flumazenil has been researched along with Anxiety in 184 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We suggest that the partial return of symptoms in response to flumazenil reflects a vulnerability to RTD in this group of panic disorder patients who had responded to treatment with CBT." | 9.15 | Rapid tryptophan depletion following cognitive behavioural therapy for panic disorder. ( Adrover, M; Argyropoulos, S; Bell, C; Frampton, C; Hince, D; Hood, S; Nash, J; Nutt, D; Potokar, J; Rich, A, 2011) |
| "Flumazenil treatment of the amygdala during the first 2 withdrawals blocked the development of sensitized anxiety seen during a third withdrawal." | 7.74 | The amygdala regulates the antianxiety sensitization effect of flumazenil during repeated chronic ethanol or repeated stress. ( Angel, RA; Breese, GR; Knapp, DJ; Navarro, M; Overstreet, DH, 2007) |
| " In the present study, we investigated the possible involvement of GABAergic modulation in the protective effect of allopregnanolone on sleep deprivation-induced anxiety-like behavior and oxidative damage in mice." | 7.74 | Possible GABAergic modulation in the protective effect of allopregnanolone on sleep deprivation-induced anxiety-like behavior and oxidative damage in mice. ( Kumar, A; Singh, A, 2008) |
| "The possible involvement of anxiety and learning/memory processes in escape-directed (struggling) behavior in a two-trial swimming test was investigated in mice, as well as the differential effects that low doses of flumazenil (a benzodiazepine receptor antagonist) could display depending on the animals' anxiety levels." | 7.69 | Struggling and flumazenil effects in the swimming test are related to the level of anxiety in mice. ( Escorihuela, RM; Fernández Teruel, A; Ferré, P; García, E; Tobeña, A; Zapata, A, 1994) |
| "The mechanism underlying the previous findings that the development of antinociceptive tolerance to morphine was significantly delayed in the presence of inflammatory pain induced by formalin was examined." | 7.69 | Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice. ( Kaneto, H; Rahman, AF; Takahashi, M, 1994) |
| "The profile of action of ondansetron was assessed in a novel animal model of anxiety." | 7.69 | Antianxiety profile of ondansetron, a selective 5-HT3 antagonist, in a novel animal model. ( Kulkarni, SK; Roychoudhury, M, 1997) |
| "The brain regions that may be functionally involved in the control of anxiety and the development of seizures were examined using quantitative 1-14C-deoxyglucose autoradiography." | 7.67 | Changes in local cerebral glucose utilization induced by the beta-carbolines FG 7142 and DMCM reveal brain structures involved in the control of anxiety and seizure activity. ( Ableitner, A; Herz, A, 1987) |
| "The effects of the beta-carboline ZK 93426, a putative benzodiazepine receptor antagonist, were investigated in the social interaction test of anxiety and in the holeboard." | 7.67 | Actions of the beta-carboline ZK 93426 in an animal test of anxiety and the holeboard: interactions with Ro 15-1788. ( File, SE; Jensen, LH; Pellow, S, 1986) |
| "We suggest that the partial return of symptoms in response to flumazenil reflects a vulnerability to RTD in this group of panic disorder patients who had responded to treatment with CBT." | 5.15 | Rapid tryptophan depletion following cognitive behavioural therapy for panic disorder. ( Adrover, M; Argyropoulos, S; Bell, C; Frampton, C; Hince, D; Hood, S; Nash, J; Nutt, D; Potokar, J; Rich, A, 2011) |
| "The benzodiazepine antagonist, flumazenil, can provoke panic attacks in some panic disorder patients." | 5.09 | Flumazenil challenge in social phobia. ( Bell, C; Coupland, NJ; Dorkins, E; Nutt, DJ; Potokar, JP, 2000) |
| "This study was designed to test whether or not flumazenil (1 mg IV) would change levels of anxiety induced by simulation of public speaking (PSS)." | 5.07 | Flumazenil has an anxiolytic effect in simulated stress. ( Curran, HV; Gray, J; Kapczinski, F; Lader, M, 1994) |
| "The goal of this study was to assess the degree of postoperative anxiety flumazenil might provide in patients when used to reverse the sedation induced by midazolam." | 5.06 | [Does flumazenil, a benzodiazepine antagonist used during the anesthesia recovery period, have an anxiogenic effect?]. ( Beauvoir, C; du Cailar, J; Pares-Herbute, N; Peschaud, JL, 1989) |
| "Benzodiazepine withdrawal, spontaneous or precipitated by the receptor antagonist, flumazenil, produces anxiety that can be measured in animal models." | 4.78 | The benzodiazepines: anxiolytic and withdrawal effects. ( Little, HJ, 1991) |
| "Rutin is a bioflavonoid found in medicinal plants used to reduce anxiety." | 3.85 | The anxiolytic-like effect of rutin in rats involves GABAA receptors in the basolateral amygdala. ( Fernández-Guasti, A; González-Trujano, ME; Hernandez-Leon, A, 2017) |
| "The present study investigated the anxiolytic-like effects of spinosin, one of the major flavonoids in Ziziphi Spinosae Semen (ZSS), in experimental models of anxiety compared with a known anxiolytic, diazepam." | 3.81 | GABA and 5-HT systems are implicated in the anxiolytic-like effect of spinosin in mice. ( Fang, N; Guo, JY; Li, J; Liu, GL; Liu, J; Liu, QT; Shi, JL; Yang, YX; Zhai, WM, 2015) |
| "The effects of annomontine, a pyrimidine- β-carboline alkaloid isolated from the root of ANNONA PURPUREA, on anxiety was studied in mice using the elevated plus-maze." | 3.77 | Annomontine, an alkaloid isolated from Annona purpurea, has anxiolytic-like effects in the elevated plus-maze. ( Cortes, D; de la Mora, MP; González-Esquinca, AR; Rejón-Orantes, Jdel C; Roldan Roldan, G, 2011) |
| "We re-investigated a 53 year old woman with SPS and profound anxiety for GABA-A receptor binding in the amygdala with (11)C-flumazenil PET scan and studied the potential pathogenic role of purified IgG from her plasma filtrates containing high-titer antibodies against GAD 65." | 3.77 | Human stiff-person syndrome IgG induces anxious behavior in rats. ( Dirkx, R; Folli, F; Geis, C; Gerlach, M; Grünewald, B; Heckmann, M; Perani, D; Reif, A; Solimena, M; Sommer, C; Toyka, KV; Weishaupt, A; Wultsch, T, 2011) |
| "Flumazenil treatment of the amygdala during the first 2 withdrawals blocked the development of sensitized anxiety seen during a third withdrawal." | 3.74 | The amygdala regulates the antianxiety sensitization effect of flumazenil during repeated chronic ethanol or repeated stress. ( Angel, RA; Breese, GR; Knapp, DJ; Navarro, M; Overstreet, DH, 2007) |
| " We hypothesized that chrysin decreases anxiety via interaction with the GABA(A) receptor in laboratory rats as measured by elevated plus-maze (EPM), corticosterone, and catecholamine assays." | 3.74 | Evaluation of the anxiolytic effects of chrysin, a Passiflora incarnata extract, in the laboratory rat. ( Brown, E'; Ceremuga, TE; Hurd, NS; McCall, S, 2007) |
| " In the present study, we investigated the possible involvement of GABAergic modulation in the protective effect of allopregnanolone on sleep deprivation-induced anxiety-like behavior and oxidative damage in mice." | 3.74 | Possible GABAergic modulation in the protective effect of allopregnanolone on sleep deprivation-induced anxiety-like behavior and oxidative damage in mice. ( Kumar, A; Singh, A, 2008) |
| "Pretreatment with R121919 attenuated the subsequent HPA axis activation, behavioral measures of anxiety, and expression of the CRF gene in the paraventricular nucleus of the hypothalamus, as measured by CRF heteronuclear RNA, which occurs after flumazenil-precipitation of withdrawal from the BZ, lorazepam." | 3.74 | The CRF1 receptor antagonist R121919 attenuates the neuroendocrine and behavioral effects of precipitated lorazepam withdrawal. ( Gutman, DA; Nemeroff, CB; Owens, MJ; Skelton, KH; Thrivikraman, KV, 2007) |
| "This study was aimed at investigating the action of the benzodiazepine receptor antagonist flumazenil, compared to that of the benzodiazepine receptor full agonist chlordiazepoxide, in an animal model of generalised anxiety disorder (the BALB/c mouse)." | 3.70 | Flumazenil induces benzodiazepine partial agonist-like effects in BALB/c but not C57BL/6 mice. ( Belzung, C; Crestani, F; Le Guisquet, AM, 2000) |
| "The neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one (allopregnanolone) was administered systemically to rats which were tested in the Geller-Seifter conflict paradigm, an established animal model of anxiety." | 3.69 | The anxiolytic-like effects of the neurosteroid allopregnanolone: interactions with GABA(A) receptors. ( Akwa, Y; Britton, KT; Brot, MD; Koob, GF; Purdy, RH, 1997) |
