Page last updated: 2024-10-27

flumazenil and Chronic Disease

flumazenil has been researched along with Chronic Disease in 40 studies

Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.

Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).

Research Excerpts

ExcerptRelevanceReference
"To evaluate the beneficial and harmful effects of flumazenil versus placebo or no intervention for people with cirrhosis and hepatic encephalopathy."8.95Flumazenil versus placebo or no intervention for people with cirrhosis and hepatic encephalopathy. ( Andersen, ML; Gluud, LL; Goh, ET; Morgan, MY, 2017)
"Therapeutic modulation of the increased GABAergic tone in chronic hepatic encephalopathy (HE) by the benzodiazepine receptor (BR) antagonist flumazenil (F) has led to conflicting results in humans and animal models for HE."7.70Improvement of chronic hepatic encephalopathy in dogs by the benzodiazepine-receptor partial inverse agonist sarmazenil, but not by the antagonist flumazenil. ( Legemate, DA; Meyer, HP; Rothuizen, J; van den Brom, W, 1998)
"The effects of the benzodiazepine antagonist flumazenil were studied in 20 episodes of hepatic encephalopathy (HE) in 17 patients with acute (n = 9) or chronic (n = 8) liver failure who had not responded to conventional therapy."7.67Improvement of hepatic encephalopathy treated with flumazenil. ( Ferenci, P; Gangl, A; Grimm, G; Katzenschlager, R; Laggner, AN; Lenz, K; Madl, C; Schneeweiss, B, 1988)
"Oral flumazenil has been proposed for long-term treatment but is not presently available on the market."5.29[Chronic hepatic encephalopathy treated by long-term intravenous administration of flumazenil in ambulatory care]. ( Frappa, B; Paolini, O; Péroux, JL; Rampal, P; Tran, A, 1996)
"Flumazenil was not found to induce significant changes in the clinical status or in maps of the cerebral activity of patients with chronic encephalopathy."5.28[Evaluation of the therapeutic effect of flumazenil in hepatic encephalopathy using cerebral cartography]. ( Bello Mimbrera, G; de la Torre Fernández, JM; de la Torre Gutiérrez, S; García de León, M; Montero Vázquez, J; Torres Salcines, J, 1989)
"To evaluate the beneficial and harmful effects of flumazenil versus placebo or no intervention for people with cirrhosis and hepatic encephalopathy."4.95Flumazenil versus placebo or no intervention for people with cirrhosis and hepatic encephalopathy. ( Andersen, ML; Gluud, LL; Goh, ET; Morgan, MY, 2017)
"Flumazenil had a significant beneficial effect on short-term improvement of hepatic encephalopathy in patients with cirrhosis and a highly favourable prognosis."4.82Benzodiazepine receptor antagonists for hepatic encephalopathy. ( Als-Nielsen, B; Gluud, C; Gluud, LL, 2004)
