flumazenil has been researched along with Coma in 82 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the efficacy of the native flumazenil for acute self-poisoning with benzodiazepines." | 9.09 | [The efficacy of the native flumazenil for acute poisoning with benzodiazepines]. ( Li, JX; Wang, F; Zhu, XH, 2000) |
| "Flumazenil may exert a beneficial effect in a subset of patients with acute hepatic encephalopathy; encephalopathy associated with bleeding is more likely to respond to flumazenil; responders to the treatment usually improve within the first 6 hours while lack of response usually represents a bad prognostic sign." | 9.09 | Flumazenil in the treatment of acute hepatic encephalopathy in cirrhotic patients: a double blind randomized placebo controlled study. ( Balzano, A; Laccetti, M; Lioniello, M; Manes, G; Rabitti, PG; Uomo, G, 2000) |
| "Flumazenil is a valuable and safe differential diagnostic tool in unclear cases of multiple drug poisoning." | 9.06 | Diagnostic utility of flumazenil in coma with suspected poisoning: a double blind, randomised controlled study. ( Baehrendtz, S; Gustafsson, LL; Höjer, J; Matell, G, 1990) |
| "The use of flumazenil, a benzodiazepine antagonist, was studied in two patients with coma of unknown etiology." | 9.06 | The diagnostic utility of flumazenil (a benzodiazepine antagonist) in coma of unknown etiology. ( Burkhart, KK; Kulig, KW, 1990) |
| "An overview of randomized controlled trials comparing flumazenil and placebo in hepatic encephalopathy in patients with cirrhosis was performed." | 8.81 | Flumazenil vs. placebo in hepatic encephalopathy in patients with cirrhosis: a meta-analysis. ( Bernard, B; Cadranel, JF; Di Martino, V; Goulenok, C; Opolon, P; Poynard, T; Thabut, D, 2002) |
| "We report the first case of a patient in a promethazine-induced coma responding to treatment with flumazenil." | 8.79 | Response of a promethazine-induced coma to flumazenil. ( MacLeod, DB; Plant, JR, 1994) |
| "BACKGROUND Olanzapine is an antipsychotic drug and is used in critical care to treat delirium." | 8.12 | Coma, Severe Hypotension, and Pinpoint Pupils After Olanzapine Intoxication in the Intensive Care Unit with Symptom Reversal After Administration of Flumazenil. ( Aiff, H; Guldberg, J; Gustafsson, JM; Pålsson, P, 2022) |
| " We present a flumazenil-reversed gabapentin-induced coma case, which, to our knowledge, is the second one described in scientific literature." | 8.02 | Flumazenil therapy for a gabapentin-induced coma: a case report. ( Foti, C; Masciullo, M; Molinari, M; Pichiorri, F; Scivoletto, G, 2021) |
| "To describe a case of gabapentin-induced coma that was reversed with flumazenil and hemodialysis." | 7.72 | Flumazenil and dialysis for gabapentin-induced coma. ( Amsden, GW; Butler, TC; Rosen, RM; Wallace, AL, 2003) |
| "Comatose patients with clinical or ECG criteria thought to contraindicate the use of flumazenil have a reasonably high risk of seizures after administration of this drug." | 7.69 | Empiric use of flumazenil in comatose patients: limited applicability of criteria to define low risk. ( Baud, FJ; Gueye, PN; Hoffman, JR; Taboulet, P; Vicaut, E, 1996) |
| "The purpose of this report is to describe the use of flumazenil as a diagnostic aid in the differential diagnosis of coma in a patient with an inadvertent overdose of benzodiazepines." | 7.69 | Flumazenil as a diagnostic tool in the differential diagnosis of coma in a critically ill patient. ( McLachlan, RS; Sharpe, MD; Sprenger, H, 1994) |
| "A study was conducted to evaluate repeated intrathecal injections of baclofen, without artificial ventilation, in the treatment of severe tetanus." | 7.68 | Treatment of severe tetanus by intrathecal injections of baclofen without artificial ventilation. ( Demazière, J; Gaye, M; Marcoux, L; Ndiaye, M; Saissy, JM; Seck, M; Vitris, M, 1992) |
| "These findings indicate that flumazenil is safe and effective in the diagnosis of benzodiazepine-induced coma." | 7.68 | Use of flumazenil in the diagnosis and treatment of patients with coma of unknown etiology. ( Almog, S; Ezra, D; Halkin, H; Kriger, D; Tirosh, MS; Winkler, E, 1993) |
| "Repeated administration of diazepam in two ventilated patients had caused drug cumulation and coma over several days." | 7.67 | [Prolonged coma caused by diazepam sedation in ventilated patients. Diagnostic and therapeutic use of the benzodiazepine antagonist Ro 15-1788]. ( Follath, F; Kehl, O; Rapold, HJ; Ritz, R; Scollo-Lavizzari, G, 1984) |
| "The stage of coma, heart rate, blood pressure and respiratory rate were monitored within the following 15 min." | 6.67 | Clinical experience with the benzodiazepine antagonist flumazenil in suspected benzodiazepine or ethanol poisoning. ( Ibe, K; Köppel, C; Martens, F; Tenczer, J; Wagemann, A, 1990) |
| "Flumazenil is an important adjunct to the diagnosis and treatment of benzodiazepine toxicity." | 6.39 | Reappraisal of the "coma cocktail". Dextrose, flumazenil, naloxone, and thiamine. ( Doyon, S; Roberts, JR, 1994) |
