flumazenil has been researched along with Brain Edema in 8 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "PET allowed prediction of malignant MCA infarction within the time window suggested for hemicraniectomy." | 2.71 | Prediction of malignant course in MCA infarction by PET and microdialysis. ( Bosche, B; Brinker, G; Dohmen, C; Graf, R; Heiss, WD; Kracht, L; Neveling, M; Sobesky, J; Staub, F, 2003) |
| "Malignant MCA infarction seems to be determined more by the volume of severe perfusional deficit than that of total perfusional deficit." | 1.38 | The severity of ischemia determines and predicts malignant brain edema in patients with large middle cerebral artery infarction. ( Bosche, B; Dohmen, C; Galldiks, N; Graf, R; Kracht, L, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dohmen, C | 3 |
| Galldiks, N | 1 |
| Bosche, B | 3 |
| Kracht, L | 3 |
| Graf, R | 3 |
| Heiss, WD | 3 |
| Staub, F | 2 |
| Sobesky, J | 2 |
| Neveling, M | 1 |
| Brinker, G | 1 |
| Toyota, S | 1 |
| Valentino, M | 1 |
| Romero Gómez, M | 1 |
| Bautista, JD | 1 |
| Grande, L | 1 |
| Ramos Guerrero, RM | 1 |
| Sánchez Muñoz, D | 1 |
| Jones, EA | 1 |
| Weissenborn, K | 1 |
| Bender, AS | 1 |
| Norenberg, MD | 1 |
| Blei, AT | 1 |
4 reviews available for flumazenil and Brain Edema
| Article | Year |
|---|---|
The ischemic penumbra: how does tissue injury evolve?
Topics: Animals; Brain; Brain Edema; Brain Ischemia; Cats; Cerebral Infarction; Cerebrovascular Circulation; | 2012 |
[New concepts in the physiopathology of hepatic encephalopathy and therapeutic prospects].
Topics: Ammonia; Brain; Brain Edema; Dipeptides; Flumazenil; Glutaminase; Glutamine; Hepatic Encephalopathy; | 2004 |
Neurology and the liver.
Topics: Ammonia; Brain Edema; Cholestasis; Diagnosis, Differential; Fatigue; Flumazenil; GABA Modulators; He | 1997 |
Brain edema and portal-systemic encephalopathy.
Topics: Brain; Brain Edema; Flumazenil; Glutamine; Hepatic Encephalopathy; Humans; Lactulose; Liver Cirrhosi | 2000 |
1 trial available for flumazenil and Brain Edema
| Article | Year |
|---|---|
Prediction of malignant course in MCA infarction by PET and microdialysis.
Topics: Biomarkers; Blood Flow Velocity; Brain Edema; Carbon Radioisotopes; Cerebrovascular Circulation; Dis | 2003 |
3 other studies available for flumazenil and Brain Edema
| Article | Year |
|---|---|
The severity of ischemia determines and predicts malignant brain edema in patients with large middle cerebral artery infarction.
Topics: Aged; Brain Edema; Cerebrovascular Circulation; Chi-Square Distribution; Decompressive Craniectomy; | 2012 |
Identification of malignant brain edema after hemispheric stroke by PET-imaging and microdialysis.
Topics: Amino Acids; Animals; Brain Edema; Cats; Cerebral Infarction; Cerebrovascular Circulation; Flumazeni | 2003 |
Effect of benzodiazepines and neurosteroids on ammonia-induced swelling in cultured astrocytes.
Topics: Ammonia; Astrocytes; Atrial Natriuretic Factor; Benzodiazepines; Benzodiazepinones; Brain Edema; Cel | 1998 |