| "Microinfusions of the benzodiazepine anxiolytic midazolam into the central or basolateral amygdaloid nuclei produced different anxiolytic effects in two tests of rat 'anxiety'." | 3.69 | The central and basolateral amygdala differentially mediate the anxiolytic effects of benzodiazepines. ( Pesold, C; Treit, D, 1995) |
| "Microinfusions of a benzodiazepine anxiolytic (midazolam) into the septum or the amygdala suppressed different fear reactions in two tests of rat "anxiety"." | 3.69 | The septum and amygdala differentially mediate the anxiolytic effects of benzodiazepines. ( Pesold, C; Treit, D, 1994) |
| "The mechanism underlying the previous findings that the development of antinociceptive tolerance to morphine was significantly delayed in the presence of inflammatory pain induced by formalin was examined." | 3.69 | Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice. ( Kaneto, H; Rahman, AF; Takahashi, M, 1994) |
| "The profile of action of ondansetron was assessed in a novel animal model of anxiety." | 3.69 | Antianxiety profile of ondansetron, a selective 5-HT3 antagonist, in a novel animal model. ( Kulkarni, SK; Roychoudhury, M, 1997) |
| "In order to investigate the role of the dorsal periaqueductal grey (DPAG) area in the anxiolytic effect of benzodiazepines male Wistar rats (N = 10), weighing 200-250 g at the time of surgery, were microinjected into this structure with midazolam (80 nmol) and submitted to the elevated plus-maze, an ethologically based model of anxiety." | 3.68 | Anxiolytic effect of midazolam microinjected into the dorsal periaqueductal grey area of rats. ( De Aguiar, JC; Graeff, FG; Guimarães, FS; Russo, AS, 1991) |
| " In BDZ-dependent animals the BDZ-receptor antagonist flumazenil (Ro 15-1788) reverses the increased anxiety and decreased seizure threshold seen when benzodiazepine treatment is withdrawn." | 3.68 | A theory of benzodiazepine dependence that can explain whether flumazenil will enhance or reverse the phenomena. ( File, SE; Hitchcott, PK, 1990) |
| " Acute administration of chlordiazepoxide (5 or 10 mg/kg) did not reverse the anxiogenic effects of Ro 15-1788; however, in animals pretreated with chlordiazepoxide (5 mg/kg) for 5 days prior to testing, there was a reduction in the anxiety produced by Ro 15-1788." | 3.67 | The anxiogenic action of Ro 15-1788 is reversed by chronic, but not by acute, treatment with chlordiazepoxide. ( File, SE; Pellow, S, 1984) |
| "The purpose of this study was to determine the mechanism by which caffeine increases anxiety." | 3.67 | Caffeine-induced anxiogenesis: the role of adenosine, benzodiazepine and noradrenergic receptors. ( Baldwin, HA; File, SE, 1989) |
| "The effects of FG 7142, CGS 8216 and Ro 15-1788, three compounds that are believed to produce anxiety by an action at benzodiazepine receptors in the CNS, are investigated on the plasma corticosterone concentrations in the rat both in the home cage and after exposure to novelty stress." | 3.67 | The effects of putative anxiogenic compounds (FG 7142, CGS 8216 and Ro 15-1788) on the rat corticosterone response. ( File, SE; Pellow, S, 1985) |
| "The effects of the beta-carboline ZK 93426, a putative benzodiazepine receptor antagonist, were investigated in the social interaction test of anxiety and in the holeboard." | 3.67 | Actions of the beta-carboline ZK 93426 in an animal test of anxiety and the holeboard: interactions with Ro 15-1788. ( File, SE; Jensen, LH; Pellow, S, 1986) |
| "The brain regions that may be functionally involved in the control of anxiety and the development of seizures were examined using quantitative 1-14C-deoxyglucose autoradiography." | 3.67 | Changes in local cerebral glucose utilization induced by the beta-carbolines FG 7142 and DMCM reveal brain structures involved in the control of anxiety and seizure activity. ( Ableitner, A; Herz, A, 1987) |
| "It then appeared to ameliorate withdrawal symptoms, quite markedly in 2 patients." | 2.67 | Flumazenil in alcohol withdrawal. ( Bailey, J; Coupland, N; Glue, P; Groves, S; Nutt, D; Wilson, S, 1993) |
| "Depression was noted especially in the FNZ group after both injections of Ro 15-1788." | 2.66 | [Benzodiazepine antagonism by RO 15-1788: psychometric, hormonal and biophysical parameters]. ( Dorow, R; Duka, T; Noderer, J, 1988) |
| "The present work aims to investigate the anxiolytic activity of 6-styryl-2-pyrone (STY), obtained from Aniba panurensis, in behavioral tests and amino acids dosage on male Swiss mice." | 1.48 | The anxiolytic-like effect of 6-styryl-2-pyrone in mice involves GABAergic mechanism of action. ( Barbosa-Filho, JM; Chaves, EMC; Dantas, LP; Honório-Júnior, JER; Lúcio, ASSC; Monteiro, VS; Nonato, DTT; Patrocínio, MCA; Sousa, CNS; Vasconcelos, SMM; Viana, GSB, 2018) |
| "Patients with PTSD have a changed sensitivity to GABA-A receptor active substances." | 1.43 | Women with PTSD have a changed sensitivity to GABA-A receptor active substances. ( Bäckström, T; Helström, L; Möller, AT; Nyberg, S; Söndergaard, HP, 2016) |
| "The data suggest that the anxiolytic-like activity observed in the light/dark box procedure after acute (5 mg/kg) or 14-day repeated (1 mg/kg/day) dosing was mediated by the serotonergic system (5-HT(1A) receptors)." | 1.39 | Citrus aurantium L. essential oil exhibits anxiolytic-like activity mediated by 5-HT(1A)-receptors and reduces cholesterol after repeated oral treatment. ( Cassettari, BO; Costa, CA; Costa, M; Cury, TC; Flório, JC; Takahira, RK, 2013) |
| "Ellagic acid is a naturally occurring flavonoid compound which is abundant in many plants and fruits." | 1.39 | Involvement of the GABAergic system in the anxiolytic-like effect of the flavonoid ellagic acid in mice. ( Arya, J; Balakrishnan, S; Girish, C; Raj, V, 2013) |
| "Flumazenil acts as a benzodiazepine receptor antagonist (subunits α1, α2, α3, and α5) or partial agonist (subunits α4 and α6)." | 1.39 | Endogenous ligands of benzodiazepine binding site have inverse agonistic properties. ( Hess, L; Malek, J; Sliva, J; Votava, M, 2013) |
| " The LD50 obtained for the acute toxicity studies using intraperitoneal route of administration was 4." | 1.38 | Evaluation of acute toxicity of a natural compound (+)-limonene epoxide and its anxiolytic-like action. ( Costa, JP; de Almeida, AA; de Carvalho, RB; de Freitas, RM; de Sousa, DP, 2012) |
| "When myristicin was combined with midazolam, an antagonist-like effect similar to the flumazenil and myristicin combination was exhibited by a decrease in anxiolysis compared with the midazolam-only group." | 1.37 | Evaluation of the anxiolytic properties of myristicin, a component of nutmeg, in the male Sprague-Dawley rat. ( Ceremuga, TE; Godwin, S; Hitchcock, G; Johnson, M; Jones, W; Leiter, E; McCall, S; Sedgwick, W, 2011) |
| "Treatment with melatonin (5 and 10 mg/kg, ip) significantly improved locomotor activity, weight loss and antianxiety effect as compared to control (sleep deprived)." | 1.37 | Possible involvement of GABAergic mechanism in protective effect of melatonin against sleep deprivation-induced behavior modification and oxidative damage in mice. ( Kumar, A; Kumar, P; Singh, A, 2011) |
| "Luteolin is a major component of the essential oil lemon balm." | 1.35 | Investigation of the anxiolytic effects of luteolin, a lemon balm flavonoid in the male Sprague-Dawley rat. ( Ceremuga, TE; Duncan, R; Jones, P; McCall, S; Moe, N; Raines, T, 2009) |
| " MRK-016 gave good receptor occupancy after oral dosing in rats, with the dose required to produce 50% occupancy being 0." | 1.35 | In vitro and in vivo properties of 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA receptor alpha5 subtype-selective inverse agonist. ( Agrawal, NG; Atack, JR; Burns, HD; Chambers, MS; Dawson, GR; Eng, WS; Evans, DC; Gibson, RE; Gingrich, K; Hargreaves, RJ; Hostetler, E; Krause, S; MacLeod, AM; Maubach, KA; McKernan, RM; Murphy, MG; Musson, DG; O'Connor, D; Petty, KJ; Rodrigues, AD; Ryan, C; Sanabria, SM; Tattersall, FD; Wafford, KA, 2009) |
| "Linalool is a major component of the essential oil of lavender." | 1.35 | Investigation of the anxiolytic effects of linalool, a lavender extract, in the male Sprague-Dawley rat. ( Bracken, S; Ceremuga, TE; Cline, M; Flores, J; McCall, S; Taylor, JE, 2008) |
| "Treatment with melatonin (5 mg/kg and 10 mg/kg, ip) significantly improved locomotor activity, weight loss and antianxiety effect as compared with control (sleep-deprived)." | 1.35 | Possible involvement of GABAergic mechanism in protective effect of melatonin against sleep deprivation-induced behaviour modification and oxidative damage in mice. ( Kumar, A; Singh, A, 2009) |
