flumazenil has been researched along with Anesthesia in 44 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5 mg oral dose of midazolam 45 min prior to the induction of anesthesia." | 9.06 | [The effectiveness of the benzodiazepine antagonist Ro 15-1788 after the induction of anesthesia with midazolam]. ( Kretz, FJ; Peisdersky, B, 1988) |
| "North American river otters (Lutra canadensis) were anesthetized with tiletamine-zolazepam or tiletamine-zolazepam-flumazenil combinations in cooperation with the North Carolina Wildlife Resources Commission Otter Restoration Project for evaluation of physiologic changes during anesthesia." | 7.69 | Tiletamine-zolazepam anesthesia in North American river otters (Lutra canadensis) and its partial antagonism with flumazenil. ( Karesh, WB; Spelman, LH; Stoskopf, MK; Summer, PW, 1997) |
| "The treatment with flumazenil completely abolished the decrease in the metabolite (P < 0." | 5.33 | Flumazenil-induced improvement of the central dopaminergic system in rats with acute hepatic failure. ( Adachi, N; Arai, T; Liu, K; Yano, M, 2005) |
| "5 mg oral dose of midazolam 45 min prior to the induction of anesthesia." | 5.06 | [The effectiveness of the benzodiazepine antagonist Ro 15-1788 after the induction of anesthesia with midazolam]. ( Kretz, FJ; Peisdersky, B, 1988) |
| " Midazolam does not induce anesthesia in healthy, small animals and, as such, can only be used in combination with other injectable agents, such as ketamine or the thiobarbiturates." | 4.78 | Other potentially useful new injectable anesthetic agents. ( Ilkiw, JE, 1992) |
| " We studied (11)C-flumazenil binding to GABA(A) receptors during sevoflurane and propofol anesthesia in the living human brain using positron emission tomography (PET)." | 3.72 | Sevoflurane and propofol increase 11C-flumazenil binding to gamma-aminobutyric acidA receptors in humans. ( Aalto, S; Hietala, J; Hinkka, S; Kaisti, KK; Korpi, ER; Metsähonkala, L; Någren, K; Oikonen, V; Salmi, E; Scheinin, H, 2004) |
| "The benzodiazepine receptor antagonist, flumazenil, at a dose of 10 mg/kg given intraperitoneally to mice, had no effect on the minimum air concentration (MAC-50) of halothane causing anesthesia in 50% of the animals and which was 1." | 3.67 | A benzodiazepine receptor antagonist improves emergence of mice from halothane anaesthesia. ( Cohen, S; Geller, E; Halpern, P; Schiff, B; Speiser, Z, 1989) |
| "In six dogs initially anesthetized with halothane-N2O-O2 for surgery and maintained during the experiment with high spinal anesthesia and local infiltration, diazepam 3." | 3.67 | Reversal of the cerebral effects of diazepam in the dog by the benzodiazepine antagonist Ro15-1788. ( Michenfelder, JD; Milde, JH; Roald, OK; Steen, PA, 1986) |
| " For instance, [3H]gamma-aminobutyric acid release in the dorsal raphe was enhanced by halothane anesthesia." | 3.66 | Chlordiazepoxide reduces in vivo serotonin release in the basal ganglia of encéphale isolé but not anesthetized cats: evidence for a dorsal raphe site of action. ( Blas, C; Ferron, A; Glowinski, J; Soubrie, P, 1983) |
| "Flumazenil has been studied for a variety of indications, including as an antidote to benzodiazepine overdose and for awakening of comatose patients, reversal of sedation after surgery and in critically ill patients, and management of hepatic encephalopathy." | 2.38 | Flumazenil: a benzodiazepine antagonist. ( Hoffman, EJ; Warren, EW, 1993) |
