flumazenil has been researched along with Complication, Postoperative in 18 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
| Excerpt | Relevance | Reference |
|---|---|---|
| "It is not known whether hypoxia, associated with upper gastrointestinal endoscopic procedures when midazolam sedation is used without narcotics, persists into the post-procedure recovery period." | 9.07 | The effects of flumazenil on alertness and hypoxia in elderly patients after ERCP. ( Bibbey, D; Green, JR; Haines, DJ, 1992) |
| " We present the case of a healthy 12-year-old girl who received preoperative midazolam with the desired anxiolytic effect, underwent a brief general anesthetic, and then exhibited postoperative delirium, consisting of a transient associative agnosia and expressive aphasia." | 7.81 | Emergence delirium with transient associative agnosia and expressive aphasia reversed by flumazenil in a pediatric patient. ( Cook-Sather, SD; DiPuppo, PM; Drobish, JK; Kelz, MB, 2015) |
| "Despite its benignity, upper respiratory infections (URIs) 1 increase the risk of postoperative respiratory complications during the perioperative and postoperative periods." | 5.48 | Flumazenil reduces respiratory complications during anesthesia emergence in children with preoperative upper respiratory tract infections. ( Gao, X; Sun, R; Wang, G; Wang, S, 2018) |
| "It is not known whether hypoxia, associated with upper gastrointestinal endoscopic procedures when midazolam sedation is used without narcotics, persists into the post-procedure recovery period." | 5.07 | The effects of flumazenil on alertness and hypoxia in elderly patients after ERCP. ( Bibbey, D; Green, JR; Haines, DJ, 1992) |
| "The goal of this study was to assess the degree of postoperative anxiety flumazenil might provide in patients when used to reverse the sedation induced by midazolam." | 5.06 | [Does flumazenil, a benzodiazepine antagonist used during the anesthesia recovery period, have an anxiogenic effect?]. ( Beauvoir, C; du Cailar, J; Pares-Herbute, N; Peschaud, JL, 1989) |
| " We present the case of a healthy 12-year-old girl who received preoperative midazolam with the desired anxiolytic effect, underwent a brief general anesthetic, and then exhibited postoperative delirium, consisting of a transient associative agnosia and expressive aphasia." | 3.81 | Emergence delirium with transient associative agnosia and expressive aphasia reversed by flumazenil in a pediatric patient. ( Cook-Sather, SD; DiPuppo, PM; Drobish, JK; Kelz, MB, 2015) |
| "2." | 2.66 | [Postoperative reversal of loss of vigilance following midazolam with the use of the antagonist flumazenil (Ro 15-1788). A comparative study with a placebo and the use of EEG-power spectra]. ( Fournell, A; Freye, E, 1988) |
| "Sedation and restlessness in all patients were controlled by midazolam administered intravenously by the attending anaesthesiologist; these parameters were later objectively confirmed by recorded actigrams." | 2.41 | The midazolam-induced paradox phenomenon is reversible by flumazenil. Epidemiology, patient characteristics and review of the literature. ( Flaishon, R; Ogorek, D; Szold, O; Weinbroum, AA, 2001) |
| "Despite its benignity, upper respiratory infections (URIs) 1 increase the risk of postoperative respiratory complications during the perioperative and postoperative periods." | 1.48 | Flumazenil reduces respiratory complications during anesthesia emergence in children with preoperative upper respiratory tract infections. ( Gao, X; Sun, R; Wang, G; Wang, S, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (27.78) | 18.7374 |