"Flumazenil had no significant effect on recovery or survival from hepatic encephalopathy."4.81Benzodiazepine receptor antagonists for acute and chronic hepatic encephalopathy. ( Als-Nielsen, B; Gluud, C; Kjaergard, LL, 2001)
" In a prospective trial in dogs with newly diagnosed epilepsy, ELB 138 markedly reduced seizure frequency and severity without significant difference to standard treatments (phenobarbital or primidone) but was much better tolerated than the standard drugs."3.72Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures. ( Löscher, W; Potschka, H; Rieck, S; Rundfeldt, C; Tipold, A, 2004)
"Therapeutic modulation of the increased GABAergic tone in chronic hepatic encephalopathy (HE) by the benzodiazepine receptor (BR) antagonist flumazenil (F) has led to conflicting results in humans and animal models for HE."3.70Improvement of chronic hepatic encephalopathy in dogs by the benzodiazepine-receptor partial inverse agonist sarmazenil, but not by the antagonist flumazenil. ( Legemate, DA; Meyer, HP; Rothuizen, J; van den Brom, W, 1998)
"The effects of the benzodiazepine antagonist flumazenil were studied in 20 episodes of hepatic encephalopathy (HE) in 17 patients with acute (n = 9) or chronic (n = 8) liver failure who had not responded to conventional therapy."3.67Improvement of hepatic encephalopathy treated with flumazenil. ( Ferenci, P; Gangl, A; Grimm, G; Katzenschlager, R; Laggner, AN; Lenz, K; Madl, C; Schneeweiss, B, 1988)
"Flumazenil was well tolerated."2.68Evaluation of the efficacy and safety of flumazenil in the treatment of portal systemic encephalopathy: a double blind, randomised, placebo controlled multicentre study. ( Amrein, R; Boulétreau, P; Fleig, WE; Gatta, A; Groeneweg, M; Gyr, K; Häussler, J; Holstege, A; Meier, R; Pomier-Layrargues, G; Schalm, SW; Scollo-Lavizzari, G; Ventura, E; Williams, R; Yoo, Y; Zeneroli, ML, 1996)
"Chronic diseases were remarkably associated with poor HRQL from 10 units in MH (Mental Health) to 34 units in RP (Role Physical)."1.42Health-Related Quality of Life of the Roma in Greece: The Role of Socio-Economic Characteristics and Housing Conditions. ( Chalkiopoulos, G; Chatzikonstantinidou, S; Niakas, D; Papadopoulos, A; Pappa, E, 2015)
"Oral flumazenil has been proposed for long-term treatment but is not presently available on the market."1.29[Chronic hepatic encephalopathy treated by long-term intravenous administration of flumazenil in ambulatory care]. ( Frappa, B; Paolini, O; Péroux, JL; Rampal, P; Tran, A, 1996)
"Flumazenil was not found to induce significant changes in the clinical status or in maps of the cerebral activity of patients with chronic encephalopathy."1.28[Evaluation of the therapeutic effect of flumazenil in hepatic encephalopathy using cerebral cartography]. ( Bello Mimbrera, G; de la Torre Fernández, JM; de la Torre Gutiérrez, S; García de León, M; Montero Vázquez, J; Torres Salcines, J, 1989)

