flumazenil has been researched along with Depressive Disorder, Major in 8 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Depressive Disorder, Major: Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we report a case of the use of the benzodiazepine antagonist flumazenil before ECT to facilitate the simultaneous use of lorazepam and ECT for the treatment of co-occurring catatonia and obsessive-compulsive disorder." | 3.78 | Successful treatment of co-occurring catatonia and obsessive-compulsive disorder with concurrent electroconvulsive therapy and benzodiazepine administration. ( Furst, BA; Kwon, GE; Makhinson, M; Shuff, MK, 2012) |
| "The antidepressive effect of sleep deprivation (SD) in depressed patients disappears after sleep of the recovery night and after early morning naps." | 2.73 | Effect of flumazenil-augmentation on microsleep and mood in depressed patients during partial sleep deprivation. ( Brand, S; Hatzinger, M; Hemmeter, U; Holsboer-Trachsler, E, 2007) |
| "Flumazenil pretreatment of elderly ECT patients with declining seizure quality and inadequate clinical response in the setting of repeated treatments may represent a novel strategy for managing such patients." | 1.38 | Flumazenil pretreatment in benzodiazepine-free patients: a novel method for managing declining ECT seizure quality. ( Azner, Y; Reti, IM; Schiavi, A; Torres, J; Vaidya, P; Yi, J, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hasler, G | 1 |
| Nugent, AC | 1 |
| Carlson, PJ | 1 |
| Carson, RE | 1 |
| Geraci, M | 1 |
| Drevets, WC | 1 |
| Klumpers, UM | 2 |
| Veltman, DJ | 2 |
| Drent, ML | 1 |
| Boellaard, R | 2 |
| Comans, EF | 1 |
| Meynen, G | 1 |
| Lammertsma, AA | 2 |
| Hoogendijk, WJ | 2 |
| Kloet, RW | 1 |
| Yi, J | 1 |
| Torres, J | 1 |
| Azner, Y | 1 |
| Vaidya, P | 1 |
| Schiavi, A | 1 |
| Reti, IM | 1 |
| Makhinson, M | 1 |
| Furst, BA | 1 |
| Shuff, MK | 1 |
| Kwon, GE | 1 |
| Kugaya, A | 1 |
| Sanacora, G | 1 |
| Verhoeff, NP | 1 |
| Fujita, M | 1 |
| Mason, GF | 1 |
| Seneca, NM | 1 |
| Bozkurt, A | 1 |
| Khan, SA | 1 |
| Anand, A | 1 |
| Degen, K | 1 |
| Charney, DS | 1 |
| Zoghbi, SS | 1 |
| Baldwin, RM | 1 |
| Seibyl, JP | 1 |
| Innis, RB | 1 |
| Hemmeter, U | 1 |
| Hatzinger, M | 1 |
| Brand, S | 1 |
| Holsboer-Trachsler, E | 1 |
| Mervaala, E | 1 |
| Könönen, M | 1 |
| Föhr, J | 1 |
| Husso-Saastamoinen, M | 1 |
| Valkonen-Korhonen, M | 1 |
| Kuikka, JT | 1 |
| Viinamäki, H | 1 |
| Tammi, AK | 1 |
| Tiihonen, J | 1 |
| Partanen, J | 1 |
| Lehtonen, J | 1 |
2 trials available for flumazenil and Depressive Disorder, Major
| Article | Year |
|---|---|
Reduced parahippocampal and lateral temporal GABAA-[11C]flumazenil binding in major depression: preliminary results.
Topics: Adult; Antidepressive Agents; Carbon Radioisotopes; Case-Control Studies; Corticotropin-Releasing Ho | 2010 |
Effect of flumazenil-augmentation on microsleep and mood in depressed patients during partial sleep deprivation.
Topics: Adult; Affect; Arousal; Attention; Combined Modality Therapy; Depressive Disorder, Major; Double-Bli | 2007 |
6 other studies available for flumazenil and Depressive Disorder, Major
| Article | Year |
|---|---|
Altered cerebral gamma-aminobutyric acid type A-benzodiazepine receptor binding in panic disorder determined by [11C]flumazenil positron emission tomography.
Topics: Adult; Brain; Brain Mapping; Carbon Radioisotopes; Cerebral Cortex; Comorbidity; Depressive Disorder | 2008 |
Parametric [11C]flumazenil images.
Topics: Adult; Brain; Carbon Radioisotopes; Case-Control Studies; Depressive Disorder, Major; Flumazenil; GA | 2012 |
Flumazenil pretreatment in benzodiazepine-free patients: a novel method for managing declining ECT seizure quality.
Topics: Aged; Aged, 80 and over; Benzodiazepines; Combined Modality Therapy; Depressive Disorder, Major; Dos | 2012 |
Successful treatment of co-occurring catatonia and obsessive-compulsive disorder with concurrent electroconvulsive therapy and benzodiazepine administration.
Topics: Adult; Benzodiazepines; Catatonia; Combined Modality Therapy; Depressive Disorder, Major; Electrocon | 2012 |
Cerebral benzodiazepine receptors in depressed patients measured with [123I]iomazenil SPECT.
Topics: Adult; Binding Sites; Brain; Depressive Disorder, Major; Female; Flumazenil; gamma-Aminobutyric Acid | 2003 |
SPECT and neuropsychological performance in severe depression treated with ECT.
Topics: Adult; Brain; Cerebral Cortex; Depressive Disorder, Major; Dominance, Cerebral; Electroconvulsive Th | 2001 |