flumazenil has been researched along with Depressive Disorder in 14 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study is to determine whether long-term use (5-20 years) of therapeutic doses of diazepam (5-20 mg/day) in anxious patients (n = 28) is associated with tolerance to its psychomotor and cognitive effects." | 2.67 | Differential acute psychomotor and cognitive effects of diazepam on long-term benzodiazepine users. ( Bernik, MA; Gorenstein, C; Pompéia, S, 1994) |
| "Total sleep deprivation is the classic variant of its clinical use." | 2.44 | Sleep deprivation therapy. ( Svestka, J, 2008) |
| "The objectives of the study were to develop a population pharmacokinetic model for (11)C-flumazenil at tracer concentrations, to assess the effects of patient-related covariates and to derive an optimal sampling protocol for clinical use." | 1.33 | Population plasma pharmacokinetics of 11C-flumazenil at tracer concentrations. ( Franssen, EJ; Greuter, HN; Huitema, AD; Lammertsma, AA; Swart, EL; van Loenen, AC; van Rij, CM, 2005) |
| " A few subjects taking higher chronic benzodiazepine dosages experienced breakthrough anxiety or withdrawal symptoms, which were well managed by dosing flumazenil immediately before the anesthetic agent and by immediate posttreatment benzodiazepine administration." | 1.30 | The use of flumazenil in the anxious and benzodiazepine-dependent ECT patient. ( Krystal, AD; Lindahl, V; Moore, S; Steffens, DC; Watts, BV; Weiner, RD, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (14.29) | 18.7374 |
| 1990's | 4 (28.57) | 18.2507 |
| 2000's | 5 (35.71) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xu, NZ | 1 |
| Ernst, M | 1 |
| Treven, M | 1 |
| Cerne, R | 1 |
| Wakulchik, M | 1 |
| Li, X | 1 |
| Jones, TM | 1 |
| Gleason, SD | 1 |
| Morrow, D | 1 |
| Schkeryantz, JM | 1 |
| Rahman, MT | 1 |
| Li, G | 1 |
| Poe, MM | 1 |
| Cook, JM | 1 |
| Witkin, JM | 1 |
| Papp, M | 1 |
| Gruca, P | 1 |
| Lason-Tyburkiewicz, M | 1 |
| Litwa, E | 1 |
| Willner, P | 1 |
| Sencion Martinez, GL | 1 |
| Samillán, K | 1 |
| Espinosa, JL | 1 |
| Rodriguez Puyol, D | 1 |
| Martinez Miguel, P | 1 |
| Villa, P | 1 |
| Svestka, J | 1 |
| Russ, MJ | 1 |
| Bailine, SH | 1 |
| van Rij, CM | 1 |
| Huitema, AD | 1 |
| Swart, EL | 1 |
| Greuter, HN | 1 |
| Lammertsma, AA | 1 |
| van Loenen, AC | 1 |
| Franssen, EJ | 1 |
| Cameron, OG | 1 |
| Huang, GC | 1 |
| Nichols, T | 1 |
| Koeppe, RA | 1 |
| Minoshima, S | 1 |
| Rose, D | 1 |
| Frey, KA | 1 |
| Ohayon, MM | 1 |
| Berigan, TR | 1 |
| Harazin, J | 1 |
| Williams, HL | 1 |
| Gorenstein, C | 1 |
| Bernik, MA | 1 |
| Pompéia, S | 1 |
| Krystal, AD | 1 |
| Watts, BV | 1 |
| Weiner, RD | 1 |
| Moore, S | 1 |
| Steffens, DC | 1 |
| Lindahl, V | 1 |
| Burton, JH | 1 |
| Lyon, L | 1 |
| Dorfman, T | 1 |
| Tomassoni, AJ | 1 |
| Wetzel, H | 2 |
| Heuser, I | 2 |
| Benkert, O | 2 |
1 review available for flumazenil and Depressive Disorder
| Article | Year |
|---|---|
Sleep deprivation therapy.
Topics: Antipsychotic Agents; Circadian Rhythm; Clinical Trials as Topic; Combined Modality Therapy; Depress | 2008 |
1 trial available for flumazenil and Depressive Disorder
| Article | Year |
|---|---|
Differential acute psychomotor and cognitive effects of diazepam on long-term benzodiazepine users.
Topics: Adult; Anxiety Disorders; Cognition; Depressive Disorder; Diazepam; Dose-Response Relationship, Drug | 1994 |
12 other studies available for flumazenil and Depressive Disorder
| Article | Year |
|---|---|
Negative allosteric modulation of alpha 5-containing GABA
Topics: Aging; Allosteric Regulation; Animals; Antidepressive Agents; Benzodiazepines; Depressive Disorder; | 2018 |
Effects of chronic mild stress on the development of drug dependence in rats.
Topics: Animals; Chronic Disease; Citalopram; Depressive Disorder; Diazepam; Disease Models, Animal; Flumaze | 2014 |
[Hemoperfusion with activated charcoal on valproic acid poisoning. A case report].
Topics: Benzodiazepines; Charcoal; Combined Modality Therapy; Depressive Disorder; Drug Overdose; Female; Fl | 2015 |
Asystole and bradycardia related to anesthetic induction during ECT: a case report.
Topics: Adult; Anesthesia, General; Antidepressive Agents; Bradycardia; Depressive Disorder; Electroconvulsi | 2004 |
Population plasma pharmacokinetics of 11C-flumazenil at tracer concentrations.
Topics: Adult; Area Under Curve; Depressive Disorder; Epilepsy; Female; Flumazenil; GABA Modulators; Humans; | 2005 |
Reduced gamma-aminobutyric acid(A)-benzodiazepine binding sites in insular cortex of individuals with panic disorder.
Topics: Adult; Binding Sites; Brain; Carbon Radioisotopes; Cerebral Cortex; Comorbidity; Depressive Disorder | 2007 |
Insomnia: a ticking clock for depression?
Topics: Combined Modality Therapy; Comorbidity; Depressive Disorder; Flumazenil; GABA Modulators; GABA-A Rec | 2007 |
Use of flumazenil in conjunction with electroconvulsive therapy.
Topics: Adult; Clonazepam; Depressive Disorder; Electroconvulsive Therapy; Female; Flumazenil; Humans; Subst | 1995 |
The use of flumazenil in the anxious and benzodiazepine-dependent ECT patient.
Topics: Adult; Aged; Anti-Anxiety Agents; Anxiety Disorders; Arousal; Depressive Disorder; Electroconvulsive | 1998 |
Continuous flumazenil infusion in the treatment of zolpidem (Ambien) and ethanol coingestion.
Topics: Antidotes; Depressive Disorder; Ethanol; Female; Flumazenil; Humans; Hypnotics and Sedatives; Infusi | 1998 |
Benzodiazepines for catatonic symptoms, stupor, and mutism.
Topics: Anti-Anxiety Agents; Benzodiazepines; Catatonia; Depressive Disorder; Diazepam; Female; Flumazenil; | 1988 |
Stupor and affective state: alleviation of psychomotor disturbances by lorazepam and recurrence of symptoms after Ro 15-1788.
Topics: Adult; Carbamazepine; Coma; Depressive Disorder; Drug Interactions; Drug Therapy, Combination; Femal | 1987 |