flumazenil has been researched along with Apoplexy in 14 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Multitracer micro-PET of ET1 focal ischemia in rats was performed using [11C]-flumazenil ([11C]FMZ) as a flow- and viability tracer and [18F]-fluoromisonidazole ([18F]FMISO) as hypoxia marker in order to characterize the physiological time-course of this model." | 7.83 | Which Aspects of Stroke Do Animal Models Capture? A Multitracer Micro-PET Study of Focal Ischemia with Endothelin-1. ( Bedell, B; Dancause, N; Dea, M; Funck, T; Heiss, WD; Kostikov, A; Quessy, S; Schirrmacher, R; Thiel, A, 2016) |
| "Central benzodiazepine receptor ligands, such as [(11)C]flumazenil (FMZ), are markers of neuronal integrity and therefore might be useful in the differentiation of functionally and morphologically damaged tissue early in ischemic stroke." | 7.70 | Early [(11)C]Flumazenil/H(2)O positron emission tomography predicts irreversible ischemic cortical damage in stroke patients receiving acute thrombolytic therapy. ( Bauer, B; Grond, M; Heiss, WD; Kracht, L; Pawlik, G; Rudolf, J; Wienhard, K, 2000) |
| "Multitracer micro-PET of ET1 focal ischemia in rats was performed using [11C]-flumazenil ([11C]FMZ) as a flow- and viability tracer and [18F]-fluoromisonidazole ([18F]FMISO) as hypoxia marker in order to characterize the physiological time-course of this model." | 3.83 | Which Aspects of Stroke Do Animal Models Capture? A Multitracer Micro-PET Study of Focal Ischemia with Endothelin-1. ( Bedell, B; Dancause, N; Dea, M; Funck, T; Heiss, WD; Kostikov, A; Quessy, S; Schirrmacher, R; Thiel, A, 2016) |
| "To establish the mechanism of neuroplasticity during the recovery phase following ischemic stroke by assessing the changes in cerebral GABA activity using [(18)F]flumazenil ([(18)F]FMZ) positron emission tomography (PET)." | 3.80 | Functional Recovery After Ischemic Stroke Is Associated With Reduced GABAergic Inhibition in the Cerebral Cortex: A GABA PET Study. ( Cho, K; Kim, YK; Lim, JY; Paik, NJ; Yang, EJ, 2014) |
| "Central benzodiazepine receptor ligands, such as [(11)C]flumazenil (FMZ), are markers of neuronal integrity and therefore might be useful in the differentiation of functionally and morphologically damaged tissue early in ischemic stroke." | 3.70 | Early [(11)C]Flumazenil/H(2)O positron emission tomography predicts irreversible ischemic cortical damage in stroke patients receiving acute thrombolytic therapy. ( Bauer, B; Grond, M; Heiss, WD; Kracht, L; Pawlik, G; Rudolf, J; Wienhard, K, 2000) |
| "Ischemic stroke is caused by interruption or significant impairment of blood supply to the brain, which leads to a cascade of metabolic and molecular alterations resulting in functional disturbance and morphologic damage." | 2.50 | Radionuclide imaging in ischemic stroke. ( Heiss, WD, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (57.14) | 29.6817 |
| 2010's | 6 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Taguchi, Y | 1 |
| Takashima, S | 1 |
| Noguchi, K | 1 |
| Tanaka, K | 1 |
| Kim, YK | 1 |
| Yang, EJ | 1 |
| Cho, K | 1 |
| Lim, JY | 1 |
| Paik, NJ | 1 |
| Heiss, WD | 7 |
| Schirrmacher, R | 1 |
| Dea, M | 1 |
| Kostikov, A | 1 |
| Funck, T | 1 |
| Quessy, S | 1 |
| Bedell, B | 1 |
| Dancause, N | 1 |
| Thiel, A | 2 |
| Sobesky, J | 2 |
| Molinaro, P | 1 |
| Cantile, M | 1 |
| Cuomo, O | 1 |
| Secondo, A | 1 |
| Pannaccione, A | 1 |
| Ambrosino, P | 1 |
| Pignataro, G | 1 |
| Fiorino, F | 1 |
| Severino, B | 1 |
| Gatta, E | 1 |
| Sisalli, MJ | 1 |
| Milanese, M | 1 |
| Scorziello, A | 1 |
| Bonanno, G | 1 |
| Robello, M | 1 |
| Santagada, V | 1 |
| Caliendo, G | 1 |
| Di Renzo, G | 1 |
| Annunziato, L | 1 |
| Müller, V | 1 |
| Saur, D | 2 |
| Klutmann, S | 1 |
| Weiller, C | 2 |
| Röther, J | 2 |
| Clausen, M | 1 |
| Dohmen, C | 1 |
| Kracht, L | 2 |
| Bosche, B | 1 |
| Staub, F | 1 |
| Toyota, S | 1 |
| Valentino, M | 1 |
| Graf, R | 1 |
| Yamauchi, H | 1 |
| Kudoh, T | 1 |
| Kishibe, Y | 1 |
| Iwasaki, J | 1 |
| Kagawa, S | 1 |
| Buchert, R | 1 |
| Knab, R | 1 |
| Grond, M | 2 |
| Rudolf, J | 1 |
| Bauer, B | 1 |
| Wienhard, K | 1 |
| Pawlik, G | 2 |
| Kracht, LW | 1 |
| Buylaert, WA | 1 |
4 reviews available for flumazenil and Apoplexy
| Article | Year |
|---|---|
PET imaging in ischemic cerebrovascular disease: current status and future directions.
