flumazenil has been researched along with Benign Psychomotor Epilepsy, Childhood in 57 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have previously shown that an imaging marker, increased periventricular [(11)C]flumazenil ([(11)C]FMZ) binding, is associated with failure to become seizure free (SF) after surgery for temporal lobe epilepsy (TLE) with hippocampal sclerosis (HS)." | 7.81 | Advanced [(18)F]FDG and [(11)C]flumazenil PET analysis for individual outcome prediction after temporal lobe epilepsy surgery for hippocampal sclerosis. ( Costes, N; Gray, KR; Hammers, A; Mauguiere, F; Ryvlin, P; Yankam Njiwa, J, 2015) |
| "Twelve adult patients considered for epilepsy surgery with medically intractable temporal lobe epilepsy (TLE; n = 7), extratemporal lobe epilepsy (ETE; n = 2), and TLE+ETE (n = 3) were prospectively examined with DWI interictally (serving as baseline) and 10 min after application of 1 mg flumazenil i." | 7.72 | Presurgical evaluation of epilepsy by brain diffusion: MR-detected effects of flumazenil on the epileptogenic focus. ( de Greiff, A; Diener, HC; Dörfler, A; Hufnagel, A; Konermann, S; Leonhardt, G; Ludwig, T; Marks, S; Weber, J; Wiedemayer, H, 2003) |
| "By using [11C]flumazenil-positron emission tomography ([11C]FMZ-PET), we have previously shown that reductions of central benzodiazepine receptors (cBZRs) are restricted to the hippocampus in mesial temporal lobe epilepsy (mTLE) caused by unilateral hippocampal sclerosis (HS)." | 7.70 | In vivo [11C]flumazenil-PET correlates with ex vivo [3H]flumazenil autoradiography in hippocampal sclerosis. ( Baird, VH; Bowery, NG; Brooks, DJ; Cunningham, VJ; Duncan, JS; Hand, KS; Koepp, MJ; Labbé, C; Richardson, MP; Van Paesschen, W, 1998) |
| "Using statistical parametric mapping and [11C]flumazenil (FMZ) PET we have previously shown reduction of central benzodiazepine receptor (cBZR) binding restricted to the hippocampus in mesial temporal lobe epilepsy due to unilateral hippocampal sclerosis." | 7.69 | Regional hippocampal [11C]flumazenil PET in temporal lobe epilepsy with unilateral and bilateral hippocampal sclerosis. ( Brooks, DJ; Cunningham, VJ; Duncan, JS; Koepp, MJ; Labbé, C; Richardson, MP; Van Paesschen, W, 1997) |
| "We have previously shown that an imaging marker, increased periventricular [(11)C]flumazenil ([(11)C]FMZ) binding, is associated with failure to become seizure free (SF) after surgery for temporal lobe epilepsy (TLE) with hippocampal sclerosis (HS)." | 3.81 | Advanced [(18)F]FDG and [(11)C]flumazenil PET analysis for individual outcome prediction after temporal lobe epilepsy surgery for hippocampal sclerosis. ( Costes, N; Gray, KR; Hammers, A; Mauguiere, F; Ryvlin, P; Yankam Njiwa, J, 2015) |
| "The objective of this investigation was to characterize quantitatively the time-dependent changes in midazolam (MDL) efficacy in the silent period after induction of status epilepticus (SE) in rats." | 3.74 | Decreased Efficacy of GABAA-receptor modulation by midazolam in the kainate model of temporal lobe epilepsy. ( Danhof, M; Gunput, RA; Liefaard, LC; Voskuyl, RA, 2007) |