| "Flumazenil is a competitive antagonist with specific action at the central benzodiazepine receptor." | 5.32 | Reversal of an antihistamine-induced coma with flumazenil. ( Cebrero, M; García-Frías, E; Gónzalez-Santiago, P; Lassaletta, A; Martino, R; Torrijos, C, 2004) |
| "Flumazenil was injected intravenously as a 0." | 5.29 | Diagnostic and therapeutic utility of flumazenil in comatose patients with drug overdose. ( Chern, TL; Deng, JF; Hu, SC; Lee, CH, 1993) |
| "To evaluate the efficacy of the native flumazenil for acute self-poisoning with benzodiazepines." | 5.09 | [The efficacy of the native flumazenil for acute poisoning with benzodiazepines]. ( Li, JX; Wang, F; Zhu, XH, 2000) |
| "Flumazenil may exert a beneficial effect in a subset of patients with acute hepatic encephalopathy; encephalopathy associated with bleeding is more likely to respond to flumazenil; responders to the treatment usually improve within the first 6 hours while lack of response usually represents a bad prognostic sign." | 5.09 | Flumazenil in the treatment of acute hepatic encephalopathy in cirrhotic patients: a double blind randomized placebo controlled study. ( Balzano, A; Laccetti, M; Lioniello, M; Manes, G; Rabitti, PG; Uomo, G, 2000) |
| "Unconscious patients (n = 110) suspected of benzodiazepine overdose, graded 2 to 4 on the Matthew and Lawson coma scale, were treated with flumazenil, the specific benzodiazepine receptor antagonist." | 5.08 | Use of flumazenil in the treatment of drug overdose: a double-blind and open clinical study in 110 patients. ( Geller, E; Halpern, P; Nevo, Y; Niv, D; Rudick, V; Sorkine, P; Weinbroum, A, 1996) |
| "The use of flumazenil, a benzodiazepine antagonist, was studied in two patients with coma of unknown etiology." | 5.06 | The diagnostic utility of flumazenil (a benzodiazepine antagonist) in coma of unknown etiology. ( Burkhart, KK; Kulig, KW, 1990) |
| "Flumazenil is a valuable and safe differential diagnostic tool in unclear cases of multiple drug poisoning." | 5.06 | Diagnostic utility of flumazenil in coma with suspected poisoning: a double blind, randomised controlled study. ( Baehrendtz, S; Gustafsson, LL; Höjer, J; Matell, G, 1990) |
| "The aim of this study is to examine if flumazenil should be used in patients with coma from suspected drug poisoning." | 4.84 | Should a benzodiazepine antagonist be used in unconscious patients presenting to the emergency department? ( Anthony, CR; Ngo, AS; Ponampalam, R; Samuel, M; Wong, E, 2007) |
| "An overview of randomized controlled trials comparing flumazenil and placebo in hepatic encephalopathy in patients with cirrhosis was performed." | 4.81 | Flumazenil vs. placebo in hepatic encephalopathy in patients with cirrhosis: a meta-analysis. ( Bernard, B; Cadranel, JF; Di Martino, V; Goulenok, C; Opolon, P; Poynard, T; Thabut, D, 2002) |
| "BACKGROUND Olanzapine is an antipsychotic drug and is used in critical care to treat delirium." | 4.12 | Coma, Severe Hypotension, and Pinpoint Pupils After Olanzapine Intoxication in the Intensive Care Unit with Symptom Reversal After Administration of Flumazenil. ( Aiff, H; Guldberg, J; Gustafsson, JM; Pålsson, P, 2022) |
| "To describe a case of gabapentin-induced coma that was reversed with flumazenil and hemodialysis." | 3.72 | Flumazenil and dialysis for gabapentin-induced coma. ( Amsden, GW; Butler, TC; Rosen, RM; Wallace, AL, 2003) |
| " In the two patients, nordazepam accumulation (main active metabolite of clorazepam) was demonstrated as the cause of the coma." | 3.70 | Prolonged sedation requiring mechanical ventilation and continuous flumazenil infusion after routine doses of clorazepam for alcohol withdrawal syndrome. ( Alzieu, M; Becquemont, L; Delhotal Landes, B; Guglielminotti, J; Guidet, B; Maury, E; Offenstadt, G, 1999) |
| "The purpose of this report is to describe the use of flumazenil as a diagnostic aid in the differential diagnosis of coma in a patient with an inadvertent overdose of benzodiazepines." | 3.69 | Flumazenil as a diagnostic tool in the differential diagnosis of coma in a critically ill patient. ( McLachlan, RS; Sharpe, MD; Sprenger, H, 1994) |
| "Comatose patients with clinical or ECG criteria thought to contraindicate the use of flumazenil have a reasonably high risk of seizures after administration of this drug." | 3.69 | Empiric use of flumazenil in comatose patients: limited applicability of criteria to define low risk. ( Baud, FJ; Gueye, PN; Hoffman, JR; Taboulet, P; Vicaut, E, 1996) |
| "We report a case of inadvertent overdose of baclofen given intrathecally resulting in coma." | 3.69 | Flumazenil: an unreliable antagonist in baclofen overdose. ( Byrnes, SM; Hardy, PA; Watson, GW, 1996) |
| " Flumazenil was efficient for leading out from coma in 86% of cases with poisoning only by benzodiazepines and 13% of cases with mixed intoxications mainly containing benzodiazepines and alcohol or carbamazepine." | 3.69 | [Suicidal poisoning with benzodiazepines]. ( Chodorowski, Z; Sein Anand, J, 1997) |
| " In all five patients, the comatose state was immediately reversed by the benzodiazepine-receptor antagonist flumazenil." | 3.69 | Prolonged sedation due to accumulation of conjugated metabolites of midazolam. ( Bauer, TM; Ha, HR; Haberthür, C; Haefeli, WE; Hunkeler, W; Ritz, R; Scollo-Lavizzari, G; Sleight, AJ, 1995) |
