flumazenil has been researched along with Down Syndrome in 3 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Flumazenil has been reported to reverse the CNS effects of zolpidem." | 1.39 | Pediatric zolpidem ingestion demonstrating zero-order kinetics treated with flumazenil. ( Carstairs, SD; Negus, E; Thornton, SL, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Thornton, SL | 1 |
| Negus, E | 1 |
| Carstairs, SD | 1 |
| Möhler, H | 1 |
| Colas, D | 1 |
| Chuluun, B | 1 |
| Garner, CC | 1 |
| Heller, HC | 1 |
1 review available for flumazenil and Down Syndrome
| Article | Year |
|---|---|
The legacy of the benzodiazepine receptor: from flumazenil to enhancing cognition in Down syndrome and social interaction in autism.
Topics: Animals; Anti-Anxiety Agents; Autistic Disorder; Benzodiazepines; Cognition; Down Syndrome; Flumazen | 2015 |
2 other studies available for flumazenil and Down Syndrome
| Article | Year |
|---|---|
Pediatric zolpidem ingestion demonstrating zero-order kinetics treated with flumazenil.
Topics: Antidotes; Central Nervous System Depressants; Child; Coma; Down Syndrome; Drug Overdose; Emergencie | 2013 |
Short-term treatment with flumazenil restores long-term object memory in a mouse model of Down syndrome.
Topics: Animals; Cognition; Disease Models, Animal; Down Syndrome; Flumazenil; GABA Modulators; Male; Memory | 2017 |