flumazenil has been researched along with Brain Vascular Disorders in 13 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To determine whether viable neurones of low functional activity are represented in in vivo neuroreceptor imaging, we undertook experiments in gerbils with cerebral infarction, in which we examined histological changes and the results of dual-tracer in vivo autoradiography of glucose utilization with 14C-labelled deoxyglucose and benzodiazepine receptor binding with 123I-labelled Ro 16-0154." | 3.69 | A potential use of a 123I-labelled benzodiazepine receptor antagonist as a predictor of neuronal cell viability: comparisons with 14C-labelled 2-deoxyglucose autoradiography and histopathological examination. ( Fujita, M; Ikuta, F; Minoshima, S; Miyashita, K; Nakajima, T; Odano, I; Takahashi, N, 1995) |
| "Ischemic stroke is caused by interruption or significant impairment of blood supply to the brain, which leads to a cascade of metabolic and molecular alterations resulting in functional disturbance and morphologic damage." | 2.50 | Radionuclide imaging in ischemic stroke. ( Heiss, WD, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (69.23) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Heiss, WD | 2 |
| Chida, K | 1 |
| Ogasawara, K | 1 |
| Suga, Y | 1 |
| Saito, H | 1 |
| Kobayashi, M | 1 |
| Yoshida, K | 1 |
| Otawara, Y | 1 |
| Ogawa, A | 1 |
| Tsukamoto, M | 1 |
| Katoh, C | 1 |
| Shiga, T | 1 |
| Kaji, T | 1 |
| Kuge, Y | 1 |
| Nakada, K | 1 |
| Tamaki, N | 1 |
| Seike, Y | 3 |
| Hashikawa, K | 3 |
| Oku, N | 3 |
| Moriwaki, H | 3 |
| Yamamoto, H | 1 |
| Fukuchi, K | 3 |
| Watanabe, Y | 2 |
| Matsumoto, M | 3 |
| Hori, M | 2 |
| Nishimura, T | 5 |
| Odano, I | 1 |
| Miyashita, K | 2 |
| Minoshima, S | 1 |
| Nakajima, T | 1 |
| Fujita, M | 2 |
| Takahashi, N | 1 |
| Ikuta, F | 1 |
| Torizuka, K | 1 |
| Uemura, K | 1 |
| Toru, M | 1 |
| Shinohara, Y | 1 |
| Yonekura, Y | 1 |
| Nakagawara, J | 1 |
| Matsuda, H | 1 |
| Sakai, F | 1 |
| Matsuda, K | 1 |
| Fukuyama, H | 1 |
| Morimoto, K | 1 |
| Ito, H | 2 |
| Goto, R | 2 |
| Koyama, M | 2 |
| Kawashima, R | 2 |
| Ono, S | 2 |
| Sato, K | 2 |
| Fukuda, H | 2 |
| Ishida, M | 2 |
| Terakawa, H | 1 |
| Uehara, T | 1 |
| Hayashida, K | 1 |
| Hirose, Y | 1 |
| Tanaka, Y | 1 |
| Ishida, Y | 1 |
| Miyake, Y | 1 |
| Grond, M | 1 |
| Thiel, A | 1 |
| Ghaemi, M | 1 |
| Sobesky, J | 1 |
| Rudolf, J | 1 |
| Bauer, B | 1 |
| Wienhard, K | 1 |
| Hatazawa, J | 1 |
| Shimosegawa, E | 1 |
2 reviews available for flumazenil and Brain Vascular Disorders
| Article | Year |
|---|---|
Radionuclide imaging in ischemic stroke.
Topics: Animals; Brain; Brain Ischemia; Carbon Radioisotopes; Cerebrovascular Disorders; Flumazenil; Humans; | 2014 |
Imaging neurochemistry of cerebrovascular disease with PET and SPECT.
Topics: Brain; Carbon Radioisotopes; Cerebrovascular Disorders; Flumazenil; Humans; Receptors, GABA-A; Tomog | 1998 |
4 trials available for flumazenil and Brain Vascular Disorders
| Article | Year |
|---|---|
Use of a standardized uptake value for parametric in vivo imaging of benzodiazepine receptor distribution on [11C]flumazenil brain PET.
Topics: Adult; Brain; Cerebrovascular Disorders; Female; Flumazenil; Humans; Image Enhancement; Image Interp | 2004 |
Evaluation of the use of a standard input function for compartment analysis of [123I]iomazenil data: factors influencing the quantitative results.
Topics: Adolescent; Adult; Aged; Algorithms; Alzheimer Disease; Brain; Cerebrovascular Disorders; Epilepsy; | 2004 |
[A phase 3 clinical trial of 123I-iomazenil, a new central-type benzodiazepine receptor imaging agent (Part 4)--Report on clinical usefulness in diagnosis of cerebrovascular diseases].
Topics: Brain; Cerebrovascular Disorders; Flumazenil; GABA-A Receptor Agonists; Humans; Iodine Radioisotopes | 1996 |
[Evaluation of 123I-iomazenil SPECT in patients with ischemic cerebrovascular disease: comparative study with 123I-IMP SPECT].
Topics: Adult; Aged; Amphetamines; Brain; Cerebrovascular Disorders; Female; Flumazenil; Humans; Iodine Radi | 1996 |
7 other studies available for flumazenil and Brain Vascular Disorders
| Article | Year |
|---|---|
Postoperative cortical neural loss associated with cerebral hyperperfusion and cognitive impairment after carotid endarterectomy: 123I-iomazenil SPECT study.
Topics: Adult; Aged; Analysis of Variance; Carotid Stenosis; Cerebral Cortex; Cerebrovascular Circulation; C | 2009 |
A potential use of a 123I-labelled benzodiazepine receptor antagonist as a predictor of neuronal cell viability: comparisons with 14C-labelled 2-deoxyglucose autoradiography and histopathological examination.
Topics: Animals; Autoradiography; Brain; Carbon Radioisotopes; Cell Survival; Cerebral Infarction; Cerebrova | 1995 |
A simple method for the quantification of benzodiazepine receptors using iodine-123 iomazenil and single-photon emission tomography.
Topics: Brain; Brain Neoplasms; Cerebrovascular Disorders; Computer Simulation; Dementia; Flumazenil; Humans | 1996 |
Reduction of 123I-iomazenil uptake in haemodynamically and metabolically impaired brain areas in patients with cerebrovascular disease.
Topics: Aged; Cerebrovascular Circulation; Cerebrovascular Disorders; Flumazenil; Humans; Iodine Radioisotop | 1996 |
A method for the quantification of benzodiazepine receptors by using 123I-iomazenil and SPECT with one scan and one blood sampling.
Topics: Adult; Aged; Autoradiography; Brain; Brain Neoplasms; Cerebrovascular Disorders; Computer Simulation | 1997 |
Permanent cortical damage detected by flumazenil positron emission tomography in acute stroke.
Topics: Aged; Carbon Radioisotopes; Cerebral Cortex; Cerebrovascular Circulation; Cerebrovascular Disorders; | 1998 |
Iodine-123-iomazenil and iodine-123-iodoamphetamine SPECT in major cerebral artery occlusive disease.
Topics: Amphetamines; Brain; Brain Ischemia; Carotid Stenosis; Case-Control Studies; Cerebrovascular Circula | 1998 |