| "There are a few case reports which suggest that flumazenil can be used as a diagnostic tool in coma of unknown aetiology but no large scale studies have proved its efficacy and cost-effectiveness." | 3.69 | The role of flumazenil in the management of patients with acute alteration of mental status in the emergency department. ( Chern, TL; Deng, JF; Hu, SC; Lee, CH, 1994) |
| " Idiopathic recurring stupor (IRS) is a syndrome of spontaneous stupor or coma that is not associated with known metabolic, toxic, or structural abnormalities but can be reversed by flumazenil, a pure benzodiazepine antagonist." | 3.68 | Endogenous benzodiazepine receptor ligands in idiopathic recurring stupor. ( Avoni, P; Cortelli, P; Guidotti, A; Lugaresi, E; Montagna, P; Plazzi, G; Rothstein, JD; Schoch, P; Tinuper, P, 1992) |
| "A study was conducted to evaluate repeated intrathecal injections of baclofen, without artificial ventilation, in the treatment of severe tetanus." | 3.68 | Treatment of severe tetanus by intrathecal injections of baclofen without artificial ventilation. ( Demazière, J; Gaye, M; Marcoux, L; Ndiaye, M; Saissy, JM; Seck, M; Vitris, M, 1992) |
| "Repeated administration of diazepam in two ventilated patients had caused drug cumulation and coma over several days." | 3.67 | [Prolonged coma caused by diazepam sedation in ventilated patients. Diagnostic and therapeutic use of the benzodiazepine antagonist Ro 15-1788]. ( Follath, F; Kehl, O; Rapold, HJ; Ritz, R; Scollo-Lavizzari, G, 1984) |
| "In 20 patients with coma (grade 4: n = 7, grade 3: n = 8, grade 2: n = 2, grade 1: n = 3) due to benzodiazepine intoxication, solely or combined with alcohol or other psychoactive drugs, the effect of a specific benzodiazepine antagonist, Flumazenil (Ro 15-1788), was evaluated." | 3.67 | [Specific therapy of acute benzodiazepine poisoning using flumazenil (Ro 15-1788)]. ( Donner, A; Grimm, G; Hruby, K; Pernecker, M; Prischl, F; Scholtz, I; Smetana, R, 1987) |
| "Flumazenil acts as an antidote for pharmacological and toxic effects due to benzodiazepines." | 2.67 | Efficacy of flumazenil in acute alcohol intoxication: double blind placebo-controlled evaluation. ( Askenasi, R; Lheureux, P, 1991) |
| "The stage of coma, heart rate, blood pressure and respiratory rate were monitored within the following 15 min." | 2.67 | Clinical experience with the benzodiazepine antagonist flumazenil in suspected benzodiazepine or ethanol poisoning. ( Ibe, K; Köppel, C; Martens, F; Tenczer, J; Wagemann, A, 1990) |
| "Flumazenil has been reported to reverse sedation from all three Z-drugs." | 2.49 | The clinical and forensic toxicology of Z-drugs. ( Gunja, N, 2013) |
| "Flumazenil is an important adjunct to the diagnosis and treatment of benzodiazepine toxicity." | 2.39 | Reappraisal of the "coma cocktail". Dextrose, flumazenil, naloxone, and thiamine. ( Doyon, S; Roberts, JR, 1994) |
| "The incidence of coma was significantly higher, and the length of hospital stay significantly longer in elderly." | 1.43 | Benzodiazepine poisoning in elderly. ( Djordjević, S; Ercegović, GV; Segrt, Z; Stosić, JJ; Vukcević, NP, 2016) |
| "A 27-year-old man, presented with deep coma, bilateral pinpoint unreactive pupils, acute respiratory failure and hypotension, complicated by hypoxic ischemic changes in the central nervous system." | 1.43 | Flubromazolam--A new life-threatening designer benzodiazepine. ( Panieński, P; Sommerfeld, K; Teżyk, A; Żaba, C; Zielińska-Psuja, B; Łukasik-Głębocka, M, 2016) |
| "A 10-year-old boy with trisomy 21 presented to the emergency department 1 hour after he was found sedate with several zolpidem 5-mg tablets in his mouth." | 1.39 | Pediatric zolpidem ingestion demonstrating zero-order kinetics treated with flumazenil. ( Carstairs, SD; Negus, E; Thornton, SL, 2013) |
| "Of 947 admissions, 222 (23%) were comatose." | 1.35 | Acute poisonings treated in hospitals in Oslo: a one-year prospective study (II): clinical outcome. ( Bjornas, MA; Ekeberg, O; Heyerdahl, F; Hovda, KE; Jacobsen, D; Opdahl, A; Skog, K; Wium, C, 2008) |
| "Flumazenil is a competitive antagonist with specific action at the central benzodiazepine receptor." | 1.32 | Reversal of an antihistamine-induced coma with flumazenil. ( Cebrero, M; García-Frías, E; Gónzalez-Santiago, P; Lassaletta, A; Martino, R; Torrijos, C, 2004) |
| "Delayed postanoxic encephalopathy is a relatively uncommon and unexplained phenomenon which becomes manifest after an initial hypoxic-ischemic event that causes stupor or coma." | 1.31 | [Delayed postanoxic encephalopathy]. ( Collantes Herrera , A; Gascón Jiménez , FJ; Navarro Gochicoa , B; Peña Rosa , MJ; Velasco Jabalquinto , MJ, 2000) |
| "Flumazenil has no role in the routine treatment of coma unless the patient is known to not be benzodiazepine dependent and the overdose is known to result only from benzos--two very difficult requirements to verify in the back of an ambulance at 2 a." | 1.31 | No more coma cocktails. Using science to dispel myths & improve patient care. ( Bledsoe, BE, 2002) |
