flumazenil has been researched along with Clasp-Knife Spasticity in 3 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Selected examples from three series of isomeric (alkylthio)-1,2,4-triazoles were prepared and examined for anticonvulsant activity versus strychnine-, maximal-electroshock-, pentylenetetrazole-, and 3-mercaptopropionic-acid-induced seizures in mice." | 3.69 | 5-Aryl-3-(alkylthio)-4H-1,2,4-triazoles as selective antagonists of strychnine-induced convulsions and potential antispastic agents. ( Dalton, CR; Dudley, MW; Kane, JM; Kehne, JH; Ketteler, HJ; McCloskey, TC; Miller, FP; Ogden, AM; Senyah, Y; Staeger, MA, 1994) |
| "Genetically spastic rats were used for studying the effect on muscle tone of beta-carboline-3-carboxylic acid methylester (beta-CCM), an inverse benzodiazepine (BDZ) agonist, and that of Ro 15-1788 and CGS 8216, both putative antagonists of pharmacological actions of BDZs." | 1.27 | Effects of methyl beta-carboline-3-carboxylate, Ro 15-1788 and CGS 8216 on muscle tone in genetically spastic rats. ( Ikonomidou, C; Klockgether, T; Schwarz, M; Sontag, KH; Turski, L, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schwarz, M | 2 |
| Turski, L | 2 |
| Sontag, KH | 2 |
| Kane, JM | 1 |
| Staeger, MA | 1 |
| Dalton, CR | 1 |
| Miller, FP | 1 |
| Dudley, MW | 1 |
| Ogden, AM | 1 |
| Kehne, JH | 1 |
| Ketteler, HJ | 1 |
| McCloskey, TC | 1 |
| Senyah, Y | 1 |
| Ikonomidou, C | 1 |
| Klockgether, T | 1 |
3 other studies available for flumazenil and Clasp-Knife Spasticity
| Article | Year |
|---|---|
CGS 8216, Ro 15-1788 and methyl-beta-carboline-3-carboxylate, but not EMD 41717 antagonize the muscle relaxant effect of diazepam in genetically spastic rats.
Topics: Animals; Benzodiazepinones; Carbolines; Convulsants; Diazepam; Electromyography; Female; Flumazenil; | 1984 |
5-Aryl-3-(alkylthio)-4H-1,2,4-triazoles as selective antagonists of strychnine-induced convulsions and potential antispastic agents.
Topics: Animals; Anticonvulsants; Cerebellum; Cerebral Cortex; Chlorides; Electroshock; Flumazenil; Male; Mi | 1994 |
Effects of methyl beta-carboline-3-carboxylate, Ro 15-1788 and CGS 8216 on muscle tone in genetically spastic rats.
Topics: Animals; Benzodiazepinones; Carbolines; Dose-Response Relationship, Drug; Electromyography; Female; | 1985 |