flumazenil has been researched along with Disease Models, Animal in 92 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " citratus essential oil (EO) and hydroalcoholic extract (E1) from its leaves, as well as of its related compounds citral (CIT) and geraniol (GER) against the effects of pentylenetetrazole (PTZ) induced seizures in zebrafish (Danio rerio)." | 8.02 | Cymbopogon citratus (DC.) Stapf, citral and geraniol exhibit anticonvulsant and neuroprotective effects in pentylenetetrazole-induced seizures in zebrafish. ( Hacke, ACM; Marques, JA; Miyoshi, E; Pereira, RP, 2021) |
| "Intra-amygdala flumazenil inhibits the development of anxiety sensitized by repeated ethanol withdrawal, stress/ethanol withdrawal, or DMCM/ethanol withdrawal." | 7.74 | The amygdala regulates the antianxiety sensitization effect of flumazenil during repeated chronic ethanol or repeated stress. ( Angel, RA; Breese, GR; Knapp, DJ; Navarro, M; Overstreet, DH, 2007) |
| "To investigate changes in free benzodiazepine receptor density in response to repeated, long-term administration of diazepam in epilepsy, we assessed 125I-iomazenil (125I-IMZ) binding in a mouse model." | 7.73 | Effects of diazepam on 125I-iomazenil-benzodiazepine receptor binding and epileptic seizures in the El mouse. ( Fukumitsu, N; Mori, Y; Ogi, S; Uchiyama, M, 2006) |
| "The protective and adverse effect potentials of levetiracetam ((S)-alpha-ethyl-2-oxo-pyrrolidine acetamide) in rodent models of seizures and epilepsy were compared with the profile of several currently prescribed and newly developed antiepileptic drugs." | 7.70 | Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. ( Gobert, J; Klitgaard, H; Matagne, A; Wülfert, E, 1998) |
| "Therapeutic modulation of the increased GABAergic tone in chronic hepatic encephalopathy (HE) by the benzodiazepine receptor (BR) antagonist flumazenil (F) has led to conflicting results in humans and animal models for HE." | 7.70 | Improvement of chronic hepatic encephalopathy in dogs by the benzodiazepine-receptor partial inverse agonist sarmazenil, but not by the antagonist flumazenil. ( Legemate, DA; Meyer, HP; Rothuizen, J; van den Brom, W, 1998) |
| "The profile of action of ondansetron was assessed in a novel animal model of anxiety." | 7.69 | Antianxiety profile of ondansetron, a selective 5-HT3 antagonist, in a novel animal model. ( Kulkarni, SK; Roychoudhury, M, 1997) |
| "Benzodiazepine withdrawal, spontaneous or precipitated by the receptor antagonist, flumazenil, produces anxiety that can be measured in animal models." | 4.78 | The benzodiazepines: anxiolytic and withdrawal effects. ( Little, HJ, 1991) |
| " citratus essential oil (EO) and hydroalcoholic extract (E1) from its leaves, as well as of its related compounds citral (CIT) and geraniol (GER) against the effects of pentylenetetrazole (PTZ) induced seizures in zebrafish (Danio rerio)." | 4.02 | Cymbopogon citratus (DC.) Stapf, citral and geraniol exhibit anticonvulsant and neuroprotective effects in pentylenetetrazole-induced seizures in zebrafish. ( Hacke, ACM; Marques, JA; Miyoshi, E; Pereira, RP, 2021) |
| "Rutin is a bioflavonoid found in medicinal plants used to reduce anxiety." | 3.85 | The anxiolytic-like effect of rutin in rats involves GABAA receptors in the basolateral amygdala. ( Fernández-Guasti, A; González-Trujano, ME; Hernandez-Leon, A, 2017) |
| "It was the aim of this study to determine the potential effect of walnut kernel extract (WKE) on experimentally induced seizures in rats and to evaluate the role of benzodiazepines and ethosuximide (ESM) within these pathways." | 3.80 | Potential mechanisms involved in the anticonvulsant effect of walnut extract on pentylenetetrazole-induced seizure. ( Asadi-Shekaari, M; Eslami, A; Joukar, S; Kalantaripour, T, 2014) |
| "Patients with depression showed a decrease in plasma and cerebrospinal fluid allopregnanolone (ALLO)." | 3.77 | Infusions of allopregnanolone into the hippocampus and amygdala, but not into the nucleus accumbens and medial prefrontal cortex, produce antidepressant effects on the learned helplessness rats. ( Fukami, G; Fukumoto, M; Hashimoto, K; Iyo, M; Muneoka, K; Shirayama, Y; Tadokoro, S, 2011) |
| " We hypothesized that chrysin decreases anxiety via interaction with the GABA(A) receptor in laboratory rats as measured by elevated plus-maze (EPM), corticosterone, and catecholamine assays." | 3.74 | Evaluation of the anxiolytic effects of chrysin, a Passiflora incarnata extract, in the laboratory rat. ( Brown, E'; Ceremuga, TE; Hurd, NS; McCall, S, 2007) |
| "Intra-amygdala flumazenil inhibits the development of anxiety sensitized by repeated ethanol withdrawal, stress/ethanol withdrawal, or DMCM/ethanol withdrawal." | 3.74 | The amygdala regulates the antianxiety sensitization effect of flumazenil during repeated chronic ethanol or repeated stress. ( Angel, RA; Breese, GR; Knapp, DJ; Navarro, M; Overstreet, DH, 2007) |
