flumazenil has been researched along with Cerebral Ischemia in 31 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Multitracer micro-PET of ET1 focal ischemia in rats was performed using [11C]-flumazenil ([11C]FMZ) as a flow- and viability tracer and [18F]-fluoromisonidazole ([18F]FMISO) as hypoxia marker in order to characterize the physiological time-course of this model." | 7.83 | Which Aspects of Stroke Do Animal Models Capture? A Multitracer Micro-PET Study of Focal Ischemia with Endothelin-1. ( Bedell, B; Dancause, N; Dea, M; Funck, T; Heiss, WD; Kostikov, A; Quessy, S; Schirrmacher, R; Thiel, A, 2016) |
| "Multitracer micro-PET of ET1 focal ischemia in rats was performed using [11C]-flumazenil ([11C]FMZ) as a flow- and viability tracer and [18F]-fluoromisonidazole ([18F]FMISO) as hypoxia marker in order to characterize the physiological time-course of this model." | 3.83 | Which Aspects of Stroke Do Animal Models Capture? A Multitracer Micro-PET Study of Focal Ischemia with Endothelin-1. ( Bedell, B; Dancause, N; Dea, M; Funck, T; Heiss, WD; Kostikov, A; Quessy, S; Schirrmacher, R; Thiel, A, 2016) |
| "To establish the mechanism of neuroplasticity during the recovery phase following ischemic stroke by assessing the changes in cerebral GABA activity using [(18)F]flumazenil ([(18)F]FMZ) positron emission tomography (PET)." | 3.80 | Functional Recovery After Ischemic Stroke Is Associated With Reduced GABAergic Inhibition in the Cerebral Cortex: A GABA PET Study. ( Cho, K; Kim, YK; Lim, JY; Paik, NJ; Yang, EJ, 2014) |
| " We have evaluated by positron emission tomography the time course of changes in brain uptake in vivo of 11C-labeled PK 11195 and flumazenil (an antagonist of central benzodiazepine receptors) as indirect and direct markers of neuronal loss, respectively, after focal cerebral ischemia." | 3.68 | In vivo mapping of brain benzodiazepine receptor changes by positron emission tomography after focal ischemia in the anesthetized baboon. ( Baron, JC; Barré, L; Derlon, JM; MacKenzie, ET; Miyazawa, H; Sette, G; Tillet, I; Travère, JM; Young, AR, 1993) |
| "Ischemic stroke is caused by interruption or significant impairment of blood supply to the brain, which leads to a cascade of metabolic and molecular alterations resulting in functional disturbance and morphologic damage." | 2.50 | Radionuclide imaging in ischemic stroke. ( Heiss, WD, 2014) |
| "The porcine ET-1 model of cerebral ischemia is easier to implement then other large animal models of stroke, and performs similarly as long as CBF is monitored using CTP to prevent reperfusion." | 1.43 | Absolute Cerebral Blood Flow Infarction Threshold for 3-Hour Ischemia Time Determined with CT Perfusion and 18F-FFMZ-PET Imaging in a Porcine Model of Cerebral Ischemia. ( Cockburn, N; d'Esterre, CD; Kovacs, M; Lee, TY; Morrison, LB; Wright, EA, 2016) |
| "Flumazenil treatment before BCAO reduced ischaemic neuronal damage exacerbated by benzodiazepine tolerance (P<0." | 1.38 | Effects of diazepam and flumazenil on forebrain ischaemia in a rat model of benzodiazepine tolerance. ( Furuya, H; Inoue, S; Iwata, M; Kawaguchi, M, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.23) | 18.7374 |
| 1990's | 9 (29.03) | 18.2507 |
| 2000's | 10 (32.26) | 29.6817 |