| "Flumazenil was administered as escalating bolus doses followed by a continuous infusion." | 1.31 | Mechanism of respiratory insufficiency in pure or mixed drug-induced coma involving benzodiazepines. ( Baud, FJ; Borron, SW; Gueye, PN; Harf, A; Lofaso, F; Mellerio, F; Vicaut, E, 2002) |
| "Flumazenil was injected intravenously as a 0." | 1.29 | Diagnostic and therapeutic utility of flumazenil in comatose patients with drug overdose. ( Chern, TL; Deng, JF; Hu, SC; Lee, CH, 1993) |
| "Only one anorectic patient became comatose after ingestion of 0." | 1.29 | [Acute overdose of Zolpidem (Stilnox)]. ( Meier-Abt, PJ; Radovanovic, D; Wyss, PA, 1996) |
| "Hepatic encephalopathy is ameliorated by drugs acting on the central GABAA-benzodiazepine receptor complex." | 1.28 | Beneficial effect of pharmacological modulation of the GABAA-benzodiazepine receptor on hepatic encephalopathy in the rat: comparison with uremic encephalopathy. ( Druml, W; Ferenci, P; Püspök, A; Steindl, P, 1991) |
| "Zolpidem is a recently introduced sleep-inducer which is thought to act on the central-type benzodiazepine receptors." | 1.28 | Zolpidem intoxication mimicking narcotic overdose: response to flumazenil. ( Askenasi, R; De Witte, O; Debailleul, G; Lheureux, P, 1990) |
| "In two cases it was used to diagnose a coma of unknown origin." | 1.28 | [The efficacy of the benzodiazepine antagonist flumazenil (Ro 15-1788) based on the EEG of mechanically ventilated intensive care patients]. ( Kulka, PJ; Lauven, PM; Rommelsheim, K; Schwilden, H, 1989) |
| "Recently it was suggested that hepatic encephalopathy (HE) is mediated by an increased GABA-ergic tone." | 1.28 | Benzodiazepine antagonist in the treatment of human hepatic encephalopathy. ( Ferenci, P; Grimm, G, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (18.29) | 18.7374 |
| 1990's | 41 (50.00) | 18.2507 |
| 2000's | 18 (21.95) | 29.6817 |
| 2010's | 5 (6.10) | 24.3611 |
| 2020's | 3 (3.66) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, SY | 1 |
| Chu, FY | 1 |
| Yang, CY | 1 |
| Tarng, DC | 1 |
| Pålsson, P | 3 |
| Guldberg, J | 3 |
| Gustafsson, JM | 3 |
| Aiff, H | 3 |
| Masciullo, M | 1 |
| Pichiorri, F | 1 |
| Scivoletto, G | 1 |
| Foti, C | 1 |
| Molinari, M | 1 |
| Gunja, N | 1 |
| Thornton, SL | 1 |
| Negus, E | 1 |
| Carstairs, SD | 1 |
| Sivilotti, ML | 1 |
| Łukasik-Głębocka, M | 1 |
| Sommerfeld, K | 1 |
| Teżyk, A | 1 |
| Zielińska-Psuja, B | 1 |
| Panieński, P | 1 |
| Żaba, C | 1 |
| Vukcević, NP | 1 |
| Ercegović, GV | 1 |
| Segrt, Z | 1 |
| Djordjević, S | 1 |
| Stosić, JJ | 1 |
| Meierhans, R | 1 |
| Stover, JF | 1 |
| Béchir, M | 1 |
| Keel, M | 1 |
| Stocker, R | 1 |
| Höjer, J | 3 |
| Salmonson, H | 1 |
| Sundin, P | 1 |
| Huberfeld, G | 1 |
| Dupont, S | 1 |
| Hazemann, P | 1 |
| Adam, C | 1 |
| Baulac, M | 1 |
| Pierrot-Deseilligny, C | 1 |
| Bledsoe, BE | 1 |
| Butler, TC | 1 |
| Rosen, RM | 1 |
| Wallace, AL | 1 |
| Amsden, GW | 1 |
| Zhu, XH | 1 |
| Li, JX | 1 |
| Wang, F | 1 |
| Trullàs, JC | 1 |
| Nogué, S | 1 |
| Miró, O | 1 |
| Munné, P | 1 |
| Lassaletta, A | 1 |
| Martino, R | 1 |
| Gónzalez-Santiago, P | 1 |
| Torrijos, C | 1 |
| Cebrero, M | 1 |
| García-Frías, E | 1 |
| Bartlett, D | 1 |
| Cortelli, P | 3 |
| Avallone, R | 1 |
| Baraldi, M | 1 |
| Zeneroli, ML | 1 |
| Mandrioli, J | 1 |
| Corsi, L | 1 |
| Riva, R | 1 |
| Tinuper, P | 5 |
| Lugaresi, E | 5 |
| Baruzzi, A | 1 |
| Montagna, P | 5 |
| Ngo, AS | 1 |
| Anthony, CR | 1 |
| Samuel, M | 1 |
| Wong, E | 1 |
| Ponampalam, R | 1 |
| Carvalho, C | 1 |
| Walker, DA | 1 |
| Heyerdahl, F | 1 |
| Bjornas, MA | 1 |
| Hovda, KE | 1 |
| Skog, K | 1 |
| Opdahl, A | 1 |
| Wium, C | 1 |
| Ekeberg, O | 1 |
| Jacobsen, D | 1 |
| Scollo-Lavizzari, G | 5 |
| Rapold, HJ | 1 |
| Follath, F | 1 |
| Kehl, O | 1 |
| Ritz, R | 3 |
| Bauer, TM | 1 |
| Haberthür, C | 1 |
| Ha, HR | 1 |
| Hunkeler, W | 1 |
| Sleight, AJ | 1 |
| Haefeli, WE | 1 |
| Plazzi, G | 3 |
| Plant, JR | 1 |
| MacLeod, DB | 1 |
| Rubio, F | 1 |
| Quintero, S | 1 |
| Hernandez, A | 1 |
| Fernandez, S | 1 |
| Cozar, L | 1 |
| Lobato, IM | 1 |
| Pantoja, S | 1 |
| Winkler, E | 1 |
| Almog, S | 1 |
| Kriger, D | 1 |
| Tirosh, MS | 1 |
| Halkin, H | 1 |
| Ezra, D | 1 |
| Sprenger, H | 1 |
| Sharpe, MD | 1 |
| McLachlan, RS | 1 |
| Doyon, S | 1 |
| Roberts, JR | 1 |
| Chern, TL | 3 |
| Hu, SC | 3 |
| Lee, CH | 3 |
| Deng, JF | 3 |
| Krenzelok, EP | 2 |
| Weinbroum, A | 2 |
| Rudick, V | 2 |
| Sorkine, P | 3 |
| Nevo, Y | 1 |
| Halpern, P | 2 |
| Geller, E | 4 |
| Niv, D | 2 |
| Fleishon, R | 1 |
| Gueye, PN | 2 |
| Hoffman, JR | 1 |
| Taboulet, P | 1 |
| Vicaut, E | 2 |
| Baud, FJ | 2 |
| Wyss, PA | 1 |
| Radovanovic, D | 1 |
| Meier-Abt, PJ | 1 |
| Byrnes, SM | 1 |
| Watson, GW | 1 |
| Hardy, PA | 1 |
| Perry, HE | 1 |
| Shannon, MW | 1 |
| Chodorowski, Z | 1 |
| Sein Anand, J | 1 |
| Gallassi, R | 2 |
| Wang, TC | 1 |
| Markey, SP | 1 |
| Rothstein, JD | 2 |
| Chern, CH | 1 |
| Wang, LM | 1 |
| Ramírez-Moreno, JM | 1 |
| Cordero, JA | 1 |
| Durán-Herrera, C | 1 |
| Roberge, RJ | 1 |
| Atchley, B | 1 |
| Ryan, K | 1 |
| Weiner, AL | 1 |
| McKay, CA | 1 |
| Palmieri, MG | 1 |
| Iani, C | 1 |
| Scalise, A | 1 |
| Desiato, MT | 1 |
