flumazenil has been researched along with Brain Ischemia in 31 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Multitracer micro-PET of ET1 focal ischemia in rats was performed using [11C]-flumazenil ([11C]FMZ) as a flow- and viability tracer and [18F]-fluoromisonidazole ([18F]FMISO) as hypoxia marker in order to characterize the physiological time-course of this model." | 7.83 | Which Aspects of Stroke Do Animal Models Capture? A Multitracer Micro-PET Study of Focal Ischemia with Endothelin-1. ( Bedell, B; Dancause, N; Dea, M; Funck, T; Heiss, WD; Kostikov, A; Quessy, S; Schirrmacher, R; Thiel, A, 2016) |
| "Multitracer micro-PET of ET1 focal ischemia in rats was performed using [11C]-flumazenil ([11C]FMZ) as a flow- and viability tracer and [18F]-fluoromisonidazole ([18F]FMISO) as hypoxia marker in order to characterize the physiological time-course of this model." | 3.83 | Which Aspects of Stroke Do Animal Models Capture? A Multitracer Micro-PET Study of Focal Ischemia with Endothelin-1. ( Bedell, B; Dancause, N; Dea, M; Funck, T; Heiss, WD; Kostikov, A; Quessy, S; Schirrmacher, R; Thiel, A, 2016) |
| "To establish the mechanism of neuroplasticity during the recovery phase following ischemic stroke by assessing the changes in cerebral GABA activity using [(18)F]flumazenil ([(18)F]FMZ) positron emission tomography (PET)." | 3.80 | Functional Recovery After Ischemic Stroke Is Associated With Reduced GABAergic Inhibition in the Cerebral Cortex: A GABA PET Study. ( Cho, K; Kim, YK; Lim, JY; Paik, NJ; Yang, EJ, 2014) |
| " We have evaluated by positron emission tomography the time course of changes in brain uptake in vivo of 11C-labeled PK 11195 and flumazenil (an antagonist of central benzodiazepine receptors) as indirect and direct markers of neuronal loss, respectively, after focal cerebral ischemia." | 3.68 | In vivo mapping of brain benzodiazepine receptor changes by positron emission tomography after focal ischemia in the anesthetized baboon. ( Baron, JC; Barré, L; Derlon, JM; MacKenzie, ET; Miyazawa, H; Sette, G; Tillet, I; Travère, JM; Young, AR, 1993) |
| "Ischemic stroke is caused by interruption or significant impairment of blood supply to the brain, which leads to a cascade of metabolic and molecular alterations resulting in functional disturbance and morphologic damage." | 2.50 | Radionuclide imaging in ischemic stroke. ( Heiss, WD, 2014) |
| "The porcine ET-1 model of cerebral ischemia is easier to implement then other large animal models of stroke, and performs similarly as long as CBF is monitored using CTP to prevent reperfusion." | 1.43 | Absolute Cerebral Blood Flow Infarction Threshold for 3-Hour Ischemia Time Determined with CT Perfusion and 18F-FFMZ-PET Imaging in a Porcine Model of Cerebral Ischemia. ( Cockburn, N; d'Esterre, CD; Kovacs, M; Lee, TY; Morrison, LB; Wright, EA, 2016) |
| "Flumazenil treatment before BCAO reduced ischaemic neuronal damage exacerbated by benzodiazepine tolerance (P<0." | 1.38 | Effects of diazepam and flumazenil on forebrain ischaemia in a rat model of benzodiazepine tolerance. ( Furuya, H; Inoue, S; Iwata, M; Kawaguchi, M, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.23) | 18.7374 |
| 1990's | 9 (29.03) | 18.2507 |
| 2000's | 10 (32.26) | 29.6817 |
