flumazenil has been researched along with Aura in 71 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clobazam (CLB), a 1,5-benzodiazepine, is a remarkably effective add-on drug for individual patients with refractory partial epilepsy." | 8.79 | Clobazam for treatment of intractable epilepsy: a critical assessment. ( Schmidt, D, 1994) |
| "The aim of the present study was to investigate if flumazenil blood-brain barrier transport and binding to the benzodiazepine site on the γ-aminobutyric acid A (GABA(A)) receptor complex is altered in an experimental model of epilepsy and subsequently to study if changes in P-glycoprotein (P-gp)-mediated efflux of flumazenil at the blood-brain barrier may confound interpretation of (11)C-flumazenil PET in epilepsy." | 7.78 | Altered GABAA receptor density and unaltered blood-brain barrier transport in a kainate model of epilepsy: an in vivo study using 11C-flumazenil and PET. ( de Lange, EC; Eriksson, J; Labots, M; Lammertsma, AA; Syvänen, S; Tagawa, Y; Voskuyl, RA; Windhorst, AD, 2012) |
| "To investigate changes in free benzodiazepine receptor density in response to repeated, long-term administration of diazepam in epilepsy, we assessed 125I-iomazenil (125I-IMZ) binding in a mouse model." | 7.73 | Effects of diazepam on 125I-iomazenil-benzodiazepine receptor binding and epileptic seizures in the El mouse. ( Fukumitsu, N; Mori, Y; Ogi, S; Uchiyama, M, 2006) |
| "Twelve adult patients considered for epilepsy surgery with medically intractable temporal lobe epilepsy (TLE; n = 7), extratemporal lobe epilepsy (ETE; n = 2), and TLE+ETE (n = 3) were prospectively examined with DWI interictally (serving as baseline) and 10 min after application of 1 mg flumazenil i." | 7.72 | Presurgical evaluation of epilepsy by brain diffusion: MR-detected effects of flumazenil on the epileptogenic focus. ( de Greiff, A; Diener, HC; Dörfler, A; Hufnagel, A; Konermann, S; Leonhardt, G; Ludwig, T; Marks, S; Weber, J; Wiedemayer, H, 2003) |
| "Using [11C]flumazenil (FMZ)-positron emission tomography (PET) imaging, 15 children (aged 1-8 years) with medically intractable epilepsy were studied." | 7.71 | Prolonged vigabatrin treatment modifies developmental changes of GABA(A)-receptor binding in young children with epilepsy. ( Chugani, DC; Chugani, HT; Janisse, J; Juhász, C; Muzik, O; Shen, C, 2001) |
| "The protective and adverse effect potentials of levetiracetam ((S)-alpha-ethyl-2-oxo-pyrrolidine acetamide) in rodent models of seizures and epilepsy were compared with the profile of several currently prescribed and newly developed antiepileptic drugs." | 7.70 | Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. ( Gobert, J; Klitgaard, H; Matagne, A; Wülfert, E, 1998) |
| "[11C]flumazenil (FMZ) PET is significantly more sensitive than 2-deoxy-2-[18F]fluoro-D-glucose (FDG) PET for the detection of cortical regions of seizure onset and frequent spiking in patients with extratemporal lobe epilepsy, whereas both FDG and FMZ PET show low sensitivity in the detection of cortical areas of rapid seizure spread." | 7.70 | Intracranial EEG versus flumazenil and glucose PET in children with extratemporal lobe epilepsy. ( Canady, A; Chugani, DC; Chugani, HT; da Silva, EA; Frost, M; Gates, J; Herholz, K; Juhasz, C; Muzik, O; Nagy, F; Ritter, F; Shah, J; von Stockhausen, HM; Watson, C, 2000) |
| "To analyze the clinical utility of [11C]flumazenil (FMZ) PET to detect perilesional and remote cortical areas of abnormal benzodiazepine receptor binding in relation to MRI, 2-deoxy-2-[18F]fluoro-d-glucose (FDG) PET, and electrocorticographic (ECoG) findings as well as clinical characteristics of the epilepsy in epileptic patients with brain lesion." | 7.70 | Electroclinical correlates of flumazenil and fluorodeoxyglucose PET abnormalities in lesional epilepsy. ( Chugani, DC; Chugani, HT; Juhász, C; Muzik, O; Shah, A; Shah, J; Watson, C, 2000) |
| "The mechanisms underlying tolerance to benzodiazepines were investigated by injecting diazepam (5 mg/kg) twice daily for 23 days in WAG/Rij rats (an animal model for non-convulsive absence epilepsy)." | 7.68 | Diazepam and Ro 15-1788 increase absence epilepsy in WAG/Rij rats chronically exposed to diazepam. ( Coenen, AM; Nutt, DJ; Peeters, BW; Titulaer, MN; Van Rijn, CM; Vossen, JM, 1990) |