| "Kava has been used for centuries by Pacific Islanders for its tranquilizing and sedative effects." | 1.32 | Extracts of kava (Piper methysticum) induce acute anxiolytic-like behavioral changes in mice. ( Basmadjian, G; Garrett, KM; Khan, IA; Schaneberg, BT; Seale, TW, 2003) |
| "Withdrawal from the neurosteroid 3alpha,5alpha-allopregnanolone after chronic administration of progesterone increases anxiety in female rats and up-regulates the alpha4 subunit of the GABA(A) receptor (GABA(A)-R) in the hippocampus." | 1.31 | Progesterone withdrawal increases the alpha4 subunit of the GABA(A) receptor in male rats in association with anxiety and altered pharmacology - a comparison with female rats. ( Gong, QH; Gulinello, M; Smith, SS, 2002) |
| "Flumazenil reversed the increase in defensiveness produced by FG-7142 in a drug-dependent manner as described in Adamec (1998a)." | 1.30 | Evidence that NMDA-dependent limbic neural plasticity in the right hemisphere mediates pharmacological stressor (FG-7142)-induced lasting increases in anxiety-like behavior: study 3--the effects on amygdala efferent physiology of block of NMDA receptors p ( Adamec, RE, 1998) |
| " To determine whether there are parallel or divergent rates of elimination of the two drugs between individuals, the pharmacokinetic profiles of midazolam and flumazenil were studied simultaneously in 12 adult male volunteers." | 1.29 | Midazolam and flumazenil pharmacokinetics and pharmacodynamics following simultaneous administration to human volunteers. ( Gin, T; Oh, TE; Short, TG; Tam, YH; Tan, P; Young, KK, 1994) |
| " Compared to behavior of vehicle-pretreated, room air-exposed rats, rat pairs exposed to nitrous oxide showed a generally inverted U-shaped dose-response curve with the maximum increase in social interaction encounters occurring at 25% and significant increase in time of active social interaction at 15-35%; higher concentrations produced a sedative effect that reduced social interaction." | 1.29 | Benzodiazepine receptor-mediated behavioral effects of nitrous oxide in the rat social interaction test. ( Curtis, BA; Czech, DA; Hodges, BL; Maillefer, RH; Quock, RM; Wetzel, PJ, 1993) |
| " These results indicate that distinct and contrasting dose-response profiles exist for these classical and atypical drugs in an animal model of anxiety based on electric shock." | 1.29 | Differential profile of the CCKB receptor antagonist CI-988 and diazepam in the four-plate test. ( Dooley, DJ; Klamt, I, 1993) |
| "Pretreatment with diazepam (1." | 1.29 | Effect of diazepam on cortical 5-HT release and behaviour in the guinea-pig on exposure to the elevated plus maze. ( Fink, H; Marsden, CA; Rex, A, 1993) |
| "In this study, the effect of the chronic administration of the benzodiazepine (BZD) receptor ligand FG 7142 on the rat conflict test was examined." | 1.27 | Long-lasting proconflict effect induced by chronic administration of the beta-carboline derivative FG 7142. ( Biggio, G; Corda, MG; Gatta, F; Giorgi, O, 1985) |
| " When the diazepam and zolpidem dose-response curves were re-established in the presence of a dose of Ro 15-1788 or CGS 8216 the depressant effects of the higher doses were antagonised." | 1.27 | Investigation of the actions of the benzodiazepine antagonists Ro 15-1788 and CGS 8216 using the schedule-controlled behavior of rats. ( Sanger, DJ, 1986) |
| " Then, the effects of clorazepate dosed at 1." | 1.27 | Anxiogenic effects of methyl-beta-carboline-3-carboxylate in a light/dark choice situation. ( Belzung, C; Chapouthier, G; Dodd, RH; Misslin, R; Vogel, E, 1987) |
| " These data suggest that antidepressants acquire anxiolytic properties following chronic administration and that this effect appears to be independent of the benzodiazepine receptor system." | 1.27 | The effects of chronic antidepressant treatment in an animal model of anxiety. ( Aitken, DH; Bodnoff, SR; Meaney, MJ; Quirion, R; Suranyi-Cadotte, B, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 46 (25.00) | 18.7374 |
| 1990's | 61 (33.15) | 18.2507 |
| 2000's | 45 (24.46) | 29.6817 |
| 2010's | 28 (15.22) | 24.3611 |
| 2020's | 4 (2.17) | 2.80 |
| Authors | Studies |
|---|---|
| Guerrini, G | 2 |
| Ciciani, G | 2 |
| Cambi, G | 1 |
| Bruni, F | 2 |
| Selleri, S | 2 |
| Melani, F | 1 |
| Montali, M | 1 |
| Martini, C | 2 |
| Ghelardini, C | 1 |
| Norcini, M | 1 |
| Costanzo, A | 2 |
| Hajizadeh Moghaddam, A | 1 |
| Mashayekhpour, MA | 1 |
| Tabari, MA | 1 |
| Islam, MS | 1 |
| Hossain, R | 1 |
| Ahmed, T | 1 |
| Rahaman, MM | 1 |
| Al-Khafaji, K | 1 |
| Khan, RA | 1 |
| Sarkar, C | 1 |
| Bappi, MH | 1 |
| de Andrade, EM | 1 |
| Araújo, IM | 1 |
| Coutinho, HDM | 1 |
| Kowalska, G | 1 |
| Kowalski, R | 1 |
| Hanif, MA | 1 |
| Islam, MT | 1 |
| Mendes Hacke, AC | 1 |
| Miyoshi, E | 1 |
| Marques, JA | 1 |
| Pereira, RP | 1 |
| Matsumoto, D | 1 |
| Ushio, S | 1 |
| Wada, Y | 1 |
| Noda, Y | 1 |
| Esumi, S | 1 |
| Izushi, Y | 1 |
| Kitamura, Y | 1 |
| Sendo, T | 1 |
| Chaves, EMC | 1 |
| Honório-Júnior, JER | 1 |
| Sousa, CNS | 1 |
| Monteiro, VS | 1 |
| Nonato, DTT | 1 |
| Dantas, LP | 1 |
| Lúcio, ASSC | 1 |
| Barbosa-Filho, JM | 1 |
| Patrocínio, MCA | 1 |
| Viana, GSB | 1 |
| Vasconcelos, SMM | 1 |
| Bernik, M | 1 |
| Ramos, RT | 1 |
| Hetem, LAB | 1 |
| Graeff, F | 1 |
| Merali, Z | 2 |
| Cayer, C | 2 |
| Kent, P | 1 |
| Liu, R | 1 |
| Cal, V | 1 |
| Harris, CS | 1 |
| Arnason, JT | 2 |
| Shen, ZC | 1 |
| Wu, PF | 1 |
| Wang, F | 1 |
| Xia, ZX | 1 |
| Deng, Q | 1 |
| Nie, TL | 1 |
| Zhang, SQ | 1 |
| Zheng, HL | 1 |
| Liu, WH | 1 |
| Lu, JJ | 1 |
| Gao, SQ | 1 |
| Yao, XP | 1 |
| Long, LH | 1 |
| Hu, ZL | 1 |
| Chen, JG | 1 |
| Kumar, D | 2 |
| Gupta, SK | 1 |
| Ganeshpurkar, A | 1 |
| Singh, R | 1 |
| Das, N | 1 |
| Krishnamurthy, S | 1 |
| Singh, SK | 1 |
| Costa, CA | 2 |
| Cury, TC | 1 |
| Cassettari, BO | 1 |
| Takahira, RK | 1 |
| Flório, JC | 2 |
| Costa, M | 2 |
| Girish, C | 1 |
| Raj, V | 1 |
| Arya, J | 1 |
| Balakrishnan, S | 1 |
| Oyemitan, IA | 1 |
| Elusiyan, CA | 1 |
| Akanmu, MA | 1 |
| Olugbade, TA | 1 |
| Sliva, J | 1 |
| Hess, L | 1 |
| Votava, M | 1 |
| Malek, J | 1 |
| de Almeida, AA | 2 |
| de Carvalho, RB | 2 |
| Silva, OA | 1 |
| de Sousa, DP | 2 |
| de Freitas, RM | 2 |
| Mullally, M | 1 |
| Kramp, K | 1 |
| Otárola Rojas, M | 1 |
| Sanchez Vindas, P | 1 |
| Garcia, M | 1 |
| Poveda Alvarez, L | 1 |
| Durst, T | 1 |
| Trudeau, VL | 1 |
| Möller, AT | 1 |
| Bäckström, T | 1 |
| Nyberg, S | 1 |
| Söndergaard, HP | 1 |
| Helström, L | 1 |
| Liu, J | 1 |
| Zhai, WM | 1 |
| Yang, YX | 1 |
| Shi, JL | 2 |
| Liu, QT | 1 |
| Liu, GL | 1 |
| Fang, N | 1 |
| Li, J | 1 |
| Guo, JY | 2 |
| Ceremuga, TE | 5 |
| Valdivieso, D | 1 |
| Kenner, C | 1 |
| Lucia, A | 1 |
| Lathrop, K | 1 |
| Stailey, O | 1 |
| Bailey, H | 1 |
| Criss, J | 1 |
| Linton, J | 1 |
| Fried, J | 1 |
| Taylor, A | 1 |
| Padron, G | 1 |
| Johnson, AD | 1 |
| Hernandez-Leon, A | 1 |
| González-Trujano, ME | 1 |
| Fernández-Guasti, A | 5 |
| dos Reis, LM | 1 |
| Canto-de-Souza, A | 2 |
| Wills, TA | 2 |
| Knapp, DJ | 9 |
| Overstreet, DH | 8 |
| Breese, GR | 9 |
| Singh, A | 3 |
| Kumar, A | 3 |
| Raines, T | 1 |
| Jones, P | 1 |
| Moe, N | 1 |
| Duncan, R | 1 |
| McCall, S | 4 |
| Kim, TW | 1 |
| Choi, HJ | 1 |
| Kim, NJ | 1 |
| Kim, DH | 1 |
| Barbalho, CA | 1 |
| Nunes-de-Souza, RL | 1 |
| Grundmann, O | 2 |
| Nakajima, J | 2 |
| Kamata, K | 1 |
| Seo, S | 2 |
| Butterweck, V | 2 |
| Evenden, J | 1 |
| Ross, L | 1 |
| Jonak, G | 1 |
| Zhou, J | 1 |
| Stachowicz, K | 2 |
| Kłodzińska, A | 1 |
| Palucha-Poniewiera, A | 1 |
| Schann, S | 1 |
| Neuville, P | 1 |
| Pilc, A | 2 |
| Esterlis, I | 1 |
| Cosgrove, KP | 1 |
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| Perry, E | 1 |
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| Dawson, GR | 2 |
| Musson, DG | 1 |
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| Roldan Roldan, G | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Safety, Tolerability and Behavioural Effects of Souroubea-Platanus in Healthy Volunteers[NCT03904511] | Phase 1 | 45 participants (Actual) | Interventional | 2019-05-15 | Completed | ||
| Combining Animal-assisted Intervention and Placebo-induced Analgesia: The Dog as Treatment in a Randomized Controlled Trial[NCT04361968] | 128 participants (Actual) | Interventional | 2020-06-15 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for flumazenil and Anxiety
| Article | Year |
|---|---|
Multiple sites of action for anxiogenic drugs: behavioural, electrophysiological and biochemical correlations.