| 2010's | 11 (35.48) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kato, H | 1 |
| Isohashi, K | 1 |
| Shimosegawa, E | 1 |
| Hatazawa, J | 1 |
| Kim, YK | 1 |
| Yang, EJ | 1 |
| Cho, K | 1 |
| Lim, JY | 1 |
| Paik, NJ | 1 |
| Heiss, WD | 8 |
| Schirrmacher, R | 2 |
| Dea, M | 1 |
| Kostikov, A | 1 |
| Funck, T | 1 |
| Quessy, S | 1 |
| Bedell, B | 1 |
| Dancause, N | 1 |
| Thiel, A | 4 |
| Wright, EA | 1 |
| d'Esterre, CD | 1 |
| Morrison, LB | 1 |
| Cockburn, N | 1 |
| Kovacs, M | 1 |
| Lee, TY | 1 |
| Sobesky, J | 2 |
| Massaweh, G | 1 |
| Schirrmacher, E | 1 |
| la Fougere, C | 1 |
| Kovacevic, M | 1 |
| Wängler, C | 1 |
| Jolly, D | 1 |
| Gravel, P | 1 |
| Reader, AJ | 1 |
| Kobayashi, M | 1 |
| Ogasawara, K | 1 |
| Aso, K | 1 |
| Chida, K | 1 |
| Kuroda, H | 1 |
| Yoshida, K | 1 |
| Ogawa, A | 1 |
| Rojas, S | 1 |
| Martín, A | 1 |
| Pareto, D | 1 |
| Herance, JR | 1 |
| Abad, S | 1 |
| Ruíz, A | 1 |
| Flotats, N | 1 |
| Gispert, JD | 1 |
| Llop, J | 1 |
| Gómez-Vallejo, V | 1 |
| Planas, AM | 1 |
| Yamauchi, H | 2 |
| Iwata, M | 1 |
| Inoue, S | 1 |
| Kawaguchi, M | 1 |
| Furuya, H | 1 |
| Kuge, Y | 2 |
| Hikosaka, K | 1 |
| Seki, K | 1 |
| Ohkura, K | 1 |
| Nishijima, KC | 1 |
| Kaji, T | 2 |
| Ueno, S | 1 |
| Tsukamoto, E | 1 |
| Tamaki, N | 2 |
| Yokota, C | 1 |
| Tagaya, M | 1 |
| Inoue, H | 1 |
| Shiga, T | 1 |
| Minematsu, K | 1 |
| Katchanov, J | 1 |
| Waeber, C | 1 |
| Gertz, K | 1 |
| Gietz, A | 1 |
| Winter, B | 1 |
| Brück, W | 1 |
| Dirnagl, U | 1 |
| Veh, RW | 1 |
| Endres, M | 1 |
| Nariai, T | 1 |
| Shimada, Y | 1 |
| Ishiwata, K | 1 |
| Nagaoka, T | 1 |
| Shimada, J | 1 |
| Kuroiwa, T | 1 |
| Ono, KI | 1 |
| Hirakawa, K | 1 |
| Senda, M | 1 |
| Ohno, K | 1 |
| Smekal, Uv | 1 |
| Kracht, LW | 2 |
| Lehnhardt, FG | 1 |
| Jacobs, AH | 1 |
| Lackner, K | 1 |
| Ricci, L | 1 |
| Valoti, M | 1 |
| Sgaragli, G | 1 |
| Frosini, M | 1 |
| Giffard, C | 1 |
| Landeau, B | 1 |
| Kerrouche, N | 1 |
| Young, AR | 2 |
| Barré, L | 2 |
| Baron, JC | 2 |
| Matsuda, H | 1 |
| Tsuji, S | 1 |
| Kuji, I | 1 |
| Shiba, K | 1 |
| Hisada, K | 1 |
| Mori, H | 1 |
| al-Tikriti, MS | 1 |
| Dey, HM | 1 |
| Zoghbi, SS | 1 |
| Baldwin, RM | 1 |
| Zea-Ponce, Y | 1 |
| Innis, RB | 1 |
| Sette, G | 1 |
| Miyazawa, H | 1 |
| Tillet, I | 1 |
| Travère, JM | 1 |
| Derlon, JM | 1 |
| MacKenzie, ET | 1 |
| Dong, Y | 1 |
| Fukuyama, H | 1 |
| Nabatame, H | 1 |
| Shibasaki, H | 1 |
| Yonekura, Y | 1 |
| Graf, R | 1 |
| Fujita, T | 1 |
| Ohta, K | 1 |
| Bauer, B | 1 |
| Löttgen, J | 1 |
| Wienhard, K | 1 |
| Ramírez-Moreno, JM | 1 |
| Cordero, JA | 1 |
| Durán-Herrera, C | 1 |
| Moriwaki, H | 1 |
| Matsumoto, M | 1 |
| Hashikawa, K | 1 |
| Oku, N | 1 |
| Ishida, M | 1 |
| Seike, Y | 1 |
| Fukuchi, K | 1 |
| Hori, M | 1 |
| Nishimura, T | 1 |
| D'Alessandro, G | 1 |
| Corso, G | 1 |
| Bottacchi, E | 1 |
| Grond, M | 1 |
| Pawlik, G | 1 |
| Johansen, FF | 1 |
| Christensen, T | 1 |
| Jensen, MS | 1 |
| Valente, E | 1 |
| Jensen, CV | 1 |
| Nathan, T | 1 |
| Lambert, JD | 1 |
| Diemer, NH | 1 |
| Kochs, E | 1 |
| Roewer, N | 1 |
| Peter, A | 1 |
| Schulte am Esch, J | 1 |
4 reviews available for flumazenil and Brain Ischemia
| Article | Year |
|---|---|
PET imaging in ischemic cerebrovascular disease: current status and future directions.