| "In PTZ-induced epileptic seizures, the i." | 5.33 | Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats. ( Hosseinzadeh, H; Mansouri, MT; Nassiri-Asl, M; Parvardeh, S, 2005) |
| "The effect on interictal EEG epileptic activity (IEA) of oral flumazenil, a benzodiazepine antagonist and potential antiepileptic drug, was studied in 12 adults with refractory epilepsy." | 5.07 | The effect of oral flumazenil on interictal epileptic activity: results of a double-blind, placebo-controlled study. ( Sander, JW; Sharief, MK; Shorvon, SD, 1993) |
| "Clobazam (CLB), a 1,5-benzodiazepine, is a remarkably effective add-on drug for individual patients with refractory partial epilepsy." | 4.79 | Clobazam for treatment of intractable epilepsy: a critical assessment. ( Schmidt, D, 1994) |
| "The aim of the present study was to investigate if flumazenil blood-brain barrier transport and binding to the benzodiazepine site on the γ-aminobutyric acid A (GABA(A)) receptor complex is altered in an experimental model of epilepsy and subsequently to study if changes in P-glycoprotein (P-gp)-mediated efflux of flumazenil at the blood-brain barrier may confound interpretation of (11)C-flumazenil PET in epilepsy." | 3.78 | Altered GABAA receptor density and unaltered blood-brain barrier transport in a kainate model of epilepsy: an in vivo study using 11C-flumazenil and PET. ( de Lange, EC; Eriksson, J; Labots, M; Lammertsma, AA; Syvänen, S; Tagawa, Y; Voskuyl, RA; Windhorst, AD, 2012) |
| "To investigate changes in free benzodiazepine receptor density in response to repeated, long-term administration of diazepam in epilepsy, we assessed 125I-iomazenil (125I-IMZ) binding in a mouse model." | 3.73 | Effects of diazepam on 125I-iomazenil-benzodiazepine receptor binding and epileptic seizures in the El mouse. ( Fukumitsu, N; Mori, Y; Ogi, S; Uchiyama, M, 2006) |
| "Twelve adult patients considered for epilepsy surgery with medically intractable temporal lobe epilepsy (TLE; n = 7), extratemporal lobe epilepsy (ETE; n = 2), and TLE+ETE (n = 3) were prospectively examined with DWI interictally (serving as baseline) and 10 min after application of 1 mg flumazenil i." | 3.72 | Presurgical evaluation of epilepsy by brain diffusion: MR-detected effects of flumazenil on the epileptogenic focus. ( de Greiff, A; Diener, HC; Dörfler, A; Hufnagel, A; Konermann, S; Leonhardt, G; Ludwig, T; Marks, S; Weber, J; Wiedemayer, H, 2003) |
| " In a prospective trial in dogs with newly diagnosed epilepsy, ELB 138 markedly reduced seizure frequency and severity without significant difference to standard treatments (phenobarbital or primidone) but was much better tolerated than the standard drugs." | 3.72 | Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures. ( Löscher, W; Potschka, H; Rieck, S; Rundfeldt, C; Tipold, A, 2004) |
| "Using [11C]flumazenil (FMZ)-positron emission tomography (PET) imaging, 15 children (aged 1-8 years) with medically intractable epilepsy were studied." | 3.71 | Prolonged vigabatrin treatment modifies developmental changes of GABA(A)-receptor binding in young children with epilepsy. ( Chugani, DC; Chugani, HT; Janisse, J; Juhász, C; Muzik, O; Shen, C, 2001) |
| "[11C]flumazenil (FMZ) PET is significantly more sensitive than 2-deoxy-2-[18F]fluoro-D-glucose (FDG) PET for the detection of cortical regions of seizure onset and frequent spiking in patients with extratemporal lobe epilepsy, whereas both FDG and FMZ PET show low sensitivity in the detection of cortical areas of rapid seizure spread." | 3.70 | Intracranial EEG versus flumazenil and glucose PET in children with extratemporal lobe epilepsy. ( Canady, A; Chugani, DC; Chugani, HT; da Silva, EA; Frost, M; Gates, J; Herholz, K; Juhasz, C; Muzik, O; Nagy, F; Ritter, F; Shah, J; von Stockhausen, HM; Watson, C, 2000) |
| "The protective and adverse effect potentials of levetiracetam ((S)-alpha-ethyl-2-oxo-pyrrolidine acetamide) in rodent models of seizures and epilepsy were compared with the profile of several currently prescribed and newly developed antiepileptic drugs." | 3.70 | Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. ( Gobert, J; Klitgaard, H; Matagne, A; Wülfert, E, 1998) |