| "The objective of this investigation was to characterize quantitatively the time-dependent changes in midazolam (MDL) efficacy in the silent period after induction of status epilepticus (SE) in rats." | 3.74 | Decreased Efficacy of GABAA-receptor modulation by midazolam in the kainate model of temporal lobe epilepsy. ( Danhof, M; Gunput, RA; Liefaard, LC; Voskuyl, RA, 2007) |
| "To investigate changes in free benzodiazepine receptor density in response to repeated, long-term administration of diazepam in epilepsy, we assessed 125I-iomazenil (125I-IMZ) binding in a mouse model." | 3.73 | Effects of diazepam on 125I-iomazenil-benzodiazepine receptor binding and epileptic seizures in the El mouse. ( Fukumitsu, N; Mori, Y; Ogi, S; Uchiyama, M, 2006) |
| " In a prospective trial in dogs with newly diagnosed epilepsy, ELB 138 markedly reduced seizure frequency and severity without significant difference to standard treatments (phenobarbital or primidone) but was much better tolerated than the standard drugs." | 3.72 | Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures. ( Löscher, W; Potschka, H; Rieck, S; Rundfeldt, C; Tipold, A, 2004) |
| "The protective and adverse effect potentials of levetiracetam ((S)-alpha-ethyl-2-oxo-pyrrolidine acetamide) in rodent models of seizures and epilepsy were compared with the profile of several currently prescribed and newly developed antiepileptic drugs." | 3.70 | Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. ( Gobert, J; Klitgaard, H; Matagne, A; Wülfert, E, 1998) |
| "Therapeutic modulation of the increased GABAergic tone in chronic hepatic encephalopathy (HE) by the benzodiazepine receptor (BR) antagonist flumazenil (F) has led to conflicting results in humans and animal models for HE." | 3.70 | Improvement of chronic hepatic encephalopathy in dogs by the benzodiazepine-receptor partial inverse agonist sarmazenil, but not by the antagonist flumazenil. ( Legemate, DA; Meyer, HP; Rothuizen, J; van den Brom, W, 1998) |
| "The profile of action of ondansetron was assessed in a novel animal model of anxiety." | 3.69 | Antianxiety profile of ondansetron, a selective 5-HT3 antagonist, in a novel animal model. ( Kulkarni, SK; Roychoudhury, M, 1997) |
| "The neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one (allopregnanolone) was administered systemically to rats which were tested in the Geller-Seifter conflict paradigm, an established animal model of anxiety." | 3.69 | The anxiolytic-like effects of the neurosteroid allopregnanolone: interactions with GABA(A) receptors. ( Akwa, Y; Britton, KT; Brot, MD; Koob, GF; Purdy, RH, 1997) |
| "The involvement of the gamma-aminobutyric acidA (GABAA) receptor complex in the pathogenesis of hepatic encephalopathy was examined in thioacetamide-treated rats with fulminant hepatic failure." | 3.67 | GABAA receptor complex in an experimental model of hepatic encephalopathy: evidence for elevated levels of an endogenous benzodiazepine receptor ligand. ( Basile, AS; Gammal, SH; Jones, EA; Skolnick, P, 1989) |
| "It is associated with allodynia and hyperalgesia." | 1.48 | Neurobiological mechanisms of antiallodynic effect of transcranial direct current stimulation (tDCS) in a mice model of neuropathic pain. ( Caumo, W; Dos Santos, ARS; Martins, DF; Martins, TC; Medeiros, LF; Nucci-Martins, C; Siteneski, A; Souza, A; Torres, ILS, 2018) |
| "The porcine ET-1 model of cerebral ischemia is easier to implement then other large animal models of stroke, and performs similarly as long as CBF is monitored using CTP to prevent reperfusion." | 1.43 | Absolute Cerebral Blood Flow Infarction Threshold for 3-Hour Ischemia Time Determined with CT Perfusion and 18F-FFMZ-PET Imaging in a Porcine Model of Cerebral Ischemia. ( Cockburn, N; d'Esterre, CD; Kovacs, M; Lee, TY; Morrison, LB; Wright, EA, 2016) |
| "Propofol was administrated to the WT and AD Tg mice once a week for 8 or 12 weeks, respectively." | 1.40 | Chronic treatment with anesthetic propofol improves cognitive function and attenuates caspase activation in both aged and Alzheimer's disease transgenic mice. ( Dong, Y; Shao, H; Xia, W; Xie, Z; Yu, B; Zhang, Y, 2014) |
| "FTA significantly increased the seizure latency and decreased the mortality in PTZ-treated mice." | 1.39 | Anticonvulsant effects of Fuzi total alkaloid on pentylenetetrazole-induced seizure in mice. ( Cui, R; Li, B; Li, Y; Liu, L; Song, Y; Tang, F; Wang, L; Wang, Y; Zhao, J; Zhou, Y, 2013) |
| "Post-ischaemic benzodiazepine administration is neuroprotective, but chronic administration of benzodiazepines can induce tolerance, such that the neuroprotective effect may be reduced." | 1.38 | Effects of diazepam and flumazenil on forebrain ischaemia in a rat model of benzodiazepine tolerance. ( Furuya, H; Inoue, S; Iwata, M; Kawaguchi, M, 2012) |