| "Flumazenil (Ro 15-1788) is a specific benzodiazepine antagonist which can prevent or abolish selectively at the receptor level all centrally mediated effects of benzodiazepines." | 2.37 | Pharmacokinetics and clinical use of flumazenil (Ro 15-1788). ( Kanto, J; Klotz, U, 1988) |
| " The addition of flumazenil showed no significant difference to atipamezole alone, but subcutaneous administration of atipamezole alone was not sufficient in the dosage used to show an advantage compared to non-reversed cats." | 1.34 | Partial antagonization of midazolam-medetomidine-ketamine in cats--atipamezole versus combined atipamezole and flumazenil. ( Baumgartner, C; Ebner, J; Erhardt, W; Henke, J; Wehr, U, 2007) |
| "The treatment with flumazenil completely abolished the decrease in the metabolite (P < 0." | 1.33 | Flumazenil-induced improvement of the central dopaminergic system in rats with acute hepatic failure. ( Adachi, N; Arai, T; Liu, K; Yano, M, 2005) |
| "Flumazenil was used most frequently after anaesthesia and in the initial management of intentional drug overdose." | 1.28 | Flumazenil: a twelve-month survey of use in a New Zealand public hospital. ( Galletly, DC; Turley, A; Ure, R, 1990) |
| " The drug was administered intramuscularly in ten dogs at a dosage of 10 mg/kg bwt of tiletamine and 10 mg/kg bwt of zolazepam and tested for its effects on hemodynamics, respiration, and the antagonistic effect of flumazenil." | 1.28 | [Anesthesia in dogs with the combination preparation Tilest 500]. ( Hess, L, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (34.09) | 18.7374 |
| 1990's | 18 (40.91) | 18.2507 |
| 2000's | 5 (11.36) | 29.6817 |
| 2010's | 3 (6.82) | 24.3611 |
| 2020's | 3 (6.82) | 2.80 |
| Authors | Studies |
|---|---|
| Kiyama, S | 1 |
| Masui, K | 1 |
| Li, C | 1 |
| Yan, J | 1 |
| Tang, D | 1 |
| Zhu, J | 1 |
| Huang, C | 1 |
| Sun, Y | 1 |
| Hu, R | 1 |
| Wang, H | 1 |
| Fu, C | 1 |
| Chen, Y | 1 |
| Jiang, H | 1 |
| Sandiego, CM | 1 |
| Jin, X | 1 |
| Mulnix, T | 1 |
| Fowles, K | 1 |
| Labaree, D | 1 |
| Ropchan, J | 1 |
| Huang, Y | 1 |
| Cosgrove, K | 1 |
| Castner, SA | 1 |
| Williams, GV | 1 |
| Wells, L | 1 |
| Rabiner, EA | 1 |
| Carson, RE | 1 |
| Heldwein, CG | 1 |
| Silva, Lde L | 1 |
| Gai, EZ | 1 |
| Roman, C | 1 |
| Parodi, TV | 1 |
| Bürger, ME | 1 |
| Baldisserotto, B | 1 |
| Flores, ÉM | 1 |
| Heinzmann, BM | 1 |
| Ueoka, N | 2 |
| Hikasa, Y | 2 |
| Salmi, E | 1 |
| Kaisti, KK | 1 |
| Metsähonkala, L | 1 |
| Oikonen, V | 1 |
| Aalto, S | 1 |
| Någren, K | 1 |
| Hinkka, S | 1 |
| Hietala, J | 1 |
| Korpi, ER | 1 |
| Scheinin, H | 1 |
| Yano, M | 1 |
| Adachi, N | 1 |
| Liu, K | 1 |
| Arai, T | 1 |
| Vesal, N | 1 |
| Zare, P | 1 |
| Ebner, J | 1 |
| Wehr, U | 1 |
| Baumgartner, C | 1 |
| Erhardt, W | 1 |
| Henke, J | 1 |
| Doenicke, A | 1 |
| Suttmann, H | 1 |
| Kapp, W | 1 |
| Kugler, J | 1 |
| Ebentheuer, H | 1 |
| Soubrie, P | 1 |
| Blas, C | 1 |
| Ferron, A | 1 |
| Glowinski, J | 1 |
| Donnelly, M | 1 |
| Browne, J | 1 |
| Fitzpatrick, G | 1 |
| Shapira, Y | 1 |
| Eilig, I | 1 |
| Bar-Lavy, Y | 1 |
| Fan, SZ | 1 |
| Liu, CC | 1 |
| Yu, HY | 1 |
| Chao, CC | 1 |
| Lin, SM | 1 |
| Hoffman, EJ | 1 |
| Warren, EW | 1 |
| Koht, A | 1 |
| Moss, JI | 1 |
| Spelman, LH | 1 |
| Summer, PW | 1 |