Topics: Action Potentials; Animals; Anxiety; Behavior, Animal; Benzodiazepinones; Binding Sites; Brain Chemi | 1984 |
Reversal of conscious sedation by flumazenil: current status and future prospects.
Topics: Anxiety; Benzodiazepines; Conscious Sedation; Flumazenil; GABA Modulators; Humans; Hypnotics and Sed | 1995 |
Naturally occurring benzodiazepines: current status of research and clinical implications.
Topics: Animals; Anxiety; Benzodiazepines; Brain; Chromatography, High Pressure Liquid; Epilepsy; Flumazenil | 2000 |
The benzodiazepines: anxiolytic and withdrawal effects.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Carbolines; Diazepam; Disease Models, Animal; Ethanol; Flumaz | 1991 |
Intrinsic actions of the benzodiazepine receptor antagonist Ro 15-1788.
Topics: Aggression; Animals; Anticonvulsants; Anxiety; Avoidance Learning; Benzodiazepinones; Body Temperatu | 1986 |
Reversal of sedation with flumazenil in regional anaesthesia: a review.
Topics: Aged; Anesthesia, Conduction; Anxiety; Female; Flumazenil; Humans | 1988 |
12 trials available for flumazenil and Anxiety
| Article | Year |
|---|---|
Effect of single doses of pindolol and d-fenfluramine on flumazenil-induced anxiety in panic disorder patients.
Topics: Adult; Anxiety; Female; Fenfluramine; Flumazenil; GABA Modulators; Humans; Male; Middle Aged; Panic | 2019 |
Rapid tryptophan depletion following cognitive behavioural therapy for panic disorder.
Topics: Adult; Anxiety; Cognitive Behavioral Therapy; Cross-Over Studies; Double-Blind Method; Female; Fluma | 2011 |
Probing GABA receptor function in schizophrenia with iomazenil.
Topics: Adult; Analysis of Variance; Anxiety; Brief Psychiatric Rating Scale; Double-Blind Method; Flumazeni | 2011 |
Placebo in emotional processing--induced expectations of anxiety relief activate a generalized modulatory network.
Topics: Adult; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Brain Mapping; Emotions; Female; Flumazenil; H | 2005 |
gamma-Aminobutyric acid-serotonin interactions in healthy men: implications for network models of psychosis and dissociation.
Topics: Analysis of Variance; Anxiety; Cross-Over Studies; Dissociative Disorders; Double-Blind Method; Drug | 2006 |
Differential effects of flumazenil in alcoholic and nonalcoholic cirrhotic patients.
Topics: Adult; Anxiety; Female; Flumazenil; Humans; Liver Cirrhosis; Liver Cirrhosis, Alcoholic; Liver Funct | 1995 |
Flumazenil in alcohol withdrawal.
Topics: Adult; Anxiety; Double-Blind Method; Ethanol; Female; Flumazenil; GABA-A Receptor Antagonists; Human | 1993 |
Flumazenil has an anxiolytic effect in simulated stress.
Topics: Adolescent; Adult; Affect; Anti-Anxiety Agents; Anxiety; Double-Blind Method; Female; Flumazenil; Ga | 1994 |
Flumazenil challenge in social phobia.
Topics: Adult; Anxiety; Benzodiazepines; Blood Pressure; Case-Control Studies; Cross-Over Studies; Double-Bl | 2000 |
[Does flumazenil, a benzodiazepine antagonist used during the anesthesia recovery period, have an anxiogenic effect?].
Topics: Adolescent; Adult; Anesthesia Recovery Period; Anxiety; Epinephrine; Flumazenil; Humans; Midazolam; | 1989 |
Changes in noradrenaline plasma levels and behavioural responses induced by benzodiazepine agonists with the benzodiazepine antagonist Ro 15-1788.
Topics: Adult; Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Blood Pressure; Double-Blind Method; | 1986 |
[Benzodiazepine antagonism by RO 15-1788: psychometric, hormonal and biophysical parameters].
Topics: Adult; Anti-Anxiety Agents; Anxiety; Depression; Flumazenil; Humans; Hydrocortisone; Male; Prolactin | 1988 |
166 other studies available for flumazenil and Anxiety
| Article | Year |
|---|---|
Novel 3-aroylpyrazolo[5,1-c][1,2,4]benzotriazine 5-oxides 8-substituted, ligands at GABAA/benzodiazepine receptor complex: synthesis, pharmacological and molecular modeling studies.
Topics: Animals; Anxiety; Behavior, Animal; Ethanol; Ligands; Male; Memory; Models, Molecular; Molecular Str | 2008 |
Anxiolytic-like effects of citral in the mouse elevated plus maze: involvement of GABAergic and serotonergic transmissions.
Topics: Acyclic Monoterpenes; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Elevated Plus Maze Te | 2023 |
Anxiolytic-like Effect of Quercetin Possibly through GABA Receptor Interaction Pathway: In Vivo and In Silico Studies.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Flumazenil; GABA Modulators; gamm | 2022 |
Anxiolytic properties of Cymbopogon citratus (DC.) stapf extract, essential oil and its constituents in zebrafish (Danio rerio).
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Cymbopogon; Disease Models, Animal; Flumaze | 2020 |
Bumetanide prevents diazepam-modified anxiety-like behavior in lipopolysaccharide-treated mice.
Topics: Animals; Anti-Anxiety Agents; Anti-Bacterial Agents; Anxiety; Behavior, Animal; Bicuculline; Bumetan | 2021 |
The anxiolytic-like effect of 6-styryl-2-pyrone in mice involves GABAergic mechanism of action.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Flumazenil; gamma-Aminobutyric Ac | 2018 |
Sacred Maya incense, copal (Protium copal - Burseraceae), has antianxiety effects in animal models.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Burseraceae; Carrier Proteins; Ceremonial B | 2018 |
Gephyrin Palmitoylation in Basolateral Amygdala Mediates the Anxiolytic Action of Benzodiazepine.
Topics: Acyltransferases; Animals; Anti-Anxiety Agents; Anxiety; Basolateral Nuclear Complex; Benzodiazepine | 2019 |
Biological profiling of piperazinediones for the management of anxiety.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Benzodiazepines; Catalytic Domain | 2019 |
Citrus aurantium L. essential oil exhibits anxiolytic-like activity mediated by 5-HT(1A)-receptors and reduces cholesterol after repeated oral treatment.
Topics: Animals; Anti-Anxiety Agents; Anticholesteremic Agents; Anxiety; Behavior, Animal; Brain; Cholestero | 2013 |
Involvement of the GABAergic system in the anxiolytic-like effect of the flavonoid ellagic acid in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Dose-Response Relationship, Drug; Ellagic Acid; Flumazenil; G | 2013 |
Hypnotic, anticonvulsant and anxiolytic effects of 1-nitro-2-phenylethane isolated from the essential oil of Dennettia tripetala in mice.