| "Diazepam effects were blocked by flumazenil." | 1.37 | Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord. ( Cardenas, R; Quintero, L; Suarez-Roca, H, 2011) |
| "Linalool is a major component of the essential oil of lavender." | 1.35 | Investigation of the anxiolytic effects of linalool, a lavender extract, in the male Sprague-Dawley rat. ( Bracken, S; Ceremuga, TE; Cline, M; Flores, J; McCall, S; Taylor, JE, 2008) |
| "Diazepam was used as a reference compound." | 1.33 | The anxiolytic-like effect of 5-HT1B receptor ligands in rats: a possible mechanism of action. ( Chojnacka-Wójcik, E; Kłodzińska, A; Tatarczyńska, E, 2005) |
| "Ramelteon did not produce benzodiazepine-like discriminative stimulus effects at doses up to 10 mg/kg." | 1.33 | Acute and chronic effects of ramelteon in rhesus monkeys (Macaca mulatta): dependence liability studies. ( Cruź, CM; France, CP; Koek, W; McMahon, LR; Weltman, RH, 2006) |
| "With midazolam, however, the increase was comparable to that of the control group." | 1.33 | Flumazenil mimics whereas midazolam abolishes ischemic preconditioning in a rabbit heart model of ischemia-reperfusion. ( Berenshtein, E; Chevion, M; Drenger, B; Gozal, Y; Raphael, J; Rivo, J, 2006) |
| "Flumazenil was administered by a randomly selected route [0." | 1.30 | Comparison of routes of flumazenil administration to reverse midazolam-induced respiratory depression in a canine model. ( Cordell, WH; Heniff, MS; Moore, GP; Nelson, DR; Trout, A, 1997) |
| "Treatment with clonazepam (CZP) (0." | 1.30 | The role of gamma-aminobutyric acid (GABA)-benzodiazepine neurotransmission in an animal model of methamphetamine-induced psychosis. ( Ito, K, 1999) |
| "Because dystonia in mutant dtsz hamsters is transient and disappears after approximately 60-70 days of age, [3H]flumazenil binding was studied at the age of maximum severity of dystonia (30-40 days) and after disappearance of the disease, to examine which neurochemical changes were related to dystonia." | 1.29 | Regionally selective and age-dependent alterations in benzodiazepine receptor binding in the genetically dystonic hamster. ( Löscher, W; Möhler, H; Pratt, GD; Richter, A, 1995) |
| "Flumazenil was without effect on normal synaptic responses; however, flumazenil reduced epileptiform discharges evoked in the presence of high [K+]o, leu-enkephalin, the BZR inverse agonist, methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM), or after a cold-shock procedure." | 1.29 | Benzodiazepine antagonists reduce epileptiform discharges in rat hippocampal slices. ( Carlen, PL; Facciponte, G; Jahromi, SS; Pelletier, MR; Polc, P; Zhang, L, 1996) |
| "The evolution of hepatic encephalopathy in this model was sufficiently slow to readily permit the staging of the syndrome." | 1.28 | Reversal of the behavioral and electrophysiological abnormalities of an animal model of hepatic encephalopathy by benzodiazepine receptor ligands. ( Basile, AS; Gammal, SH; Geller, D; Jones, EA; Skolnick, P, 1990) |
| "In this study, the effect of the chronic administration of the benzodiazepine (BZD) receptor ligand FG 7142 on the rat conflict test was examined." | 1.27 | Long-lasting proconflict effect induced by chronic administration of the beta-carboline derivative FG 7142. ( Biggio, G; Corda, MG; Gatta, F; Giorgi, O, 1985) |
| " These data suggest that antidepressants acquire anxiolytic properties following chronic administration and that this effect appears to be independent of the benzodiazepine receptor system." | 1.27 | The effects of chronic antidepressant treatment in an animal model of anxiety. ( Aitken, DH; Bodnoff, SR; Meaney, MJ; Quirion, R; Suranyi-Cadotte, B, 1988) |
| " In a separate experiment, Ro 15-1788 produced a PTZ-like stimulus when given at 2-day intervals during chronic administration of DZP." | 1.27 | Withdrawal from diazepam substitutes for the discriminative stimulus properties of pentylenetetrazol. ( Emmett-Oglesby, MW; Harris, CM; Idemudia, SO; Lal, H; Mathis, DA, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (14.13) | 18.7374 |
| 1990's | 17 (18.48) | 18.2507 |
| 2000's | 29 (31.52) | 29.6817 |
| 2010's | 27 (29.35) | 24.3611 |
| 2020's | 6 (6.52) | 2.80 |
| Authors | Studies |
|---|---|
| Damont, A | 1 |
| Boisgard, R | 1 |
| Kuhnast, B | 1 |
| Lemée, F | 1 |
| Raggiri, G | 1 |
| Scarf, AM | 1 |
| Da Pozzo, E | 1 |
| Selleri, S | 1 |
| Martini, C | 1 |
| Tavitian, B | 1 |
| Kassiou, M | 1 |
| Dollé, F | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Ji, MH | 1 |
| Zhang, L | 2 |
| Mao, MJ | 1 |
| Zhang, H | 1 |
| Yang, JJ | 1 |
| Qiu, LL | 1 |
| Mendes Hacke, AC | 1 |
| Miyoshi, E | 2 |
| Marques, JA | 2 |
| Pereira, RP | 2 |
| Zhang, N | 1 |
| Luo, M | 1 |
| He, L | 1 |