| Loberti, M | 1 |
| Telera, S | 1 |
| Caramia, MD | 1 |
| Guglielminotti, J | 1 |
| Maury, E | 1 |
| Alzieu, M | 1 |
| Delhotal Landes, B | 1 |
| Becquemont, L | 1 |
| Guidet, B | 1 |
| Offenstadt, G | 1 |
| Gascón Jiménez , FJ | 1 |
| Navarro Gochicoa , B | 1 |
| Velasco Jabalquinto , MJ | 1 |
| Collantes Herrera , A | 1 |
| Peña Rosa , MJ | 1 |
| Buylaert, WA | 1 |
| Laccetti, M | 1 |
| Manes, G | 1 |
| Uomo, G | 1 |
| Lioniello, M | 1 |
| Rabitti, PG | 1 |
| Balzano, A | 1 |
| Goulenok, C | 1 |
| Bernard, B | 1 |
| Cadranel, JF | 1 |
| Thabut, D | 1 |
| Di Martino, V | 1 |
| Opolon, P | 1 |
| Poynard, T | 1 |
| Lofaso, F | 1 |
| Borron, SW | 1 |
| Mellerio, F | 1 |
| Harf, A | 1 |
| Avoni, P | 2 |
| Lugaresi, A | 1 |
| Schoch, P | 2 |
| Bonetti, EP | 1 |
| Sforza, E | 1 |
| Guidotti, A | 1 |
| Saissy, JM | 1 |
| Demazière, J | 1 |
| Vitris, M | 1 |
| Seck, M | 1 |
| Marcoux, L | 1 |
| Gaye, M | 1 |
| Ndiaye, M | 1 |
| Steindl, P | 1 |
| Püspök, A | 1 |
| Druml, W | 1 |
| Ferenci, P | 2 |
| Lheureux, P | 2 |
| Askenasi, R | 2 |
| Skielboe, M | 1 |
| Andersen, PM | 1 |
| Weber, M | 1 |
| Jarnvig, IL | 1 |
| Sztuk, F | 1 |
| Jorgensen, I | 1 |
| Dorado Pombo, MS | 1 |
| Coto López, A | 1 |
| González Gómez, C | 1 |
| LaFleche, FR | 1 |
| Milzman, DP | 1 |
| Crome, P | 1 |
| Schaller, MD | 1 |
| Marchant, B | 1 |
| Ectors, M | 1 |
| Baehrendtz, S | 1 |
| Matell, G | 1 |
| Gustafsson, LL | 1 |
| Hodgkinson, DW | 1 |
| Driscoll, P | 1 |
| Ahmad, Z | 1 |
| Herepath, M | 1 |
| Ebden, P | 1 |
| Grimm, G | 2 |
| Burkhart, KK | 1 |
| Kulig, KW | 1 |
| Debailleul, G | 1 |
| De Witte, O | 1 |
| Martens, F | 1 |
| Köppel, C | 1 |
| Ibe, K | 1 |
| Wagemann, A | 1 |
| Tenczer, J | 1 |
| Kulka, PJ | 1 |
| Lauven, PM | 1 |
| Schwilden, H | 1 |
| Rommelsheim, K | 1 |
| Gijsenbergh, FP | 1 |
| Pillen, EJ | 1 |
| Delooz, HH | 1 |
| Sfez, M | 1 |
| Berg, A | 1 |
| Saint-Maurice, C | 1 |
| Hofer, P | 1 |
| Hruby, K | 1 |
| Prischl, F | 1 |
| Smetana, R | 1 |
| Pernecker, M | 1 |
| Donner, A | 1 |
| Scholtz, I | 1 |
| Aarseth, HP | 1 |
| Bredesen, JE | 1 |
| Grynne, B | 1 |
| Lyngdal, PT | 1 |
| Storstein, L | 1 |
| Wiik-Larsen, E | 1 |
| Weinbrum, A | 1 |
| Silbiger, A | 1 |
| Elsasser, S | 1 |
| Schwander, J | 1 |
| Wood, C | 1 |
| Bismuth, C | 1 |
| Oriot, D | 1 |
| Devictor, D | 1 |
| Huault, G | 1 |
| Wetzel, H | 1 |
| Heuser, I | 1 |
| Benkert, O | 1 |
| Knudsen, L | 1 |
| Lonka, L | 1 |
| Sørensen, BH | 1 |
| Kirkegaard, L | 1 |
| Jensen, OV | 1 |
| Jensen, S | 1 |
| Chiolero, RL | 1 |
| Ravussin, P | 1 |
| Anderes, JP | 1 |
| Ledermann, P | 1 |
| de Tribolet, N | 1 |
| Ume, EO | 1 |
| Gelb, AW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Flumazenil on Hypoactive Delirium in the ICU: A Double-Blind, Placebo-Controlled Pilot Study[NCT02899156] | Phase 4 | 22 participants (Actual) | Interventional | 2016-03-31 | Terminated (stopped due to A planned interim analysis led to the trial being stopped early based on the observed size effect and power analysis.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
average duration of time patient was randomized to each infusion up to 72 hours (NCT02899156)
Timeframe: up to 72 hours after the start of the infusion
| Intervention | hours (Mean) |
|---|---|
| Flumazenil Group | 54.8 |
| Placebo Group | 58.2 |
average maximum rate (ml/hr) during the 72 hours after study infusion (NCT02899156)
Timeframe: up to 72 hours after the start of the infusion
| Intervention | milliliters per hour (Mean) |
|---|---|
| Flumazenil Group | 5 |
| Placebo Group | 5.2 |
length of time that the patient was admitted to an intensive care unit service during the hospital stay (NCT02899156)
Timeframe: duration of admission to the intensive care unit
| Intervention | days (Mean) |
|---|---|
| Flumazenil Group | 7.8 |
| Placebo Group | 7 |
Defined by the number of days in the 14-day period after randomization that the patient was alive and not delirious (i.e. CAM-ICU negative). Zero delirium-free days will be observed for patients that die within the 14-day period. (NCT02899156)
Timeframe: up to 14 days after randomization
| Intervention | days (Median) |
|---|---|
| Flumazenil Group | 12.7 |
| Placebo Group | 9.2 |
number of days within the first 28 days after enrollment that the patient was free from needing mechanical ventilation (NCT02899156)
Timeframe: up to 28 days after randomization
| Intervention | days (Mean) |
|---|---|
| Flumazenil Group | 23.6 |
| Placebo Group | 24.9 |
defined by the proportion of patients who were delirium free at 14 days after randomization (NCT02899156)
Timeframe: up to 14 days after randomization
| Intervention | Participants (Count of Participants) |
|---|---|
| Flumazenil Group | 9 |
| Placebo Group | 7 |
number of times that a RASS score of + 2 to +4 occurred that did not resolve with decreasing study infusion (NCT02899156)
Timeframe: up to 72 hours after the start of the infusion
| Intervention | Participants (Count of Participants) |
|---|---|
| Flumazenil Group | 0 |
| Placebo Group | 0 |
11 reviews available for flumazenil and Coma
| Article | Year |
|---|---|
The clinical and forensic toxicology of Z-drugs.