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-19902 (5.00)18.7374
1990's12 (30.00)18.2507
2000's10 (25.00)29.6817
2010's12 (30.00)24.3611
2020's4 (10.00)2.80

Authors

AuthorsStudies
Gómez García, A1
Navas Vinagre, I1
Herranz Bárcenas, A1
Hayashi, S1
Inaji, M1
Nariai, T1
Oda, K1
Sakata, M1
Toyohara, J1
Ishii, K1
Ishiwata, K1
Maehara, T1
Goh, ET1
Andersen, ML1
Morgan, MY1
Gluud, LL2
Kato, H1
Isohashi, K1
Shimosegawa, E1
Hatazawa, J1
Papp, M1
Gruca, P1
Lason-Tyburkiewicz, M1
Litwa, E1
Willner, P1
Als-Nielsen, B2
Gluud, C2
Löscher, W1
Potschka, H1
Rieck, S1
Tipold, A1
Rundfeldt, C1
Giffard, C1
Landeau, B1
Kerrouche, N1
Young, AR1
Barré, L1
Baron, JC1
Luat, AF1
Chugani, HT1
Matsuda, H2
Tsuji, S2
Kuji, I2
Shiba, K1
Hisada, K2
Mori, H1
Péroux, JL1
Paolini, O1
Tran, A1
Frappa, B1
Rampal, P1
Gyr, K1
Meier, R1
Häussler, J1
Boulétreau, P1
Fleig, WE1
Gatta, A1
Holstege, A1
Pomier-Layrargues, G1
Schalm, SW2
Groeneweg, M1
Scollo-Lavizzari, G1
Ventura, E1
Zeneroli, ML1
Williams, R1
Yoo, Y1
Amrein, R1
Schröder, J1
Bubeck, B1
Demisch, S1
Sauer, H1
Pandey, GN1
Conley, RR1
Pandey, SC1
Goel, S1
Roberts, RC1
Tamminga, CA1
Chute, D1
Smialek, J1
Perney, P1
Butterworth, RF1
Mousseau, DD1
Lavoie, J1
Fabbro-Peray, P1
Blanc, F1
Layrargues, GP1
Meyer, HP1
Legemate, DA1
van den Brom, W1
Rothuizen, J1
Kjaergard, LL1
Koczorek, M1
Baktai, G1
Székely, E1
Márialigeti, T1
Kovács, L1
van der Rijt, CC1
Drost, RH1
Schramel, M1
Bello Mimbrera, G1
García de León, M1
de la Torre Gutiérrez, S1
Montero Vázquez, J1
Torres Salcines, J1
de la Torre Fernández, JM1
Grimm, G1
Ferenci, P1
Katzenschlager, R1
Madl, C1
Schneeweiss, B1
Laggner, AN1
Lenz, K1
Gangl, A1
Anastasaki, M1
van Bree, EM1
Brakema, EA1
Tsiligianni, I1
Sifaki-Pistolla, D1
Chatzea, VE1
Crone, MC1
Karelis, A1
van der Kleij, RMJJ1
Poot, CC1
Reis, R1
Chavannes, NH1
Lionis, C1
Keohane, DM1
Ghosh, TS1
Jeffery, IB1
Molloy, MG1
O'Toole, PW1
Shanahan, F1
Petraki, I1
Kalpourtzi, N1
Terzidis, A1
Gavana, M1
Vantarakis, A1
Rachiotis, G1
Karakosta, A1
Sypsa, V1
Touloumi, G1
La Parra-Casado, D1
Mosquera, PA1
Vives-Cases, C1
San Sebastian, M1
Veselíny, E1
Janicko, M1
Drazilová, S1
Siegfried, L1
Pastvová, L1
Schréter, I1
Kristian, P1
Viág, L1
Jarcuska, P2
Valková, I1
Cáriková, K1
Senajová, G1
Fedacko, J1
Pella, D1
Mareková, M1
Gecková, AM1
Martín-Pérez, M1
Hernández Barrera, V1
López de Andrés, A1
Jiménez-Trujillo, I1
Jiménez-García, R1
Carrasco-Garrido, P1
Pappa, E1
Chatzikonstantinidou, S1
Chalkiopoulos, G1
Papadopoulos, A1
Niakas, D1
La Parra Casado, D1
Gil González, D1
de la Torre Esteve, M1
Gadalean, F1
Lighezan, D1
Stoian, D1
Schiller, O1
Timar, R1
Timar, B1
Bob, F1
Donciu, MD1
Munteanu, M1
Mihaescu, A1
Covic, A1
Schiller, A1
Kanapeckiene, V1
Valinteliene, R1
Berzanskyte, A1
Kevalas, R1
Supranowicz, P1
Roman, G2
Enache, A2
Pârvu, A2
Gramma, R2
Moisa, ŞM2
Dumitraş, S2
Ioan, B2
Chirita, R1
Zeman, CL1
Depken, DE1
Senchina, DS1
Parry, G1
Van Cleemput, P1
Peters, J1
Walters, S1
Thomas, K1
Cooper, C1
Jaques, AK1
Arroja, I1
Araújo, C1
Azevedo, J1
Borges, A1
Santos, I1
Cabral, A1
Campos, MJ1
Mansinho, K1
Borges, F1
Pérez Brea, A1
Ruiz Moreno, M1
Leal Orozco, A1
Escorihuela Esteban, R1
Otero Fraguas, M1
Cabedo García, VR1
Ortells i Ros, E1
Baquero Toledo, L1
Bosch Girona, N1
Montero Royo, A1
Nácher Fernández, A1
Sánchez-Peral Sánchez, B1
Tamborero Sanjuán, MA1

Reviews

7 reviews available for flumazenil and Chronic Disease

ArticleYear
Flumazenil versus placebo or no intervention for people with cirrhosis and hepatic encephalopathy.
    The Cochrane database of systematic reviews, 2017, 07-26, Volume: 7

