flumazenil has been researched along with Disorders of Excessive Somnolence in 3 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Disorders of Excessive Somnolence: Disorders characterized by hypersomnolence during normal waking hours that may impair cognitive functioning. Subtypes include primary hypersomnia disorders (e.g., IDIOPATHIC HYPERSOMNOLENCE; NARCOLEPSY; and KLEINE-LEVIN SYNDROME) and secondary hypersomnia disorders where excessive somnolence can be attributed to a known cause (e.g., drug affect, MENTAL DISORDERS, and SLEEP APNEA SYNDROME). (From J Neurol Sci 1998 Jan 8;153(2):192-202; Thorpy, Principles and Practice of Sleep Medicine, 2nd ed, p320)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The biology underlying excessive daytime sleepiness (hypersomnolence) is incompletely understood." | 2.77 | Modulation of vigilance in the primary hypersomnias by endogenous enhancement of GABAA receptors. ( Bliwise, DL; Fairley, J; Freeman, A; Garcia, PS; Jenkins, A; Owens, MJ; Parker, K; Ritchie, JC; Rye, DB; Saini, P; Trotti, LM, 2012) |
| "Patients with central disorders of hypersomnolence sometimes do not achieve satisfactory symptom control with currently available wake-promoting medications." | 1.43 | Flumazenil for the Treatment of Refractory Hypersomnolence: Clinical Experience with 153 Patients. ( Bliwise, DL; Koola, C; LaBarbera, V; Rye, DB; Saini, P; Trotti, LM, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Trotti, LM | 2 |
| Saini, P | 2 |
| Koola, C | 1 |
| LaBarbera, V | 1 |
| Bliwise, DL | 2 |
| Rye, DB | 2 |
| Parker, K | 1 |
| Fairley, J | 1 |
| Freeman, A | 1 |
| Garcia, PS | 1 |
| Owens, MJ | 1 |
| Ritchie, JC | 1 |
| Jenkins, A | 1 |
| Ozone, M | 1 |
| Itoh, H | 1 |
| Ohbuchi, K | 1 |
| Ohyama, E | 1 |
| Hayashida, K | 1 |
| Sato, M | 1 |
| Sasaki, M | 1 |
| Ushijima, S | 1 |
| Tanifuji, Y | 1 |
2 trials available for flumazenil and Disorders of Excessive Somnolence
| Article | Year |
|---|---|
Modulation of vigilance in the primary hypersomnias by endogenous enhancement of GABAA receptors.
Topics: Adult; Arousal; Behavior; Chloride Channels; Disorders of Excessive Somnolence; Female; Flumazenil; | 2012 |
The effects of flumazenil on sleepiness, task performance and nocturnal sleep after anesthesia with midazolam.
Topics: Adult; Anesthetics, Intravenous; Disorders of Excessive Somnolence; Flumazenil; GABA Modulators; Hum | 2001 |
1 other study available for flumazenil and Disorders of Excessive Somnolence
| Article | Year |
|---|---|
Flumazenil for the Treatment of Refractory Hypersomnolence: Clinical Experience with 153 Patients.
Topics: Adult; Disorders of Excessive Somnolence; Female; Flumazenil; GABA Modulators; Humans; Male; Retrosp | 2016 |