Topics: Acetamides; Azabicyclo Compounds; Coma; Drug Overdose; Flumazenil; GABA Modulators; GABA-A Receptor | 2013 |
Flumazenil, naloxone and the 'coma cocktail'.
Topics: Analgesics, Opioid; Antidotes; Benzodiazepines; Coma; Drug Overdose; Flumazenil; Humans; Naloxone | 2016 |
The coma cocktail: indications, contraindications, adverse effects, proper dose, and proper route.
Topics: Adult; Antidotes; Child; Coma; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Ov | 2004 |
Endozepines in recurrent stupor.
Topics: Coma; Diazepam Binding Inhibitor; Electroencephalography; Flumazenil; Hepatic Encephalopathy; Humans | 2005 |
Should a benzodiazepine antagonist be used in unconscious patients presenting to the emergency department?
Topics: Antidotes; Benzodiazepines; Coma; Flumazenil; Glasgow Coma Scale; Humans; Randomized Controlled Tria | 2007 |
Response of a promethazine-induced coma to flumazenil.
Topics: Aged; Aged, 80 and over; Coma; Flumazenil; Glasgow Coma Scale; Humans; Male; Medication Errors; Prom | 1994 |
Reappraisal of the "coma cocktail". Dextrose, flumazenil, naloxone, and thiamine.
Topics: Animals; Coma; Emergencies; Flumazenil; Glucose; Humans; Naloxone; Thiamine | 1994 |
Diagnosis and management of opioid- and benzodiazepine-induced comatose overdose in children.
Topics: Adolescent; Antidotes; Benzodiazepines; Child; Child, Preschool; Coma; Drug Overdose; Flumazenil; Hu | 1996 |
Coma induced by intoxication.
Topics: Accidental Falls; Alcohol-Induced Disorders, Nervous System; Alcoholic Intoxication; Antidotes; Brai | 2000 |
Flumazenil vs. placebo in hepatic encephalopathy in patients with cirrhosis: a meta-analysis.
Topics: Coma; Double-Blind Method; Electroencephalography; Female; Flumazenil; Hepatic Encephalopathy; Human | 2002 |
Risks and benefits of therapy with flumazenil (Anexate) in mixed drug intoxications.
Topics: Antidepressive Agents, Tricyclic; Benzodiazepines; Coma; Drug Interactions; Drug Overdose; Flumazeni | 1991 |
10 trials available for flumazenil and Coma
| Article | Year |
|---|---|
[The efficacy of the native flumazenil for acute poisoning with benzodiazepines].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; Antidotes; Coma; Female; Flumazenil | 2000 |
Use of flumazenil in the treatment of drug overdose: a double-blind and open clinical study in 110 patients.
Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Antidotes; Barbiturates; Benzodiazepines; Coma; Diagn | 1996 |
Continuous flumazenil infusion in preventing complications arising from severe benzodiazepine intoxication.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anti-Anxiety Agents; Antidotes; Coma; Female; Flumazeni | 1998 |
Flumazenil in the treatment of acute hepatic encephalopathy in cirrhotic patients: a double blind randomized placebo controlled study.
Topics: Coma; Double-Blind Method; Female; Flumazenil; GABA Modulators; Hemorrhage; Hepatic Encephalopathy; | 2000 |
Efficacy of flumazenil in acute alcohol intoxication: double blind placebo-controlled evaluation.
Topics: Adolescent; Adult; Aged; Alcoholic Intoxication; Benzodiazepines; Coma; Double-Blind Method; Drug Ov | 1991 |
Diagnostic utility of flumazenil in coma with suspected poisoning: a double blind, randomised controlled study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; Antidepressive Agents; Coma; Double | 1990 |
The diagnostic utility of flumazenil (a benzodiazepine antagonist) in coma of unknown etiology.
Topics: Adult; Alprazolam; Carbon Monoxide Poisoning; Clinical Trials as Topic; Coma; Double-Blind Method; D | 1990 |
Clinical experience with the benzodiazepine antagonist flumazenil in suspected benzodiazepine or ethanol poisoning.
Topics: Adolescent; Adult; Aged; Alcoholic Intoxication; Benzodiazepines; Chromatography, High Pressure Liqu | 1990 |
Benzodiazepine-receptor antagonist, a clinical double blind study.
Topics: Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; Coma; Double-Blind Method; Female; Flumazenil; | 1988 |
Benzodiazepine intoxication treated with flumazenil (Anexate, RO 15-1788).
Topics: Adolescent; Adult; Aged; Benzodiazepines; Coma; Drug Evaluation; Female; Flumazenil; Humans; Male; M | 1988 |
61 other studies available for flumazenil and Coma
| Article | Year |
|---|---|
Flumazenil partially reverses gamma-hydroxybutyrate (GHB)-induced coma: a case report.
Topics: Baclofen; Coma; Flumazenil; Humans; Sodium Oxybate | 2022 |
Coma, Severe Hypotension, and Pinpoint Pupils After Olanzapine Intoxication in the Intensive Care Unit with Symptom Reversal After Administration of Flumazenil.
Topics: Aged; Benzodiazepines; Coma; Delirium; Flumazenil; Humans; Hypotension; Intensive Care Units; Male; | 2022 |
Coma, Severe Hypotension, and Pinpoint Pupils After Olanzapine Intoxication in the Intensive Care Unit with Symptom Reversal After Administration of Flumazenil.
Topics: Aged; Benzodiazepines; Coma; Delirium; Flumazenil; Humans; Hypotension; Intensive Care Units; Male; | 2022 |
Coma, Severe Hypotension, and Pinpoint Pupils After Olanzapine Intoxication in the Intensive Care Unit with Symptom Reversal After Administration of Flumazenil.
Topics: Aged; Benzodiazepines; Coma; Delirium; Flumazenil; Humans; Hypotension; Intensive Care Units; Male; | 2022 |
Coma, Severe Hypotension, and Pinpoint Pupils After Olanzapine Intoxication in the Intensive Care Unit with Symptom Reversal After Administration of Flumazenil.
Topics: Aged; Benzodiazepines; Coma; Delirium; Flumazenil; Humans; Hypotension; Intensive Care Units; Male; | 2022 |
Flumazenil therapy for a gabapentin-induced coma: a case report.
Topics: Aged; Antidotes; Coma; Flumazenil; Gabapentin; Humans; Male; Quality of Life | 2021 |
Pediatric zolpidem ingestion demonstrating zero-order kinetics treated with flumazenil.