| 1990's | 5 (27.78) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 6 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sun, R | 1 |
| Wang, G | 1 |
| Gao, X | 1 |
| Wang, S | 1 |
| Fujimoto, A | 1 |
| Okanishi, T | 1 |
| Kanai, S | 1 |
| Sato, K | 1 |
| Itamura, S | 1 |
| Baba, S | 1 |
| Nishimura, M | 1 |
| Masui, T | 1 |
| Enoki, H | 1 |
| Drobish, JK | 1 |
| Kelz, MB | 1 |
| DiPuppo, PM | 1 |
| Cook-Sather, SD | 1 |
| Chida, K | 1 |
| Ogasawara, K | 1 |
| Suga, Y | 1 |
| Saito, H | 1 |
| Kobayashi, M | 1 |
| Yoshida, K | 1 |
| Otawara, Y | 1 |
| Ogawa, A | 1 |
| Bosanko, NC | 1 |
| Barrett, D | 1 |
| Emm, C | 1 |
| Lycett, W | 1 |
| O'Toole, S | 1 |
| Evans, K | 1 |
| Hearing, SD | 1 |
| Porras Perez, F | 1 |
| Wells, C | 1 |
| Dwarakanath, D | 1 |
| Chatterjee, S | 1 |
| Gibb, A | 1 |
| Porter, J | 1 |
| Rinehart, JB | 1 |
| Baker, B | 1 |
| Raphael, D | 1 |
| Negus, BH | 1 |
| Street, NE | 1 |
| Dhonneur, G | 1 |
| Combes, X | 1 |
| Leroux, B | 1 |
| Duvaldestin, P | 1 |
| Weinbroum, AA | 1 |
| Szold, O | 1 |
| Ogorek, D | 1 |
| Flaishon, R | 1 |
| Gröger, P | 1 |
| Sydow, M | 1 |
| Michaelis, HC | 1 |
| Steinwachs, M | 1 |
| Kolenda, H | 1 |
| Kettler, D | 1 |
| Haines, DJ | 1 |
| Bibbey, D | 1 |
| Green, JR | 1 |
| Restall, J | 1 |
| Johnston, IG | 1 |
| Robinson, DN | 1 |
| Beauvoir, C | 1 |
| Peschaud, JL | 1 |
| Pares-Herbute, N | 1 |
| du Cailar, J | 1 |
| Tolksdorf, W | 1 |
| Bremer, H | 1 |
| Tokic, B | 1 |
| Rodrigo, MR | 1 |
| Rosenquist, JB | 1 |
| Raeder, JC | 1 |
| Hole, A | 1 |
| Arnulf, V | 1 |
| Grynne, BH | 1 |
| Freye, E | 1 |
| Fournell, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| TAP) Block in Morbid Obese Patients Undergoing Laparoscopic Gastric Bypass Surgery: A Prospective,Randomized, Blinded Study[NCT01075087] | 19 participants (Actual) | Interventional | 2010-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
24 Hour total opioid consumption translated into IV morphine equivalents. (NCT01075087)
Timeframe: 24 hours
| Intervention | miligram IV morphine equivalents (Median) |
|---|---|
| Placebo | 13 |
| Active Comparator | 7.5 |
Quality of Recovery 40 Score at 24 hours postoperative. (NCT01075087)
Timeframe: 24 hours post operatively
| Intervention | units on scale 40 (low) - 200 (high) (Median) |
|---|---|
| Placebo | 170 |
| Active Comparator | 175.5 |
1 review available for flumazenil and Complication, Postoperative
| Article | Year |
|---|---|
The midazolam-induced paradox phenomenon is reversible by flumazenil. Epidemiology, patient characteristics and review of the literature.
Topics: Aged; Aggression; Anesthesia, Epidural; Anesthesia, Spinal; Anti-Anxiety Agents; Female; Flumazenil; | 2001 |
8 trials available for flumazenil and Complication, Postoperative
| Article | Year |
|---|---|
Postoperative obstructive apnea.
Topics: Adult; Anesthesia, General; Anesthetics, Intravenous; Diaphragm; Electromyography; Flumazenil; GABA | 1999 |
The effects of flumazenil on alertness and hypoxia in elderly patients after ERCP.
Topics: Aged; Aged, 80 and over; Cholangiopancreatography, Endoscopic Retrograde; Double-Blind Method; Femal | 1992 |
Flumazenil in ketamine and midazolam anaesthesia.
