flumazenil has been researched along with Chronic Disease in 40 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
Excerpt | Relevance | Reference |
---|---|---|
"To evaluate the beneficial and harmful effects of flumazenil versus placebo or no intervention for people with cirrhosis and hepatic encephalopathy." | 8.95 | Flumazenil versus placebo or no intervention for people with cirrhosis and hepatic encephalopathy. ( Andersen, ML; Gluud, LL; Goh, ET; Morgan, MY, 2017) |
"Therapeutic modulation of the increased GABAergic tone in chronic hepatic encephalopathy (HE) by the benzodiazepine receptor (BR) antagonist flumazenil (F) has led to conflicting results in humans and animal models for HE." | 7.70 | Improvement of chronic hepatic encephalopathy in dogs by the benzodiazepine-receptor partial inverse agonist sarmazenil, but not by the antagonist flumazenil. ( Legemate, DA; Meyer, HP; Rothuizen, J; van den Brom, W, 1998) |
"The effects of the benzodiazepine antagonist flumazenil were studied in 20 episodes of hepatic encephalopathy (HE) in 17 patients with acute (n = 9) or chronic (n = 8) liver failure who had not responded to conventional therapy." | 7.67 | Improvement of hepatic encephalopathy treated with flumazenil. ( Ferenci, P; Gangl, A; Grimm, G; Katzenschlager, R; Laggner, AN; Lenz, K; Madl, C; Schneeweiss, B, 1988) |
"Oral flumazenil has been proposed for long-term treatment but is not presently available on the market." | 5.29 | [Chronic hepatic encephalopathy treated by long-term intravenous administration of flumazenil in ambulatory care]. ( Frappa, B; Paolini, O; Péroux, JL; Rampal, P; Tran, A, 1996) |
"Flumazenil was not found to induce significant changes in the clinical status or in maps of the cerebral activity of patients with chronic encephalopathy." | 5.28 | [Evaluation of the therapeutic effect of flumazenil in hepatic encephalopathy using cerebral cartography]. ( Bello Mimbrera, G; de la Torre Fernández, JM; de la Torre Gutiérrez, S; García de León, M; Montero Vázquez, J; Torres Salcines, J, 1989) |
"To evaluate the beneficial and harmful effects of flumazenil versus placebo or no intervention for people with cirrhosis and hepatic encephalopathy." | 4.95 | Flumazenil versus placebo or no intervention for people with cirrhosis and hepatic encephalopathy. ( Andersen, ML; Gluud, LL; Goh, ET; Morgan, MY, 2017) |
"Flumazenil had a significant beneficial effect on short-term improvement of hepatic encephalopathy in patients with cirrhosis and a highly favourable prognosis." | 4.82 | Benzodiazepine receptor antagonists for hepatic encephalopathy. ( Als-Nielsen, B; Gluud, C; Gluud, LL, 2004) |
"Flumazenil had no significant effect on recovery or survival from hepatic encephalopathy." | 4.81 | Benzodiazepine receptor antagonists for acute and chronic hepatic encephalopathy. ( Als-Nielsen, B; Gluud, C; Kjaergard, LL, 2001) |