| "Twelve adult patients considered for epilepsy surgery with medically intractable temporal lobe epilepsy (TLE; n = 7), extratemporal lobe epilepsy (ETE; n = 2), and TLE+ETE (n = 3) were prospectively examined with DWI interictally (serving as baseline) and 10 min after application of 1 mg flumazenil i." | 3.72 | Presurgical evaluation of epilepsy by brain diffusion: MR-detected effects of flumazenil on the epileptogenic focus. ( de Greiff, A; Diener, HC; Dörfler, A; Hufnagel, A; Konermann, S; Leonhardt, G; Ludwig, T; Marks, S; Weber, J; Wiedemayer, H, 2003) |
| "By using [11C]flumazenil-positron emission tomography ([11C]FMZ-PET), we have previously shown that reductions of central benzodiazepine receptors (cBZRs) are restricted to the hippocampus in mesial temporal lobe epilepsy (mTLE) caused by unilateral hippocampal sclerosis (HS)." | 3.70 | In vivo [11C]flumazenil-PET correlates with ex vivo [3H]flumazenil autoradiography in hippocampal sclerosis. ( Baird, VH; Bowery, NG; Brooks, DJ; Cunningham, VJ; Duncan, JS; Hand, KS; Koepp, MJ; Labbé, C; Richardson, MP; Van Paesschen, W, 1998) |
| "In 4 patients whose seizures were generated by mesial temporal lobe structures, BZ receptor density was measured with [11C]flumazenil PET before, and 1 year after the epilepsy surgery and cessation of seizures." | 3.70 | Regional increases in [11C]flumazenil binding after epilepsy surgery. ( Blomqvist, G; Gulyas, B; Halldin, C; Litton, JE; Savic, I, 1998) |
| "Using statistical parametric mapping and 11C-flumazenil (FMZ) PET we have previously shown reduction of central benzodiazepine receptor (cBZR) binding restricted to the hippocampus in mesial temporal lobe epilepsy (mTLE) due to hippocampal sclerosis (HS)." | 3.69 | 11C-flumazenil PET, volumetric MRI, and quantitative pathology in mesial temporal lobe epilepsy. ( Ashburner, J; Brooks, DJ; Cunningham, VJ; Duncan, JS; Koepp, MJ; Labbé, C; Revesz, T; Richardson, MP; Van Paesschen, W, 1997) |
| " Binding of [11C]-flumazenil to this complex in vivo is reduced in hippocampal sclerosis (HS)." | 3.69 | Central benzodiazepine receptor autoradiography in hippocampal sclerosis. ( Baird, VH; Bowery, NG; Duncan, JS; Hand, KS; Harkness, WF; Koepp, MJ; Revesz, T; Thom, M; Van Paesschen, W, 1997) |
| "Using statistical parametric mapping and [11C]flumazenil (FMZ) PET we have previously shown reduction of central benzodiazepine receptor (cBZR) binding restricted to the hippocampus in mesial temporal lobe epilepsy due to unilateral hippocampal sclerosis." | 3.69 | Regional hippocampal [11C]flumazenil PET in temporal lobe epilepsy with unilateral and bilateral hippocampal sclerosis. ( Brooks, DJ; Cunningham, VJ; Duncan, JS; Koepp, MJ; Labbé, C; Richardson, MP; Van Paesschen, W, 1997) |
| "When flumazenil (3 mg) was administered immediately after intravenous diazepam (10 mg), the reduction in interictal epileptic activity was not significantly different from that produced by diazepam alone." | 2.67 | The effect of intravenous flumazenil on interictal electroencephalographic epileptic activity: results of a placebo-controlled study. ( Hart, YM; Meinardi, H; Nutt, DJ; Sander, JW; Shorvon, SD, 1991) |