| Yao, L | 1 |
| Ghosh, KK | 1 |
| Padmanabhan, P | 1 |
| Yang, CT | 1 |
| Wang, Z | 1 |
| Palanivel, M | 1 |
| Ng, KC | 1 |
| Lu, J | 1 |
| Carlstedt-Duke, J | 1 |
| Halldin, C | 2 |
| Gulyás, B | 1 |
| Hacke, ACM | 1 |
| Mograbi, KM | 1 |
| de Castro, AC | 1 |
| de Oliveira, JA | 1 |
| Sales, PJ | 1 |
| Covolan, L | 1 |
| Del Bel, EA | 1 |
| de Souza, AS | 1 |
| Souza, A | 1 |
| Martins, DF | 1 |
| Medeiros, LF | 1 |
| Nucci-Martins, C | 1 |
| Martins, TC | 1 |
| Siteneski, A | 1 |
| Caumo, W | 1 |
| Dos Santos, ARS | 1 |
| Torres, ILS | 1 |
| Merali, Z | 1 |
| Cayer, C | 1 |
| Kent, P | 1 |
| Liu, R | 1 |
| Cal, V | 1 |
| Harris, CS | 1 |
| Arnason, JT | 1 |
| Horder, J | 1 |
| Andersson, M | 1 |
| Mendez, MA | 1 |
| Singh, N | 1 |
| Tangen, Ä | 1 |
| Lundberg, J | 1 |
| Gee, A | 1 |
| Veronese, M | 1 |
| Bölte, S | 1 |
| Farde, L | 1 |
| Sementa, T | 1 |
| Cash, D | 1 |
| Higgins, K | 1 |
| Spain, D | 1 |
| Turkheimer, F | 1 |
| Mick, I | 1 |
| Selvaraj, S | 1 |
| Nutt, DJ | 1 |
| Lingford-Hughes, A | 1 |
| Howes, OD | 1 |
| Murphy, DG | 1 |
| Borg, J | 1 |
| Caioli, S | 1 |
| Pieri, M | 1 |
| Antonini, A | 1 |
| Guglielmotti, A | 1 |
| Severini, C | 1 |
| Zona, C | 1 |
| Li, B | 1 |
| Tang, F | 1 |
| Wang, L | 1 |
| Liu, L | 1 |
| Zhao, J | 1 |
| Zhou, Y | 1 |
| Wang, Y | 1 |
| Song, Y | 1 |
| Li, Y | 1 |
| Cui, R | 1 |
| Shao, H | 1 |
| Zhang, Y | 1 |
| Dong, Y | 1 |
| Yu, B | 1 |
| Xia, W | 1 |
| Xie, Z | 1 |
| Zhang, C | 1 |
| Mao, X | 1 |
| Zhao, X | 1 |
| Liu, Z | 1 |
| Liu, B | 1 |
| Li, H | 1 |
| Bi, K | 1 |
| Jia, Y | 1 |
| Papp, M | 1 |
| Gruca, P | 1 |
| Lason-Tyburkiewicz, M | 1 |
| Litwa, E | 1 |
| Willner, P | 1 |
| Asadi-Shekaari, M | 1 |
| Eslami, A | 1 |
| Kalantaripour, T | 1 |
| Joukar, S | 1 |
| Ceremuga, TE | 3 |
| Valdivieso, D | 1 |
| Kenner, C | 1 |
| Lucia, A | 1 |
| Lathrop, K | 1 |
| Stailey, O | 1 |
| Bailey, H | 1 |
| Criss, J | 1 |
| Linton, J | 1 |
| Fried, J | 1 |
| Taylor, A | 1 |
| Padron, G | 1 |
| Johnson, AD | 1 |
| Wright, EA | 1 |
| d'Esterre, CD | 1 |
| Morrison, LB | 1 |
| Cockburn, N | 1 |
| Kovacs, M | 1 |
| Lee, TY | 1 |
| Hernandez-Leon, A | 1 |
| González-Trujano, ME | 1 |
| Fernández-Guasti, A | 1 |
| Colas, D | 1 |
| Chuluun, B | 1 |
| Garner, CC | 1 |
| Heller, HC | 1 |
| dos Reis, LM | 1 |
| Canto-de-Souza, A | 1 |
| de Almeida, RN | 1 |
| de Sousa, DP | 1 |
| Nóbrega, FF | 1 |
| Claudino, Fde S | 1 |
| Araújo, DA | 1 |
| Leite, JR | 1 |
| Mattei, R | 1 |
| Ya'u, J | 1 |
| Yaro, AH | 1 |
| Abubakar, MS | 1 |
| Anuka, JA | 1 |
| Hussaini, IM | 1 |
| Vasconcelos, SM | 1 |
| Lima, SR | 1 |
| Soares, PM | 1 |
| Assreuy, AM | 1 |
| de Sousa, FC | 1 |
| Lobato, Rde F | 1 |
| Vasconcelos, GS | 1 |
| Santi-Gadelha, T | 1 |
| Bezerra, EH | 1 |
| Cavada, BS | 1 |
| Patrocínio, MC | 1 |
| Kamei, J | 1 |
| Miyata, S | 1 |
| Ohsawa, M | 1 |
| Ochalski, PG | 1 |
| Fellows-Mayle, W | 1 |
| Hsieh, LB | 1 |
| Srinivas, R | 1 |
| Okonkwo, DO | 1 |
| Dixon, CE | 1 |
| Adelson, PD | 1 |
| Shirayama, Y | 1 |
| Muneoka, K | 1 |
| Fukumoto, M | 1 |
| Tadokoro, S | 1 |
| Fukami, G | 1 |
| Hashimoto, K | 1 |
| Iyo, M | 1 |
| de Carvalho, RS | 1 |
| Duarte, FS | 1 |
| de Lima, TC | 1 |
| Rojas, S | 1 |
| Martín, A | 1 |
| Pareto, D | 1 |
| Herance, JR | 1 |
| Abad, S | 1 |
| Ruíz, A | 1 |
| Flotats, N | 1 |
| Gispert, JD | 1 |
| Llop, J | 1 |
| Gómez-Vallejo, V | 1 |
| Planas, AM | 1 |
| Quintero, L | 1 |
| Cardenas, R | 1 |
| Suarez-Roca, H | 1 |
| Costa, CA | 1 |
| Kohn, DO | 1 |
| de Lima, VM | 1 |
| Gargano, AC | 1 |
| Flório, JC | 1 |
| Costa, M | 1 |
| Wierońska, JM | 1 |
| Stachowicz, K | 2 |
| Brański, P | 1 |
| Pałucha-Poniewiera, A | 1 |
| Pilc, A | 2 |
| Fajemiroye, JO | 1 |
| Galdino, PM | 1 |
| Alves, SF | 1 |
| de Paula, JA | 1 |
| de Paula, JR | 1 |
| Ghedini, PC | 1 |
| Costa, EA | 1 |
| Sotoing Taïwe, G | 1 |
| Ngo Bum, E | 1 |
| Talla, E | 1 |
| Dawe, A | 1 |
| Okomolo Moto, FC | 1 |
| Temkou Ngoupaye, G | 1 |
| Sidiki, N | 1 |
| Dabole, B | 1 |
| Djomeni Dzeufiet, PD | 1 |
| Dimo, T | 1 |
| De Waard, M | 1 |
| Iwata, M | 1 |
| Inoue, S | 1 |
| Kawaguchi, M | 1 |
| Furuya, H | 1 |
| da Cruz, GM | 1 |
| Felipe, CF | 1 |
| Scorza, FA | 1 |
| da Costa, MA | 1 |
| Tavares, AF | 1 |
| Menezes, ML | 1 |
| de Andrade, GM | 1 |
| Leal, LK | 1 |
| Brito, GA | 1 |
| da Graça Naffah-Mazzacoratti, M | 1 |
| Cavalheiro, EA | 1 |
| de Barros Viana, GS | 1 |
| Kuge, Y | 2 |
| Hikosaka, K | 1 |
| Seki, K | 1 |
| Ohkura, K | 1 |
| Nishijima, KC | 1 |
| Kaji, T | 2 |
| Ueno, S | 1 |
| Tsukamoto, E | 1 |
| Tamaki, N | 2 |
| Yokota, C | 1 |
| Tagaya, M | 1 |
| Inoue, H | 1 |
| Shiga, T | 1 |
| Minematsu, K | 1 |
| Katchanov, J | 1 |
| Waeber, C | 1 |
| Gertz, K | 1 |
| Gietz, A | 1 |
| Winter, B | 1 |
| Brück, W | 1 |
| Dirnagl, U | 1 |
| Veh, RW | 1 |
| Endres, M | 1 |
| Leroy, C | 1 |
| Poisbeau, P | 1 |
| Keller, AF | 1 |