" In a prospective trial in dogs with newly diagnosed epilepsy, ELB 138 markedly reduced seizure frequency and severity without significant difference to standard treatments (phenobarbital or primidone) but was much better tolerated than the standard drugs." | 3.72 | Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures. ( Löscher, W; Potschka, H; Rieck, S; Rundfeldt, C; Tipold, A, 2004) |
"Therapeutic modulation of the increased GABAergic tone in chronic hepatic encephalopathy (HE) by the benzodiazepine receptor (BR) antagonist flumazenil (F) has led to conflicting results in humans and animal models for HE." | 3.70 | Improvement of chronic hepatic encephalopathy in dogs by the benzodiazepine-receptor partial inverse agonist sarmazenil, but not by the antagonist flumazenil. ( Legemate, DA; Meyer, HP; Rothuizen, J; van den Brom, W, 1998) |
"The effects of the benzodiazepine antagonist flumazenil were studied in 20 episodes of hepatic encephalopathy (HE) in 17 patients with acute (n = 9) or chronic (n = 8) liver failure who had not responded to conventional therapy." | 3.67 | Improvement of hepatic encephalopathy treated with flumazenil. ( Ferenci, P; Gangl, A; Grimm, G; Katzenschlager, R; Laggner, AN; Lenz, K; Madl, C; Schneeweiss, B, 1988) |
"Flumazenil was well tolerated." | 2.68 | Evaluation of the efficacy and safety of flumazenil in the treatment of portal systemic encephalopathy: a double blind, randomised, placebo controlled multicentre study. ( Amrein, R; Boulétreau, P; Fleig, WE; Gatta, A; Groeneweg, M; Gyr, K; Häussler, J; Holstege, A; Meier, R; Pomier-Layrargues, G; Schalm, SW; Scollo-Lavizzari, G; Ventura, E; Williams, R; Yoo, Y; Zeneroli, ML, 1996) |
"Chronic diseases were remarkably associated with poor HRQL from 10 units in MH (Mental Health) to 34 units in RP (Role Physical)." | 1.42 | Health-Related Quality of Life of the Roma in Greece: The Role of Socio-Economic Characteristics and Housing Conditions. ( Chalkiopoulos, G; Chatzikonstantinidou, S; Niakas, D; Papadopoulos, A; Pappa, E, 2015) |
"Oral flumazenil has been proposed for long-term treatment but is not presently available on the market." | 1.29 | [Chronic hepatic encephalopathy treated by long-term intravenous administration of flumazenil in ambulatory care]. ( Frappa, B; Paolini, O; Péroux, JL; Rampal, P; Tran, A, 1996) |
"Flumazenil was not found to induce significant changes in the clinical status or in maps of the cerebral activity of patients with chronic encephalopathy." | 1.28 | [Evaluation of the therapeutic effect of flumazenil in hepatic encephalopathy using cerebral cartography]. ( Bello Mimbrera, G; de la Torre Fernández, JM; de la Torre Gutiérrez, S; García de León, M; Montero Vázquez, J; Torres Salcines, J, 1989) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (5.00) | 18.7374 |
1990's | 12 (30.00) | 18.2507 |