| "To analyze the clinical utility of [11C]flumazenil (FMZ) PET to detect perilesional and remote cortical areas of abnormal benzodiazepine receptor binding in relation to MRI, 2-deoxy-2-[18F]fluoro-d-glucose (FDG) PET, and electrocorticographic (ECoG) findings as well as clinical characteristics of the epilepsy in epileptic patients with brain lesion." | 3.70 | Electroclinical correlates of flumazenil and fluorodeoxyglucose PET abnormalities in lesional epilepsy. ( Chugani, DC; Chugani, HT; Juhász, C; Muzik, O; Shah, A; Shah, J; Watson, C, 2000) |
| "Using [11C]flumazenil-PET and statistical parametric mapping (SPM), we have shown recently that regions of increased and decreased benzodiazepine receptor density may be seen in patients with localization-related epilepsy due to malformations of cortical development." | 3.69 | Cortical grey matter and benzodiazepine receptors in malformations of cortical development. A voxel-based comparison of structural and functional imaging data. ( Ashburner, J; Brooks, DJ; Duncan, JS; Free, SL; Friston, KJ; Koepp, MJ; Richardson, MP; Sisodiya, SM, 1997) |
| "We objectively delineated the extent of abnormalities in central benzodiazepine receptor (cBZR) binding using [11C]flumazenil (FMZ)-PET and high resolution volumetric MRI in 12 patients with mesial temporal lobe epilepsy (mTLE) associated with unilateral hippocampal sclerosis, who underwent presurgical evaluation and subsequent temporal lobe surgery." | 3.69 | Cerebral benzodiazepine receptors in hippocampal sclerosis. An objective in vivo analysis. ( Brooks, DJ; Duncan, JS; Friston, KJ; Koepp, MJ; Poline, JB; Richardson, MP; Van Paesschen, W, 1996) |
| "The mechanisms underlying tolerance to benzodiazepines were investigated by injecting diazepam (5 mg/kg) twice daily for 23 days in WAG/Rij rats (an animal model for non-convulsive absence epilepsy)." | 3.68 | Diazepam and Ro 15-1788 increase absence epilepsy in WAG/Rij rats chronically exposed to diazepam. ( Coenen, AM; Nutt, DJ; Peeters, BW; Titulaer, MN; Van Rijn, CM; Vossen, JM, 1990) |
| "The clinical anti-convulsant effect of flumazenil in epilepsy has been demonstrated: (i) by acute i." | 3.67 | The clinical anti-convulsant effects of flumazenil, a benzodiazepine antagonist. ( Scollo-Lavizzari, G, 1988) |
| "When flumazenil (3 mg) was administered immediately after intravenous diazepam (10 mg), the reduction in interictal epileptic activity was not significantly different from that produced by diazepam alone." | 2.67 | The effect of intravenous flumazenil on interictal electroencephalographic epileptic activity: results of a placebo-controlled study. ( Hart, YM; Meinardi, H; Nutt, DJ; Sander, JW; Shorvon, SD, 1991) |
| "Most complex seizures arise from the temporal lobes and the condition of 20-30% of these patients is refractory to medication." | 2.41 | [Functional imaging (PET and SPECT) in epilepsy]. ( Borbély, K, 2001) |
| "Epilepsy was seen by some as a divine punishment or resulting from black magic." | 1.56 | Traditional practices and perceptions of epilepsy among people in Roma communities in Bulgaria. ( Antimov, P; Sander, JW; Tournev, I; Zhelyazkova, S, 2020) |
| "Kainic acid (KA) solution was injected stereotaxically into medial and lateral sites of the sensori-motor cortex." | 1.33 | Focal cortical dysplasia: pathophysiological approach. ( Hashizume, K; Hodozuka, A; Tanaka, T; Tsuda, H, 2006) |
| " Mean population pharmacokinetic parameters (percent coefficient of variation) were: CL 1530 mL min(-1) (6." | 1.33 | Population plasma pharmacokinetics of 11C-flumazenil at tracer concentrations. ( Franssen, EJ; Greuter, HN; Huitema, AD; Lammertsma, AA; Swart, EL; van Loenen, AC; van Rij, CM, 2005) |
| "In PTZ-induced epileptic seizures, the i." | 1.33 | Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats. ( Hosseinzadeh, H; Mansouri, MT; Nassiri-Asl, M; Parvardeh, S, 2005) |