Topics: Brain Ischemia; Flumazenil; Humans; Microglia; Positron-Emission Tomography; Stroke | 2014 |
Radionuclide imaging in ischemic stroke.
Topics: Animals; Brain; Brain Ischemia; Carbon Radioisotopes; Cerebrovascular Disorders; Flumazenil; Humans; | 2014 |
Comparison of PET and DW/PW-MRI in acute ischemic stroke.
Topics: Brain; Brain Ischemia; Carbon Radioisotopes; Diagnostic Imaging; Diffusion Magnetic Resonance Imagin | 2008 |
Coma induced by intoxication.
Topics: Accidental Falls; Alcohol-Induced Disorders, Nervous System; Alcoholic Intoxication; Antidotes; Brai | 2000 |
2 trials available for flumazenil and Apoplexy
| Article | Year |
|---|---|
Experience with 123I-iomazenil SPECT in acute cerebral infarction.
Topics: Adult; Aged; Aged, 80 and over; Cerebral Infarction; Data Interpretation, Statistical; Female; Fluma | 2002 |
Penumbral probability thresholds of cortical flumazenil binding and blood flow predicting tissue outcome in patients with cerebral ischaemia.
Topics: Aged; Blood Flow Velocity; Brain Ischemia; Cerebral Cortex; Cerebrovascular Circulation; Disease Pro | 2001 |
8 other studies available for flumazenil and Apoplexy
| Article | Year |
|---|---|
Findings of 123I-iomazenil SPECT during and after stroke-like episodes in a patient with MELAS.
Topics: Adult; Female; Flumazenil; Humans; Iodine Radioisotopes; MELAS Syndrome; Stroke; Tomography, Emissio | 2014 |
Functional Recovery After Ischemic Stroke Is Associated With Reduced GABAergic Inhibition in the Cerebral Cortex: A GABA PET Study.
Topics: Aged; Brain Ischemia; Cerebellum; Cerebral Cortex; Female; Flumazenil; Fluorine Radioisotopes; Follo | 2014 |
Which Aspects of Stroke Do Animal Models Capture? A Multitracer Micro-PET Study of Focal Ischemia with Endothelin-1.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Endothelin-1; Flumazenil; Infarction, M | 2016 |
Neurounina-1, a novel compound that increases Na+/Ca2+ exchanger activity, effectively protects against stroke damage.
Topics: Animals; Benzodiazepinones; Calcium; Cell Death; Cells, Cultured; Cricetinae; Dogs; Flumazenil; GABA | 2013 |
Identification of malignant brain edema after hemispheric stroke by PET-imaging and microdialysis.
Topics: Amino Acids; Animals; Brain Edema; Cats; Cerebral Infarction; Cerebrovascular Circulation; Flumazeni | 2003 |
Selective neuronal damage and borderzone infarction in carotid artery occlusive disease: a 11C-flumazenil PET study.
Topics: Arterial Occlusive Diseases; Carotid Artery Diseases; Cerebellum; Cerebral Cortex; Flumazenil; GABA | 2005 |
Iomazenil-single-photon emission computed tomography reveals selective neuronal loss in magnetic resonance-defined mismatch areas.
Topics: Adult; Aged; Cell Count; Cerebral Infarction; Female; Flumazenil; Follow-Up Studies; Humans; Magneti | 2006 |
Early [(11)C]Flumazenil/H(2)O positron emission tomography predicts irreversible ischemic cortical damage in stroke patients receiving acute thrombolytic therapy.
Topics: Aged; Cerebral Cortex; Female; Fibrinolytic Agents; Flumazenil; Humans; Male; Middle Aged; Predictiv | 2000 |