Topics: Animals; Annonaceae; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Avoidance Learning; Benzene Deri | 2013 |
Endogenous ligands of benzodiazepine binding site have inverse agonistic properties.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Binding Sites; Flumazenil; GABA-A Receptor A | 2013 |
Potential antioxidant and anxiolytic effects of (+)-limonene epoxide in mice after marble-burying test.
Topics: Animals; Anti-Anxiety Agents; Antioxidants; Anxiety; Catalase; Cyclohexane Monoterpenes; Diazepam; F | 2014 |
Souroubea sympetala (Marcgraviaceae): a medicinal plant that exerts anxiolysis through interaction with the GABAA benzodiazepine receptor.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Flumazenil; GABA Agonists; GABA Antagonists; Male; Phytothera | 2014 |
Women with PTSD have a changed sensitivity to GABA-A receptor active substances.
Topics: Adolescent; Adult; Anxiety; Diagnostic and Statistical Manual of Mental Disorders; Diazepam; Female; | 2016 |
GABA and 5-HT systems are implicated in the anxiolytic-like effect of spinosin in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Drugs, Chinese Herbal; Flavonoids; Flumazen | 2015 |
Evaluation of the anxiolytic and antidepressant effects of asiatic acid, a compound from Gotu kola or Centella asiatica, in the male Sprague Dawley rat.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Centella; Depression; Disease Models, | 2015 |
The anxiolytic-like effect of rutin in rats involves GABAA receptors in the basolateral amygdala.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Basolateral Nuclear Complex; Diazepam; Disease Models, Animal | 2017 |
Intra-periaqueductal gray matter injections of midazolam fail to alter anxiety in plus-maze experienced mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Avoidance Learning; Disease Models, Animal | 2008 |
Sensitization, duration, and pharmacological blockade of anxiety-like behavior following repeated ethanol withdrawal in adolescent and adult rats.
Topics: Aging; Alcohol Drinking; Animals; Anxiety; Buspirone; Central Nervous System Depressants; Ethanol; F | 2009 |
Possible GABAergic modulation in the protective effect of allopregnanolone on sleep deprivation-induced anxiety-like behavior and oxidative damage in mice.
Topics: Animals; Anxiety; Behavior, Animal; Body Weight; Catalase; Dose-Response Relationship, Drug; Flumaze | 2008 |
Investigation of the anxiolytic effects of luteolin, a lemon balm flavonoid in the male Sprague-Dawley rat.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Drug Therapy, Combination; Flumazenil; GABA Modulators; Luteo | 2009 |
Anxiolytic-like effects of ginsenosides Rg3 and Rh2 from red ginseng in the elevated plus-maze model.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Buspirone; Flumazenil; Ginsenosides; Male; | 2009 |
Similar anxiolytic-like effects following intra-amygdala infusions of benzodiazepine receptor agonist and antagonist: evidence for the release of an endogenous benzodiazepine inverse agonist in mice exposed to elevated plus-maze test.
Topics: Amygdala; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Carbolines; Catheterization; | 2009 |
Kaempferol from the leaves of Apocynum venetum possesses anxiolytic activities in the elevated plus maze test in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Apocynum; Behavior, Animal; Diazepam; Dose-Response Relations | 2009 |
A novel operant conflict procedure using incrementing shock intensities to assess the anxiolytic and anxiogenic effects of drugs.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Aripiprazole; Benzodiazepines; Chlordiazepoxide; Conditioning | 2009 |
The group III mGlu receptor agonist ACPT-I exerts anxiolytic-like but not antidepressant-like effects, mediated by the serotonergic and GABA-ergic systems.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Cyclopentanes; Depression; Flumazenil; | 2009 |
GABAA-benzodiazepine receptor availability in smokers and nonsmokers: relationship to subsyndromal anxiety and depression.
Topics: Adult; Anxiety; Brain; Brain Mapping; Depression; Female; Flumazenil; Humans; Magnetic Resonance Ima | 2009 |
Involvement of the benzodiazepine system in the anxiolytic-like effect of Yokukansan (Yi-gan san).
Topics: Analysis of Variance; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Benzodiazepines; Di | 2009 |
In vitro and in vivo properties of 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA receptor alpha5 subtype-selective inverse agonist.
Topics: Animals; Anxiety; Behavior, Animal; Convulsants; Dogs; Dose-Response Relationship, Drug; Electric St | 2009 |
Possible involvement of GABAergic mechanism in protective effect of melatonin against sleep deprivation-induced behaviour modification and oxidative damage in mice.
Topics: Animals; Antioxidants; Anxiety; Behavior, Animal; Body Weight; Dose-Response Relationship, Drug; Fem | 2009 |
Annomontine, an alkaloid isolated from Annona purpurea, has anxiolytic-like effects in the elevated plus-maze.
Topics: Animals; Annona; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Benzodiazepines; Binding Sites; Car | 2011 |
Human stiff-person syndrome IgG induces anxious behavior in rats.
Topics: Adult; Amygdala; Animals; Anxiety; Behavior, Animal; Carbon Radioisotopes; Cells, Cultured; Female; | 2011 |
Possible involvement of GABAergic mechanism in protective effect of melatonin against sleep deprivation-induced behavior modification and oxidative damage in mice.
Topics: Animals; Antioxidants; Anxiety; Behavior, Animal; Flumazenil; GABA Modulators; gamma-Aminobutyric Ac | 2011 |
Evaluation of the anxiolytic properties of myristicin, a component of nutmeg, in the male Sprague-Dawley rat.
Topics: Allylbenzene Derivatives; Animals; Anti-Anxiety Agents; Anxiety; Benzyl Compounds; Dioxolanes; Drug | 2011 |
The GABAergic system contributes to the anxiolytic-like effect of essential oil from Cymbopogon citratus (lemongrass).
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Cymbopogon; Disease Models, Animal; Dose-Re | 2011 |
Evaluation of acute toxicity of a natural compound (+)-limonene epoxide and its anxiolytic-like action.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Cyclohexane Monoterpenes; Diazepam; Dose-Re | 2012 |
Involvement of 5-HT1A in the anxiolytic-like effect of dichloromethane fraction of Pimenta pseudocaryophyllus.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Disease Models, Animal; Ethanol; Flumazenil | 2012 |
βCCT, an antagonist selective for α(1)GABA(A) receptors, reverses diazepam withdrawal-induced anxiety in rats.
Topics: Animals; Anxiety; Carbolines; Diazepam; Flumazenil; GABA-A Receptor Antagonists; Hypnotics and Sedat | 2013 |
Evaluation of anxiolytic activity of compound Valeriana jatamansi Jones in mice.
Topics: Albizzia; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Drugs, Chinese Herbal; Flumazenil | 2012 |
Progesterone withdrawal increases the alpha4 subunit of the GABA(A) receptor in male rats in association with anxiety and altered pharmacology - a comparison with female rats.
Topics: Animals; Anxiety; Blotting, Western; Female; Flumazenil; GABA Modulators; Hippocampus; Lorazepam; Ma | 2002 |
Diazepam withdrawal-induced anxiety and place aversion in the rat: differential effects of two chronic diazepam treatment regimes.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Conditioning, Operant; Diazepam; Flumazen | 2002 |
Anxiogenic effects of neurosteroid exposure: sex differences and altered GABAA receptor pharmacology in adult rats.
Topics: Acoustic Stimulation; Aging; Animals; Anti-Anxiety Agents; Anxiety; Exploratory Behavior; Female; Fl | 2003 |
Extracts of kava (Piper methysticum) induce acute anxiolytic-like behavioral changes in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA- | 2003 |
SB242084, flumazenil, and CRA1000 block ethanol withdrawal-induced anxiety in rats.
Topics: Alcohol Drinking; Aminopyridines; Animals; Anxiety; Ethanol; Flumazenil; Indoles; Male; Pyridines; P | 2004 |
Prior multiple ethanol withdrawals enhance stress-induced anxiety-like behavior: inhibition by CRF1- and benzodiazepine-receptor antagonists and a 5-HT1a-receptor agonist.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Buspirone; Central Ne | 2005 |
Pharmacological modulation of repeated ethanol withdrawal-induced anxiety-like behavior differs in alcohol-preferring P and Sprague-Dawley rats.
Topics: Alcohol Drinking; Animals; Anxiety; Ethanol; Flumazenil; Indoles; Interpersonal Relations; Male; Pyr | 2005 |
Anxiolytic-like actions of testosterone in the burying behavior test: role of androgen and GABA-benzodiazepine receptors.