| " Marked differences in drug sensitivity were observed between models based on single and chronic administration of PTZ showing that the two sets of models are fundamentally different." | 1.32 | Anticonvulsant and antiepileptogenic effects of GABAA receptor ligands in pentylenetetrazole-kindled mice. ( Hansen, SL; Sánchez, C; Sperling, BB, 2004) |
| "[11C]flumazenil was found to be a more sensitive and accurate focus localiser than [18F]FDG." | 1.29 | Comparison of [11C]flumazenil and [18F]FDG as PET markers of epileptic foci. ( Ingvar, M; Savic, I; Stone-Elander, S, 1993) |
| "Flumazenil was without effect on normal synaptic responses; however, flumazenil reduced epileptiform discharges evoked in the presence of high [K+]o, leu-enkephalin, the BZR inverse agonist, methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM), or after a cold-shock procedure." | 1.29 | Benzodiazepine antagonists reduce epileptiform discharges in rat hippocampal slices. ( Carlen, PL; Facciponte, G; Jahromi, SS; Pelletier, MR; Polc, P; Zhang, L, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (5.63) | 18.7374 |
| 1990's | 29 (40.85) | 18.2507 |
| 2000's | 26 (36.62) | 29.6817 |
| 2010's | 10 (14.08) | 24.3611 |
| 2020's | 2 (2.82) | 2.80 |
| Authors | Studies |
|---|---|
| Niu, N | 1 |
| Xing, H | 1 |
| Wu, M | 1 |
| Ma, Y | 1 |
| Liu, Y | 1 |
| Ba, J | 1 |
| Zhu, S | 1 |
| Li, F | 1 |
| Huo, L | 1 |
| Erfanparast, A | 1 |
| Tamaddonfard, E | 1 |
| Henareh-Chareh, F | 1 |
| Fujimoto, A | 1 |
| Okanishi, T | 1 |
| Kanai, S | 1 |
| Sato, K | 1 |
| Itamura, S | 1 |
| Baba, S | 1 |
| Nishimura, M | 1 |
| Masui, T | 1 |
| Enoki, H | 1 |
| de Almeida, RN | 1 |
| de Sousa, DP | 1 |
| Nóbrega, FF | 1 |
| Claudino, Fde S | 1 |
| Araújo, DA | 1 |
| Leite, JR | 1 |
| Mattei, R | 1 |
| Liefaard, LC | 1 |
| Ploeger, BA | 1 |
| Molthoff, CF | 1 |
| de Jong, HW | 1 |
| Dijkstra, J | 1 |
| van der Weerd, L | 1 |
| Lammertsma, AA | 3 |
| Danhof, M | 1 |
| Voskuyl, RA | 2 |
| Liu, DS | 1 |
| O'Brien, TJ | 1 |
| Williams, DA | 1 |
| Hicks, RJ | 1 |
| Myers, DE | 1 |
| Horky, LL | 1 |
| Treves, ST | 1 |
| Higurashi, N | 1 |
| Hamano, S | 1 |
| Oritsu, T | 1 |
| Minamitani, M | 1 |
| Sasaki, M | 1 |
| Ida, H | 1 |
| Mori, T | 1 |
| Mori, K | 1 |
| Fujii, E | 1 |
| Toda, Y | 1 |
| Miyazaki, M | 1 |
| Harada, M | 1 |
| Kagami, S | 1 |
| Kuki, I | 2 |
| Kawawaki, H | 2 |
| Okazaki, S | 2 |
| Inoue, T | 1 |
| Nukui, M | 1 |
| Tomiwa, K | 2 |
| Amou, K | 1 |
| Togawa, M | 1 |
| Shiomi, M | 1 |
| Kato, H | 2 |
| Matsuda, K | 2 |
| Baba, K | 1 |
| Shimosegawa, E | 2 |
| Isohashi, K | 1 |
| Imaizumi, M | 1 |
| Hatazawa, J | 2 |
| Syvänen, S | 1 |
| Labots, M | 1 |
| Tagawa, Y | 1 |
| Eriksson, J | 1 |
| Windhorst, AD | 1 |
| de Lange, EC | 1 |
| da Cruz, GM | 1 |
| Felipe, CF | 1 |
| Scorza, FA | 1 |
| da Costa, MA | 1 |
| Tavares, AF | 1 |
| Menezes, ML | 1 |
| de Andrade, GM | 1 |
| Leal, LK | 1 |
| Brito, GA | 1 |
| da Graça Naffah-Mazzacoratti, M | 1 |
| Cavalheiro, EA | 1 |
| de Barros Viana, GS | 1 |
| Konermann, S | 1 |
| Marks, S | 1 |
| Ludwig, T | 1 |
| Weber, J | 1 |
| de Greiff, A | 1 |
| Dörfler, A | 1 |
| Leonhardt, G | 1 |
| Wiedemayer, H | 1 |
| Diener, HC | 1 |
| Hufnagel, A | 1 |
| Csaba, J | 1 |
| Levêque, P | 1 |
| Sanabria-Bohorquez, S | 1 |
| Bol, A | 1 |
| De Volder, A | 1 |
| Labar, D | 1 |
| Van Rijckevorsel, K | 1 |
| Gallez, B | 1 |
| Hansen, SL | 1 |
| Sperling, BB | 1 |
| Sánchez, C | 1 |
| Löscher, W | 1 |
| Potschka, H | 1 |
| Rieck, S | 1 |
| Tipold, A | 1 |
| Rundfeldt, C | 1 |
| Seike, Y | 1 |
| Hashikawa, K | 1 |
| Oku, N | 2 |
| Moriwaki, H | 1 |
| Yamamoto, H | 1 |
| Fukuchi, K | 1 |
| Watanabe, Y | 1 |
| Matsumoto, M | 1 |
| Hori, M | 1 |
| Nishimura, T | 2 |
| Jäger, AK | 1 |
| Mohoto, SP | 1 |
| van Heerden, FR | 1 |
| Viljoen, AM | 1 |
| Hosseinzadeh, H | 1 |
| Parvardeh, S | 1 |
| Nassiri-Asl, M | 1 |
| Mansouri, MT | 1 |
| van Rij, CM | 1 |
| Huitema, AD | 1 |
| Swart, EL | 1 |
| Greuter, HN | 1 |
| van Loenen, AC | 1 |
| Franssen, EJ | 1 |
| Hodozuka, A | 1 |
| Tsuda, H | 1 |
| Hashizume, K | 1 |
| Tanaka, T | 1 |
| Ikeda, S | 1 |
| Fukumitsu, N | 2 |
| Ogi, S | 1 |
| Uchiyama, M | 2 |
| Mori, Y | 2 |
| Kitagawa, K | 1 |
| Kishima, H | 1 |
| Saitoh, Y | 1 |