    Topics: Acute Disease; Antidotes; Cause of Death; Chronic Disease; Flumazenil; GABA Modulators; GABA-A Recep

2017
Benzodiazepine receptor antagonists for hepatic encephalopathy.
    The Cochrane database of systematic reviews, 2004, Issue:2

    Topics: Acute Disease; Antidotes; Chronic Disease; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists;

2004
Molecular and diffusion tensor imaging of epileptic networks.
    Epilepsia, 2008, Volume: 49 Suppl 3

    Topics: Adolescent; Age Factors; Brain Mapping; Carbon Radioisotopes; Cerebral Cortex; Child; Chronic Diseas

2008
Benzodiazepine receptor antagonists for acute and chronic hepatic encephalopathy.
    The Cochrane database of systematic reviews, 2001, Issue:4

    Topics: Acute Disease; Antidotes; Chronic Disease; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists;

2001
Socioeconomic Inequalities in the Use of Healthcare Services: Comparison between the Roma and General Populations in Spain.
    International journal of environmental research and public health, 2018, Jan-12, Volume: 15, Issue:1

    Topics: Chronic Disease; Emergency Service, Hospital; Health Services; Health Surveys; Hospitalization; Huma

2018
Roma health issues: a review of the literature and discussion.
    Ethnicity & health, 2003, Volume: 8, Issue:3

    Topics: Chromosome Mapping; Chronic Disease; Communicable Diseases; Cultural Characteristics; Databases, Bib

2003
[Visceral leishmaniasis refractory to treatment: the efficacy of amphotericin B].
    Anales espanoles de pediatria, 1996, Volume: 44, Issue:2

    Topics: Amphotericin B; Animals; Anti-Bacterial Agents; Antimony; Antiprotozoal Agents; Child, Preschool; Ch

1996

Trials

2 trials available for flumazenil and Chronic Disease

ArticleYear
Evaluation of the efficacy and safety of flumazenil in the treatment of portal systemic encephalopathy: a double blind, randomised, placebo controlled multicentre study.
    Gut, 1996, Volume: 39, Issue:2

    Topics: Chronic Disease; Double-Blind Method; Electroencephalography; Female; Flumazenil; Hepatic Encephalop

1996
Use of midazolam ('Dormicum') and flumazenil ('Anexate') in paediatric bronchology.
    Current medical research and opinion, 1992, Volume: 12, Issue:9

    Topics: Anesthesia; Atropine; Bronchoscopy; Child, Preschool; Chronic Disease; Drug Administration Schedule;

1992

Other Studies

31 other studies available for flumazenil and Chronic Disease

ArticleYear
Video NeuroImages: Idiopathic Recurring Stupor: An Unusual Clinical Condition Responding to Flumazenil.
    Neurology, 2021, 03-23, Volume: 96, Issue:12

    Topics: Aged; Chronic Disease; Female; Flumazenil; GABA Modulators; Humans; Stupor

2021
Increased Binding Potential of Brain Adenosine A
    Journal of neurotrauma, 2018, 01-01, Volume: 35, Issue:1

    Topics: Adult; Carbon Radioisotopes; Chronic Disease; Diffuse Axonal Injury; Female; Flumazenil; Fluorodeoxy

2018
Increase in extraction of I-123 iomazenil in patients with chronic cerebral ischemia.
    PloS one, 2018, Volume: 13, Issue:1

    Topics: Aged; Brain Ischemia; Cerebrovascular Circulation; Chronic Disease; Female; Flumazenil; Humans; Iodi

2018
Effects of chronic mild stress on the development of drug dependence in rats.
    Behavioural pharmacology, 2014, Volume: 25, Issue:5-6

    Topics: Animals; Chronic Disease; Citalopram; Depressive Disorder; Diazepam; Disease Models, Animal; Flumaze

2014
Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures.
    Epilepsia, 2004, Volume: 45, Issue:10

    Topics: Animals; Anticonvulsants; Bromides; Chronic Disease; Disease Models, Animal; Dog Diseases; Dogs; Dru