Topics: Antidotes; Central Nervous System Depressants; Child; Coma; Down Syndrome; Drug Overdose; Emergencie | 2013 |
Flubromazolam--A new life-threatening designer benzodiazepine.
Topics: Adult; Antidotes; Benzodiazepines; Coma; Combined Modality Therapy; Designer Drugs; Drug Overdose; F | 2016 |
Benzodiazepine poisoning in elderly.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antidotes; Benzodiazepines; Bromazepam; Coh | 2016 |
Reduced midazolam clearance must be considered in prolonged coma.
Topics: Adult; Anesthetics, Intravenous; Antidotes; Cholinesterase Inhibitors; Coma; Flumazenil; Humans; Mal | 2008 |
Zaleplon-induced coma and bluish-green urine: possible antidotal effect by flumazenil.
Topics: Acetamides; Aged; Antidotes; Color; Coma; Female; Flumazenil; Humans; Hypnotics and Sedatives; Male; | 2002 |
[Recurrent idiopathic stupor in a patient: responsibility of exogenous or endogenous benzodiazepines?].
Topics: Benzodiazepines; Coma; Flumazenil; GABA Modulators; Humans; Middle Aged; Recurrence | 2002 |
No more coma cocktails. Using science to dispel myths & improve patient care.
Topics: Coma; Drug Combinations; Emergency Medical Services; Evidence-Based Medicine; Flumazenil; GABA Modul | 2002 |
Flumazenil and dialysis for gabapentin-induced coma.
Topics: Acetates; Aged; Aged, 80 and over; Amines; Analgesics; Antidotes; Coma; Cyclohexanecarboxylic Acids; | 2003 |
[Criminal use of psychoactive drugs. A cluster of 4 cases].
Topics: Adult; Antidotes; Benzodiazepines; Coma; Crime; Crime Victims; Flumazenil; Humans; Male; Middle Aged | 2003 |
Reversal of an antihistamine-induced coma with flumazenil.
Topics: Child Abuse; Coma; Diphenhydramine; Flumazenil; GABA-A Receptor Antagonists; Histamine H1 Antagonist | 2004 |
Coma cocktail: a role for flumazenil?
Topics: Antidotes; Benzodiazepines; Coma; Drug Overdose; Evidence-Based Medicine; Flumazenil; Humans | 2007 |
Acute poisonings treated in hospitals in Oslo: a one-year prospective study (II): clinical outcome.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidotes; Coma; Cross-Sectional Studies; Ethanol; Femal | 2008 |
First clinical investigation of the benzodiazepine antagonist Ro 15-1788 in comatose patients.
Topics: Adult; Aged; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Coma; Diagnosis, Differential; | 1983 |
[Prolonged coma caused by diazepam sedation in ventilated patients. Diagnostic and therapeutic use of the benzodiazepine antagonist Ro 15-1788].
Topics: Aged; Benzodiazepinones; Coma; Convulsants; Diazepam; Electroencephalography; Female; Flumazenil; Hu | 1984 |
Prolonged sedation due to accumulation of conjugated metabolites of midazolam.
Topics: Aged; Aged, 80 and over; Animals; Coma; Electroencephalography; Female; Flumazenil; Glucuronates; Hu | 1995 |
Transient unresponsiveness in the elderly: possible episodes of idiopathic recurring stupor.
Topics: Aged; Carrier Proteins; Coma; Diazepam Binding Inhibitor; Flumazenil; Humans | 1995 |
Flumazenil for coma reversal in children after cannabis.
Topics: Cannabinoids; Child, Preschool; Coma; Flumazenil; Humans; Infant; Infusions, Intravenous; Male; Pois | 1993 |
Use of flumazenil in the diagnosis and treatment of patients with coma of unknown etiology.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; Coma; Female; Flumazenil; Humans; M | 1993 |
Flumazenil as a diagnostic tool in the differential diagnosis of coma in a critically ill patient.
Topics: Aged; Bacterial Infections; Coma; Critical Illness; Diagnosis, Differential; Diazepam; Flumazenil; H | 1994 |
The role of flumazenil in the management of patients with acute alteration of mental status in the emergency department.
Topics: Adult; Aged; Aged, 80 and over; Coma; Consciousness; Emergency Medical Services; Female; Flumazenil; | 1994 |
Judicious use of flumazenil.
Topics: Benzodiazepines; Coma; Drug Overdose; Flumazenil; Humans; Risk Factors | 1993 |
Diagnostic and therapeutic utility of flumazenil in comatose patients with drug overdose.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Benzodiazepines; Coma; Drug Overdose; Emergencies; Femal | 1993 |
Long-term intravenous and oral flumazenil treatment of acute diazepam overdose in an older patient.
Topics: Administration, Oral; Aged; Antidotes; Coma; Diazepam; Female; Flumazenil; Glasgow Coma Scale; Human | 1996 |
Empiric use of flumazenil in comatose patients: limited applicability of criteria to define low risk.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidotes; Coma; Drug Overdose; Female; Flumazenil; Huma | 1996 |
[Acute overdose of Zolpidem (Stilnox)].
Topics: Adolescent; Adult; Aged; Antidotes; Coma; Drug Overdose; Female; Flumazenil; Humans; Hypnotics and S | 1996 |
Flumazenil: an unreliable antagonist in baclofen overdose.
Topics: Adult; Antidotes; Baclofen; Coma; Female; Flumazenil; GABA Modulators; Humans; Muscle Relaxants, Cen | 1996 |
[Suicidal poisoning with benzodiazepines].
Topics: Adolescent; Adult; Aged; Alcoholism; Benzodiazepines; Carbamazepine; Coma; Ethanol; Female; Flumazen | 1997 |
Endozepine stupor. Recurring stupor linked to endozepine-4 accumulation.
Topics: Adult; Aged; Carrier Proteins; Coma; Diazepam Binding Inhibitor; Electroencephalography; Female; Flu | 1998 |
[Transitory comatose situation secondary to an infarction of the posterior circulation, reversed by naloxone?].
Topics: Adult; Brain Ischemia; Cerebral Infarction; Coma; Drug Therapy, Combination; Emergency Medical Servi | 1998 |
Two chlorzoxazone (Parafon forte) overdoses and coma in one patient: reversal with flumazenil.