| Kato, A | 1 |
| Yoshimine, T | 1 |
| Luat, AF | 1 |
| Chugani, HT | 8 |
| Savic, I | 3 |
| Thorell, JO | 1 |
| Roland, P | 1 |
| Nagata, T | 1 |
| Saji, H | 1 |
| Nishizawa, S | 1 |
| Yonekura, Y | 2 |
| Yamamoto, I | 1 |
| Iida, Y | 1 |
| Magata, Y | 1 |
| Konishi, J | 1 |
| Serikawa, T | 1 |
| Yokoyama, A | 1 |
| Reisner-Keller, LA | 1 |
| Pham, Z | 1 |
| Schmidt, D | 1 |
| Jibiki, I | 1 |
| Kurokawa, K | 1 |
| Matsuda, H | 2 |
| Fukushima, T | 1 |
| Tsuji, S | 1 |
| Yamaguchi, N | 1 |
| Hisada, K | 1 |
| Sharief, MK | 1 |
| Sander, JW | 5 |
| Shorvon, SD | 3 |
| Duncan, S | 1 |
| Gillen, GJ | 1 |
| Brodie, MJ | 1 |
| Ingvar, M | 1 |
| Stone-Elander, S | 2 |
| Torizuka, K | 1 |
| Uemura, K | 1 |
| Toru, M | 1 |
| Shinohara, Y | 1 |
| Nakagawara, J | 1 |
| Sakai, F | 1 |
| Fukuyama, H | 1 |
| Morimoto, K | 1 |
| Sadzot, B | 1 |
| Nakamura, F | 1 |
| Suzuki, S | 1 |
| Nishimura, S | 1 |
| Yagi, K | 1 |
| Seino, M | 1 |
| Polc, P | 2 |
| Jahromi, SS | 1 |
| Facciponte, G | 1 |
| Pelletier, MR | 1 |
| Zhang, L | 1 |
| Carlen, PL | 1 |
| Koepp, MJ | 2 |
| Richardson, MP | 3 |
| Brooks, DJ | 3 |
| Poline, JB | 1 |
| Van Paesschen, W | 1 |
| Friston, KJ | 2 |
| Duncan, JS | 4 |
| Henry, TR | 1 |
| Sue, H | 1 |
| Kawakami, K | 1 |
| Decoo, D | 1 |
| Destée, A | 1 |
| Sisodiya, SM | 1 |
| Ashburner, J | 1 |
| Free, SL | 1 |
| Lamusuo, S | 1 |
| Ruottinen, HM | 1 |
| Knuuti, J | 1 |
| Härkönen, R | 1 |
| Ruotsalainen, U | 1 |
| Bergman, J | 1 |
| Haaparanta, M | 1 |
| Solin, O | 1 |
| Mervaala, E | 1 |
| Nousiainen, U | 1 |
| Jääskeläinen, S | 1 |
| Ylinen, A | 1 |
| Kälviäinen, R | 1 |
| Rinne, JK | 1 |
| Vapalahti, M | 1 |
| Rinne, JO | 1 |
| Klitgaard, H | 1 |
| Matagne, A | 1 |
| Gobert, J | 1 |
| Wülfert, E | 1 |
| Juhász, C | 6 |
| Nagy, F | 3 |
| Muzik, O | 7 |
| Watson, C | 5 |
| Shah, J | 5 |
| Chugani, DC | 6 |
| da Silva, EA | 2 |
| Kupsky, W | 1 |
| Canady, A | 2 |
| Niimura, K | 1 |
| Shen, C | 2 |
| von Stockhausen, HM | 1 |
| Herholz, K | 2 |
| Gates, J | 1 |
| Frost, M | 1 |
| Ritter, F | 1 |
| Shah, A | 2 |
| Rössler, AS | 1 |
| Launay, JM | 1 |
| Venault, P | 1 |
| Dodd, RH | 2 |
| Chapouthier, G | 1 |
| Sand, P | 1 |
| Kavvadias, D | 1 |
| Feineis, D | 1 |
| Riederer, P | 1 |
| Schreier, P | 1 |
| Kleinschnitz, M | 1 |
| Czygan, FC | 1 |
| Abou-Mandour, A | 1 |
| Bringmann, G | 1 |
| Beckmann, H | 1 |
| Hammers, A | 1 |
| Janisse, J | 1 |
| Borbély, K | 1 |
| Szelies, B | 1 |
| Sobesky, J | 1 |
| Pawlik, G | 1 |
| Mielke, R | 1 |
| Bauer, B | 1 |
| Heiss, WD | 1 |
| Ducić, I | 1 |
| Hart, YM | 2 |
| Meinardi, H | 2 |
| Nutt, DJ | 3 |
| Widén, L | 1 |
| Peeters, BW | 1 |
| Van Rijn, CM | 1 |
| Titulaer, MN | 1 |
| Vossen, JM | 1 |
| Coenen, AM | 1 |
| Beer, HF | 1 |
| Bläuenstein, PA | 1 |
| Hasler, PH | 1 |
| Delaloye, B | 1 |
| Riccabona, G | 1 |
| Bangerl, I | 1 |
| Hunkeler, W | 1 |
| Bonetti, EP | 1 |
| Pieri, L | 1 |
| Richards, JG | 1 |
| Brouillet, E | 1 |
| Chavoix, C | 1 |
| de la Sayette, V | 1 |
| Hantraye, P | 1 |
| Kunimoto, M | 1 |
| Khalili-Varasteh, M | 1 |
| Guibert, B | 1 |
| Fournier, D | 1 |
| Naquet, R | 1 |
| Porter, RJ | 1 |
| Scollo-Lavizzari, G | 1 |
| Pedder, SC | 1 |
| Wilcox, R | 1 |
| Tuchek, JM | 1 |
| Crawford, RD | 1 |
| Johnson, DD | 1 |
| Antimov, P | 1 |
| Tournev, I | 2 |
| Zhelyazkova, S | 2 |
| Azmanov, DN | 1 |
| Dimova, PS | 1 |
| Radionova, M | 1 |
| Bojinova, V | 1 |
| Florez, L | 1 |
| Smith, SJ | 1 |
| Jablensky, A | 1 |
| Mulley, J | 1 |
| Scheffer, I | 1 |
| Kalaydjieva, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Imaging After Stereotactic Radiosurgery for Brain Metastases or Primary Tumor Can Hybrid PET-MRI Differentiate Between Radiation Effects and Disease ?[NCT03068520] | 140 participants (Anticipated) | Interventional | 2017-03-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 reviews available for flumazenil and Aura
| Article | Year |
|---|---|
Performance of PET imaging for the localization of epileptogenic zone in patients with epilepsy: a meta-analysis.
Topics: Epilepsy; Epilepsy, Temporal Lobe; Flumazenil; Fluorodeoxyglucose F18; Humans; Magnetic Resonance Im | 2021 |
PET and SPECT in brain tumors and epilepsy.