Topics: Brain Ischemia; Flumazenil; Humans; Microglia; Positron-Emission Tomography; Stroke | 2014 |
Radionuclide imaging in ischemic stroke.
Topics: Animals; Brain; Brain Ischemia; Carbon Radioisotopes; Cerebrovascular Disorders; Flumazenil; Humans; | 2014 |
Comparison of PET and DW/PW-MRI in acute ischemic stroke.
Topics: Brain; Brain Ischemia; Carbon Radioisotopes; Diagnostic Imaging; Diffusion Magnetic Resonance Imagin | 2008 |
The ischemic penumbra: how does tissue injury evolve?
Topics: Animals; Brain; Brain Edema; Brain Ischemia; Cats; Cerebral Infarction; Cerebrovascular Circulation; | 2012 |
1 trial available for flumazenil and Brain Ischemia
| Article | Year |
|---|---|
Penumbral probability thresholds of cortical flumazenil binding and blood flow predicting tissue outcome in patients with cerebral ischaemia.
Topics: Aged; Blood Flow Velocity; Brain Ischemia; Cerebral Cortex; Cerebrovascular Circulation; Disease Pro | 2001 |
26 other studies available for flumazenil and Brain Ischemia
| Article | Year |
|---|---|
Increase in extraction of I-123 iomazenil in patients with chronic cerebral ischemia.
Topics: Aged; Brain Ischemia; Cerebrovascular Circulation; Chronic Disease; Female; Flumazenil; Humans; Iodi | 2018 |
Functional Recovery After Ischemic Stroke Is Associated With Reduced GABAergic Inhibition in the Cerebral Cortex: A GABA PET Study.
Topics: Aged; Brain Ischemia; Cerebellum; Cerebral Cortex; Female; Flumazenil; Fluorine Radioisotopes; Follo | 2014 |
Which Aspects of Stroke Do Animal Models Capture? A Multitracer Micro-PET Study of Focal Ischemia with Endothelin-1.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Endothelin-1; Flumazenil; Infarction, M | 2016 |
Absolute Cerebral Blood Flow Infarction Threshold for 3-Hour Ischemia Time Determined with CT Perfusion and 18F-FFMZ-PET Imaging in a Porcine Model of Cerebral Ischemia.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Cerebrovascular Circulation; Disease Models, Animal; F | 2016 |
Improved work-up procedure for the production of [(18)F]flumazenil and first results of its use with a high-resolution research tomograph in human stroke.
Topics: Brain Ischemia; Flumazenil; Fluorine Radioisotopes; Humans; Infarction, Middle Cerebral Artery; Posi | 2009 |
Interesting image. I-123 iomazenil SPECT imaging in a patient with hemispheric brain damage due to cerebral ischemia during carotid endarterectomy.
Topics: Brain Damage, Chronic; Brain Ischemia; Endarterectomy, Carotid; Flumazenil; Humans; Male; Middle Age | 2010 |
Positron emission tomography with 11C-flumazenil in the rat shows preservation of binding sites during the acute phase after 2 h-transient focal ischemia.
Topics: Acute Disease; Animals; Binding Sites; Brain Ischemia; Disease Models, Animal; Flumazenil; Male; Ner | 2011 |
[Ischemic cortical neuronal damage and cognitive impairments in atherosclerotic occlusive disease of the major cerebral artery: a PET study].
Topics: Aged; Brain Ischemia; Carbon Radioisotopes; Carotid Artery Diseases; Cerebral Cortex; Cognition Diso | 2011 |
Effects of diazepam and flumazenil on forebrain ischaemia in a rat model of benzodiazepine tolerance.
Topics: Analysis of Variance; Animals; Benzodiazepines; Brain Ischemia; Diazepam; Disease Models, Animal; Dr | 2012 |
Characteristic brain distribution of 1-(14)C-octanoate in a rat model of focal cerebral ischemia in comparison with those of (123)I-IMP and (123)I-iomazenil.