| Nehlig, A | 1 |
| Abe, K | 1 |
| Kashiwagi, Y | 1 |
| Tokumura, M | 1 |
| Hosoi, R | 1 |
| Hatazawa, J | 1 |
| Inoue, O | 1 |
| Löscher, W | 3 |
| Potschka, H | 1 |
| Rieck, S | 1 |
| Tipold, A | 1 |
| Rundfeldt, C | 2 |
| Fukumitsu, N | 2 |
| Ogi, S | 2 |
| Uchiyama, M | 2 |
| Mori, Y | 2 |
| Chojnacka-Wójcik, E | 2 |
| Kłodzińska, A | 1 |
| Tatarczyńska, E | 1 |
| Morimoto, K | 1 |
| Tamagami, H | 1 |
| Matsuda, K | 1 |
| France, CP | 1 |
| Weltman, RH | 1 |
| Koek, W | 1 |
| Cruź, CM | 1 |
| McMahon, LR | 1 |
| Rivo, J | 1 |
| Raphael, J | 1 |
| Drenger, B | 1 |
| Berenshtein, E | 1 |
| Chevion, M | 1 |
| Gozal, Y | 1 |
| Kłak, K | 1 |
| Grundmann, O | 1 |
| Nakajima, J | 1 |
| Seo, S | 1 |
| Butterweck, V | 1 |
| Liefaard, LC | 1 |
| Gunput, RA | 1 |
| Danhof, M | 1 |
| Voskuyl, RA | 1 |
| Breese, GR | 2 |
| Knapp, DJ | 2 |
| Overstreet, DH | 2 |
| Navarro, M | 2 |
| Wills, TA | 1 |
| Angel, RA | 2 |
| Nassiri-Asl, M | 1 |
| Shariati-Rad, S | 1 |
| Zamansoltani, F | 1 |
| Brown, E' | 1 |
| Hurd, NS | 1 |
| McCall, S | 2 |
| McLeod, MC | 1 |
| Sundram, S | 1 |
| Dean, B | 1 |
| Lee, DC | 1 |
| Satz, WA | 1 |
| Dougherty, T | 1 |
| Greene, T | 1 |
| Cline, M | 1 |
| Taylor, JE | 1 |
| Flores, J | 1 |
| Bracken, S | 1 |
| Crawley, JN | 1 |
| Skolnick, P | 5 |
| Paul, SM | 3 |
| Ninan, PT | 1 |
| Insel, TM | 1 |
| Cohen, RM | 1 |
| Cook, JM | 1 |
| File, SE | 1 |
| Lister, RG | 1 |
| Albertson, TE | 1 |
| Bowyer, JF | 1 |
| Paule, MG | 1 |
| Pratt, GD | 1 |
| Richter, A | 1 |
| Möhler, H | 1 |
| Pesce, ME | 1 |
| Acevedo, X | 1 |
| Pinardi, G | 1 |
| Miranda, HF | 1 |
| Jones, EA | 5 |
| Basile, AS | 4 |
| Yurdaydin, C | 1 |
| Skolnich, P | 1 |
| Leong, DK | 1 |
| Oliva, L | 1 |
| Butterworth, RF | 1 |
| Polc, P | 1 |
| Jahromi, SS | 1 |
| Facciponte, G | 1 |
| Pelletier, MR | 1 |
| Carlen, PL | 1 |
| Roychoudhury, M | 1 |
| Kulkarni, SK | 2 |
| Brot, MD | 1 |
| Akwa, Y | 1 |
| Purdy, RH | 1 |
| Koob, GF | 1 |
| Britton, KT | 1 |
| Heniff, MS | 1 |
| Moore, GP | 1 |
| Trout, A | 1 |
| Cordell, WH | 1 |
| Nelson, DR | 1 |
| Klitgaard, H | 1 |
| Matagne, A | 1 |
| Gobert, J | 1 |
| Wülfert, E | 1 |
| Meyer, HP | 1 |
| Legemate, DA | 1 |
| van den Brom, W | 1 |
| Rothuizen, J | 1 |
| Toyama, H | 1 |
| Matsumura, K | 1 |
| Nakashima, H | 1 |
| Takeda, K | 1 |
| Takeuchi, A | 1 |
| Koga, S | 1 |
| Yoshida, T | 1 |
| Ichise, M | 1 |
| Watson, GS | 1 |
| Roach, JT | 1 |
| Sufka, KJ | 1 |
| Ito, K | 1 |
| Rössler, AS | 1 |
| Launay, JM | 1 |
| Venault, P | 1 |
| Dodd, RH | 1 |
| Chapouthier, G | 1 |
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| Kaur, G | 1 |
| Little, HJ | 1 |
| Baker, BL | 1 |
| Morrow, AL | 1 |
| Vergalla, J | 1 |
| Gammal, SH | 2 |
| Geller, D | 1 |
| Chan, AW | 1 |
| Leong, FW | 1 |
| Schanley, DL | 1 |
| Langan, MC | 1 |
| Penetrante, ML | 1 |
| Engel, JA | 1 |
| Egbe, P | 1 |
| Liljequist, S | 1 |
| Söderpalm, B | 1 |
| Preston, GC | 1 |
| Ward, C | 1 |
| Lines, CR | 1 |
| Poppleton, P | 1 |
| Haigh, JR | 1 |
| Traub, M | 1 |
| Marczynski, TJ | 1 |
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| Corda, MG | 1 |
| Giorgi, O | 1 |
| Gatta, F | 1 |
| Biggio, G | 1 |
| Bodnoff, SR | 1 |
| Suranyi-Cadotte, B | 1 |
| Aitken, DH | 1 |
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| Meaney, MJ | 1 |
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| Idemudia, SO | 1 |
| Lal, H | 1 |
3 reviews available for flumazenil and Disease Models, Animal
| Article | Year |
|---|---|
Do benzodiazepine ligands contribute to hepatic encephalopathy?
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Disease Models, Animal; Flumazenil; GABA-A Rece | 1993 |
The pathogenesis and treatment of hepatic encephalopathy: evidence for the involvement of benzodiazepine receptor ligands.
Topics: Ammonia; Animals; Disease Models, Animal; Flumazenil; Hepatic Encephalopathy; Humans; Ligands; Neuro | 1991 |
The benzodiazepines: anxiolytic and withdrawal effects.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Carbolines; Diazepam; Disease Models, Animal; Ethanol; Flumaz | 1991 |
89 other studies available for flumazenil and Disease Models, Animal
| Article | Year |
|---|---|
Synthesis of 6-[¹⁸F]fluoro-PBR28, a novel radiotracer for imaging the TSPO 18 kDa with PET.
Topics: Acetamides; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminopyridines; Animals; Corpu | 2011 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Overinhibition mediated by parvalbumin interneurons might contribute to depression-like behavior and working memory impairment induced by lipopolysaccharide challenge.
Topics: Animals; Behavior, Animal; Depression; Disease Models, Animal; Excitatory Amino Acid Antagonists; Fl | 2020 |
Anxiolytic properties of Cymbopogon citratus (DC.) stapf extract, essential oil and its constituents in zebrafish (Danio rerio).