Topics: Antidotes; Chlorzoxazone; Coma; Drug Overdose; Emergency Treatment; Flumazenil; GABA Modulators; Hum | 1998 |
Endotracheal administration of flumazenil.
Topics: Anti-Anxiety Agents; Antidotes; Coma; Emergency Treatment; Flumazenil; Humans; Instillation, Drug; I | 1998 |
The effect of benzodiazepines and flumazenil on motor cortical excitability in the human brain.
Topics: Adolescent; Adult; Benzodiazepines; Coma; Electromagnetic Fields; Evoked Potentials, Motor; Female; | 1999 |
Prolonged sedation requiring mechanical ventilation and continuous flumazenil infusion after routine doses of clorazepam for alcohol withdrawal syndrome.
Topics: Aged; Alcohol Withdrawal Seizures; Anticonvulsants; Antidotes; Bronchitis; Clorazepate Dipotassium; | 1999 |
[Delayed postanoxic encephalopathy].
Topics: Child; Coma; Diagnosis, Differential; Flumazenil; GABA Modulators; Humans; Hypoxia, Brain; Male; Par | 2000 |
Mechanism of respiratory insufficiency in pure or mixed drug-induced coma involving benzodiazepines.
Topics: Adult; Aged; Aged, 80 and over; Airway Resistance; Anti-Anxiety Agents; Antidotes; Coma; Drug Overdo | 2002 |
Idiopathic recurring stupor: a case with possible involvement of the gamma-aminobutyric acid (GABA)ergic system.
Topics: Benzodiazepines; Coma; Electroencephalography; Flumazenil; GABA-A Receptor Antagonists; gamma-Aminob | 1992 |
Endogenous benzodiazepine receptor ligands in idiopathic recurring stupor.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Coma; Diazepam Binding Inhibitor; Electroencephal | 1992 |
Treatment of severe tetanus by intrathecal injections of baclofen without artificial ventilation.
Topics: Adolescent; Adult; Africa; Age Factors; Aged; Baclofen; Blood Gas Analysis; Coma; Creatine Kinase; D | 1992 |
Beneficial effect of pharmacological modulation of the GABAA-benzodiazepine receptor on hepatic encephalopathy in the rat: comparison with uremic encephalopathy.
Topics: Animals; Azides; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Coma; Flumazenil; Hepatic Enc | 1991 |
Reversal of benzodiazepine intoxication by flumazenil.
Topics: Adult; Anti-Anxiety Agents; Coma; Flumazenil; Glasgow Coma Scale; Humans; Middle Aged; Suicide, Atte | 1991 |
[Flumazenil--a valuable diagnostic agent in coma but only with clear indications].
Topics: Benzodiazepines; Coma; Contraindications; Diagnosis, Differential; Flumazenil; Humans | 1992 |
[Efficacy of flumazenil in hypercapnic encephalopathy: preliminary communication].
Topics: Aged; Coma; Flumazenil; Humans; Hypercapnia; Male; Middle Aged | 1991 |
Flumazenil & coma.
Topics: Cerebrovascular Circulation; Coma; Flumazenil; Humans; Intracranial Pressure | 1991 |
Diagnostic utility of flumazenil in coma with suspected poisoning.
Topics: Antidepressive Agents, Tricyclic; Coma; Flumazenil; Humans | 1991 |
Diagnostic utility of flumazenil in coma with suspected poisoning.
Topics: Azabicyclo Compounds; Coma; Flumazenil; Humans; Hypnotics and Sedatives; Male; Middle Aged; Piperazi | 1991 |
Benzodiazepine antagonist in the treatment of human hepatic encephalopathy.
Topics: Benzodiazepines; Coma; Evoked Potentials, Somatosensory; Flumazenil; Hepatic Encephalopathy; Humans; | 1990 |
Zolpidem intoxication mimicking narcotic overdose: response to flumazenil.
Topics: Adult; Antidotes; Coma; Ethanol; Flumazenil; Humans; Hypnotics and Sedatives; Male; Narcotics; Pyrid | 1990 |
[The efficacy of the benzodiazepine antagonist flumazenil (Ro 15-1788) based on the EEG of mechanically ventilated intensive care patients].
Topics: Adult; Aged; Arousal; Benzodiazepines; Coma; Critical Care; Electroencephalography; Flumazenil; Huma | 1989 |
Differential diagnostic value and influence on EEG of Anexate (Flumazenil, Ro 15-1788) in benzodiazepine-intoxication. A case report.
Topics: Anti-Anxiety Agents; Arousal; Bromazepam; Coma; Diagnosis, Differential; Electroencephalography; Evo | 1989 |
[The use of flumazenil at a pediatric surgical resuscitation unit].
Topics: Adolescent; Anti-Anxiety Agents; Child; Coma; Electroencephalography; Female; Flumazenil; Humans; Ma | 1989 |
Benzodiazepine antagonist Ro 15-1788 in self-poisoning. Diagnostic and therapeutic use.
Topics: Adult; Aged; Anti-Anxiety Agents; Antidotes; Benzodiazepinones; Coma; Diazepam; Electroencephalograp | 1985 |
[Specific therapy of acute benzodiazepine poisoning using flumazenil (Ro 15-1788)].
Topics: Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; Coma; Female; Flumazenil; Humans; Male; Middle | 1987 |
The use of flumazenil in the treatment of 34 intoxicated patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; Coma; Drug Evaluation; Female; Flum | 1988 |
Controlled sedation in ventilated intensive care patients.
Topics: Adult; Aged; Anti-Anxiety Agents; Coma; Critical Care; Diazepam; Female; Flumazenil; Humans; Injecti | 1988 |
[Reversibility of coma caused by benzodiazepine by an infusion of flumazenil in a child].
Topics: Benzodiazepines; Child, Preschool; Coma; Flumazenil; Humans | 1987 |
Stupor and affective state: alleviation of psychomotor disturbances by lorazepam and recurrence of symptoms after Ro 15-1788.
Topics: Adult; Carbamazepine; Coma; Depressive Disorder; Drug Interactions; Drug Therapy, Combination; Femal | 1987 |
The effects of midazolam reversal by RO 15-1788 on cerebral perfusion pressure in patients with severe head injury.
Topics: Adult; Cerebrovascular Circulation; Coma; Craniocerebral Trauma; Female; Flumazenil; Humans; Intracr | 1988 |
Reversal of iatrogenic diazepam overdose with flumazenil.
Topics: Aged; Coma; Diazepam; Flumazenil; Humans; Intensive Care Units; Male | 1988 |