Topics: Androgen Antagonists; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Dose-Response Relatio | 2005 |
Benzodiazepine receptor ligands. 8: synthesis and pharmacological evaluation of new pyrazolo[5,1-c] [1,2,4]benzotriazine 5-oxide 3- and 8-disubstituted: high affinity ligands endowed with inverse-agonist pharmacological efficacy.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Binding, Competitive; Brain; Cattle; Flumaze | 2006 |
Anxiolytic-like effect of group III mGlu receptor antagonist is serotonin-dependent.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Conflict, Psychological; Cyclopentanes; Dis | 2007 |
Anti-anxiety effects of Apocynum venetum L. in the elevated plus maze test.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Apocynum; Behavior, Animal; Buspirone; Diazepam; Disease Mode | 2007 |
The CRF1 receptor antagonist R121919 attenuates the neuroendocrine and behavioral effects of precipitated lorazepam withdrawal.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Flumazenil; Gene Expression; Hypnotics and | 2007 |
Baclofen blocks expression and sensitization of anxiety-like behavior in an animal model of repeated stress and ethanol withdrawal.
Topics: Alcohol Drinking; Animals; Anxiety; Baclofen; Body Weight; Central Nervous System Depressants; Diet; | 2007 |
Repeated lipopolysaccharide (LPS) or cytokine treatments sensitize ethanol withdrawal-induced anxiety-like behavior.
Topics: Analysis of Variance; Animals; Antidotes; Anxiety; Behavior, Animal; Body Weight; Cytokines; Disease | 2008 |
Anxiolytic-like effects of sinapic acid in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Bicuculline; Cerebral Cortex; Chloride Channels; Coumaric Aci | 2007 |
Drug challenges reveal differences in mediation of stress facilitation of voluntary alcohol drinking and withdrawal-induced anxiety in alcohol-preferring P rats.
Topics: Alcohol Drinking; Aminopyridines; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Benzodiaz | 2007 |
The amygdala regulates the antianxiety sensitization effect of flumazenil during repeated chronic ethanol or repeated stress.
Topics: Alcohol Drinking; Alcoholism; Amygdala; Animals; Anxiety; Behavior, Animal; Body Weight; Disease Mod | 2007 |
Evaluation of the anxiolytic effects of chrysin, a Passiflora incarnata extract, in the laboratory rat.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Catecholamines; Corti | 2007 |
Investigation of the anxiolytic effects of linalool, a lavender extract, in the male Sprague-Dawley rat.
Topics: Acyclic Monoterpenes; Animals; Anti-Anxiety Agents; Antidotes; Anxiety; Behavior, Animal; Disease Mo | 2008 |
Absence of intrinsic antagonist actions of benzodiazepine antagonists on an exploratory model of anxiety in the mouse.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepinones; Carbolines; Disease Models, Animal; Dose-R | 1984 |
Reversal of the antiaversive and anticonvulsant actions of diazepam, but not of progabide, by a selective antagonist of benzodiazepine receptors.
Topics: Animals; Anxiety; Benzodiazepinones; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Humans; Rats; Re | 1981 |
Benzodiazepine receptor-mediated experimental "anxiety" in primates.
Topics: Animals; Anxiety; Benzodiazepinones; Blood Pressure; Carbolines; Disease Models, Animal; Epinephrine | 1982 |
Anxiogenic and non-anxiogenic benzodiazepine antagonists.
Topics: Animals; Anxiety; Benzodiazepines; Benzodiazepinones; Carbolines; Diazepam; Flumazenil; Food Depriva | 1983 |
Interactions of ethyl-beta-carboline-3-carboxylate and Ro 15-1788 with CGS 8216 in an animal model of anxiety.
Topics: Animals; Anxiety; Benzodiazepinones; Carbolines; Disease Models, Animal; Drug Interactions; Flumazen | 1983 |
New concepts in the neurobiology of anxiety.
Topics: Animals; Anxiety; Barbiturates; Behavior; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Carb | 1983 |
Involvement of GABA in the facilitation of punishment suppressed behavior induced by beta-carbolines in rat.
Topics: Animals; Anxiety; Benzodiazepinones; Carbolines; Conditioning, Operant; Diazepam; Drug Interactions; | 1983 |
Anxiogenic aspects of diazepam withdrawal can be detected in animals.
Topics: Animals; Anxiety; Benzodiazepinones; Diazepam; Discrimination Learning; Flumazenil; Humans; Male; Pe | 1983 |
The anxiogenic action of Ro 15-1788 is reversed by chronic, but not by acute, treatment with chlordiazepoxide.
Topics: Animals; Anxiety; Benzodiazepinones; Chlordiazepoxide; Flumazenil; Humans; Male; Motor Activity; Rat | 1984 |
Anxiogenic action of benzodiazepine antagonists Ro 15-1788 and CGS 8216 in the rat.
Topics: Animals; Anxiety; Benzodiazepines; Benzodiazepinones; Convulsants; Dose-Response Relationship, Drug; | 1984 |
The anxiogenic action of FG 7142 in the social interaction test is reversed by chlordiazepoxide and Ro 15-1788 but not by CGS 8216.
Topics: Animals; Anxiety; Benzodiazepinones; Carbolines; Chlordiazepoxide; Convulsants; Flumazenil; Humans; | 1984 |
The anxiogenic action of benzodiazepine antagonists.
Topics: Animals; Anxiety; Benzodiazepines; Benzodiazepinones; Carbolines; Flumazenil; Humans; Indoles; Inter | 1982 |
Effect of diazepam on cortical 5-HT release and behaviour in the guinea-pig on exposure to the elevated plus maze.
Topics: Animals; Anxiety; Behavior, Animal; Diazepam; Exploratory Behavior; Extracellular Space; Female; Flu | 1993 |
Effects of training, early handling, and perinatal flumazenil on shuttle box acquisition in Roman low-avoidance rats: toward overcoming a genetic deficit.
Topics: Animals; Animals, Newborn; Anxiety; Avoidance Learning; Electroshock; Emotions; Flumazenil; GABA Mod | 1995 |
Decreased predator avoidance in parasitized mice: neuromodulatory correlates.
Topics: Animals; Anxiety; Avoidance Learning; Bicuculline; Cats; Coccidiosis; Dizocilpine Maleate; Eimeria; | 1995 |
Defeat engenders pentylenetetrazole-appropriate responding in rats: antagonism by midazolam.
Topics: Agonistic Behavior; Animals; Anxiety; Conditioning, Operant; Discrimination, Psychological; Flumazen | 1994 |
The central and basolateral amygdala differentially mediate the anxiolytic effects of benzodiazepines.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Flumazenil; Injections; Male; Mid | 1995 |
Evidence for central benzodiazepine receptor heterogeneity from behavior tests.
Topics: Animals; Anxiety; Behavior, Animal; Benzodiazepines; Body Temperature; Central Nervous System; Dose- | 1994 |
Nitrous oxide induces an anxiolytic-like effect in the conditioned defensive burying paradigm, which can be reversed with a benzodiazepine receptor blocker.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Chlordiazepoxide; Conditioning, Operant; Dose-Response Relati | 1993 |
Role of benzodiazepine receptors located in the dorsal periaqueductal grey of rats in anxiety.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Anxiety; Appetite Depressants; C | 1993 |
The benzodiazepine antagonist flumazenil blocks the effects of CCK receptor agonists and antagonists in the elevated plus-maze.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Exploratory Behavior; Flumazenil; Male; Rat | 1993 |
"Anxiolytic" and "anxiogenic" benzodiazepines and beta-carbolines: effects on aggressive and social behavior in rats and squirrel monkeys.
Topics: Aggression; Animals; Anti-Anxiety Agents; Anxiety; Azides; Benzodiazepines; Carbolines; Dose-Respons | 1993 |
Differential profile of the CCKB receptor antagonist CI-988 and diazepam in the four-plate test.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Dose-Response Relationship, Drug; Electroshock; Exp | 1993 |
Flumazenil reversal of benzodiazepine-induced sedation for a patient with severe pre-ECT anxiety.
Topics: Adult; Anti-Anxiety Agents; Anxiety; Electroconvulsive Therapy; Flumazenil; Humans; Lorazepam; Male; | 1994 |
Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice.
Topics: Animals; Anxiety; Aspirin; Diazepam; Drug Tolerance; Flumazenil; Formaldehyde; Indomethacin; Inflamm | 1994 |
Midazolam and flumazenil pharmacokinetics and pharmacodynamics following simultaneous administration to human volunteers.
Topics: Adult; Anxiety; Awareness; Flicker Fusion; Flumazenil; Half-Life; Humans; Male; Midazolam; Protein B | 1994 |
Anxiogenic-like effects of yohimbine and idazoxan in two behavioral situations in mice.
Topics: Adrenergic alpha-Antagonists; Animals; Anxiety; Behavior, Animal; Choice Behavior; Clonidine; Condit | 1993 |
Struggling and flumazenil effects in the swimming test are related to the level of anxiety in mice.
Topics: Animals; Anxiety; Escape Reaction; Flumazenil; Male; Mice; Receptors, GABA-A; Swimming | 1994 |
The septum and amygdala differentially mediate the anxiolytic effects of benzodiazepines.
Topics: Amygdala; Animals; Anxiety; Avoidance Learning; Brain; Flumazenil; Infusions, Parenteral; Learning; | 1994 |
Benzodiazepine receptor-mediated behavioral effects of nitrous oxide in the rat social interaction test.
Topics: Animals; Anxiety; Chlordiazepoxide; Dose-Response Relationship, Drug; Flumazenil; GABA-A Receptor An | 1993 |
Stressor controllability, social interaction, and benzodiazepine systems.