| "We observed an early-onset partial epilepsy syndrome with seizure semiology strongly suggestive of temporal lobe epilepsy (TLE), with mild intellectual deficit co-occurring in a large proportion of the patients." | 1.35 | Partial epilepsy syndrome in a Gypsy family linked to 5q31.3-q32. ( Angelicheva, D; Azmanov, DN; Bojinova, V; Brown, M; Carter, K; Guergueltcheva, V; Jablensky, A; Kalaydjieva, L; Kaneva, R; Mihaylova, V; Morar, B; Radionova, M; Sander, JW; Smith, SJ; Stevens, JM; Tournev, I; Zlatareva, D, 2009) |
| "Unilateral mesial temporal lobe epilepsy is associated with insular hypometabolism and benzodiazepine receptor loss." | 1.31 | Insular cortex involvement in mesiotemporal lobe epilepsy: a positron emission tomography study. ( Baulac, M; Bouilleret, V; Dupont, S; Samson, Y; Semah, F; Spelle, L, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.75) | 18.7374 |
| 1990's | 24 (42.11) | 18.2507 |
| 2000's | 23 (40.35) | 29.6817 |
| 2010's | 8 (14.04) | 24.3611 |
| 2020's | 1 (1.75) | 2.80 |
| Authors | Studies |
|---|---|
| Avendaño-Estrada, A | 1 |
| Velasco, F | 1 |
| Velasco, AL | 1 |
| Cuellar-Herrera, M | 1 |
| Saucedo-Alvarado, PE | 1 |
| Marquez-Franco, R | 1 |
| Rivera-Bravo, B | 1 |
| Ávila-Rodríguez, MA | 1 |
| Niu, N | 1 |
| Xing, H | 1 |
| Wu, M | 1 |
| Ma, Y | 1 |
| Liu, Y | 1 |
| Ba, J | 1 |
| Zhu, S | 1 |
| Li, F | 1 |
| Huo, L | 1 |
| Fujitani, S | 1 |
| Matsuda, K | 4 |
| Nakamura, F | 2 |
| Baba, K | 2 |
| Usui, N | 2 |
| Tottori, T | 2 |
| Mihara, T | 3 |
| Terada, K | 3 |
| Usui, K | 2 |
| Inoue, Y | 2 |
| Kajita, Y | 1 |
| Wakabayashi, T | 1 |
| Vivash, L | 2 |
| Gregoire, MC | 3 |
| Lau, EW | 1 |
| Ware, RE | 1 |
| Binns, D | 2 |
| Roselt, P | 2 |
| Bouilleret, V | 3 |
| Myers, DE | 2 |
| Cook, MJ | 1 |
| Hicks, RJ | 2 |
| O'Brien, TJ | 2 |
| Berard, A | 1 |
| Wimberley, C | 1 |
| Katsifis, A | 1 |
| Dedeurwaerdere, S | 1 |
| Yankam Njiwa, J | 1 |
| Gray, KR | 1 |
| Costes, N | 1 |
| Mauguiere, F | 5 |
| Ryvlin, P | 5 |
| Hammers, A | 6 |
| Stanišić, M | 1 |
| Coello, C | 1 |
| Ivanović, J | 1 |
| Egge, A | 1 |
| Danfors, T | 1 |
| Hald, J | 1 |
| Heminghyt, E | 1 |
| Mikkelsen, MM | 1 |
| Krossnes, BK | 1 |
| Pripp, AH | 1 |
| Larsson, PG | 1 |
| Hosomi, K | 1 |
| Kishima, H | 1 |
| Oshino, S | 1 |
| Hirata, M | 1 |
| Tani, N | 1 |
| Maruo, T | 1 |
| Khoo, HM | 1 |
| Shimosegawa, E | 1 |
| Hatazawa, J | 1 |
| Kato, A | 1 |
| Yoshimine, T | 1 |
| Sata, Y | 1 |
| Aihara, M | 1 |
| Yagi, K | 1 |
| Yonekura, Y | 2 |
| Koepp, MJ | 9 |
| Hurlemann, R | 1 |
| Thom, M | 3 |
| Richardson, MP | 4 |
| Brooks, DJ | 8 |
| Duncan, JS | 9 |
| Coste, S | 1 |
| Hermier, M | 1 |
| Konermann, S | 1 |
| Marks, S | 1 |
| Ludwig, T | 1 |
| Weber, J | 1 |
| de Greiff, A | 1 |
| Dörfler, A | 1 |
| Leonhardt, G | 1 |
| Wiedemayer, H | 1 |
| Diener, HC | 1 |
| Hufnagel, A | 1 |
| Leroy, C | 1 |
| Poisbeau, P | 1 |
| Keller, AF | 1 |
| Nehlig, A | 1 |
| Shuke, N | 1 |
| Hashizume, K | 1 |
| Kiriyama, K | 1 |
| Okizaki, A | 1 |
| Yamamoto, W | 1 |
| Zhao, C | 1 |
