flumazenil has been researched along with Congenital Stiff-Man Syndrome in 3 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We re-investigated a 53 year old woman with SPS and profound anxiety for GABA-A receptor binding in the amygdala with (11)C-flumazenil PET scan and studied the potential pathogenic role of purified IgG from her plasma filtrates containing high-titer antibodies against GAD 65." | 3.77 | Human stiff-person syndrome IgG induces anxious behavior in rats. ( Dirkx, R; Folli, F; Geis, C; Gerlach, M; Grünewald, B; Heckmann, M; Perani, D; Reif, A; Solimena, M; Sommer, C; Toyka, KV; Weishaupt, A; Wultsch, T, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Galldiks, N | 1 |
| Thiel, A | 1 |
| Haense, C | 1 |
| Fink, GR | 1 |
| Hilker, R | 1 |
| Geis, C | 1 |
| Weishaupt, A | 1 |
| Grünewald, B | 1 |
| Wultsch, T | 1 |
| Reif, A | 1 |
| Gerlach, M | 1 |
| Dirkx, R | 1 |
| Solimena, M | 1 |
| Perani, D | 1 |
| Heckmann, M | 1 |
| Toyka, KV | 1 |
| Folli, F | 1 |
| Sommer, C | 1 |
| Kim, MJ | 1 |
| Lim, YM | 1 |
| Kim, JS | 1 |
| Kim, KK | 1 |
3 other studies available for flumazenil and Congenital Stiff-Man Syndrome
| Article | Year |
|---|---|
11C-flumazenil positron emission tomography demonstrates reduction of both global and local cerebral benzodiazepine receptor binding in a patient with Stiff Person Syndrome.
Topics: Aged; Binding, Competitive; Brain; Carbon Radioisotopes; Cerebral Cortex; Dominance, Cerebral; Femal | 2008 |
Human stiff-person syndrome IgG induces anxious behavior in rats.
Topics: Adult; Amygdala; Animals; Anxiety; Behavior, Animal; Carbon Radioisotopes; Cells, Cultured; Female; | 2011 |
GABAergic changes in (11)C-flumazenil PET in the drug-naïve Stiff-Person syndrome.
Topics: Adult; Carbon Radioisotopes; Female; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Glutamate | 2013 |