2004
Decreased chronic-stage cortical 11C-flumazenil binding after focal ischemia-reperfusion in baboons: a marker of selective neuronal loss?
    Stroke, 2008, Volume: 39, Issue:3

    Topics: Animals; Brain Ischemia; Carbon Isotopes; Cerebral Cortex; Chronic Disease; Flumazenil; Hemodynamics

2008
Dual-tracer autoradiography using 125I-iomazenil and 99Tcm-HMPAO in experimental brain ischaemia.
    Nuclear medicine communications, 1995, Volume: 16, Issue:7

    Topics: Acute Disease; Animals; Autoradiography; Brain; Brain Ischemia; Chronic Disease; Flumazenil; Functio

1995
[Central type benzodiazepine receptor and cerebral blood flow in experimental chronic brain infarction--evaluation using a double-tracer autoradiography technique].
    Kaku igaku. The Japanese journal of nuclear medicine, 1993, Volume: 30, Issue:6

    Topics: Animals; Autoradiography; Brain; Cerebral Infarction; Cerebrovascular Circulation; Chronic Disease;

1993
[Chronic hepatic encephalopathy treated by long-term intravenous administration of flumazenil in ambulatory care].
    Gastroenterologie clinique et biologique, 1996, Volume: 20, Issue:1

    Topics: Ambulatory Care; Chronic Disease; Esophageal and Gastric Varices; Flumazenil; GABA Modulators; Hepat

1996
Benzodiazepine receptor distribution and diazepam binding in schizophrenia: an exploratory study.
    Psychiatry research, 1997, Feb-07, Volume: 68, Issue:2-3

    Topics: Adult; Benzodiazepines; Binding Sites; Chronic Disease; Diazepam; Flumazenil; Frontal Lobe; Growth H

1997
Benzodiazepine receptors in the post-mortem brain of suicide victims and schizophrenic subjects.
    Psychiatry research, 1997, Aug-08, Volume: 71, Issue:3

    Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Chronic Disease; Drug Therapy, Combination; Fema

1997
Plasma and CSF benzodiazepine receptor ligand concentrations in cirrhotic patients with hepatic encephalopathy: relationship to severity of encephalopathy and to pharmaceutical benzodiazepine intake.
    Metabolic brain disease, 1998, Volume: 13, Issue:3

    Topics: Animals; Benzodiazepines; Binding, Competitive; Cell Fractionation; Cerebellum; Chronic Disease; Clo

1998
Improvement of chronic hepatic encephalopathy in dogs by the benzodiazepine-receptor partial inverse agonist sarmazenil, but not by the antagonist flumazenil.
    Metabolic brain disease, 1998, Volume: 13, Issue:3

    Topics: Ammonia; Animals; Benzodiazepines; Chronic Disease; Disease Models, Animal; Dogs; Electroencephalogr

1998
[Chronic liver diseases. The nihilism has gone].
    MMW Fortschritte der Medizin, 2001, Dec-13, Volume: 143, Issue:51-52

    Topics: Amantadine; Antioxidants; Antiviral Agents; Chronic Disease; Dipeptides; Drug Therapy, Combination;

2001
Pharmacokinetics of flumazenil in fulminant hepatic failure.
    European journal of clinical pharmacology, 1991, Volume: 41, Issue:5

    Topics: Adolescent; Chronic Disease; Female; Flumazenil; Humans; Liver Diseases; Male

1991
[Evaluation of the therapeutic effect of flumazenil in hepatic encephalopathy using cerebral cartography].
    Revista espanola de las enfermedades del aparato digestivo, 1989, Volume: 75, Issue:3

    Topics: Acute Disease; Aged; Brain Mapping; Chronic Disease; Drug Evaluation; Female; Flumazenil; Hepatic En

1989
Improvement of hepatic encephalopathy treated with flumazenil.
    Lancet (London, England), 1988, Dec-17, Volume: 2, Issue:8625

    Topics: Acute Disease; Adolescent; Adult; Aged; Brain; Child; Chronic Disease; Evoked Potentials, Somatosens