2000's | 10 (25.00) | 29.6817 |
2010's | 12 (30.00) | 24.3611 |
2020's | 4 (10.00) | 2.80 |
Authors | Studies |
---|---|
Gómez García, A | 1 |
Navas Vinagre, I | 1 |
Herranz Bárcenas, A | 1 |
Hayashi, S | 1 |
Inaji, M | 1 |
Nariai, T | 1 |
Oda, K | 1 |
Sakata, M | 1 |
Toyohara, J | 1 |
Ishii, K | 1 |
Ishiwata, K | 1 |
Maehara, T | 1 |
Goh, ET | 1 |
Andersen, ML | 1 |
Morgan, MY | 1 |
Gluud, LL | 2 |
Kato, H | 1 |
Isohashi, K | 1 |
Shimosegawa, E | 1 |
Hatazawa, J | 1 |
Papp, M | 1 |
Gruca, P | 1 |
Lason-Tyburkiewicz, M | 1 |
Litwa, E | 1 |
Willner, P | 1 |
Als-Nielsen, B | 2 |
Gluud, C | 2 |
Löscher, W | 1 |
Potschka, H | 1 |
Rieck, S | 1 |
Tipold, A | 1 |
Rundfeldt, C | 1 |
Giffard, C | 1 |
Landeau, B | 1 |
Kerrouche, N | 1 |
Young, AR | 1 |
Barré, L | 1 |
Baron, JC | 1 |
Luat, AF | 1 |
Chugani, HT | 1 |
Matsuda, H | 2 |
Tsuji, S | 2 |
Kuji, I | 2 |
Shiba, K | 1 |
Hisada, K | 2 |
Mori, H | 1 |
Péroux, JL | 1 |
Paolini, O | 1 |
Tran, A | 1 |
Frappa, B | 1 |
Rampal, P | 1 |
Gyr, K | 1 |
Meier, R | 1 |
Häussler, J | 1 |
Boulétreau, P | 1 |
Fleig, WE | 1 |
Gatta, A | 1 |
Holstege, A | 1 |
Pomier-Layrargues, G | 1 |
Schalm, SW | 2 |
Groeneweg, M | 1 |
Scollo-Lavizzari, G | 1 |
Ventura, E | 1 |
Zeneroli, ML | 1 |
Williams, R | 1 |
Yoo, Y | 1 |
Amrein, R | 1 |
Schröder, J | 1 |
Bubeck, B | 1 |
Demisch, S | 1 |
Sauer, H | 1 |
Pandey, GN | 1 |
Conley, RR | 1 |
Pandey, SC | 1 |
Goel, S | 1 |
Roberts, RC | 1 |
Tamminga, CA | 1 |
Chute, D | 1 |
Smialek, J | 1 |
Perney, P | 1 |
Butterworth, RF | 1 |
Mousseau, DD | 1 |
Lavoie, J | 1 |
Fabbro-Peray, P | 1 |
Blanc, F | 1 |
Layrargues, GP | 1 |
Meyer, HP | 1 |
Legemate, DA | 1 |
van den Brom, W | 1 |
Rothuizen, J | 1 |
Kjaergard, LL | 1 |
Koczorek, M | 1 |
Baktai, G | 1 |
Székely, E | 1 |
Márialigeti, T | 1 |
Kovács, L | 1 |
van der Rijt, CC | 1 |
Drost, RH | 1 |
Schramel, M | 1 |
Bello Mimbrera, G | 1 |
García de León, M | 1 |
de la Torre Gutiérrez, S | 1 |
Montero Vázquez, J | 1 |
Torres Salcines, J | 1 |
de la Torre Fernández, JM | 1 |
Grimm, G | 1 |
Ferenci, P | 1 |
Katzenschlager, R | 1 |
Madl, C | 1 |
Schneeweiss, B | 1 |
Laggner, AN | 1 |
Lenz, K | 1 |
Gangl, A | 1 |
Anastasaki, M | 1 |
van Bree, EM | 1 |
Brakema, EA | 1 |
Tsiligianni, I | 1 |
Sifaki-Pistolla, D | 1 |
Chatzea, VE | 1 |
Crone, MC | 1 |
Karelis, A | 1 |
van der Kleij, RMJJ | 1 |
Poot, CC | 1 |
Reis, R | 1 |
Chavannes, NH | 1 |
Lionis, C | 1 |
Keohane, DM | 1 |
Ghosh, TS | 1 |
Jeffery, IB | 1 |
Molloy, MG | 1 |
O'Toole, PW | 1 |
Shanahan, F | 1 |
Petraki, I | 1 |
Kalpourtzi, N | 1 |
Terzidis, A | 1 |
Gavana, M | 1 |
Vantarakis, A | 1 |
Rachiotis, G | 1 |
Karakosta, A | 1 |
Sypsa, V | 1 |
Touloumi, G | 1 |
La Parra-Casado, D | 1 |
Mosquera, PA | 1 |
Vives-Cases, C | 1 |
San Sebastian, M | 1 |
Veselíny, E | 1 |
Janicko, M | 1 |
Drazilová, S | 1 |
Siegfried, L | 1 |
Pastvová, L | 1 |
Schréter, I | 1 |
Kristian, P | 1 |
Viág, L | 1 |