Topics: Animals; Anxiety; Carbolines; Chlordiazepoxide; Dose-Response Relationship, Drug; Electroshock; Flum | 1993 |
Flumazenil blocks the anxiolytic action of allopregnanolone.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Drug Interactions; Female; Flumazenil; GABA | 1995 |
The hyperphagic effect of 3 alpha-hydroxylated pregnane steroids in male rats.
Topics: Animals; Anxiety; Dose-Response Relationship, Drug; Eating; Feeding Behavior; Flumazenil; GABA Antag | 1996 |
Anxiolytic activity of intraventricularly administered atrial natriuretic peptide in the rat.
Topics: Animals; Anxiety; Atrial Natriuretic Factor; Behavior, Animal; Drug Interactions; Feeding Behavior; | 1996 |
Evaluation of perinatal flumazenil effects on the behavior of female RLA/Verh rats in anxiety tests and shuttle box avoidance.
Topics: Animals; Animals, Newborn; Anxiety; Avoidance Learning; Behavior, Animal; Female; Flumazenil; GABA M | 1996 |
A five minute experience in the elevated plus-maze alters the state of the benzodiazepine receptor in the dorsal raphe nucleus.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Flumazenil; GABA-A Receptor Agonists; GABA- | 1997 |
Genetic factors regulate processes related to anxiety in mice.
Topics: Animals; Anxiety; Behavior, Animal; Brain; Choice Behavior; Chromosome Mapping; Darkness; Flumazenil | 1997 |
Antianxiety profile of ondansetron, a selective 5-HT3 antagonist, in a novel animal model.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Conflict, Psychological; Diazepam; Disease | 1997 |
The anxiolytic-like effects of the neurosteroid allopregnanolone: interactions with GABA(A) receptors.
Topics: Affinity Labels; Animals; Anti-Anxiety Agents; Anxiety; Azides; Behavior, Animal; Benzodiazepines; B | 1997 |
Convulsive effects of a benzodiazepine receptor inverse agonist: are they related to anxiogenic processes?
Topics: Animals; Anxiety; Behavior, Animal; Carbolines; Convulsants; Female; Flumazenil; GABA Modulators; GA | 1997 |
The effects of flumazenil, Ro 15-4513 and beta-CCM on the behaviour of control and stressed mice in the plus-maze test.
Topics: Animals; Anxiety; Azides; Behavior, Animal; Benzodiazepines; Carbolines; Dose-Response Relationship, | 1997 |
Flumazenil blockade of anxiety following ethanol withdrawal in rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Corticotropin-Releasing Hormone; Ethanol; Fl | 1997 |
Reversal of benzodiazepine inverse agonist FG 7142-induced anxiety syndrome by neurosteroids in mice.
Topics: Animals; Anxiety; Benzodiazepines; Benzodiazepinones; Carbolines; Flumazenil; GABA Antagonists; GABA | 1997 |
Modification of the anxiolytic action of 5-HT1A compounds by GABA-benzodiazepine agents in rats.
Topics: 5-Methoxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; | 1998 |
The octadecaneuropeptide ODN induces anxiety in rodents: possible involvement of a shorter biologically active fragment.
Topics: Amino Acid Sequence; Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Diazepam Binding Inhibitor; Di | 1998 |
Striking changes in anxiety in Huntington's disease transgenic mice.
Topics: Animals; Anxiety; Exploratory Behavior; Female; Flumazenil; Huntington Disease; Maze Learning; Mice; | 1998 |
Stimulation of benzodiazepine receptors in the dorsal hippocampus and median raphé reveals differential GABAergic control in two animal tests of anxiety.
Topics: Animals; Anxiety; Behavior, Animal; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Hippocampu | 1998 |
Behavioral effects of diazepam in the murine plus-maze: flumazenil antagonism of enhanced head dipping but not the disinhibition of open-arm avoidance.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Behavior, Animal; Diazepam; Dose-Response | 1999 |
Lack of sex differences in anxiety behaviors during precipitated benzodiazepine withdrawal in rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Corticosterone; Diazepam; Estradiol; Female; Flumazenil; GABA | 1999 |
Effects of melatonin on neophobic responses in different strains of mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Exploratory Behavior; Flumazenil; GABA Modu | 1999 |
Effects of the benzodiazepine antagonist flumazenil on conditioned fear stress in rats.
Topics: Animals; Anxiety; Conditioning, Classical; Fear; Flumazenil; GABA Modulators; Male; Rats; Rats, Spra | 1999 |
Gabaergic-benzodiazepine system is involved in the crotoxin-induced anxiogenic effect.
Topics: Animals; Anxiety; Behavior, Animal; Crotoxin; Diazepam; Dose-Response Relationship, Drug; Flumazenil | 2000 |
Flumazenil induces benzodiazepine partial agonist-like effects in BALB/c but not C57BL/6 mice.
Topics: Animals; Anxiety; Avoidance Learning; Behavior, Animal; Chlordiazepoxide; Darkness; Dose-Response Re | 2000 |
Evidence that NMDA-dependent limbic neural plasticity in the right hemisphere mediates pharmacological stressor (FG-7142)-induced lasting increases in anxiety-like behavior: study 3--the effects on amygdala efferent physiology of block of NMDA receptors p
Topics: Amygdala; Animals; Anxiety; Behavior, Animal; Carbolines; Cats; Electrodes, Implanted; Evoked Potent | 1998 |
Evidence that long-lasting potentiation in limbic circuits mediating defensive behaviour in the right hemisphere underlies pharmacological stressor (FG-7142) induced lasting increases in anxiety-like behaviour: role of benzodiazepine receptors.
Topics: Aggression; Animals; Anxiety; Behavior, Animal; Carbolines; Catheterization; Cats; Flumazenil; Funct | 2000 |
Evidence that long-lasting potentiation of amygdala efferents in the right hemisphere underlies pharmacological stressor (FG-7142) induced lasting increases in anxiety-like behaviour: role of GABA tone in initiation of brain and behavioural changes.
Topics: Aggression; Amygdala; Animals; Anticonvulsants; Anxiety; Behavior, Animal; Brain Chemistry; Carbolin | 2000 |
Effects of diazepam and beta-CCM on working memory in mice: relationships with emotional reactivity.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Carbolines; Convulsants; Diazepam; Emotions; Flumazenil; GABA | 2001 |
Use of negatively reinforcing electrical brain stimulation to detect conventional and nonconventional anxiolytics as well as an anxiogenic drug.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Brain; Buspirone; Carbolines; Convulsants; Diazepam; Electric | 2001 |
Behavioral effects of agents active at the gamma-aminobutyric acid receptor complex in the staircase paradigm.
Topics: Acetates; Adjuvants, Immunologic; Amines; Animals; Anti-Anxiety Agents; Anxiety; Azabicyclo Compound | 2001 |
Interactions between LY354740, a group II metabotropic agonist and the GABA(A)-benzodiazepine receptor complex in the rat elevated plus-maze.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Bridged Bicyclo Compounds; Chlordiazepoxide; Dose-Response Re | 2001 |
Comparison of behavioral and central BDZ binding profile in three rat lines.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Behavior, Animal; Binding, Competitive; Body | 1992 |
beta-Carboline and pentylenetetrazol effects on conflict behavior in the rat.
Topics: Animals; Anxiety; Behavior, Animal; Carbolines; Conflict, Psychological; Dose-Response Relationship, | 1992 |
Effects of nitrendipine, chlordiazepoxide, flumazenil and baclofen on the increased anxiety resulting from alcohol withdrawal.
Topics: Animals; Anxiety; Baclofen; Chlordiazepoxide; Diazepam; Ethanol; Flumazenil; Interpersonal Relations | 1992 |
A comparison of methods for the separation of [11C]Ro 15-1788 (flumazenil) from its metabolites in the blood of rabbits, baboons and humans.
Topics: Animals; Anxiety; Carbon Radioisotopes; Chromatography, Thin Layer; Female; Flumazenil; Humans; Male | 1991 |
Effects of DN-2327, a new anxiolytic, diazepam and buspirone on exploratory activity of the rat in an elevated plus-maze.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Buspirone; Conflict, Psychological; Diazepam; Dose-Response R | 1991 |
[Use of flumazenil to reverse the effects of midazolam in children].
Topics: Adolescent; Age Factors; Anxiety; Child; Child, Preschool; Flumazenil; Humans; Hypnotics and Sedativ | 1991 |
Effects of benzodiazepine receptor antagonist, flumazenil, on antinociceptive and behavioural responses to the elevated plus-maze in mice.
Topics: Analgesia; Animals; Anxiety; Behavior, Animal; Flumazenil; Ligands; Male; Mice; Mice, Inbred DBA; Pa | 1991 |
Anxiolytic effect of midazolam microinjected into the dorsal periaqueductal grey area of rats.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Drug Synergism; Electric Stimulation; Flum | 1991 |
A theory of benzodiazepine dependence that can explain whether flumazenil will enhance or reverse the phenomena.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Flumazenil; Male; Rats; Substance Withdrawal Syndro | 1990 |
The anxiogenic beta-carboline FG 7142 selectively increases dopamine release in rat prefrontal cortex as measured by microdialysis.
