flumazenil has been researched along with Ataxia in 11 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Ataxia: Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Zolpidem and triazolam produced dose-dependent reductions in locomotion and environment-directed behavior and increased ataxia and procumbent posture." | 3.71 | Selective antagonism of the ataxic effects of zolpidem and triazolam by the GABAA/alpha1-preferring antagonist beta-CCt in squirrel monkeys. ( Cook, J; Ma, C; Platt, DM; Rowlett, JK; Spealman, RD, 2002) |
| "Diazepam (2 mg/kg) induced significant ataxia and muscle relaxation, which were completely prevented by pretreatment with flumazenil (10 mg/kg) and βCCt (20 mg/kg)." | 1.38 | The role of α1 and α5 subunit-containing GABAA receptors in motor impairment induced by benzodiazepines in rats. ( Cook, JM; Divljaković, J; Milić, M; Rallapalli, S; Savić, MM; Timić, T; van Linn, ML, 2012) |
| "Zolpidem (Stilnox) is a non-benzodiazepine hypnotic drug of the imidazopyridine class intended for treatment of insomnia in humans." | 1.36 | Zolpidem poisoning in a cat. ( Czopowicz, M; Frymus, T; Szalus-Jordanow, O, 2010) |
| "Flumazenil treatment of ethanol-dependent mice 14 hr before isolation of brain membrane vesicles partially reversed the augmentation of Ro15-4513 inhibition of muscimol-stimulated 36Cl- uptake in vitro." | 1.28 | Reversal of alcohol dependence and tolerance by a single administration of flumazenil. ( Buck, KJ; Harris, RA; Heim, H, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (27.27) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ahn, JO | 1 |
| Jaung, WJ | 1 |
| Won, SH | 1 |
| Ryu, MO | 1 |
| Song, WJ | 1 |
| Jeon, KO | 1 |
| Chung, JY | 1 |
| Youn, HY | 1 |
| Czopowicz, M | 1 |
| Szalus-Jordanow, O | 1 |
| Frymus, T | 1 |
| Milić, M | 1 |
| Divljaković, J | 1 |
| Rallapalli, S | 1 |
| van Linn, ML | 1 |
| Timić, T | 1 |
| Cook, JM | 1 |
| Savić, MM | 1 |
| Bamitale, KD | 1 |
| Akanmu, MA | 1 |
| Ukponmwan, OE | 1 |
| Platt, DM | 1 |
| Rowlett, JK | 1 |
| Spealman, RD | 1 |
| Cook, J | 1 |
| Ma, C | 1 |
| Jensen, LH | 1 |
| Petersen, EN | 1 |
| Braestrup, C | 1 |
| Honoré, T | 1 |
| Kehr, W | 1 |
| Stephens, DN | 1 |
| Schneider, H | 1 |
| Seidelmann, D | 1 |
| Schmiechen, R | 1 |
| Buck, KJ | 1 |
| Heim, H | 1 |
| Harris, RA | 1 |
| Giusti, P | 1 |
| Guidetti, G | 1 |
| Costa, E | 1 |
| Guidotti, A | 1 |
| Chan, AW | 1 |
| Leong, FW | 1 |
| Schanley, DL | 1 |
| Langan, MC | 1 |
| Penetrante, F | 1 |
| Shannon, HE | 1 |
| Katzman, NJ | 1 |
| Kardos, M | 1 |
| Nagy, I | 1 |
| Schultz, K | 1 |
| Kiss, I | 1 |
| Gastonyi, V | 1 |
11 other studies available for flumazenil and Ataxia
| Article | Year |
|---|---|
Accidental afloqualone intoxication in two dogs.
Topics: Animals; Ataxia; Bradycardia; Dog Diseases; Dogs; Flumazenil; Male; Quinazolines; Respiratory Insuff | 2018 |
Zolpidem poisoning in a cat.
Topics: Animals; Antidotes; Ataxia; Cat Diseases; Cats; Flumazenil; Hyperkinesis; Hypnotics and Sedatives; M | 2010 |
The role of α1 and α5 subunit-containing GABAA receptors in motor impairment induced by benzodiazepines in rats.
Topics: Animals; Ataxia; Benzodiazepines; Benzodiazepinones; Carbolines; Diazepam; Flumazenil; GABA-A Recept | 2012 |
Neuropharmacological profile of aqueous extract of Anaphe venata larva (Notondotidae) in rats.
Topics: Amphetamine; Animals; Ataxia; Behavior, Animal; Dose-Response Relationship, Drug; Flumazenil; Groomi | 2011 |
Selective antagonism of the ataxic effects of zolpidem and triazolam by the GABAA/alpha1-preferring antagonist beta-CCt in squirrel monkeys.
Topics: Animals; Ataxia; Benzodiazepines; Carbolines; Dose-Response Relationship, Drug; Drug Interactions; F | 2002 |
Evaluation of the beta-carboline ZK 93 426 as a benzodiazepine receptor antagonist.
Topics: Animals; Anticonvulsants; Ataxia; Benzodiazepinones; Binding, Competitive; Carbolines; Diazepam; Dis | 1984 |
Reversal of alcohol dependence and tolerance by a single administration of flumazenil.
Topics: Alcoholism; Animals; Ataxia; Behavior, Animal; Brain; Carbolines; Chlorides; Drug Administration Sch | 1991 |
The preferential antagonism of pentylenetetrazole proconflict responses differentiates a class of anxiolytic benzodiazepines with potential antipanic action.
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Ataxia; Behavior, Animal; Conflict, Psychological; | 1991 |
Flumazenil (Ro15-1788) does not affect ethanol tolerance and dependence.
Topics: Animals; Ataxia; Behavior, Animal; Body Temperature; Diet; Drug Tolerance; Ethanol; Flumazenil; Hand | 1991 |
CGS 8216: agonist and diazepam-antagonist effects in rodents.
Topics: Animals; Ataxia; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Fl | 1986 |
[Congenital type I antithrombin III deficiency with serious complications in a 7-year-old girl].
Topics: Acenocoumarol; Antithrombin III Deficiency; Ataxia; Blood Coagulation Disorders; Child; Epilepsies, | 1989 |