| Karesh, WB | 1 |
| Stoskopf, MK | 1 |
| Ghoneim, MM | 1 |
| Larson, JS | 1 |
| Lunn, JJ | 1 |
| Gross, ME | 1 |
| Tranquilli, WJ | 1 |
| Thurmon, JC | 1 |
| Benson, GJ | 1 |
| Olson, WA | 1 |
| Baktai, G | 1 |
| Székely, E | 1 |
| Márialigeti, T | 1 |
| Kovács, L | 1 |
| Ilkiw, JE | 1 |
| Grande, LM | 1 |
| Guerra-Narducci, P | 1 |
| Arpino, I | 1 |
| Stefanelli, A | 1 |
| Roscetti, A | 1 |
| Dordoni, PL | 1 |
| Cannelli, G | 1 |
| Camaioni, D | 1 |
| Deacon, RM | 1 |
| Budhram, P | 1 |
| Thomson, TA | 1 |
| Gardner, CR | 1 |
| Galletly, DC | 1 |
| Ure, R | 1 |
| Turley, A | 1 |
| Hess, L | 1 |
| Collins, S | 1 |
| Carter, JA | 1 |
| Camu, F | 1 |
| Lebrault, C | 1 |
| Costes, H | 1 |
| Guirimand, F | 1 |
| Chauvin, M | 1 |
| Duvaldestin, P | 1 |
| Barakat, T | 1 |
| Lechat, JP | 1 |
| Laurent, P | 1 |
| Fletcher, D | 1 |
| Clergue, F | 1 |
| Viars, P | 1 |
| Bougeois, B | 1 |
| Servin, F | 1 |
| Farinotti, R | 1 |
| Desmonts, JM | 1 |
| Geller, E | 1 |
| Schiff, B | 1 |
| Halpern, P | 1 |
| Speiser, Z | 1 |
| Cohen, S | 1 |
| Albertson, TE | 1 |
| Joy, RM | 1 |
| Marty, J | 1 |
| Joyon, D | 1 |
| Baehrendtz, S | 1 |
| Höjer, J | 1 |
| Breimer, LT | 1 |
| Hennis, PJ | 1 |
| Bovill, JG | 1 |
| Spierdijk, J | 1 |
| Roald, OK | 1 |
| Steen, PA | 1 |
| Milde, JH | 1 |
| Michenfelder, JD | 1 |
| Klotz, U | 1 |
| Kanto, J | 1 |
| Kretz, FJ | 1 |
| Peisdersky, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Neurotoxic Effect of Sevoflurane-Based Anaesthesia Guided by Significant Short-Term Olfactory Identification Impairment in Old Age[NCT03726580] | 600 participants (Actual) | Observational [Patient Registry] | 2017-03-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for flumazenil and Anesthesia
| Article | Year |
|---|---|
[Flumazenil].
Topics: Anesthesia; Flumazenil; GABA Modulators; Humans | 1995 |
Flumazenil: a benzodiazepine antagonist.
Topics: Anesthesia; Benzodiazepines; Drug Interactions; Drug Overdose; Flumazenil; Hepatic Encephalopathy; H | 1993 |
Comparing drugs for short-term sedation.
Topics: Anesthesia; Benzodiazepines; Conscious Sedation; Diazepam; Flumazenil; Humans; Lorazepam; Midazolam; | 1994 |
Other potentially useful new injectable anesthetic agents.
Topics: Anesthesia; Anesthetics; Animals; Cats; Dogs; Flumazenil; Midazolam; Propofol | 1992 |
Experience of Anexate in anesthesiology.
Topics: Adjuvants, Anesthesia; Anesthesia; Benzodiazepines; Flumazenil; Humans; Time Factors | 1989 |
Haemodynamic responses following reversal of benzodiazepine-induced anaesthesia or sedation with flumazenil.
Topics: Anesthesia; Benzodiazepines; Double-Blind Method; Flumazenil; Hemodynamics; Humans; Receptors, GABA- | 1988 |
Flumazenil in self-induced benzodiazepine poisoning.
Topics: Anesthesia; Benzodiazepines; Emergencies; Flumazenil; Humans; Receptors, GABA-A | 1988 |
Pharmacokinetics and clinical use of flumazenil (Ro 15-1788).
Topics: Anesthesia; Benzodiazepines; Diazepam; Flumazenil; Humans; Injections, Intravenous; Poisoning | 1988 |
7 trials available for flumazenil and Anesthesia
| Article | Year |
|---|---|
Clinical evaluation of intranasal benzodiazepines, alpha-agonists and their antagonists in canaries.
Topics: Administration, Intranasal; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthesia; Ani | 2006 |
Lack of effect of flumazenil on the reversal of propofol anaesthesia.