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Cymbopogon; Disease Models, Animal; Flumaze | 2020 |
Chemical Composition of Essential Oil from Flower of 'Shanzhizi' (
Topics: Administration, Inhalation; Animals; Anti-Anxiety Agents; Biogenic Monoamines; Cyclohexanes; Disease | 2020 |
An In Vivo Study of a Rat Fluid-Percussion-Induced Traumatic Brain Injury Model with [
Topics: Acetamides; Animals; Brain Injuries, Traumatic; Carbon Radioisotopes; Disease Models, Animal; Flumaz | 2021 |
Cymbopogon citratus (DC.) Stapf, citral and geraniol exhibit anticonvulsant and neuroprotective effects in pentylenetetrazole-induced seizures in zebrafish.
Topics: Acyclic Monoterpenes; Animals; Anticonvulsants; Brain Chemistry; Catalase; Cymbopogon; Disease Model | 2021 |
Effects of GABAa receptor antagonists on motor behavior in pharmacological Parkinson's disease model in mice.
Topics: Animals; Behavior, Animal; Bicuculline; Disease Models, Animal; Flumazenil; GABA-A Receptor Antagoni | 2017 |
Neurobiological mechanisms of antiallodynic effect of transcranial direct current stimulation (tDCS) in a mice model of neuropathic pain.
Topics: Adenosine A1 Receptor Antagonists; Animals; Caffeine; Central Nervous System Stimulants; Disease Mod | 2018 |
Sacred Maya incense, copal (Protium copal - Burseraceae), has antianxiety effects in animal models.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Burseraceae; Carrier Proteins; Ceremonial B | 2018 |
GABA
Topics: Adult; Animals; Autism Spectrum Disorder; Azides; Behavior; Benzodiazepines; Carbon Radioisotopes; C | 2018 |
Monocyte Chemoattractant Protein-1 upregulates GABA-induced current: evidence of modified GABAA subunit composition in cortical neurons from the G93A mouse model of Amyotrophic Lateral Sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cells, Cultured; Cerebral Cortex; Chemokine CCL2; Disease Mo | 2013 |
Anticonvulsant effects of Fuzi total alkaloid on pentylenetetrazole-induced seizure in mice.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Diterpenes; Dose-Response Relatio | 2013 |
Chronic treatment with anesthetic propofol improves cognitive function and attenuates caspase activation in both aged and Alzheimer's disease transgenic mice.
Topics: Aging; Alzheimer Disease; Amyloidogenic Proteins; Animals; Brain; Caspases; Cell Line, Tumor; Cognit | 2014 |
Gomisin N isolated from Schisandra chinensis augments pentobarbital-induced sleep behaviors through the modification of the serotonergic and GABAergic system.
Topics: Animals; Behavior, Animal; Cyclooctanes; Disease Models, Animal; Drug Synergism; Flumazenil; Fruit; | 2014 |
Effects of chronic mild stress on the development of drug dependence in rats.
Topics: Animals; Chronic Disease; Citalopram; Depressive Disorder; Diazepam; Disease Models, Animal; Flumaze | 2014 |
Potential mechanisms involved in the anticonvulsant effect of walnut extract on pentylenetetrazole-induced seizure.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug S | 2014 |
Evaluation of the anxiolytic and antidepressant effects of asiatic acid, a compound from Gotu kola or Centella asiatica, in the male Sprague Dawley rat.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Centella; Depression; Disease Models, | 2015 |
Absolute Cerebral Blood Flow Infarction Threshold for 3-Hour Ischemia Time Determined with CT Perfusion and 18F-FFMZ-PET Imaging in a Porcine Model of Cerebral Ischemia.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Cerebrovascular Circulation; Disease Models, Animal; F | 2016 |
The anxiolytic-like effect of rutin in rats involves GABAA receptors in the basolateral amygdala.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Basolateral Nuclear Complex; Diazepam; Disease Models, Animal | 2017 |
Short-term treatment with flumazenil restores long-term object memory in a mouse model of Down syndrome.
Topics: Animals; Cognition; Disease Models, Animal; Down Syndrome; Flumazenil; GABA Modulators; Male; Memory | 2017 |
Intra-periaqueductal gray matter injections of midazolam fail to alter anxiety in plus-maze experienced mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Avoidance Learning; Disease Models, Animal | 2008 |
Anticonvulsant effect of a natural compound alpha,beta-epoxy-carvone and its action on the nerve excitability.
Topics: Action Potentials; Animals; Anticonvulsants; Convulsants; Cyclohexane Monoterpenes; Disease Models, | 2008 |
Anticonvulsant activity of Carissa edulis (Vahl) (Apocynaceae) root bark extract.
Topics: Administration, Oral; Animals; Anticonvulsants; Apocynaceae; Chickens; Disease Models, Animal; Dose- | 2008 |
Central action of Araucaria angustifolia seed lectin in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Rela | 2009 |
Involvement of the benzodiazepine system in the anxiolytic-like effect of Yokukansan (Yi-gan san).
Topics: Analysis of Variance; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Benzodiazepines; Di | 2009 |
Flumazenil administration attenuates cognitive impairment in immature rats after controlled cortical impact.
Topics: Animals; Brain; Brain Chemistry; Brain Injuries; Cognition Disorders; Disease Models, Animal; Dose-R | 2010 |
Infusions of allopregnanolone into the hippocampus and amygdala, but not into the nucleus accumbens and medial prefrontal cortex, produce antidepressant effects on the learned helplessness rats.
Topics: Amygdala; Animals; Antidepressive Agents; Avoidance Learning; CA3 Region, Hippocampal; Depression; D | 2011 |
Involvement of GABAergic non-benzodiazepine sites in the anxiolytic-like and sedative effects of the flavonoid baicalein in mice.
Topics: Animals; Anti-Anxiety Agents; Dehydroepiandrosterone Sulfate; Disease Models, Animal; Dose-Response | 2011 |
Positron emission tomography with 11C-flumazenil in the rat shows preservation of binding sites during the acute phase after 2 h-transient focal ischemia.
Topics: Acute Disease; Animals; Binding Sites; Brain Ischemia; Disease Models, Animal; Flumazenil; Male; Ner | 2011 |
Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord.
Topics: Analgesics; Animals; Diazepam; Disease Models, Animal; Excitatory Postsynaptic Potentials; Flumazeni | 2011 |
The GABAergic system contributes to the anxiolytic-like effect of essential oil from Cymbopogon citratus (lemongrass).
