flumazenil has been researched along with Brain Injuries in 13 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Traumatic brain injuries demonstrate various symptoms, including the disturbance of higher brain function, which is not visualized as a morphological lesion on magnetic resonance (MR) imaging." | 1.39 | Evaluation of cerebral function using iomazenil SPECT for patients with traumatic brain injury. ( Endo, K; Shibata, Y, 2013) |
| "Four patients with homonymous hemianopia and 15 healthy subjects were examined using PET to measure cerebral glucose metabolism, C-flumazenil (FMZ) binding to the central benzodiazepine receptor, and MPDX binding to A1R." | 1.38 | Increased adenosine A1 receptor levels in hemianopia patients after cerebral injury: an application of PET using 11C-8-dicyclopropylmethyl-1-methyl-3-propylxanthine. ( Ishii, K; Ishiwata, K; Kimura, Y; Kiyosawa, M; Mochizuki, M; Nariai, T; Oda, K; Suzuki, Y, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 9 (69.23) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Sebastiani, A | 1 |
| Bender, S | 1 |
| Schäfer, MKE | 1 |
| Thal, SC | 1 |
| Koizumi, H | 2 |
| Fujisawa, H | 2 |
| Suehiro, E | 2 |
| Iwanaga, H | 2 |
| Nakagawara, J | 3 |
| Suzuki, M | 2 |
| Kamiyama, K | 1 |
| Takahashi, M | 1 |
| Nakamura, H | 1 |
| Shibata, Y | 1 |
| Endo, K | 1 |
| Qin, P | 1 |
| Wu, X | 2 |
| Duncan, NW | 1 |
| Bao, W | 1 |
| Tang, W | 1 |
| Zhang, Z | 1 |
| Hu, J | 1 |
| Jin, Y | 1 |
| Gao, L | 1 |
| Lu, L | 1 |
| Guan, Y | 1 |
| Lane, T | 1 |
| Huang, Z | 1 |
| Bodien, YG | 1 |
| Giacino, JT | 1 |
| Mao, Y | 1 |
| Northoff, G | 1 |
| Ochalski, PG | 2 |
| Okonkwo, DO | 2 |
| Bell, MJ | 1 |
| Adelson, PD | 2 |
| Fellows-Mayle, W | 1 |
| Hsieh, LB | 1 |
| Srinivas, R | 1 |
| Dixon, CE | 1 |
| Kurokawa, T | 1 |
| Heiss, WD | 1 |
| Kawai, N | 1 |
| Maeda, Y | 1 |
| Kudomi, N | 1 |
| Yamamoto, Y | 1 |
| Nishiyama, Y | 1 |
| Tamiya, T | 1 |
| Suzuki, Y | 1 |
| Nariai, T | 1 |
| Kiyosawa, M | 1 |
| Mochizuki, M | 1 |
| Kimura, Y | 1 |
| Oda, K | 1 |
| Ishii, K | 1 |
| Ishiwata, K | 1 |
| Buylaert, WA | 1 |
| Sihver, S | 1 |
| Marklund, N | 1 |
| Hillered, L | 1 |
| Långström, B | 1 |
| Watanabe, Y | 1 |
| Bergström, M | 1 |
1 review available for flumazenil and Brain Injuries
| Article | Year |
|---|---|
Coma induced by intoxication.
Topics: Accidental Falls; Alcohol-Induced Disorders, Nervous System; Alcoholic Intoxication; Antidotes; Brai | 2000 |
12 other studies available for flumazenil and Brain Injuries
| Article | Year |
|---|---|
Posttraumatic midazolam administration does not influence brain damage after experimental traumatic brain injury.
Topics: Animals; Benzodiazepines; Brain; Brain Injuries; Brain Injuries, Traumatic; Flumazenil; Humans; Mice | 2022 |
Cortical damage following traumatic brain injury evaluated by iomazenil SPECT and in vivo microdialysis.
Topics: Brain Injuries; Cerebral Cortex; Female; Flumazenil; Humans; Middle Aged; Time Factors; Tomography, | 2013 |
Cortical neuron loss in post-traumatic higher brain dysfunction using (123)I-iomazenil SPECT.
Topics: Adult; Aged; Brain; Brain Injuries; Brain Mapping; Cell Death; Female; Flumazenil; Humans; Male; Mid | 2013 |
Evaluation of cerebral function using iomazenil SPECT for patients with traumatic brain injury.
Topics: Adolescent; Aged; Brain Injuries; Brain Mapping; Flumazenil; Humans; Magnetic Resonance Imaging; Mal | 2013 |
GABAA receptor deficits predict recovery in patients with disorders of consciousness: A preliminary multimodal [(11) C]Flumazenil PET and fMRI study.
Topics: Adult; Behavior; Brain Injuries; Consciousness Disorders; Female; Flumazenil; Gyrus Cinguli; Humans; | 2015 |
Reversal of sedation with flumazenil in a child after traumatic brain injury.
Topics: Accidents, Traffic; Benzodiazepines; Brain Injuries; Child; Female; Flumazenil; Humans; Hypnotics an | 2009 |
Flumazenil administration attenuates cognitive impairment in immature rats after controlled cortical impact.
Topics: Animals; Brain; Brain Chemistry; Brain Injuries; Cognition Disorders; Disease Models, Animal; Dose-R | 2010 |
Recovered neuronal viability revealed by Iodine-123-iomazenil SPECT following traumatic brain injury.
Topics: Adult; Aged; Brain; Brain Injuries; Cell Survival; Female; Flumazenil; Humans; Iodine Radioisotopes; | 2010 |
Reversible dysfunction of receptors in traumatic brain injury?
Topics: Brain Injuries; Flumazenil; Humans; Iodine Radioisotopes; Neurons; Receptors, GABA-A | 2010 |
Focal neuronal damage in patients with neuropsychological impairment after diffuse traumatic brain injury: evaluation using ¹¹C-flumazenil positron emission tomography with statistical image analysis.
Topics: Adult; Brain; Brain Injuries; Brain Mapping; Carbon Isotopes; Cognition; Cognition Disorders; Female | 2010 |
Increased adenosine A1 receptor levels in hemianopia patients after cerebral injury: an application of PET using 11C-8-dicyclopropylmethyl-1-methyl-3-propylxanthine.
Topics: Adult; Aged; Brain Injuries; Female; Flumazenil; Glucose; Hemianopsia; Humans; Male; Middle Aged; Po | 2012 |
Changes in mACh, NMDA and GABA(A) receptor binding after lateral fluid-percussion injury: in vitro autoradiography of rat brain frozen sections.
Topics: Animals; Autoradiography; Binding Sites; Brain; Brain Injuries; Cerebral Cortex; Dizocilpine Maleate | 2001 |