Topics: Adult; Anesthesia; Double-Blind Method; Drug Interactions; Female; Flumazenil; Humans; Propofol | 1995 |
Use of midazolam ('Dormicum') and flumazenil ('Anexate') in paediatric bronchology.
Topics: Anesthesia; Atropine; Bronchoscopy; Child, Preschool; Chronic Disease; Drug Administration Schedule; | 1992 |
Haemodynamic responses following reversal of benzodiazepine-induced anaesthesia or sedation with flumazenil.
Topics: Anesthesia; Benzodiazepines; Double-Blind Method; Flumazenil; Hemodynamics; Humans; Receptors, GABA- | 1988 |
Flumazenil in self-induced benzodiazepine poisoning.
Topics: Anesthesia; Benzodiazepines; Emergencies; Flumazenil; Humans; Receptors, GABA-A | 1988 |
The efficacy of flumazenil versus physostigmine after midazolam-alfentanil anaesthesia in man.
Topics: Adult; Alfentanil; Anesthesia; Anesthesia Recovery Period; Double-Blind Method; Female; Fentanyl; Fl | 1988 |
[The effectiveness of the benzodiazepine antagonist Ro 15-1788 after the induction of anesthesia with midazolam].
Topics: Adult; Anesthesia; Anesthesia Recovery Period; Double-Blind Method; Drug Evaluation; Female; Flumaze | 1988 |
31 other studies available for flumazenil and Anesthesia
| Article | Year |
|---|---|
Re-sedation after a large dose of flumazenil.
Topics: Anesthesia; Benzodiazepines; Flumazenil; Midazolam | 2023 |
Reply to "Re-sedation after a large dose of flumazenil".
Topics: Anesthesia; Flumazenil; Midazolam | 2023 |
GluN2A-selective positive allosteric modulator-nalmefene-flumazenil reverses ketamine-fentanyl-dexmedetomidine-induced anesthesia and analgesia in rats.
Topics: Adjuvants, Anesthesia; Allosteric Regulation; Analgesia; Anesthesia; Animals; Delayed Emergence from | 2020 |
Awake nonhuman primate brain PET imaging with minimal head restraint: evaluation of GABAA-benzodiazepine binding with 11C-flumazenil in awake and anesthetized animals.
Topics: Anesthesia; Animals; Benzodiazepines; Brain; Carbon Radioisotopes; Female; Flumazenil; gamma-Aminobu | 2013 |
S-(+)-Linalool from Lippia alba: sedative and anesthetic for silver catfish (Rhamdia quelen).
Topics: Acyclic Monoterpenes; Anesthesia; Anesthetics; Animals; Catfishes; Central Nervous System; Diazepam; | 2014 |
Effects in cats of atipamezole, flumazenil and 4-aminopyridine on stress-related neurohormonal and metabolic responses induced by medetomidine, midazolam and ketamine.
Topics: 4-Aminopyridine; Anesthesia; Anesthetics, Combined; Animals; Arousal; Cats; Dose-Response Relationsh | 2015 |
Sevoflurane and propofol increase 11C-flumazenil binding to gamma-aminobutyric acidA receptors in humans.
Topics: Adult; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Blood Gas Analysis; Brain; Car | 2004 |
Flumazenil-induced improvement of the central dopaminergic system in rats with acute hepatic failure.
Topics: Ammonia; Anesthesia; Animals; Biogenic Monoamines; Brain Chemistry; Central Nervous System; Dopamine | 2005 |
Antagonistic effects of atipamezole, flumazenil and 4-aminopyridine against anaesthesia with medetomidine, midazolam and ketamine combination in cats.
Topics: 4-Aminopyridine; Anesthesia; Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Intraven | 2008 |
Partial antagonization of midazolam-medetomidine-ketamine in cats--atipamezole versus combined atipamezole and flumazenil.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Anesthetics, Combined; Anesthetics, Dissociative; Anesthet | 2007 |
[The action of the benzodiazepine antagonist Ro 15-1788].
Topics: Anesthesia; Animals; Anti-Anxiety Agents; Benzodiazepinones; Brain; Electroencephalography; Flumazen | 1984 |
Chlordiazepoxide reduces in vivo serotonin release in the basal ganglia of encéphale isolé but not anesthetized cats: evidence for a dorsal raphe site of action.
Topics: Anesthesia; Animals; Basal Ganglia; Benzodiazepinones; Brain Stem; Cats; Chlordiazepoxide; Decerebra | 1983 |
Anaesthesia for thyroplasty.