Topics: Brain; Brain Neoplasms; Cell Proliferation; Dideoxynucleosides; Epilepsy; Flumazenil; Fluorodeoxyglu | 2011 |
[Usefulness of 123I-iomazenil SPECT in pediatric patients with neurological disease].
Topics: Brain; Epilepsy; Flumazenil; Humans; Iodine Radioisotopes; Nervous System Diseases; Radiopharmaceuti | 2012 |
Molecular and diffusion tensor imaging of epileptic networks.
Topics: Adolescent; Age Factors; Brain Mapping; Carbon Radioisotopes; Cerebral Cortex; Child; Chronic Diseas | 2008 |
Clobazam for treatment of intractable epilepsy: a critical assessment.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clinical Trials a | 1994 |
Functional neuroimaging with positron emission tomography.
Topics: Anticonvulsants; Brain; Cerebrovascular Circulation; Deoxyglucose; Epilepsy; Epilepsy, Temporal Lobe | 1996 |
Imaging and epilepsy.
Topics: Cerebral Cortex; Cerebrovascular Circulation; Deoxyglucose; Epilepsy; Flumazenil; Fluorodeoxyglucose | 1997 |
PET studies in epilepsy.
Topics: Brain; Carbon Radioisotopes; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Fentanyl; Flumaze | 1997 |
Relationship between EEG and positron emission tomography abnormalities in clinical epilepsy.
Topics: Biomarkers; Brain Diseases; Brain Diseases, Metabolic; Electroencephalography; Epilepsy; Epilepsy, T | 2000 |
Naturally occurring benzodiazepines: current status of research and clinical implications.
Topics: Animals; Anxiety; Benzodiazepines; Brain; Chromatography, High Pressure Liquid; Epilepsy; Flumazenil | 2000 |
[Functional imaging (PET and SPECT) in epilepsy].
Topics: Animals; Brain; Cerebrovascular Circulation; Epilepsy; Flumazenil; Fluorodeoxyglucose F18; GABA Modu | 2001 |
8 trials available for flumazenil and Aura
| Article | Year |
|---|---|
Quantification of human brain benzodiazepine receptors using [18F]fluoroethylflumazenil: a first report in volunteers and epileptic patients.
Topics: Adult; Brain; Epilepsy; Female; Flumazenil; Humans; Image Processing, Computer-Assisted; Male; Metab | 2003 |
Evaluation of the use of a standard input function for compartment analysis of [123I]iomazenil data: factors influencing the quantitative results.
Topics: Adolescent; Adult; Aged; Algorithms; Alzheimer Disease; Brain; Cerebrovascular Disorders; Epilepsy; | 2004 |
The effect of oral flumazenil on interictal epileptic activity: results of a double-blind, placebo-controlled study.
Topics: Administration, Oral; Adult; Anticonvulsants; Double-Blind Method; Electroencephalography; Epilepsy; | 1993 |
Lack of effect of concomitant clobazam on interictal 123I-iomazenil SPECT.
Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Brain; Clobazam; Ep | 1993 |
[A phase 3 clinical trial of 123I-iomazenil, a new central-type benzodiazepine receptor imaging agent (Part 3)--Report on clinical usefulness in epilepsy].
Topics: Adult; Brain; Epilepsy; Female; Flumazenil; GABA-A Receptor Agonists; Humans; Iodine Radioisotopes; | 1996 |
[Assessment of cerebral benzodiazepine receptor distribution in epilepsy by 123I-iomazenil-SPECT].
Topics: Adult; Amphetamines; Brain; Cerebrovascular Circulation; Epilepsy; Female; Flumazenil; Humans; Iodin | 1997 |
Comparison of [18F]FDG-PET, [99mTc]-HMPAO-SPECT, and [123I]-iomazenil-SPECT in localising the epileptogenic cortex.
Topics: Adolescent; Adult; Atrophy; Cerebral Cortex; Electroencephalography; Epilepsy; Female; Flumazenil; F | 1997 |
The effect of intravenous flumazenil on interictal electroencephalographic epileptic activity: results of a placebo-controlled study.
Topics: Adult; Anticonvulsants; Brain; Diazepam; Dose-Response Relationship, Drug; Drug Therapy, Combination | 1991 |
52 other studies available for flumazenil and Aura
| Article | Year |
|---|---|
Intra-hippocampal microinjection of oxytocin produced antiepileptic effect on the pentylenetetrazol-induced epilepsy in rats.
Topics: Animals; Anticonvulsants; Diazepam; Epilepsy; Flumazenil; Hippocampus; Male; Microinjections; Oxytoc | 2017 |
Double match of
Topics: Adolescent; Adult; Child; Epilepsy; Female; Flumazenil; Fluorodeoxyglucose F18; Humans; Magnetic Res | 2018 |
Anticonvulsant effect of a natural compound alpha,beta-epoxy-carvone and its action on the nerve excitability.
Topics: Action Potentials; Animals; Anticonvulsants; Convulsants; Cyclohexane Monoterpenes; Disease Models, | 2008 |
Changes in GABAA receptor properties in amygdala kindled animals: in vivo studies using [11C]flumazenil and positron emission tomography.
Topics: Amygdala; Animals; Electroencephalography; Epilepsy; Flumazenil; GABA Modulators; Kindling, Neurolog | 2009 |
Lamina-specific changes in hippocampal GABA(A)/cBZR and mossy fibre sprouting during and following amygdala kindling in the rat.