Jarcuska, P | 2 |
Valková, I | 1 |
Cáriková, K | 1 |
Senajová, G | 1 |
Fedacko, J | 1 |
Pella, D | 1 |
Mareková, M | 1 |
Gecková, AM | 1 |
Martín-Pérez, M | 1 |
Hernández Barrera, V | 1 |
López de Andrés, A | 1 |
Jiménez-Trujillo, I | 1 |
Jiménez-García, R | 1 |
Carrasco-Garrido, P | 1 |
Pappa, E | 1 |
Chatzikonstantinidou, S | 1 |
Chalkiopoulos, G | 1 |
Papadopoulos, A | 1 |
Niakas, D | 1 |
La Parra Casado, D | 1 |
Gil González, D | 1 |
de la Torre Esteve, M | 1 |
Gadalean, F | 1 |
Lighezan, D | 1 |
Stoian, D | 1 |
Schiller, O | 1 |
Timar, R | 1 |
Timar, B | 1 |
Bob, F | 1 |
Donciu, MD | 1 |
Munteanu, M | 1 |
Mihaescu, A | 1 |
Covic, A | 1 |
Schiller, A | 1 |
Kanapeckiene, V | 1 |
Valinteliene, R | 1 |
Berzanskyte, A | 1 |
Kevalas, R | 1 |
Supranowicz, P | 1 |
Roman, G | 2 |
Enache, A | 2 |
Pârvu, A | 2 |
Gramma, R | 2 |
Moisa, ŞM | 2 |
Dumitraş, S | 2 |
Ioan, B | 2 |
Chirita, R | 1 |
Zeman, CL | 1 |
Depken, DE | 1 |
Senchina, DS | 1 |
Parry, G | 1 |
Van Cleemput, P | 1 |
Peters, J | 1 |
Walters, S | 1 |
Thomas, K | 1 |
Cooper, C | 1 |
Jaques, AK | 1 |
Arroja, I | 1 |
Araújo, C | 1 |
Azevedo, J | 1 |
Borges, A | 1 |
Santos, I | 1 |
Cabral, A | 1 |
Campos, MJ | 1 |
Mansinho, K | 1 |
Borges, F | 1 |
Pérez Brea, A | 1 |
Ruiz Moreno, M | 1 |
Leal Orozco, A | 1 |
Escorihuela Esteban, R | 1 |
Otero Fraguas, M | 1 |
Cabedo García, VR | 1 |
Ortells i Ros, E | 1 |
Baquero Toledo, L | 1 |
Bosch Girona, N | 1 |
Montero Royo, A | 1 |
Nácher Fernández, A | 1 |
Sánchez-Peral Sánchez, B | 1 |
Tamborero Sanjuán, MA | 1 |
7 reviews available for flumazenil and Chronic Disease
Article | Year |
---|---|
Flumazenil versus placebo or no intervention for people with cirrhosis and hepatic encephalopathy.
Topics: Acute Disease; Antidotes; Cause of Death; Chronic Disease; Flumazenil; GABA Modulators; GABA-A Recep | 2017 |
Benzodiazepine receptor antagonists for hepatic encephalopathy.
Topics: Acute Disease; Antidotes; Chronic Disease; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; | 2004 |
Molecular and diffusion tensor imaging of epileptic networks.
Topics: Adolescent; Age Factors; Brain Mapping; Carbon Radioisotopes; Cerebral Cortex; Child; Chronic Diseas | 2008 |
Benzodiazepine receptor antagonists for acute and chronic hepatic encephalopathy.
Topics: Acute Disease; Antidotes; Chronic Disease; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; | 2001 |
Socioeconomic Inequalities in the Use of Healthcare Services: Comparison between the Roma and General Populations in Spain.
Topics: Chronic Disease; Emergency Service, Hospital; Health Services; Health Surveys; Hospitalization; Huma | 2018 |
Roma health issues: a review of the literature and discussion.
Topics: Chromosome Mapping; Chronic Disease; Communicable Diseases; Cultural Characteristics; Databases, Bib | 2003 |
[Visceral leishmaniasis refractory to treatment: the efficacy of amphotericin B].