| Nakai, H | 1 |
| Tanaka, T | 1 |
| Aburano, T | 1 |
| Padma, MV | 1 |
| Simkins, R | 1 |
| White, P | 1 |
| Satter, M | 1 |
| Christian, BT | 1 |
| Dunigan, K | 1 |
| Lee, C | 1 |
| Jacobs, M | 1 |
| Mukherjee, J | 1 |
| Mantil, JC | 1 |
| Morimoto, K | 2 |
| Tamagami, H | 1 |
| Kaneko, K | 1 |
| Sasaki, M | 1 |
| Morioka, T | 1 |
| Koga, H | 1 |
| Abe, K | 1 |
| Sawamoto, H | 1 |
| Ohya, N | 1 |
| Yoshiura, T | 1 |
| Mihara, F | 1 |
| Honda, H | 1 |
| Liefaard, LC | 1 |
| Gunput, RA | 1 |
| Danhof, M | 1 |
| Voskuyl, RA | 1 |
| Panagoda, P | 1 |
| Heckemann, RA | 1 |
| Kelsch, W | 1 |
| Turkheimer, FE | 1 |
| Umeoka, S | 1 |
| Fujiwara, T | 1 |
| Robertson, HA | 1 |
| Bartenstein, P | 2 |
| Koepp, M | 1 |
| Burdette, DE | 1 |
| Sakurai, SY | 1 |
| Henry, TR | 3 |
| Ross, DA | 2 |
| Pennell, PB | 2 |
| Frey, KA | 2 |
| Sackellares, JC | 2 |
| Albin, RL | 1 |
| Staedt, J | 1 |
| Stoppe, G | 1 |
| Kögler, A | 1 |
| Steinhoff, BJ | 1 |
| Gilman, S | 1 |
| Koeppe, RA | 1 |
| Brunberg, JA | 1 |
| Berent, S | 1 |
| Young, AB | 1 |
| Kuhl, DE | 1 |
| Savic, I | 2 |
| Thorell, JO | 1 |
| Tanaka, F | 1 |
| Ikeda, A | 1 |
| Mikuni, N | 1 |
| Nishizawa, S | 1 |
| Ishizu, K | 1 |
| Okazawa, H | 1 |
| Hattori, N | 1 |
| Shibasaki, H | 1 |
| Konishi, J | 1 |
| Onishi, Y | 1 |
| Debets, RM | 1 |
| Sadzot, B | 1 |
| van Isselt, JW | 2 |
| Brekelmans, GJ | 1 |
| Meiners, LC | 1 |
| van Huffelen, AO | 1 |
| Franck, G | 2 |
| van Veelen, CW | 2 |
| Labbé, C | 5 |
| Cunningham, VJ | 4 |
| Ashburner, J | 1 |
| Van Paesschen, W | 4 |
| Revesz, T | 2 |
| Hand, KS | 2 |
| Baird, VH | 2 |
| Harkness, WF | 1 |
| Bowery, NG | 2 |
| Szelies, B | 1 |
| Weber-Luxenburger, G | 1 |
| Pawlik, G | 1 |
| Kessler, J | 1 |
| Holthoff, V | 1 |
| Mielke, R | 1 |
| Herholz, K | 1 |
| Bauer, B | 1 |
| Wienhard, K | 1 |
| Heiss, WD | 1 |
| Venz, S | 1 |
| Hierholzer, J | 1 |
| Cordes, M | 1 |
| Straub, HB | 1 |
| Keske, U | 1 |
| Meencke, HJ | 1 |
| Eichstädt, H | 1 |
| Felix, R | 1 |
| Blomqvist, G | 1 |
| Halldin, C | 1 |
| Litton, JE | 1 |
| Gulyas, B | 1 |
| Bouvard, S | 2 |
| Le Bars, D | 2 |
| De Lamérie, G | 1 |
| Kahane, P | 1 |
| Froment, JC | 1 |
| Juhász, C | 2 |
| Nagy, F | 1 |
| Watson, C | 2 |
| da Silva, EA | 1 |
| Muzik, O | 2 |
| Chugani, DC | 2 |
| Shah, J | 2 |
| Chugani, HT | 2 |
| Woermann, FG | 1 |
| Shah, A | 1 |
| Lamusuo, S | 1 |
| Pitkänen, A | 1 |
| Jutila, L | 1 |
| Ylinen, A | 1 |
| Partanen, K | 1 |
| Kälviäinen, R | 1 |
| Ruottinen, HM | 1 |
| Oikonen, V | 1 |
| Någren, K | 1 |
| Lehikoinen, P | 1 |
| Vapalahti, M | 1 |
| Vainio, P | 1 |
| Rinne, JO | 1 |
| Matheja, P | 1 |
| Lüdemann, P | 1 |
| Kuwert, T | 1 |
| Weckesser, M | 1 |
| Kellinghaus, C | 1 |
| Weitemeyer, L | 1 |
| Diehl, B | 1 |
| Schuierer, G | 1 |
| Ringelstein, EB | 1 |
| Schober, O | 2 |
| Dupont, S | 1 |
| Spelle, L | 1 |
| Baulac, M | 1 |
| Samson, Y | 1 |
| Semah, F | 1 |
| Munkácsy, C | 1 |
| Clemens, B | 1 |
| Ménes, A | 1 |
| Mikecz, P | 1 |
| Trón, L | 1 |
| Sikula, J | 1 |
| Kollár, J | 1 |
| Emri, M | 1 |
| Johnson, EW | 1 |
| de Lanerolle, NC | 1 |
| Kim, JH | 1 |
| Sundaresan, S | 1 |