Topics: Adolescent; Adult; Anesthesia Recovery Period; Anesthesia, Intravenous; Double-Blind Method; Female; | 1990 |
[Does flumazenil, a benzodiazepine antagonist used during the anesthesia recovery period, have an anxiogenic effect?].
Topics: Adolescent; Adult; Anesthesia Recovery Period; Anxiety; Epinephrine; Flumazenil; Humans; Midazolam; | 1989 |
[Postoperative, opiate-induced respiratory depression is not dependent on arousal].
Topics: Adult; Anesthesia, General; Anesthesia, Intravenous; Arousal; Arthroscopy; Clinical Trials as Topic; | 1989 |
The effect of Ro15-1788 (Anexate) on conscious sedation produced with midazolam.
Topics: Adolescent; Adult; Anesthesia, Dental; Blood Pressure; Flumazenil; Humans; Hypnotics and Sedatives; | 1987 |
Total intravenous anaesthesia with midazolam and flumazenil in outpatient clinics. A comparison with isoflurane or thiopentone.
Topics: Adult; Aged; Ambulatory Surgical Procedures; Anesthesia, Intravenous; Dilatation and Curettage; Elec | 1987 |
[Postoperative reversal of loss of vigilance following midazolam with the use of the antagonist flumazenil (Ro 15-1788). A comparative study with a placebo and the use of EEG-power spectra].
Topics: Adult; Arousal; Clinical Trials as Topic; Double-Blind Method; Electroencephalography; Flumazenil; H | 1988 |
9 other studies available for flumazenil and Complication, Postoperative
| Article | Year |
|---|---|
Flumazenil reduces respiratory complications during anesthesia emergence in children with preoperative upper respiratory tract infections.
Topics: Anesthesia Recovery Period; Antidotes; Child; Child, Preschool; Female; Flumazenil; Humans; Male; Ox | 2018 |
Double match of
Topics: Adolescent; Adult; Child; Epilepsy; Female; Flumazenil; Fluorodeoxyglucose F18; Humans; Magnetic Res | 2018 |
Emergence delirium with transient associative agnosia and expressive aphasia reversed by flumazenil in a pediatric patient.
Topics: Adjuvants, Anesthesia; Agnosia; Anesthesia, General; Aphasia, Broca; Child; Delirium; Female; Flumaz | 2015 |
Postoperative cortical neural loss associated with cerebral hyperperfusion and cognitive impairment after carotid endarterectomy: 123I-iomazenil SPECT study.
Topics: Adult; Aged; Analysis of Variance; Carotid Stenosis; Cerebral Cortex; Cerebrovascular Circulation; C | 2009 |
The routine use of a flumazenil infusion following percutaneous endoscopic gastrostomy placement to reduce early post-procedure mortality.
Topics: Adult; Aged; Aged, 80 and over; Enteral Nutrition; Female; Flumazenil; GABA Modulators; Gastrostomy; | 2010 |
The routine use of flumazenil infusion following percutaneous endoscopic gastrostomy placement to reduce early post-procedure mortality.
Topics: Female; Flumazenil; GABA Modulators; Gastrostomy; Humans; Male; Postoperative Complications | 2011 |
Postoperative global amnesia reversed with flumazenil.
Topics: Amnesia; Analgesics; Anesthesia, General; Cholangiopancreatography, Endoscopic Retrograde; Desfluran | 2012 |
Midazolam-opioid combination and postoperative upper airway obstruction in children.
Topics: Adenoidectomy; Airway Obstruction; Anesthesia, Intravenous; Child; Flumazenil; Humans; Male; Midazol | 1994 |
[Extreme duration of action of diazepam as a cause of respiratory insufficiency in a female geriatric patient].
Topics: Aged; Diazepam; Female; Flumazenil; Humans; Postoperative Complications; Respiratory Insufficiency; | 1992 |