| 2010's | 11 (35.48) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kato, H | 1 |
| Isohashi, K | 1 |
| Shimosegawa, E | 1 |
| Hatazawa, J | 1 |
| Kim, YK | 1 |
| Yang, EJ | 1 |
| Cho, K | 1 |
| Lim, JY | 1 |
| Paik, NJ | 1 |
| Heiss, WD | 8 |
| Schirrmacher, R | 2 |
| Dea, M | 1 |
| Kostikov, A | 1 |
| Funck, T | 1 |
| Quessy, S | 1 |
| Bedell, B | 1 |
| Dancause, N | 1 |
| Thiel, A | 4 |
| Wright, EA | 1 |
| d'Esterre, CD | 1 |
| Morrison, LB | 1 |
| Cockburn, N | 1 |
| Kovacs, M | 1 |
| Lee, TY | 1 |
| Sobesky, J | 2 |
| Massaweh, G | 1 |
| Schirrmacher, E | 1 |
| la Fougere, C | 1 |
| Kovacevic, M | 1 |
| Wängler, C | 1 |
| Jolly, D | 1 |
| Gravel, P | 1 |
| Reader, AJ | 1 |
| Kobayashi, M | 1 |
| Ogasawara, K | 1 |
| Aso, K | 1 |
| Chida, K | 1 |
| Kuroda, H | 1 |
| Yoshida, K | 1 |
| Ogawa, A | 1 |
| Rojas, S | 1 |
| Martín, A | 1 |
| Pareto, D | 1 |
| Herance, JR | 1 |
| Abad, S | 1 |
| Ruíz, A | 1 |
| Flotats, N | 1 |
| Gispert, JD | 1 |
| Llop, J | 1 |
| Gómez-Vallejo, V | 1 |
| Planas, AM | 1 |
| Yamauchi, H | 2 |
| Iwata, M | 1 |
| Inoue, S | 1 |
| Kawaguchi, M | 1 |
| Furuya, H | 1 |
| Kuge, Y | 2 |
| Hikosaka, K | 1 |
| Seki, K | 1 |
| Ohkura, K | 1 |
| Nishijima, KC | 1 |
| Kaji, T | 2 |
| Ueno, S | 1 |
| Tsukamoto, E | 1 |
| Tamaki, N | 2 |
| Yokota, C | 1 |
| Tagaya, M | 1 |
| Inoue, H | 1 |
| Shiga, T | 1 |
| Minematsu, K | 1 |
| Katchanov, J | 1 |
| Waeber, C | 1 |
| Gertz, K | 1 |
| Gietz, A | 1 |
| Winter, B | 1 |
| Brück, W | 1 |
| Dirnagl, U | 1 |
| Veh, RW | 1 |
| Endres, M | 1 |
| Nariai, T | 1 |
| Shimada, Y | 1 |
| Ishiwata, K | 1 |
| Nagaoka, T | 1 |
| Shimada, J | 1 |
| Kuroiwa, T | 1 |
| Ono, KI | 1 |
| Hirakawa, K | 1 |
| Senda, M | 1 |
| Ohno, K | 1 |
| Smekal, Uv | 1 |
| Kracht, LW | 2 |
| Lehnhardt, FG | 1 |
| Jacobs, AH | 1 |
| Lackner, K | 1 |
| Ricci, L | 1 |
| Valoti, M | 1 |
| Sgaragli, G | 1 |
| Frosini, M | 1 |
| Giffard, C | 1 |
| Landeau, B | 1 |
| Kerrouche, N | 1 |
| Young, AR | 2 |
| Barré, L | 2 |
| Baron, JC | 2 |
| Matsuda, H | 1 |
| Tsuji, S | 1 |
| Kuji, I | 1 |
| Shiba, K | 1 |
| Hisada, K | 1 |
| Mori, H | 1 |
| al-Tikriti, MS | 1 |
| Dey, HM | 1 |
| Zoghbi, SS | 1 |
| Baldwin, RM | 1 |
| Zea-Ponce, Y | 1 |
| Innis, RB | 1 |
| Sette, G | 1 |
| Miyazawa, H | 1 |
| Tillet, I | 1 |
| Travère, JM | 1 |
| Derlon, JM | 1 |
| MacKenzie, ET | 1 |
| Dong, Y | 1 |
| Fukuyama, H | 1 |
| Nabatame, H | 1 |
| Shibasaki, H | 1 |
| Yonekura, Y | 1 |
| Graf, R | 1 |
| Fujita, T | 1 |
| Ohta, K | 1 |
| Bauer, B | 1 |
| Löttgen, J | 1 |
| Wienhard, K | 1 |
| Ramírez-Moreno, JM | 1 |
| Cordero, JA | 1 |
| Durán-Herrera, C | 1 |
| Moriwaki, H | 1 |
| Matsumoto, M | 1 |
| Hashikawa, K | 1 |
| Oku, N | 1 |
| Ishida, M | 1 |
| Seike, Y | 1 |
| Fukuchi, K | 1 |
| Hori, M | 1 |
| Nishimura, T | 1 |
| D'Alessandro, G | 1 |
| Corso, G | 1 |
| Bottacchi, E | 1 |
| Grond, M | 1 |
| Pawlik, G | 1 |
| Johansen, FF | 1 |
| Christensen, T | 1 |
| Jensen, MS | 1 |
| Valente, E | 1 |
| Jensen, CV | 1 |
| Nathan, T | 1 |
| Lambert, JD | 1 |
| Diemer, NH | 1 |
| Kochs, E | 1 |
| Roewer, N | 1 |
| Peter, A | 1 |
| Schulte am Esch, J | 1 |
4 reviews available for flumazenil and Cerebral Ischemia
| Article | Year |
|---|---|
PET imaging in ischemic cerebrovascular disease: current status and future directions.