Topics: Anesthesia; Flumazenil; Humans; Larynx; Midazolam; Vocal Cord Paralysis | 1995 |
Does midazolam cause retrograde amnesia, and can flumazenil reverse that amnesia?
Topics: Amnesia, Retrograde; Anesthesia; Anesthetics, Intravenous; Anti-Anxiety Agents; Benzodiazepines; Flu | 1997 |
Tiletamine-zolazepam anesthesia in North American river otters (Lutra canadensis) and its partial antagonism with flumazenil.
Topics: Anesthesia; Anesthetics, Dissociative; Animals; Antidotes; Body Temperature; Female; Flumazenil; Hea | 1997 |
Transient global amnesia: a cause for postanesthetic memory disorder.
Topics: Amnesia; Anesthesia; Flumazenil; Humans | 1998 |
Yohimbine/flumazenil antagonism of hemodynamic alterations induced by a combination of midazolam, xylazine, and butorphanol in dogs.
Topics: Anesthesia; Anesthetics; Animals; Blood Pressure; Butorphanol; Cardiac Output; Dogs; Female; Flumaze | 1992 |
[Use of flumazenil in anesthesia. Personal experience].
Topics: Anesthesia; Anti-Anxiety Agents; Flumazenil; Humans | 1991 |
[Pure benzodiazepine anesthesia: psychometric evaluation of the recovery state obtained with flumazenil (anexate)].
Topics: Anesthesia; Anti-Anxiety Agents; Female; Flumazenil; Humans; Middle Aged; Psychological Tests; Wakef | 1991 |
Differential interactions of Ro 15-4513 with benzodiazepines, ethanol and pentobarbital.
Topics: Anesthesia; Animals; Anti-Anxiety Agents; Azides; Behavior, Animal; Benzodiazepines; Diazepam; Drug | 1990 |
Flumazenil: a twelve-month survey of use in a New Zealand public hospital.
Topics: Adult; Anesthesia; Anti-Anxiety Agents; Dose-Response Relationship, Drug; Drug Utilization; Female; | 1990 |
[Anesthesia in dogs with the combination preparation Tilest 500].
Topics: Analgesia; Anesthesia; Animals; Arrhythmias, Cardiac; Blood Pressure; Coronary Disease; Dog Diseases | 1991 |
Resedation after bolus administration of midazolam to an infant and its reversal by flumazenil.
Topics: Anesthesia; Flumazenil; Hematoma, Subdural; Humans; Infant; Male; Midazolam | 1991 |
Midazolam and flumazenil--the agonist-antagonist concept for sedation and anaesthesia. Proceedings of an international symposium. Sardinia, April 1989.
Topics: Anesthesia; Flumazenil; Humans; Midazolam | 1990 |
Papers presented at the international symposium on "Sedation in intensive care medicine and flumazenil". Brussels, December 3, 1988.
Topics: Anesthesia; Animals; Critical Care; Flumazenil; Humans | 1989 |
[Antagonism of the effects of midazolam by flumazenil on the consumption of oxygen by the body].
Topics: Anesthesia; Flumazenil; Humans; Lorazepam; Midazolam; Oxygen Consumption; Postoperative Period; Prea | 1989 |
[Respiratory effect of flumazenil after anesthesia with midazolam].
Topics: Adult; Anesthesia; Flumazenil; Humans; Male; Midazolam; Respiration; Respiratory Function Tests; Spi | 1989 |
[The effects of flumazenil given for resuscitation from midazolam anesthesia in patients over 80 years of age].
Topics: Aged; Aged, 80 and over; Anesthesia; Flumazenil; Humans; Midazolam; Postoperative Period | 1989 |
A benzodiazepine receptor antagonist improves emergence of mice from halothane anaesthesia.
Topics: Anesthesia; Animals; Flumazenil; Halothane; Male; Mice; Mice, Inbred ICR; Motor Activity; Postural B | 1989 |
Modification of evoked hippocampal dentate inhibition by diazepam and three antagonists in urethane-anesthetized rats.
Topics: Anesthesia; Animals; Diazepam; Evoked Potentials; Flumazenil; gamma-Aminobutyric Acid; Hippocampus; | 1989 |
Reversal of the cerebral effects of diazepam in the dog by the benzodiazepine antagonist Ro15-1788.
Topics: Anesthesia; Animals; Benzodiazepinones; Brain; Cerebrovascular Circulation; Diazepam; Dogs; Electroe | 1986 |