Topics: Animals; Autoradiography; Brain; Brain Ischemia; Caprylates; Disease Models, Animal; Flumazenil; Iof | 2003 |
Characterisation of [123I]iomazenil distribution in a rat model of focal cerebral ischaemia in relation to histopathological findings.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Flumazenil; Iodine Radioisotopes; Male; Metabolic C | 2004 |
Selective neuronal vulnerability following mild focal brain ischemia in the mouse.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antidotes; Antineoplastic Agents; Autoradiography; Binding Sit | 2003 |
PET neuroreceptor imaging as predictor of severe cerebral ischemic insult.
Topics: Animals; Brain; Brain Ischemia; Cats; Cerebrovascular Circulation; Contrast Media; Flumazenil; Fluor | 2003 |
Probability of cortical infarction predicted by flumazenil binding and diffusion-weighted imaging signal intensity: a comparative positron emission tomography/magnetic resonance imaging study in early ischemic stroke.
Topics: Adult; Aged; Brain Infarction; Brain Ischemia; Diffusion Magnetic Resonance Imaging; Female; Flumaze | 2004 |
Neuroprotection afforded by diazepam against oxygen/glucose deprivation-induced injury in rat cortical brain slices.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GA | 2007 |
Decreased chronic-stage cortical 11C-flumazenil binding after focal ischemia-reperfusion in baboons: a marker of selective neuronal loss?
Topics: Animals; Brain Ischemia; Carbon Isotopes; Cerebral Cortex; Chronic Disease; Flumazenil; Hemodynamics | 2008 |
Dual-tracer autoradiography using 125I-iomazenil and 99Tcm-HMPAO in experimental brain ischaemia.
Topics: Acute Disease; Animals; Autoradiography; Brain; Brain Ischemia; Chronic Disease; Flumazenil; Functio | 1995 |
Dual-isotope autoradiographic measurement of regional blood flow and benzodiazepine receptor availability following unilateral middle cerebral artery occlusion.
Topics: Amphetamines; Animals; Autoradiography; Brain; Brain Ischemia; Cerebral Arteries; Flumazenil; Iodine | 1994 |
In vivo mapping of brain benzodiazepine receptor changes by positron emission tomography after focal ischemia in the anesthetized baboon.
Topics: Animals; Brain Ischemia; Brain Mapping; Cerebral Infarction; Flumazenil; Isoquinolines; Macrophages; | 1993 |
Assessment of benzodiazepine receptors using iodine-123-labeled iomazenil single-photon emission computed tomography in patients with ischemic cerebrovascular disease. A comparison with PET study.
Topics: Aged; Brain; Brain Ischemia; Flumazenil; Humans; Iodine Radioisotopes; Male; Middle Aged; Radiograph | 1997 |
Early detection of irreversibly damaged ischemic tissue by flumazenil positron emission tomography in cats.
Topics: Animals; Brain; Brain Ischemia; Cats; Female; Flumazenil; Glucose; Magnetic Resonance Imaging; Male; | 1997 |
[Transitory comatose situation secondary to an infarction of the posterior circulation, reversed by naloxone?].
Topics: Adult; Brain Ischemia; Cerebral Infarction; Coma; Drug Therapy, Combination; Emergency Medical Servi | 1998 |
Iodine-123-iomazenil and iodine-123-iodoamphetamine SPECT in major cerebral artery occlusive disease.
Topics: Amphetamines; Brain; Brain Ischemia; Carotid Stenosis; Case-Control Studies; Cerebrovascular Circula | 1998 |
Could flumazenil reverse neurological deficits in acute cerebral ischemia?
Topics: Acute Disease; Brain Ischemia; Carotid Artery Thrombosis; Carotid Artery, Internal; Cerebral Angiogr | 1999 |
Inhibition in postischemic rat hippocampus: GABA receptors, GABA release, and inhibitory postsynaptic potentials.
Topics: Animals; Autoradiography; Brain Ischemia; Dialysis; Electrophysiology; Flumazenil; gamma-Aminobutyri | 1991 |
[Effect of flumazenil on global cerebral blood flow and on intracranial pressure in the reperfusion phase following incomplete global cerebral ischemia].
Topics: Animals; Brain Ischemia; Cerebrovascular Circulation; Flumazenil; Goats; Intracranial Pressure; Perf | 1988 |