1988
Beliefs, Perceptions, and Behaviors Regarding Chronic Respiratory Diseases of Roma in Crete, Greece: A Qualitative FRESH AIR Study.
    Frontiers in public health, 2022, Volume: 10

    Topics: Chronic Disease; Focus Groups; Greece; Health Knowledge, Attitudes, Practice; Health Personnel; Huma

2022
Microbiome and health implications for ethnic minorities after enforced lifestyle changes.
    Nature medicine, 2020, Volume: 26, Issue:7

    Topics: Adult; Chronic Disease; Ethnicity; Feces; Gastrointestinal Microbiome; Genetics, Population; Humans;

2020
Living in Roma Settlements in Greece: Self-Perceived Health Status, Chronic Diseases and Associated Social Determinants of Health.
    International journal of environmental research and public health, 2021, 08-09, Volume: 18, Issue:16

    Topics: Adult; Chronic Disease; Cross-Sectional Studies; Female; Greece; Health Status; Humans; Male; Reside

2021
High hepatitis B and low hepatitis C prevalence in Roma population in eastern Slovakia.
    Central European journal of public health, 2014, Volume: 22 Suppl

    Topics: Adolescent; Adult; Age Distribution; Chronic Disease; Comorbidity; Cross-Sectional Studies; Female;

2014
Predictors of medication use in the Roma population in Spain: a population-based national study.
    Public health, 2015, Volume: 129, Issue:5

    Topics: Adolescent; Adult; Attitude to Health; Chronic Disease; Cross-Sectional Studies; Female; Health Surv

2015
Health-Related Quality of Life of the Roma in Greece: The Role of Socio-Economic Characteristics and Housing Conditions.
    International journal of environmental research and public health, 2015, Jun-12, Volume: 12, Issue:6

    Topics: Adolescent; Adult; Chronic Disease; Cross-Sectional Studies; Female; Greece; Health Status; Health S

2015
The social class gradient in health in Spain and the health status of the Spanish Roma.
    Ethnicity & health, 2016, Volume: 21, Issue:5

    Topics: Adult; Aged; Chronic Disease; Dental Caries; Disabled Persons; Female; Health Status; Health Status

2016
The Survival of Roma Minority Patients on Chronic Hemodialysis Therapy - A Romanian Multicenter Survey.
    PloS one, 2016, Volume: 11, Issue:5

    Topics: Adult; Aged; Chronic Disease; End Stage Liver Disease; Female; Humans; Male; Middle Aged; Multivaria

2016
Health of Roma children in Vilnius and Ventspils.
    Medicina (Kaunas, Lithuania), 2009, Volume: 45, Issue:2

    Topics: Adolescent; Age Factors; Alcohol Drinking; Chi-Square Distribution; Child; Chronic Disease; Emotions

2009
Ethical issues in communication of diagnosis and end-of-life decision-making process in some of the Romanian Roma communities.
    Medicine, health care, and philosophy, 2013, Volume: 16, Issue:3

    Topics: Adult; Aged; Chronic Disease; Communication; Culture; Decision Making; Family; Female; Humans; Inter

2013
Dying and death in some Roma communities: ethical challenges.
    Journal of immigrant and minority health, 2014, Volume: 16, Issue:2

    Topics: Adaptation, Psychological; Adult; Aged; Attitude to Death; Caregivers; Chronic Disease; Cultural Cha

2014
Health status of Gypsies and Travellers in England.
    Journal of epidemiology and community health, 2007, Volume: 61, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Chronic Disease; England; Female; Health Status; Health

2007
[The acquired immunodeficiency syndrome, hypertrophic myocardiopathy and multivalvular infectious endocarditis. Apropos a clinical case].
    Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology, 1995, Volume: 14, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Aortic Valve; Card

1995
[What are Gypsies like and what do they suffer from?].
    Atencion primaria, 2000, Jun-15, Volume: 26, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Chronic Disease; Cross-Sectional Studies; Family

2000