| Spencer, DD | 1 |
| Mattson, RH | 1 |
| Zoghbi, SS | 1 |
| Baldwin, RM | 1 |
| Hoffer, PB | 1 |
| Seibyl, JP | 1 |
| Haldemann, RC | 1 |
| Bicik, I | 1 |
| Pfeiffer, A | 1 |
| Wieser, HG | 1 |
| Hasler, PH | 1 |
| Schubiger, P | 1 |
| von Schulthess, GK | 1 |
| Ludolph, A | 1 |
| Lottes, G | 1 |
| Scheidhauer, K | 1 |
| Sciuk, J | 1 |
| Beer, HF | 1 |
| Hart, YM | 1 |
| Meinardi, H | 1 |
| Sander, JW | 3 |
| Nutt, DJ | 1 |
| Shorvon, SD | 1 |
| van Huffelen, AC | 1 |
| van Rijk, PP | 1 |
| van Bentum, AM | 1 |
| Dive, D | 1 |
| Maquet, P | 1 |
| Velis, DN | 1 |
| van Emde Boas, W | 1 |
| Angelicheva, D | 2 |
| Tournev, I | 2 |
| Guergueltcheva, V | 1 |
| Mihaylova, V | 1 |
| Azmanov, DN | 2 |
| Morar, B | 2 |
| Radionova, M | 2 |
| Smith, SJ | 1 |
| Zlatareva, D | 2 |
| Stevens, JM | 1 |
| Kaneva, R | 2 |
| Bojinova, V | 1 |
| Carter, K | 1 |
| Brown, M | 1 |
| Jablensky, A | 1 |
| Kalaydjieva, L | 2 |
| Zhelyazkova, S | 1 |
7 reviews available for flumazenil and Benign Psychomotor Epilepsy, Childhood
| Article | Year |
|---|---|
Performance of PET imaging for the localization of epileptogenic zone in patients with epilepsy: a meta-analysis.
Topics: Epilepsy; Epilepsy, Temporal Lobe; Flumazenil; Fluorodeoxyglucose F18; Humans; Magnetic Resonance Im | 2021 |
[Functional neuroimaging in adults].
Topics: Adult; Anterior Temporal Lobectomy; Anticonvulsants; Carbon Radioisotopes; Combined Modality Therapy | 2004 |
[Benzodiazepine receptor imaging with positron emission tomography and single photon emission tomography].
Topics: Brain; Brain Damage, Chronic; Brain Mapping; Cerebral Cortex; Epilepsies, Partial; Epilepsy, Tempora | 1995 |
Functional neuroimaging with positron emission tomography.
Topics: Anticonvulsants; Brain; Cerebrovascular Circulation; Deoxyglucose; Epilepsy; Epilepsy, Temporal Lobe | 1996 |
[Benzodiazepine receptor imaging in the brain: recent developments and clinical validity].
Topics: Brain; Carbon Radioisotopes; Epilepsy, Temporal Lobe; Flumazenil; Humans; Iodine Radioisotopes; Pani | 1999 |
Relationship between EEG and positron emission tomography abnormalities in clinical epilepsy.
Topics: Biomarkers; Brain Diseases; Brain Diseases, Metabolic; Electroencephalography; Epilepsy; Epilepsy, T | 2000 |
PET: cholinergic neuroreceptor mapping.
Topics: Benzilates; Brain; Calcium Channel Blockers; Epilepsy, Temporal Lobe; Flumazenil; GABA Modulators; H | 2000 |
5 trials available for flumazenil and Benign Psychomotor Epilepsy, Childhood
| Article | Year |
|---|---|
18F-flumazenil: a γ-aminobutyric acid A-specific PET radiotracer for the localization of drug-resistant temporal lobe epilepsy.
Topics: Adolescent; Adult; Aged; Aminobutyrates; Case-Control Studies; Drug Resistance; Epilepsy, Temporal L | 2013 |
Pre-surgical identification of epileptogenic areas in temporal lobe epilepsy by 123I-iomazenil SPECT: a comparison with IMP SPECT and FDG PET.
Topics: Adolescent; Adult; Epilepsy, Temporal Lobe; Female; Flumazenil; Fluorodeoxyglucose F18; Humans; Iodi | 2006 |
11C-flumazenil PET in patients with refractory temporal lobe epilepsy and normal MRI.