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Cymbopogon; Disease Models, Animal; Dose-Re | 2011 |
On the mechanism of anti-hyperthermic effects of LY379268 and LY487379, group II mGlu receptors activators, in the stress-induced hyperthermia in singly housed mice.
Topics: Amino Acids; Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, | 2012 |
Involvement of 5-HT1A in the anxiolytic-like effect of dichloromethane fraction of Pimenta pseudocaryophyllus.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Disease Models, Animal; Ethanol; Flumazenil | 2012 |
Antipsychotic and sedative effects of the leaf extract of Crassocephalum bauchiense (Hutch.) Milne-Redh (Asteraceae) in rodents.
Topics: Animals; Antipsychotic Agents; Apomorphine; Asteraceae; Behavior, Animal; Body Temperature; Brain; C | 2012 |
Effects of diazepam and flumazenil on forebrain ischaemia in a rat model of benzodiazepine tolerance.
Topics: Analysis of Variance; Animals; Benzodiazepines; Brain Ischemia; Diazepam; Disease Models, Animal; Dr | 2012 |
Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms.
Topics: Alkaloids; Amino Acids; Animals; Anticonvulsants; Antioxidants; Atropine; Benzodioxoles; Biogenic Mo | 2013 |
Characteristic brain distribution of 1-(14)C-octanoate in a rat model of focal cerebral ischemia in comparison with those of (123)I-IMP and (123)I-iomazenil.
Topics: Animals; Autoradiography; Brain; Brain Ischemia; Caprylates; Disease Models, Animal; Flumazenil; Iof | 2003 |
Characterisation of [123I]iomazenil distribution in a rat model of focal cerebral ischaemia in relation to histopathological findings.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Flumazenil; Iodine Radioisotopes; Male; Metabolic C | 2004 |
Selective neuronal vulnerability following mild focal brain ischemia in the mouse.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antidotes; Antineoplastic Agents; Autoradiography; Binding Sit | 2003 |
Pharmacological plasticity of GABA(A) receptors at dentate gyrus synapses in a rat model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Diazepam; Disease Models, Animal; Electric Conductivity; Ep | 2004 |
Discrepancy between cell injury and benzodiazepine receptor binding after transient middle cerebral artery occlusion in rats.
Topics: Animals; Autoradiography; Benzazepines; Benzilates; Binding Sites; Binding, Competitive; Cerebral Co | 2004 |
Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures.
Topics: Animals; Anticonvulsants; Bromides; Chronic Disease; Disease Models, Animal; Dog Diseases; Dogs; Dru | 2004 |
Benzodiazepine effect of (125)I-iomazenil-benzodiazepine receptor binding and serum corticosterone level in a rat model.
Topics: Animals; Brain; Corticosterone; Diazepam; Disease Models, Animal; Flumazenil; Male; Radionuclide Ima | 2005 |
The anxiolytic-like effect of 5-HT1B receptor ligands in rats: a possible mechanism of action.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzamides; Conflict, Psychological; Diazepam; Disea | 2005 |
Central-type benzodiazepine receptors and epileptogenesis: basic mechanisms and clinical validity.
Topics: Adult; Amygdala; Animals; Autoradiography; Cerebral Cortex; Dentate Gyrus; Disease Models, Animal; E | 2005 |
Acute and chronic effects of ramelteon in rhesus monkeys (Macaca mulatta): dependence liability studies.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzodiazepines; Conditioning, Classical; Condition | 2006 |
Flumazenil mimics whereas midazolam abolishes ischemic preconditioning in a rabbit heart model of ischemia-reperfusion.
Topics: Animals; Disease Models, Animal; Flumazenil; Heart Rate; Ischemic Preconditioning, Myocardial; Midaz | 2006 |
Anxiolytic-like effect of group III mGlu receptor antagonist is serotonin-dependent.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Conflict, Psychological; Cyclopentanes; Dis | 2007 |
Anti-anxiety effects of Apocynum venetum L. in the elevated plus maze test.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Apocynum; Behavior, Animal; Buspirone; Diazepam; Disease Mode | 2007 |
Effects of diazepam on 125I-iomazenil-benzodiazepine receptor binding and epileptic seizures in the El mouse.
Topics: Animals; Anticonvulsants; Autoradiography; Brain; Diazepam; Disease Models, Animal; Epilepsy; Flumaz | 2006 |
Decreased Efficacy of GABAA-receptor modulation by midazolam in the kainate model of temporal lobe epilepsy.
Topics: Animals; Autoradiography; Beta Rhythm; Disease Models, Animal; Electroencephalography; Epilepsy, Tem | 2007 |
Repeated lipopolysaccharide (LPS) or cytokine treatments sensitize ethanol withdrawal-induced anxiety-like behavior.
Topics: Analysis of Variance; Animals; Antidotes; Anxiety; Behavior, Animal; Body Weight; Cytokines; Disease | 2008 |
Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors.
Topics: Animals; Anticonvulsants; Antidotes; Convulsants; Diazepam; Disease Models, Animal; Dose-Response Re | 2007 |
The amygdala regulates the antianxiety sensitization effect of flumazenil during repeated chronic ethanol or repeated stress.
Topics: Alcohol Drinking; Alcoholism; Amygdala; Animals; Anxiety; Behavior, Animal; Body Weight; Disease Mod | 2007 |
Evaluation of the anxiolytic effects of chrysin, a Passiflora incarnata extract, in the laboratory rat.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Catecholamines; Corti | 2007 |
Treatment with haloperidol and diazepam alters GABA(A) receptor density in the rat brain.
Topics: Animals; Antipsychotic Agents; Autoradiography; Benzodiazepines; Binding Sites; Brain; Diazepam; Dis | 2008 |
An investigation of flumazenil to antagonize gamma-hydroxybutyrate intoxication in a murine model.
Topics: Animals; Antidotes; Behavior, Animal; Disease Models, Animal; Flumazenil; Mice; Pilot Projects; Pois | 2006 |
Investigation of the anxiolytic effects of linalool, a lavender extract, in the male Sprague-Dawley rat.
Topics: Acyclic Monoterpenes; Animals; Anti-Anxiety Agents; Antidotes; Anxiety; Behavior, Animal; Disease Mo | 2008 |
Absence of intrinsic antagonist actions of benzodiazepine antagonists on an exploratory model of anxiety in the mouse.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepinones; Carbolines; Disease Models, Animal; Dose-R | 1984 |
Benzodiazepine receptor-mediated experimental "anxiety" in primates.