Topics: Amygdala; Animals; Autoradiography; Cell Count; Cell Death; Electric Stimulation; Electrodes, Implan | 2009 |
Iomazenil hyperfixation in single photon emission computed tomography study of malformations of cortical development during infancy.
Topics: Cerebral Cortex; Child, Preschool; Epilepsy; Flumazenil; Humans; Infant; Iodine Radioisotopes; Male; | 2011 |
Neuroradiological and neurofunctional examinations for patients with 22q11.2 deletion.
Topics: Case-Control Studies; Child; Child, Preschool; DiGeorge Syndrome; Electroencephalography; Epilepsy; | 2011 |
MR imaging-based correction for partial volume effect improves detectability of intractable epileptogenic foci on iodine 123 iomazenil brain SPECT images: an extended study with a larger sample size.
Topics: Adult; Algorithms; Artifacts; Brain; Epilepsy; False Negative Reactions; Female; Flumazenil; Humans; | 2012 |
Altered GABAA receptor density and unaltered blood-brain barrier transport in a kainate model of epilepsy: an in vivo study using 11C-flumazenil and PET.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain | 2012 |
Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms.
Topics: Alkaloids; Amino Acids; Animals; Anticonvulsants; Antioxidants; Atropine; Benzodioxoles; Biogenic Mo | 2013 |
Presurgical evaluation of epilepsy by brain diffusion: MR-detected effects of flumazenil on the epileptogenic focus.
Topics: Adult; Brain Mapping; Cerebral Cortex; Diffusion Magnetic Resonance Imaging; Epilepsy; Epilepsy, Tem | 2003 |
Positron emission tomography in presurgical localization of epileptic foci.
Topics: Adolescent; Adult; Brain; Carbon Radioisotopes; Electroencephalography; Epilepsy; Female; Flumazenil | 2003 |
Anticonvulsant and antiepileptogenic effects of GABAA receptor ligands in pentylenetetrazole-kindled mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Dehydroepiandrosterone Sulfate; Diazepam; Dose-R | 2004 |
Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures.
Topics: Animals; Anticonvulsants; Bromides; Chronic Disease; Disease Models, Animal; Dog Diseases; Dogs; Dru | 2004 |
Activity of a traditional South African epilepsy remedy in the GABA-benzodiazepine receptor assay.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Epilepsy; Flumazenil; Humans; In Vitro Techniques; Medici | 2005 |
Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats.
Topics: Animals; Anticonvulsants; Benzoquinones; Convulsants; Diazepam; Epilepsy; Flumazenil; Injections, In | 2005 |
Population plasma pharmacokinetics of 11C-flumazenil at tracer concentrations.
Topics: Adult; Area Under Curve; Depressive Disorder; Epilepsy; Female; Flumazenil; GABA Modulators; Humans; | 2005 |
Focal cortical dysplasia: pathophysiological approach.
Topics: Adolescent; Animals; Animals, Newborn; Autoradiography; Behavior, Animal; Brain Diseases; Brain Mapp | 2006 |
[Influence of benzodiazepines on 123I iomazenil SPECT].
Topics: Adolescent; Benzodiazepines; Child; Child, Preschool; Epilepsy; Female; Flumazenil; Humans; Infant; | 2006 |
Effects of diazepam on 125I-iomazenil-benzodiazepine receptor binding and epileptic seizures in the El mouse.
Topics: Animals; Anticonvulsants; Autoradiography; Brain; Diazepam; Disease Models, Animal; Epilepsy; Flumaz | 2006 |
MRI-based correction for partial-volume effect improves detectability of intractable epileptogenic foci on 123I-iomazenil brain SPECT images.
Topics: Adult; Artifacts; Brain; Epilepsy; Female; Flumazenil; Humans; Image Enhancement; Imaging, Three-Dim | 2008 |
[11C]flumazenil positron emission tomography visualizes frontal epileptogenic regions.
Topics: Adult; Electroencephalography; Epilepsy; Epilepsy, Frontal Lobe; Female; Flumazenil; Humans; Male; M | 1995 |
[125I]iomazenil binding in the brains of spontaneously epileptic rats: an ex vivo quantitative autoradiographic study.
Topics: Animals; Autoradiography; Brain; Cerebrovascular Circulation; Epilepsy; Flumazenil; Iodine Radioisot | 1995 |
Oral flumazenil in the treatment of epilepsy.
Topics: Administration, Oral; Clinical Trials as Topic; Diazepam; Drug Therapy, Combination; Epilepsy; Epile | 1995 |
Comparison of benzodiazepine receptor and regional cerebral blood flow imaging of epileptiform foci in hippocampal kindled rabbits: a preliminary report.
Topics: Animals; Autoradiography; Cerebrovascular Circulation; Epilepsy; Flumazenil; Hippocampus; Iodine Rad | 1994 |
Comparison of [11C]flumazenil and [18F]FDG as PET markers of epileptic foci.
Topics: Adult; Analysis of Variance; Carbon Radioisotopes; Deoxyglucose; Electroencephalography; Epilepsy; F | 1993 |
Neuroimaging in epilepsy: is there a future for positron emission tomography.
Topics: Brain; Carbon Radioisotopes; Deoxyglucose; Epilepsy; Flumazenil; Fluorine Radioisotopes; Fluorodeoxy | 1996 |
Effects of clobazam and its active metabolite on GABA-activated currents in rat cerebral neurons in culture.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Cells, Cultured; | 1996 |
Benzodiazepine antagonists reduce epileptiform discharges in rat hippocampal slices.