Topics: Adult; Carbon Radioisotopes; Epilepsy, Temporal Lobe; Female; Flumazenil; GABA Modulators; Hippocamp | 2000 |
[11 C]Flumazenil binding in the medial temporal lobe in patients with temporal lobe epilepsy: correlation with hippocampal MR volumetry, T2 relaxometry, and neuropathology.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Epilepsy, Temporal Lobe; Female; Flumazenil; GA | 2000 |
The effect of intravenous flumazenil on interictal electroencephalographic epileptic activity: results of a placebo-controlled study.
Topics: Adult; Anticonvulsants; Brain; Diazepam; Dose-Response Relationship, Drug; Drug Therapy, Combination | 1991 |
45 other studies available for flumazenil and Benign Psychomotor Epilepsy, Childhood
| Article | Year |
|---|---|
Quantitative Analysis of [18F]FFMZ and [18F]FDG PET Studies in the Localization of Seizure Onset Zone in Drug-Resistant Temporal Lobe Epilepsy.
Topics: Adolescent; Adult; Brain Mapping; Drug Resistant Epilepsy; Epilepsy, Temporal Lobe; Female; Flumazen | 2019 |
Statistical parametric mapping of interictal 123I-iomazenil SPECT in temporal lobe epilepsy surgery.
Topics: Adolescent; Adult; Brain Mapping; Drug Resistance; Epilepsy, Temporal Lobe; Female; Flumazenil; Func | 2013 |
In vivo measurement of hippocampal GABAA/cBZR density with [18F]-flumazenil PET for the study of disease progression in an animal model of temporal lobe epilepsy.
Topics: Animals; Disease Progression; Epilepsy, Temporal Lobe; Flumazenil; Hippocampus; Male; Models, Animal | 2014 |
Advanced [(18)F]FDG and [(11)C]flumazenil PET analysis for individual outcome prediction after temporal lobe epilepsy surgery for hippocampal sclerosis.
Topics: Adult; Carbon Radioisotopes; Epilepsy, Temporal Lobe; Female; Flumazenil; Fluorodeoxyglucose F18; Hi | 2015 |
Seizure outcomes in relation to the extent of resection of the perifocal fluorodeoxyglucose and flumazenil PET abnormalities in anteromedial temporal lobectomy.
Topics: Adolescent; Adult; Anterior Temporal Lobectomy; Child; Epilepsy, Temporal Lobe; Female; Flumazenil; | 2015 |
Altered extrafocal iomazenil activity in mesial temporal lobe epilepsy.
Topics: Adult; Epilepsy, Temporal Lobe; Female; Flumazenil; Follow-Up Studies; Functional Laterality; Humans | 2013 |
Quantitative analysis of benzodiazepine receptor in temporal lobe epilepsy: [(125)I]iomazenil autoradiographic study of surgically resected specimens.
Topics: Adolescent; Adult; Autoradiography; Benzodiazepines; Cell Count; Child; Child, Preschool; Epilepsy, | 2002 |
Abnormalities of grey and white matter [11C]flumazenil binding in temporal lobe epilepsy with normal MRI.
Topics: Adolescent; Adult; Brain; Carbon Radioisotopes; Epilepsy, Temporal Lobe; Female; Flumazenil; Humans; | 2002 |
Temporal pole MRI abnormalities in temporal lobe epilepsy.
Topics: Atrophy; Epilepsy, Temporal Lobe; Flumazenil; GABA Modulators; Humans; Magnetic Resonance Imaging; T | 2002 |
Presurgical evaluation of epilepsy by brain diffusion: MR-detected effects of flumazenil on the epileptogenic focus.
Topics: Adult; Brain Mapping; Cerebral Cortex; Diffusion Magnetic Resonance Imaging; Epilepsy; Epilepsy, Tem | 2003 |
Pharmacological plasticity of GABA(A) receptors at dentate gyrus synapses in a rat model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Diazepam; Disease Models, Animal; Electric Conductivity; Ep | 2004 |
Correct localization of epileptogenic focus with I-123 iomazenil cerebral benzodiazepine receptor imaging: a case report of temporal lobe epilepsy with discordant ictal cerebral blood flow SPECT.
Topics: Adult; Brain Mapping; Cerebrovascular Circulation; Epilepsy, Temporal Lobe; Female; Flumazenil; Huma | 2004 |
Clinical utility of 11C-flumazenil positron emission tomography in intractable temporal lobe epilepsy.