Topics: Animals; Anxiety; Benzodiazepinones; Blood Pressure; Carbolines; Disease Models, Animal; Epinephrine | 1982 |
Interactions of ethyl-beta-carboline-3-carboxylate and Ro 15-1788 with CGS 8216 in an animal model of anxiety.
Topics: Animals; Anxiety; Benzodiazepinones; Carbolines; Disease Models, Animal; Drug Interactions; Flumazen | 1983 |
Modification of the anticonvulsant efficacy of diazepam by Ro-15-1788 in the kindled amygdaloid seizure model.
Topics: Amygdala; Animals; Anticonvulsants; Benzodiazepinones; Diazepam; Disease Models, Animal; Dose-Respon | 1982 |
Regionally selective and age-dependent alterations in benzodiazepine receptor binding in the genetically dystonic hamster.
Topics: Aging; Animals; Binding Sites; Brain; Cerebellum; Corpus Striatum; Cricetinae; Disease Models, Anima | 1995 |
Gender differences in diazepam withdrawal syndrome in mice.
Topics: Animals; Body Weight; Castration; Diazepam; Disease Models, Animal; Estrogens; Female; Flumazenil; I | 1994 |
Quantitative autoradiography using selective radioligands for central and peripheral-type benzodiazepine receptors in experimental Wernicke's encephalopathy: implications for positron emission tomography imaging.
Topics: Animals; Autoradiography; Brain; Brain Mapping; Disease Models, Animal; Flumazenil; GABA Modulators; | 1996 |
Benzodiazepine antagonists reduce epileptiform discharges in rat hippocampal slices.
Topics: Animals; Carbolines; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electric | 1996 |
Antianxiety profile of ondansetron, a selective 5-HT3 antagonist, in a novel animal model.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Conflict, Psychological; Diazepam; Disease | 1997 |
The anxiolytic-like effects of the neurosteroid allopregnanolone: interactions with GABA(A) receptors.
Topics: Affinity Labels; Animals; Anti-Anxiety Agents; Anxiety; Azides; Behavior, Animal; Benzodiazepines; B | 1997 |
Comparison of routes of flumazenil administration to reverse midazolam-induced respiratory depression in a canine model.
Topics: Administration, Rectal; Administration, Sublingual; Animals; Antidotes; Cross-Over Studies; Disease | 1997 |
Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Carbolines; Convulsants; Diazepam; Disease Mod | 1998 |
Improvement of chronic hepatic encephalopathy in dogs by the benzodiazepine-receptor partial inverse agonist sarmazenil, but not by the antagonist flumazenil.
Topics: Ammonia; Animals; Benzodiazepines; Chronic Disease; Disease Models, Animal; Dogs; Electroencephalogr | 1998 |
Characterization of neuronal damage by iomazenil binding and cerebral blood flow in an ischemic rat model.
Topics: Animals; Brain; Cerebrovascular Circulation; Disease Models, Animal; Flumazenil; Iodine Radioisotope | 1998 |
Benzodiazepine receptor function in the chick social separation-stress procedure.
Topics: Alprazolam; Analgesia; Animals; Anti-Anxiety Agents; Chickens; Chlordiazepoxide; Disease Models, Ani | 1999 |
The role of gamma-aminobutyric acid (GABA)-benzodiazepine neurotransmission in an animal model of methamphetamine-induced psychosis.
Topics: Animals; Behavior, Animal; Central Nervous System Stimulants; Clonazepam; Depression, Chemical; Dise | 1999 |
Changes in benzodiazepine binding in a subkindling situation.
Topics: Animals; Carbolines; Convulsants; Disease Models, Animal; Epilepsy; Flumazenil; GABA Antagonists; Ki | 2000 |
Anti-depressant action of melatonin in chronic forced swimming-induced behavioral despair in mice, role of peripheral benzodiazepine receptor modulation.
Topics: Alprazolam; Analysis of Variance; Animals; Anti-Anxiety Agents; Antioxidants; Benzodiazepinones; Bic | 2000 |
Gamma-aminobutyric acid (GABAA) receptor-function in a rat model of hepatic encephalopathy.
Topics: Animals; Cerebral Cortex; Chlorides; Disease Models, Animal; Flumazenil; Hepatic Encephalopathy; Rad | 1990 |
Reversal of the behavioral and electrophysiological abnormalities of an animal model of hepatic encephalopathy by benzodiazepine receptor ligands.
Topics: Animals; Azides; Benzodiazepines; Disease Models, Animal; Electrophysiology; Evoked Potentials, Visu | 1990 |
A liquid diet model of chlordiazepoxide dependence in mice.
Topics: Animals; Chlordiazepoxide; Diet; Disease Models, Animal; Drinking; Flumazenil; Male; Mice; Mice, Inb | 1989 |
GABAA receptor complex in an experimental model of hepatic encephalopathy: evidence for elevated levels of an endogenous benzodiazepine receptor ligand.
Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Cerebellum; Cerebral Cortex; Disease Models, An | 1989 |
Intermittent flumazenil and benzodiazepine tolerance: discouraging findings in rats.
Topics: Animals; Benzodiazepines; Disease Models, Animal; Drug Administration Schedule; Drug Tolerance; Flum | 1989 |
Effects of amperozide in two animal models of anxiety.
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Brain Chemistry; Conflict, Psychological; Disease Models, | 1989 |
Scopolamine and benzodiazepine models of dementia: cross-reversals by Ro 15-1788 and physostigmine.
Topics: Acoustic Stimulation; Adult; Anti-Anxiety Agents; Attention; Cognition Disorders; Dementia; Disease | 1989 |
Animal models of chronic anxiety and "fearlessness".
Topics: Animals; Anxiety; Brain; Cats; Diazepam; Disease Models, Animal; Fear; Female; Flumazenil; Flunitraz | 1988 |
Long-lasting proconflict effect induced by chronic administration of the beta-carboline derivative FG 7142.
Topics: Animals; Anxiety; Benzodiazepinones; Carbolines; Conflict, Psychological; Disease Models, Animal; Dr | 1985 |
The effects of chronic antidepressant treatment in an animal model of anxiety.
Topics: Amitriptyline; Animals; Antidepressive Agents; Anxiety; Desipramine; Diazepam; Disease Models, Anima | 1988 |
Withdrawal from diazepam substitutes for the discriminative stimulus properties of pentylenetetrazol.
Topics: Animals; Diazepam; Discrimination Learning; Disease Models, Animal; Flumazenil; Male; Pentylenetetra | 1988 |