Topics: Brain Ischemia; Flumazenil; Humans; Microglia; Positron-Emission Tomography; Stroke | 2014 |
Radionuclide imaging in ischemic stroke.
Topics: Animals; Brain; Brain Ischemia; Carbon Radioisotopes; Cerebrovascular Disorders; Flumazenil; Humans; | 2014 |
Comparison of PET and DW/PW-MRI in acute ischemic stroke.
Topics: Brain; Brain Ischemia; Carbon Radioisotopes; Diagnostic Imaging; Diffusion Magnetic Resonance Imagin | 2008 |
The ischemic penumbra: how does tissue injury evolve?
Topics: Animals; Brain; Brain Edema; Brain Ischemia; Cats; Cerebral Infarction; Cerebrovascular Circulation; | 2012 |
1 trial available for flumazenil and Cerebral Ischemia
| Article | Year |
|---|---|
Penumbral probability thresholds of cortical flumazenil binding and blood flow predicting tissue outcome in patients with cerebral ischaemia.
Topics: Aged; Blood Flow Velocity; Brain Ischemia; Cerebral Cortex; Cerebrovascular Circulation; Disease Pro | 2001 |
26 other studies available for flumazenil and Cerebral Ischemia
| Article | Year |
|---|---|
Increase in extraction of I-123 iomazenil in patients with chronic cerebral ischemia.
Topics: Aged; Brain Ischemia; Cerebrovascular Circulation; Chronic Disease; Female; Flumazenil; Humans; Iodi | 2018 |
Functional Recovery After Ischemic Stroke Is Associated With Reduced GABAergic Inhibition in the Cerebral Cortex: A GABA PET Study.
Topics: Aged; Brain Ischemia; Cerebellum; Cerebral Cortex; Female; Flumazenil; Fluorine Radioisotopes; Follo | 2014 |
Which Aspects of Stroke Do Animal Models Capture? A Multitracer Micro-PET Study of Focal Ischemia with Endothelin-1.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Endothelin-1; Flumazenil; Infarction, M | 2016 |
Absolute Cerebral Blood Flow Infarction Threshold for 3-Hour Ischemia Time Determined with CT Perfusion and 18F-FFMZ-PET Imaging in a Porcine Model of Cerebral Ischemia.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Cerebrovascular Circulation; Disease Models, Animal; F | 2016 |
Improved work-up procedure for the production of [(18)F]flumazenil and first results of its use with a high-resolution research tomograph in human stroke.
Topics: Brain Ischemia; Flumazenil; Fluorine Radioisotopes; Humans; Infarction, Middle Cerebral Artery; Posi | 2009 |
Interesting image. I-123 iomazenil SPECT imaging in a patient with hemispheric brain damage due to cerebral ischemia during carotid endarterectomy.
Topics: Brain Damage, Chronic; Brain Ischemia; Endarterectomy, Carotid; Flumazenil; Humans; Male; Middle Age | 2010 |
Positron emission tomography with 11C-flumazenil in the rat shows preservation of binding sites during the acute phase after 2 h-transient focal ischemia.
Topics: Acute Disease; Animals; Binding Sites; Brain Ischemia; Disease Models, Animal; Flumazenil; Male; Ner | 2011 |
[Ischemic cortical neuronal damage and cognitive impairments in atherosclerotic occlusive disease of the major cerebral artery: a PET study].
Topics: Aged; Brain Ischemia; Carbon Radioisotopes; Carotid Artery Diseases; Cerebral Cortex; Cognition Diso | 2011 |
Effects of diazepam and flumazenil on forebrain ischaemia in a rat model of benzodiazepine tolerance.
Topics: Analysis of Variance; Animals; Benzodiazepines; Brain Ischemia; Diazepam; Disease Models, Animal; Dr | 2012 |
Characteristic brain distribution of 1-(14)C-octanoate in a rat model of focal cerebral ischemia in comparison with those of (123)I-IMP and (123)I-iomazenil.