Topics: Animals; Carbolines; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electric | 1996 |
Cerebral benzodiazepine receptors in hippocampal sclerosis. An objective in vivo analysis.
Topics: Adult; Binding, Competitive; Epilepsy; Female; Flumazenil; Hippocampus; Humans; Male; Middle Aged; R | 1996 |
Cortical grey matter and benzodiazepine receptors in malformations of cortical development. A voxel-based comparison of structural and functional imaging data.
Topics: Adolescent; Adult; Antidotes; Brain Mapping; Carbon Radioisotopes; Cerebral Cortex; Child; Epilepsy; | 1997 |
Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Carbolines; Convulsants; Diazepam; Disease Mod | 1998 |
[11C]Flumazenil PET in patients with epilepsy with dual pathology.
Topics: Adolescent; Adult; Carbon Radioisotopes; Cerebral Cortex; Electroencephalography; Epilepsy; Female; | 1999 |
Altered in vitro and in vivo flumazenil binding in human epileptogenic neocortex.
Topics: Adolescent; Adult; Binding Sites; Child; Child, Preschool; Epilepsy; Female; Flumazenil; GABA Modula | 1999 |
[11C]flumazenil PET: activity images versus parametric images for the detection of neocortical epileptic foci.
Topics: Adult; Carbon Radioisotopes; Cerebral Cortex; Child; Epilepsy; Female; Flumazenil; Humans; Male; Neo | 1999 |
Intracranial EEG versus flumazenil and glucose PET in children with extratemporal lobe epilepsy.
Topics: Adolescent; Blood Glucose; Brain; Child; Child, Preschool; Electroencephalography; Epilepsy; Female; | 2000 |
Changes in benzodiazepine binding in a subkindling situation.
Topics: Animals; Carbolines; Convulsants; Disease Models, Animal; Epilepsy; Flumazenil; GABA Antagonists; Ki | 2000 |
Electroclinical correlates of flumazenil and fluorodeoxyglucose PET abnormalities in lesional epilepsy.
Topics: Adolescent; Adult; Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Flumazenil; Fl | 2000 |
Benzodiazepine-GABA(A) receptor binding is very low in dysembryoplastic neuroepithelial tumor: a PET study.
Topics: Adult; Amygdala; Brain Neoplasms; Carbon Radioisotopes; Cerebral Cortex; Epilepsy; Female; Flumazeni | 2001 |
Prolonged vigabatrin treatment modifies developmental changes of GABA(A)-receptor binding in young children with epilepsy.
Topics: Age Factors; Brain; Brain Mapping; Carbon Radioisotopes; Child; Child, Preschool; Epilepsy; Female; | 2001 |
Impaired benzodiazepine receptor binding in peri-lesional cortex of patients with symptomatic epilepsies studied by [(11)C]-flumazenil PET.
Topics: Adult; Carbon Radioisotopes; Epilepsy; Female; Flumazenil; GABA Modulators; Humans; Magnetic Resonan | 2002 |
Benzodiazepine antagonist flumazenil reduces bicuculline-induced enhancement of neuronal activity in the spinal cord.
Topics: Animals; Bicuculline; Cats; Epilepsy; Evoked Potentials; Flumazenil; Male; Motor Neurons; Receptors, | 1991 |
Feasibility of reversing benzodiazepine tolerance with flumazenil.
Topics: Adult; Benzodiazepines; Drug Tolerance; Electroencephalography; Epilepsy; Feasibility Studies; Fluma | 1991 |
Flumazenil as an anti-epileptic agent.
Topics: Diazepam; Drug Evaluation; Epilepsy; Flumazenil; Humans; Time Factors | 1991 |
Diazepam and Ro 15-1788 increase absence epilepsy in WAG/Rij rats chronically exposed to diazepam.
Topics: Animals; Diazepam; Electroencephalography; Epilepsy; Flumazenil; Hypnotics and Sedatives; Male; Rats | 1990 |
In vitro and in vivo evaluation of iodine-123-Ro 16-0154: a new imaging agent for SPECT investigations of benzodiazepine receptors.
Topics: Animals; Brain; Cerebrovascular Circulation; Drug Stability; Epilepsy; Female; Flumazenil; Humans; I | 1990 |
Anticonvulsant activity of the diaryltriazine, LY81067: studies using electroencephalographic recording and positron emission tomography.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzodiazepinones; Brain; Convulsants; Electroencephalog | 1989 |
Mechanisms of action of new antiepileptic drugs.
Topics: Acetamides; Acetates; Amines; Aminocaproates; Aminopyridines; Anti-Anxiety Agents; Anticonvulsants; | 1989 |
The clinical anti-convulsant effects of flumazenil, a benzodiazepine antagonist.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Electroencephalography; Epilepsy; Female; Flumazenil; Huma | 1988 |
Benzodiazepine antagonist Ro 15-1788 (flumazepil) attenuates the anticonvulsant activity of diazepam in epileptic fowl.
Topics: Animals; Chickens; Diazepam; Epilepsy; Female; Flumazenil; Male; Poultry Diseases | 1987 |
Traditional practices and perceptions of epilepsy among people in Roma communities in Bulgaria.
Topics: Bulgaria; Child; Epilepsy; Female; Humans; Male; Medicine, Traditional; Perception; Roma; Social Sti | 2020 |
Mosaicism of a missense SCN1A mutation and Dravet syndrome in a Roma/Gypsy family.
Topics: Adolescent; Alleles; Electroencephalography; Epilepsy; Follow-Up Studies; Genetic Carrier Screening; | 2010 |