Topics: Adult; Electrophysiology; Epilepsy, Temporal Lobe; Female; Flumazenil; Fluorodeoxyglucose F18; Funct | 2004 |
Periventricular white matter flumazenil binding and postoperative outcome in hippocampal sclerosis.
Topics: Adult; Brain; Cerebral Ventricles; Epilepsy, Temporal Lobe; Female; Flumazenil; Hippocampus; Humans; | 2005 |
Central-type benzodiazepine receptors and epileptogenesis: basic mechanisms and clinical validity.
Topics: Adult; Amygdala; Animals; Autoradiography; Cerebral Cortex; Dentate Gyrus; Disease Models, Animal; E | 2005 |
Decreased Efficacy of GABAA-receptor modulation by midazolam in the kainate model of temporal lobe epilepsy.
Topics: Animals; Autoradiography; Beta Rhythm; Disease Models, Animal; Electroencephalography; Epilepsy, Tem | 2007 |
[11C]Flumazenil PET in temporal lobe epilepsy: do we need an arterial input function or kinetic modeling?
Topics: Adult; Carbon Isotopes; Cerebrovascular Circulation; Epilepsy, Temporal Lobe; Female; Flumazenil; GA | 2008 |
Usefulness of 123I-iomazenil single-photon emission computed tomography in discriminating between mesial and lateral temporal lobe epilepsy in patients in whom magnetic resonance imaging demonstrates normal findings.
Topics: Adult; Electroencephalography; Epilepsy, Temporal Lobe; Female; Flumazenil; Humans; Iodine Radioisot | 2007 |
Evidence for distinct benzodiazepine receptors for anticonvulsant and sedative actions: implications for the treatment of temporal lobe epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Benzodiazepinones; Diazepam; Epilepsy, Temporal Lobe; Flumazenil | 1983 |
Temporal lobe central benzodiazepine binding in unilateral mesial temporal lobe epilepsy.
Topics: Adult; Analysis of Variance; Autoradiography; Epilepsy, Temporal Lobe; Female; Flumazenil; Flunitraz | 1995 |
Changes of central benzodiazepine receptor density in the course of anticonvulsant treatment in temporal lobe epilepsy.
Topics: Adult; Brain Mapping; Carbamazepine; Epilepsy, Temporal Lobe; Female; Flumazenil; Humans; Image Proc | 1995 |
In vivo cerebral metabolism and central benzodiazepine-receptor binding in temporal lobe epilepsy.
Topics: Adult; Brain; Carbon Radioisotopes; Cerebral Cortex; Deoxyglucose; Electroencephalography; Epilepsy, | 1993 |
Localized cerebellar reductions in benzodiazepine receptor density in human partial epilepsy.
Topics: Adult; Cerebellum; Deoxyglucose; Epilepsies, Partial; Epilepsy, Frontal Lobe; Epilepsy, Temporal Lob | 1996 |
Presurgical identification of epileptic foci with iodine-123 iomazenil SPET: comparison with brain perfusion SPET and FDG PET.
Topics: Adult; Brain; Deoxyglucose; Electroencephalography; Epilepsy, Frontal Lobe; Epilepsy, Temporal Lobe; | 1997 |
Is 11C-flumazenil PET superior to 18FDG PET and 123I-iomazenil SPECT in presurgical evaluation of temporal lobe epilepsy?
Topics: Adolescent; Adult; Carbon Radioisotopes; Deoxyglucose; Electroencephalography; Epilepsy, Temporal Lo | 1997 |
11C-flumazenil PET, volumetric MRI, and quantitative pathology in mesial temporal lobe epilepsy.
Topics: Adult; Brain Diseases; Carbon Radioisotopes; Epilepsy, Temporal Lobe; Female; Flumazenil; Hippocampu | 1997 |
Central benzodiazepine receptor autoradiography in hippocampal sclerosis.
Topics: Adult; Autoradiography; Epilepsy, Temporal Lobe; Flumazenil; GABA-A Receptor Antagonists; Hippocampu | 1997 |
MRI-guided flumazenil- and FDG-PET in temporal lobe epilepsy.
Topics: Adult; Blood Glucose; Brain Mapping; Epilepsy, Temporal Lobe; Female; Flumazenil; Fluorodeoxyglucose | 1996 |
Regional hippocampal [11C]flumazenil PET in temporal lobe epilepsy with unilateral and bilateral hippocampal sclerosis.