Topics: Animals; Autoradiography; Brain; Brain Ischemia; Caprylates; Disease Models, Animal; Flumazenil; Iof | 2003 |
Characterisation of [123I]iomazenil distribution in a rat model of focal cerebral ischaemia in relation to histopathological findings.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Flumazenil; Iodine Radioisotopes; Male; Metabolic C | 2004 |
Selective neuronal vulnerability following mild focal brain ischemia in the mouse.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antidotes; Antineoplastic Agents; Autoradiography; Binding Sit | 2003 |
PET neuroreceptor imaging as predictor of severe cerebral ischemic insult.
Topics: Animals; Brain; Brain Ischemia; Cats; Cerebrovascular Circulation; Contrast Media; Flumazenil; Fluor | 2003 |
Probability of cortical infarction predicted by flumazenil binding and diffusion-weighted imaging signal intensity: a comparative positron emission tomography/magnetic resonance imaging study in early ischemic stroke.
Topics: Adult; Aged; Brain Infarction; Brain Ischemia; Diffusion Magnetic Resonance Imaging; Female; Flumaze | 2004 |
Neuroprotection afforded by diazepam against oxygen/glucose deprivation-induced injury in rat cortical brain slices.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GA | 2007 |
Decreased chronic-stage cortical 11C-flumazenil binding after focal ischemia-reperfusion in baboons: a marker of selective neuronal loss?
Topics: Animals; Brain Ischemia; Carbon Isotopes; Cerebral Cortex; Chronic Disease; Flumazenil; Hemodynamics | 2008 |
Dual-tracer autoradiography using 125I-iomazenil and 99Tcm-HMPAO in experimental brain ischaemia.
Topics: Acute Disease; Animals; Autoradiography; Brain; Brain Ischemia; Chronic Disease; Flumazenil; Functio | 1995 |
Dual-isotope autoradiographic measurement of regional blood flow and benzodiazepine receptor availability following unilateral middle cerebral artery occlusion.
Topics: Amphetamines; Animals; Autoradiography; Brain; Brain Ischemia; Cerebral Arteries; Flumazenil; Iodine | 1994 |
In vivo mapping of brain benzodiazepine receptor changes by positron emission tomography after focal ischemia in the anesthetized baboon.
Topics: Animals; Brain Ischemia; Brain Mapping; Cerebral Infarction; Flumazenil; Isoquinolines; Macrophages; | 1993 |
Assessment of benzodiazepine receptors using iodine-123-labeled iomazenil single-photon emission computed tomography in patients with ischemic cerebrovascular disease. A comparison with PET study.
Topics: Aged; Brain; Brain Ischemia; Flumazenil; Humans; Iodine Radioisotopes; Male; Middle Aged; Radiograph | 1997 |
Early detection of irreversibly damaged ischemic tissue by flumazenil positron emission tomography in cats.
Topics: Animals; Brain; Brain Ischemia; Cats; Female; Flumazenil; Glucose; Magnetic Resonance Imaging; Male; | 1997 |
[Transitory comatose situation secondary to an infarction of the posterior circulation, reversed by naloxone?].
Topics: Adult; Brain Ischemia; Cerebral Infarction; Coma; Drug Therapy, Combination; Emergency Medical Servi | 1998 |
Iodine-123-iomazenil and iodine-123-iodoamphetamine SPECT in major cerebral artery occlusive disease.
Topics: Amphetamines; Brain; Brain Ischemia; Carotid Stenosis; Case-Control Studies; Cerebrovascular Circula | 1998 |
Could flumazenil reverse neurological deficits in acute cerebral ischemia?
Topics: Acute Disease; Brain Ischemia; Carotid Artery Thrombosis; Carotid Artery, Internal; Cerebral Angiogr | 1999 |
Inhibition in postischemic rat hippocampus: GABA receptors, GABA release, and inhibitory postsynaptic potentials.
Topics: Animals; Autoradiography; Brain Ischemia; Dialysis; Electrophysiology; Flumazenil; gamma-Aminobutyri | 1991 |
[Effect of flumazenil on global cerebral blood flow and on intracranial pressure in the reperfusion phase following incomplete global cerebral ischemia].
Topics: Animals; Brain Ischemia; Cerebrovascular Circulation; Flumazenil; Goats; Intracranial Pressure; Perf | 1988 |