Topics: Amphotericin B; Animals; Anti-Bacterial Agents; Antimony; Antiprotozoal Agents; Child, Preschool; Ch | 1996 |
2 trials available for flumazenil and Chronic Disease
Article | Year |
---|---|
Evaluation of the efficacy and safety of flumazenil in the treatment of portal systemic encephalopathy: a double blind, randomised, placebo controlled multicentre study.
Topics: Chronic Disease; Double-Blind Method; Electroencephalography; Female; Flumazenil; Hepatic Encephalop | 1996 |
Use of midazolam ('Dormicum') and flumazenil ('Anexate') in paediatric bronchology.
Topics: Anesthesia; Atropine; Bronchoscopy; Child, Preschool; Chronic Disease; Drug Administration Schedule; | 1992 |
31 other studies available for flumazenil and Chronic Disease
Article | Year |
---|---|
Video NeuroImages: Idiopathic Recurring Stupor: An Unusual Clinical Condition Responding to Flumazenil.
Topics: Aged; Chronic Disease; Female; Flumazenil; GABA Modulators; Humans; Stupor | 2021 |
Increased Binding Potential of Brain Adenosine A
Topics: Adult; Carbon Radioisotopes; Chronic Disease; Diffuse Axonal Injury; Female; Flumazenil; Fluorodeoxy | 2018 |
Increase in extraction of I-123 iomazenil in patients with chronic cerebral ischemia.
Topics: Aged; Brain Ischemia; Cerebrovascular Circulation; Chronic Disease; Female; Flumazenil; Humans; Iodi | 2018 |
Effects of chronic mild stress on the development of drug dependence in rats.
Topics: Animals; Chronic Disease; Citalopram; Depressive Disorder; Diazepam; Disease Models, Animal; Flumaze | 2014 |
Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures.
Topics: Animals; Anticonvulsants; Bromides; Chronic Disease; Disease Models, Animal; Dog Diseases; Dogs; Dru | 2004 |
Decreased chronic-stage cortical 11C-flumazenil binding after focal ischemia-reperfusion in baboons: a marker of selective neuronal loss?
Topics: Animals; Brain Ischemia; Carbon Isotopes; Cerebral Cortex; Chronic Disease; Flumazenil; Hemodynamics | 2008 |
Dual-tracer autoradiography using 125I-iomazenil and 99Tcm-HMPAO in experimental brain ischaemia.
Topics: Acute Disease; Animals; Autoradiography; Brain; Brain Ischemia; Chronic Disease; Flumazenil; Functio | 1995 |
[Central type benzodiazepine receptor and cerebral blood flow in experimental chronic brain infarction--evaluation using a double-tracer autoradiography technique].
Topics: Animals; Autoradiography; Brain; Cerebral Infarction; Cerebrovascular Circulation; Chronic Disease; | 1993 |
[Chronic hepatic encephalopathy treated by long-term intravenous administration of flumazenil in ambulatory care].
Topics: Ambulatory Care; Chronic Disease; Esophageal and Gastric Varices; Flumazenil; GABA Modulators; Hepat | 1996 |
Benzodiazepine receptor distribution and diazepam binding in schizophrenia: an exploratory study.
Topics: Adult; Benzodiazepines; Binding Sites; Chronic Disease; Diazepam; Flumazenil; Frontal Lobe; Growth H | 1997 |
Benzodiazepine receptors in the post-mortem brain of suicide victims and schizophrenic subjects.
Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Chronic Disease; Drug Therapy, Combination; Fema | 1997 |
Plasma and CSF benzodiazepine receptor ligand concentrations in cirrhotic patients with hepatic encephalopathy: relationship to severity of encephalopathy and to pharmaceutical benzodiazepine intake.
Topics: Animals; Benzodiazepines; Binding, Competitive; Cell Fractionation; Cerebellum; Chronic Disease; Clo | 1998 |
Improvement of chronic hepatic encephalopathy in dogs by the benzodiazepine-receptor partial inverse agonist sarmazenil, but not by the antagonist flumazenil.
Topics: Ammonia; Animals; Benzodiazepines; Chronic Disease; Disease Models, Animal; Dogs; Electroencephalogr | 1998 |
[Chronic liver diseases. The nihilism has gone].