Topics: Adolescent; Adult; Carbon Radioisotopes; Child; Child, Preschool; Electroencephalography; Epilepsy, | 1997 |
Quantitative estimation of I-123-Iomazenil receptor binding in temporal lobe epilepsies using two SPECT acquisitions--comparison with the regional cerebral blood flow and a compartment model.
Topics: Adult; Brain; Cerebrovascular Circulation; Electroencephalography; Epilepsy, Temporal Lobe; Female; | 1998 |
In vivo [11C]flumazenil-PET correlates with ex vivo [3H]flumazenil autoradiography in hippocampal sclerosis.
Topics: Adult; Autoradiography; Carbon Radioisotopes; Electroencephalography; Epilepsy, Temporal Lobe; Femal | 1998 |
Regional increases in [11C]flumazenil binding after epilepsy surgery.
Topics: Adult; Carbon Radioisotopes; Cerebral Cortex; Confidence Intervals; Epilepsy, Temporal Lobe; Female; | 1998 |
Clinical utility of flumazenil-PET versus [18F]fluorodeoxyglucose-PET and MRI in refractory partial epilepsy. A prospective study in 100 patients.
Topics: Brain; Electroencephalography; Epilepsies, Partial; Epilepsy, Frontal Lobe; Epilepsy, Temporal Lobe; | 1998 |
Transient and falsely lateralizing flumazenil-PET asymmetries in temporal lobe epilepsy.
Topics: Adult; Epilepsy, Temporal Lobe; Flumazenil; Hippocampus; Humans; Reference Values; Time Factors; Tom | 1999 |
Glucose and [11C]flumazenil positron emission tomography abnormalities of thalamic nuclei in temporal lobe epilepsy.
Topics: Adolescent; Adult; Amygdala; Blood Glucose; Brain Mapping; Dominance, Cerebral; Electroencephalograp | 1999 |
Neocortical abnormalities of [11C]-flumazenil PET in mesial temporal lobe epilepsy.
Topics: Adult; Carbon Radioisotopes; Epilepsy, Temporal Lobe; Female; Flumazenil; Humans; Male; Middle Aged; | 2001 |
Disturbed benzodiazepine receptor function at the onset of temporal lobe epilepsy--lomanzenil-binding in de-novo TLE.
Topics: Adolescent; Adult; Binding Sites; Disease Progression; Epilepsy, Temporal Lobe; Female; Flumazenil; | 2001 |
Insular cortex involvement in mesiotemporal lobe epilepsy: a positron emission tomography study.
Topics: Adolescent; Adult; Carbon Radioisotopes; Cerebral Cortex; Epilepsy, Temporal Lobe; Female; Flumazeni | 2002 |
[Effect of flumazenil on the regional cerebral blood flow measured by [15O]-butanol PET scan and transcranial Doppler ultrasonography].
Topics: Adult; Anti-Anxiety Agents; Brain; Butanols; Cerebrovascular Circulation; Epilepsy, Temporal Lobe; F | 2002 |
"Central" and "peripheral" benzodiazepine receptors: opposite changes in human epileptogenic tissue.
Topics: Adult; Autoradiography; Epilepsy, Temporal Lobe; Female; Flumazenil; Hippocampus; Humans; Male; Rece | 1992 |
123I-iomazenil: a quantitative study of the central benzodiazepine receptor distribution.
Topics: Adult; Aged; Amygdala; Epilepsy, Temporal Lobe; Female; Flumazenil; Hippocampus; Humans; Iodine Radi | 1992 |
Benzodiazepine receptors and cerebral blood flow in partial epilepsy.
Topics: Adult; Brain; Cerebrovascular Circulation; Epilepsy, Temporal Lobe; Female; Flumazenil; Humans; Iodi | 1991 |
Identification of the side of epileptic focus with 123I-Iomazenil SPECT. A comparison with 18FDG-PET and ictal EEG findings in patients with medically intractable complex partial seizures.
Topics: Adult; Blood Glucose; Deoxyglucose; Dominance, Cerebral; Electroencephalography; Epilepsy, Temporal | 1990 |
Partial epilepsy syndrome in a Gypsy family linked to 5q31.3-q32.
Topics: Adolescent; Adult; Child; Chromosomes, Human, Pair 5; Electroencephalography; Epilepsies, Partial; E | 2009 |
Focal epilepsy of probable temporal lobe origin in a Gypsy family showing linkage to a novel locus on 7p21.3.
Topics: Adolescent; Adult; Age of Onset; Child; Chromosome Mapping; Chromosomes, Human, Pair 7; Electroencep | 2011 |