Topics: Animals; Anxiety; Benzodiazepines; Carbolines; Corpus Striatum; Dialysis; Dopamine; Flumazenil; Fron | 1991 |
Infantile stimulation and perinatal administration of Ro 15-1788: additive anxiety-reducing effects in rats.
Topics: Animals; Animals, Newborn; Anxiety; Behavior, Animal; Female; Flumazenil; Physical Stimulation; Preg | 1990 |
Pharmacological manipulation of anxiety and male rat sexual behavior.
Topics: Animals; Anxiety; Carbolines; Copulation; Diazepam; Flumazenil; Male; Psychomotor Performance; Rats; | 1990 |
Enhancing effects of Ro 15-1788 on straw-climbing behavior as measured with the straw-suspension method: reversal by diazepam.
Topics: Animals; Anxiety; Diazepam; Drug Interactions; Flumazenil; Male; Motor Activity; Rats; Rats, Inbred | 1990 |
Blockade of hoarding in rats by diazepam: an analysis of the anxiety and object value hypotheses of hoarding.
Topics: Animals; Anxiety; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Eating; Female; Flum | 1990 |
Effects of benzodiazepine agonist, inverse agonist and antagonist drugs in the mouse staircase test.
Topics: Animals; Anxiety; Behavior, Animal; Carbolines; Flumazenil; Male; Mice; Mice, Inbred ICR; Midazolam; | 1990 |
Proconflict effect of ACTH1-24: interaction with benzodiazepines.
Topics: Adrenocorticotropic Hormone; alpha-MSH; Animals; Anxiety; Conflict, Psychological; Cosyntropin; Diaz | 1990 |
Flumazenil prevents the development of chlordiazepoxide withdrawal in rats tested in the social interaction test of anxiety.
Topics: Animals; Anxiety; Chlordiazepoxide; Flumazenil; Interpersonal Relations; Male; Motor Activity; Rats; | 1989 |
Anxiogenic effects of noreleagnine, a water soluble beta-carboline in rats.
Topics: Animals; Anxiety; Carbolines; Chlordiazepoxide; Conflict, Psychological; Flumazenil; Male; Rats; Rat | 1989 |
Flumazenil but not nitrendipine reverses the increased anxiety during ethanol withdrawal in the rat.
Topics: Animals; Anxiety; Behavior, Animal; Ethanol; Flumazenil; Male; Nitrendipine; Rats; Substance Withdra | 1989 |
Does the PCPA induced anticonflict effect involve activation of the GABAA/benzodiazepine chloride ionophore receptor complex?
Topics: Animals; Anxiety; Bicuculline; Brain; Dose-Response Relationship, Drug; Fenclonine; Flumazenil; Male | 1989 |
Caffeine-induced anxiogenesis: the role of adenosine, benzodiazepine and noradrenergic receptors.
Topics: 2-Chloroadenosine; Adenosine; Alprazolam; Anxiety; Caffeine; Chlordiazepoxide; Clonidine; Flumazenil | 1989 |
Reversal of increased anxiety during benzodiazepine withdrawal: evidence for an anxiogenic endogenous ligand for the benzodiazepine receptor.
Topics: Animals; Anxiety; Behavior, Animal; Chlordiazepoxide; Flumazenil; Male; Rats; Receptors, GABA-A; Sub | 1988 |
Propranolol antagonizes the enhanced conditioned fear produced by corticotropin releasing factor.
Topics: Animals; Anxiety; Carbolines; Conditioning, Psychological; Corticotropin-Releasing Hormone; Fear; Fl | 1988 |
Animal models of chronic anxiety and "fearlessness".
Topics: Animals; Anxiety; Brain; Cats; Diazepam; Disease Models, Animal; Fear; Female; Flumazenil; Flunitraz | 1988 |
Anxiolytic properties of amygdaloid kindling unrelated to benzodiazepine receptors.
Topics: Amygdala; Animals; Anxiety; Cerebral Cortex; Chlordiazepoxide; Electric Stimulation; Flumazenil; Kin | 1988 |
Self-regulation of ICSS duration: effects of anxiogenic substances, benzodiazepine antagonists and antidepressants.
Topics: Adrenergic alpha-Antagonists; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Benzodia | 1985 |
Interoceptive stimuli produced by an anxiogenic drug are mimicked by benzodiazepine antagonists in rats pretreated with isoniazid.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepinones; Brain Chemistry; Convulsants; Discriminati | 1985 |
Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Benzodiazepinones; Buspirone; Carbolines; Co | 1986 |
A new method for screening anxiolytic drugs in rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Azabicyclo Compounds; Diazepam; Drug Evaluation, Preclinical; | 1987 |
Flumazenil: a possible treatment for benzodiazepine withdrawal anxiety.
Topics: Animals; Anxiety; Benzodiazepines; Chlordiazepoxide; Flumazenil; Rats; Substance Withdrawal Syndrome | 1987 |
Flumazenil and benzodiazepine withdrawal.
Topics: Animals; Anxiety; Benzodiazepines; Flumazenil; Lorazepam; Male; Mice; Rats; Rats, Inbred Strains; Re | 1987 |
The anxiogenic action of RO 5-4864 in the social interaction test: effect of chlordiazepoxide, RO 15-1788 and CGS 8216.
Topics: Animals; Anxiety; Benzodiazepinones; Chlordiazepoxide; Convulsants; Drug Interactions; Flumazenil; H | 1985 |
The effects of putative anxiogenic compounds (FG 7142, CGS 8216 and Ro 15-1788) on the rat corticosterone response.
Topics: Animals; Anxiety; Benzodiazepinones; Carbolines; Corticosterone; Flumazenil; Male; Pyrazoles; Rats; | 1985 |
Antianxiety effect of cannabis: involvement of central benzodiazepine receptors.
Topics: Adult; Aggression; Animals; Anxiety; Benzodiazepinones; Cannabinoids; Diazepam; Dronabinol; Electros | 1986 |
Long-lasting proconflict effect induced by chronic administration of the beta-carboline derivative FG 7142.
Topics: Animals; Anxiety; Benzodiazepinones; Carbolines; Conflict, Psychological; Disease Models, Animal; Dr | 1985 |
Actions of the beta-carboline ZK 93426 in an animal test of anxiety and the holeboard: interactions with Ro 15-1788.
Topics: Animals; Anxiety; Benzodiazepinones; Carbolines; Drug Synergism; Exploratory Behavior; Flumazenil; I | 1986 |
Do the intrinsic actions of benzodiazepine receptor antagonists imply the existence of an endogenous ligand for benzodiazepine receptors?
Topics: Animals; Anxiety; Behavior, Animal; Benzodiazepinones; Carbolines; Convulsants; Diazepam Binding Inh | 1986 |
A selective imidazobenzodiazepine antagonist of ethanol in the rat.
Topics: Animals; Anxiety; Azides; Benzodiazepines; Chlorides; Ethanol; Flumazenil; Male; Pyrazoles; Rats; Ra | 1986 |
Investigation of the actions of the benzodiazepine antagonists Ro 15-1788 and CGS 8216 using the schedule-controlled behavior of rats.
Topics: Animals; Anxiety; Behavior, Animal; Benzodiazepines; Diazepam; Drug Interactions; Flumazenil; Male; | 1986 |
Changes in local cerebral glucose utilization induced by the beta-carbolines FG 7142 and DMCM reveal brain structures involved in the control of anxiety and seizure activity.
Topics: Animals; Anxiety; Autoradiography; Brain; Carbolines; Convulsants; Deoxyglucose; Flumazenil; Glucose | 1987 |
Anxiogenic effects of methyl-beta-carboline-3-carboxylate in a light/dark choice situation.
Topics: Animals; Anxiety; Benzodiazepines; Carbolines; Choice Behavior; Clorazepate Dipotassium; Darkness; D | 1987 |
The effects of chronic antidepressant treatment in an animal model of anxiety.
Topics: Amitriptyline; Animals; Antidepressive Agents; Anxiety; Desipramine; Diazepam; Disease Models, Anima | 1988 |
Proconvulsant and 'anxiogenic' effects of n-butyl beta carboline-3-carboxylate, an endogenous benzodiazepine binding inhibitor from brain.
Topics: Animals; Anxiety; Benzodiazepines; Brain Chemistry; Carbolines; Convulsants; Exploratory Behavior; F | 1988 |
Chlordiazepoxide enhances the anxiogenic action of CGS 8216 in the social interaction test: evidence for benzodiazepine withdrawal?
Topics: Animals; Anxiety; Benzodiazepinones; Carbolines; Chlordiazepoxide; Flumazenil; Humans; Male; Pyrazol | 1985 |
Anxiety and sense of coherence in Roma and non-Roma coronary heart disease patients.
Topics: Adult; Aged; Anxiety; Coronary Disease; Female; Humans; Linear Models; Male; Middle Aged; Psychologi | 2014 |
Shame and Anxiety Feelings of a Roma Population in Greece.
Topics: Adult; Anxiety; Emotions; Female; Greece; Humans; Male; Middle Aged; Minority Groups; Personality In | 2015 |