazepines; Drug Overdose; Emergency Medicine; Flumazenil; Humans; Risk Assessment | 1997 |
Use of inhalational and intravenous sedation in dentistry.
Topics: Accidents; Anesthesia, Dental; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthesia, Local; A | 1997 |
Two chlorzoxazone (Parafon forte) overdoses and coma in one patient: reversal with flumazenil.
Topics: Antidotes; Chlorzoxazone; Coma; Drug Overdose; Emergency Treatment; Flumazenil; GABA Modulators; Hum | 1998 |
Endotracheal administration of flumazenil.
Topics: Anti-Anxiety Agents; Antidotes; Drug Overdose; Emergency Treatment; Flumazenil; Humans; Instillation | 1998 |
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Flumazenil and suspected benzodiazepine overdose.
Topics: Adult; Antidotes; Benzodiazepines; Drug Overdose; Flumazenil; Humans | 2000 |
Massive dose of diazepam poisoning.
Topics: Diazepam; Dose-Response Relationship, Drug; Drug Overdose; Flumazenil; Gastric Lavage; Humans; Infus | 1998 |
Mechanism of respiratory insufficiency in pure or mixed drug-induced coma involving benzodiazepines.
Topics: Adult; Aged; Aged, 80 and over; Airway Resistance; Anti-Anxiety Agents; Antidotes; Coma; Drug Overdo | 2002 |
Flumazenil.
Topics: Anesthesia, General; Anti-Anxiety Agents; Conscious Sedation; Drug Overdose; Flumazenil; Humans; Hyp | 1992 |
Anterograde amnesia in triazolam overdose despite flumazenil treatment: a case report.
Topics: Adolescent; Amnesia; Drug Overdose; Flumazenil; Humans; Male; Suicide, Attempted; Triazolam | 1992 |
[Flumazenil-induced contractile seizure in poisoning by a combination of tricyclic antidepressants and benzodiazepine in a young woman].
Topics: Adult; Antidepressive Agents, Tricyclic; Benzodiazepines; Drug Overdose; Female; Flumazenil; Humans; | 1991 |
Local anesthetic-induced toxicity may be modified by low doses of flumazenil.
Topics: Anesthesia, Local; Animals; Drug Overdose; Etidocaine; Flumazenil; Lidocaine; Male; Mepivacaine; Mic | 1992 |
Seizures after flumazenil administration in a case of combined benzodiazepine and tricyclic antidepressant overdose.
Topics: Adult; Clonazepam; Diazepam; Drug Overdose; Epilepsy, Tonic-Clonic; Female; Flumazenil; Humans; Imip | 1992 |
Risks of flumazenil in mixed benzodiazepine-tricyclic antidepressant overdose: report of a preliminary study in the dog.
Topics: Amitriptyline; Animals; Clomipramine; Dogs; Drug Overdose; Female; Flumazenil; Male; Risk Factors | 1992 |
Benzodiazepine antagonist approved by FDA.
Topics: Benzodiazepines; Drug Overdose; Drugs, Investigational; Flumazenil; Humans; United States; United St | 1992 |
Flumazenil in mixed benzodiazepine/tricyclic antidepressant overdose: a placebo-controlled study in the dog.
Topics: Amitriptyline; Animals; Arrhythmias, Cardiac; Dogs; Drug Interactions; Drug Overdose; Electrocardiog | 1992 |
Complete heart block after flumazenil.
Topics: Acetaminophen; Aged; Drug Overdose; Female; Flumazenil; Heart Block; Humans; Temazepam | 1991 |
Administration of flumazenil.
Topics: Animals; Benzodiazepines; Dogs; Drug Overdose; Flumazenil; Humans; Seizures; Swine | 1991 |
[Difficulties in antagonizing dipotassium chlorazepate using flumazenil in cases of acute poisoning].
Topics: Adult; Clorazepate Dipotassium; Drug Overdose; Female; Flumazenil; Humans; Male; Middle Aged | 1991 |
Benzodiazepine withdrawal syndrome after a benzodiazepine antagonist.
Topics: Adolescent; Akathisia, Drug-Induced; Diazepam; Drug Overdose; Flumazenil; Humans; Injections, Intrav | 1990 |