flumazenil has been researched along with Brain Diseases in 11 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Brain Diseases: Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Using statistical parametric mapping and 11C-flumazenil (FMZ) PET we have previously shown reduction of central benzodiazepine receptor (cBZR) binding restricted to the hippocampus in mesial temporal lobe epilepsy (mTLE) due to hippocampal sclerosis (HS)." | 3.69 | 11C-flumazenil PET, volumetric MRI, and quantitative pathology in mesial temporal lobe epilepsy. ( Ashburner, J; Brooks, DJ; Cunningham, VJ; Duncan, JS; Koepp, MJ; Labbé, C; Revesz, T; Richardson, MP; Van Paesschen, W, 1997) |
| "Kainic acid (KA) solution was injected stereotaxically into medial and lateral sites of the sensori-motor cortex." | 1.33 | Focal cortical dysplasia: pathophysiological approach. ( Hashizume, K; Hodozuka, A; Tanaka, T; Tsuda, H, 2006) |
| "The purpose of this study is to evaluate the central benzodiazepine (BZP) receptor binding of iomazenil (IMZ) by pharmacokinetic analysis and to establish a methodology for the diagnosis of CNS disorders with abnormalities in BZP receptor binding." | 1.30 | Pharmacokinetic analysis of benzodiazepine receptor binding of [123I]iomazenil in human brain. ( Iga, T; Ito, K; Katashima, M; Kojima, Y; Kotaki, H; Momose, T; Sasaki, Y; Sawada, Y; Yamamoto, K, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 8 (72.73) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hodozuka, A | 1 |
| Tsuda, H | 1 |
| Hashizume, K | 1 |
| Tanaka, T | 1 |
| Neidl, KF | 1 |
| Hermes, M | 1 |
| Voges, M | 1 |
| Kujat, C | 1 |
| Hagspiel, KD | 1 |
| Torizuka, K | 3 |
| Uemura, K | 3 |
| Toru, M | 1 |
| Shinohara, Y | 1 |
| Nishimura, T | 1 |
| Yonekura, Y | 3 |
| Nakagawara, J | 3 |
| Matsuda, H | 1 |
| Sakai, F | 1 |
| Matsuda, K | 3 |
| Fukuyama, H | 3 |
| Morimoto, K | 3 |
| Tohru, M | 1 |
| Thoru, M | 1 |
| Millet, P | 1 |
| Delforge, J | 1 |
| Pappata, S | 1 |
| Syrota, A | 1 |
| Cinotti, L | 1 |
| Yanagimoto, S | 1 |
| Ono, S | 1 |
| Sone, T | 1 |
| Morita, K | 1 |
| Nagai, K | 1 |
| Otsuka, N | 1 |
| Mimura, H | 1 |
| Tomomitsu, T | 1 |
| Fukunaga, M | 1 |
| Muranaka, A | 1 |
| Itaya, M | 1 |
| Kitayama, A | 1 |
| Ito, K | 1 |
| Momose, T | 1 |
| Kotaki, H | 1 |
| Kojima, Y | 1 |
| Yamamoto, K | 1 |
| Katashima, M | 1 |
| Sawada, Y | 1 |
| Sasaki, Y | 1 |
| Iga, T | 1 |
| Koepp, MJ | 1 |
| Richardson, MP | 1 |
| Labbé, C | 1 |
| Brooks, DJ | 1 |
| Cunningham, VJ | 1 |
| Ashburner, J | 1 |
| Van Paesschen, W | 1 |
| Revesz, T | 1 |
| Duncan, JS | 1 |
| Juhász, C | 1 |
| Chugani, DC | 1 |
| Muzik, O | 1 |
| Watson, C | 1 |
| Shah, J | 1 |
| Shah, A | 1 |
| Chugani, HT | 1 |
| Chiolero, RL | 1 |
| Ravussin, PA | 1 |
| Freeman, J | 1 |
2 reviews available for flumazenil and Brain Diseases
| Article | Year |
|---|---|
[Single photon emission tomography (SPECT). Cerebral function diagnosis for the clinical routine. Indications and radiotracers].
Topics: Benzamides; Brain Diseases; Flumazenil; Humans; Iodine Radioisotopes; Organotechnetium Compounds; Ox | 1993 |
Relationship between EEG and positron emission tomography abnormalities in clinical epilepsy.
Topics: Biomarkers; Brain Diseases; Brain Diseases, Metabolic; Electroencephalography; Epilepsy; Epilepsy, T | 2000 |
3 trials available for flumazenil and Brain Diseases
| Article | Year |
|---|---|
[A phase 3 clinical trial of 123I-iomazenil, a new central-type benzodiazepine receptor imaging agent (Part 1)--report on clinical usefulness in diagnosis of various brain diseases].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Brain; Brain Diseases; Flumazenil; GABA-A Receptor Agoni | 1996 |
[Phase 2 clinical study of 123I-iomazenil in various cerebral diseases: part 1--examination of injection dose and clinical indications].
Topics: Adult; Brain Diseases; Female; Flumazenil; Humans; Iodine Radioisotopes; Male; Mental Disorders; Mid | 1996 |
[Phase 2 clinical study of 123I-iomazenil in various cerebral diseases: part 2--clinical evaluation of central-type benzodiazepine receptor imaging with 123I-iomazenil SPECT].
Topics: Adult; Brain Diseases; Female; Flumazenil; Humans; Iodine Radioisotopes; Male; Mental Disorders; Mid | 1996 |
6 other studies available for flumazenil and Brain Diseases
| Article | Year |
|---|---|
Focal cortical dysplasia: pathophysiological approach.
Topics: Adolescent; Animals; Animals, Newborn; Autoradiography; Behavior, Animal; Brain Diseases; Brain Mapp | 2006 |
Error analysis on parameter estimates in the ligand-receptor model: application to parameter imaging using PET data.
Topics: Brain; Brain Diseases; Carbon Radioisotopes; Flumazenil; Humans; Kinetics; Models, Theoretical; Radi | 1996 |
[Compartment analysis of 123I-iomazenil brain on early and delayed SPECT].
Topics: Adult; Brain; Brain Diseases; Cerebrovascular Circulation; Female; Flumazenil; Humans; Iodine Radioi | 1997 |
Pharmacokinetic analysis of benzodiazepine receptor binding of [123I]iomazenil in human brain.
Topics: Blood-Brain Barrier; Brain; Brain Diseases; Flumazenil; Humans; Injections, Intravenous; Iodine Radi | 1997 |
11C-flumazenil PET, volumetric MRI, and quantitative pathology in mesial temporal lobe epilepsy.
Topics: Adult; Brain Diseases; Carbon Radioisotopes; Epilepsy, Temporal Lobe; Female; Flumazenil; Hippocampu | 1997 |
[Use of flumazenil (RO 15-1788) after prolonged infusion of midazolam in anesthesia for intracranial surgery].
Topics: Adult; Aged; Anesthesia Recovery Period; Anesthesia, Intravenous; Brain Diseases; Female; Flumazenil | 1988 |