Topics: Amantadine; Antioxidants; Antiviral Agents; Chronic Disease; Dipeptides; Drug Therapy, Combination; | 2001 |
Pharmacokinetics of flumazenil in fulminant hepatic failure.
Topics: Adolescent; Chronic Disease; Female; Flumazenil; Humans; Liver Diseases; Male | 1991 |
[Evaluation of the therapeutic effect of flumazenil in hepatic encephalopathy using cerebral cartography].
Topics: Acute Disease; Aged; Brain Mapping; Chronic Disease; Drug Evaluation; Female; Flumazenil; Hepatic En | 1989 |
Improvement of hepatic encephalopathy treated with flumazenil.
Topics: Acute Disease; Adolescent; Adult; Aged; Brain; Child; Chronic Disease; Evoked Potentials, Somatosens | 1988 |
Beliefs, Perceptions, and Behaviors Regarding Chronic Respiratory Diseases of Roma in Crete, Greece: A Qualitative FRESH AIR Study.
Topics: Chronic Disease; Focus Groups; Greece; Health Knowledge, Attitudes, Practice; Health Personnel; Huma | 2022 |
Microbiome and health implications for ethnic minorities after enforced lifestyle changes.
Topics: Adult; Chronic Disease; Ethnicity; Feces; Gastrointestinal Microbiome; Genetics, Population; Humans; | 2020 |
Living in Roma Settlements in Greece: Self-Perceived Health Status, Chronic Diseases and Associated Social Determinants of Health.
Topics: Adult; Chronic Disease; Cross-Sectional Studies; Female; Greece; Health Status; Humans; Male; Reside | 2021 |
High hepatitis B and low hepatitis C prevalence in Roma population in eastern Slovakia.
Topics: Adolescent; Adult; Age Distribution; Chronic Disease; Comorbidity; Cross-Sectional Studies; Female; | 2014 |
Predictors of medication use in the Roma population in Spain: a population-based national study.
Topics: Adolescent; Adult; Attitude to Health; Chronic Disease; Cross-Sectional Studies; Female; Health Surv | 2015 |
Health-Related Quality of Life of the Roma in Greece: The Role of Socio-Economic Characteristics and Housing Conditions.
Topics: Adolescent; Adult; Chronic Disease; Cross-Sectional Studies; Female; Greece; Health Status; Health S | 2015 |
The social class gradient in health in Spain and the health status of the Spanish Roma.
Topics: Adult; Aged; Chronic Disease; Dental Caries; Disabled Persons; Female; Health Status; Health Status | 2016 |
The Survival of Roma Minority Patients on Chronic Hemodialysis Therapy - A Romanian Multicenter Survey.
Topics: Adult; Aged; Chronic Disease; End Stage Liver Disease; Female; Humans; Male; Middle Aged; Multivaria | 2016 |
Health of Roma children in Vilnius and Ventspils.
Topics: Adolescent; Age Factors; Alcohol Drinking; Chi-Square Distribution; Child; Chronic Disease; Emotions | 2009 |
Ethical issues in communication of diagnosis and end-of-life decision-making process in some of the Romanian Roma communities.
Topics: Adult; Aged; Chronic Disease; Communication; Culture; Decision Making; Family; Female; Humans; Inter | 2013 |
Dying and death in some Roma communities: ethical challenges.
Topics: Adaptation, Psychological; Adult; Aged; Attitude to Death; Caregivers; Chronic Disease; Cultural Cha | 2014 |
Health status of Gypsies and Travellers in England.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Chronic Disease; England; Female; Health Status; Health | 2007 |
[The acquired immunodeficiency syndrome, hypertrophic myocardiopathy and multivalvular infectious endocarditis. Apropos a clinical case].
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Aortic Valve; Card | 1995 |
[What are Gypsies like and what do they suffer from?].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Chronic Disease; Cross-Sectional Studies; Family | 2000 |