Page last updated: 2024-10-27

flumazenil and Anesthesia

flumazenil has been researched along with Anesthesia in 44 studies

Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.

Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.

Research Excerpts

ExcerptRelevanceReference
"5 mg oral dose of midazolam 45 min prior to the induction of anesthesia."9.06[The effectiveness of the benzodiazepine antagonist Ro 15-1788 after the induction of anesthesia with midazolam]. ( Kretz, FJ; Peisdersky, B, 1988)
"North American river otters (Lutra canadensis) were anesthetized with tiletamine-zolazepam or tiletamine-zolazepam-flumazenil combinations in cooperation with the North Carolina Wildlife Resources Commission Otter Restoration Project for evaluation of physiologic changes during anesthesia."7.69Tiletamine-zolazepam anesthesia in North American river otters (Lutra canadensis) and its partial antagonism with flumazenil. ( Karesh, WB; Spelman, LH; Stoskopf, MK; Summer, PW, 1997)
"The treatment with flumazenil completely abolished the decrease in the metabolite (P < 0."5.33Flumazenil-induced improvement of the central dopaminergic system in rats with acute hepatic failure. ( Adachi, N; Arai, T; Liu, K; Yano, M, 2005)
"5 mg oral dose of midazolam 45 min prior to the induction of anesthesia."5.06[The effectiveness of the benzodiazepine antagonist Ro 15-1788 after the induction of anesthesia with midazolam]. ( Kretz, FJ; Peisdersky, B, 1988)
" Midazolam does not induce anesthesia in healthy, small animals and, as such, can only be used in combination with other injectable agents, such as ketamine or the thiobarbiturates."4.78Other potentially useful new injectable anesthetic agents. ( Ilkiw, JE, 1992)
" We studied (11)C-flumazenil binding to GABA(A) receptors during sevoflurane and propofol anesthesia in the living human brain using positron emission tomography (PET)."3.72Sevoflurane and propofol increase 11C-flumazenil binding to gamma-aminobutyric acidA receptors in humans. ( Aalto, S; Hietala, J; Hinkka, S; Kaisti, KK; Korpi, ER; Metsähonkala, L; Någren, K; Oikonen, V; Salmi, E; Scheinin, H, 2004)
"The benzodiazepine receptor antagonist, flumazenil, at a dose of 10 mg/kg given intraperitoneally to mice, had no effect on the minimum air concentration (MAC-50) of halothane causing anesthesia in 50% of the animals and which was 1."3.67A benzodiazepine receptor antagonist improves emergence of mice from halothane anaesthesia. ( Cohen, S; Geller, E; Halpern, P; Schiff, B; Speiser, Z, 1989)
"In six dogs initially anesthetized with halothane-N2O-O2 for surgery and maintained during the experiment with high spinal anesthesia and local infiltration, diazepam 3."3.67Reversal of the cerebral effects of diazepam in the dog by the benzodiazepine antagonist Ro15-1788. ( Michenfelder, JD; Milde, JH; Roald, OK; Steen, PA, 1986)
" For instance, [3H]gamma-aminobutyric acid release in the dorsal raphe was enhanced by halothane anesthesia."3.66Chlordiazepoxide reduces in vivo serotonin release in the basal ganglia of encéphale isolé but not anesthetized cats: evidence for a dorsal raphe site of action. ( Blas, C; Ferron, A; Glowinski, J; Soubrie, P, 1983)
"Flumazenil has been studied for a variety of indications, including as an antidote to benzodiazepine overdose and for awakening of comatose patients, reversal of sedation after surgery and in critically ill patients, and management of hepatic encephalopathy."2.38Flumazenil: a benzodiazepine antagonist. ( Hoffman, EJ; Warren, EW, 1993)
"Flumazenil (Ro 15-1788) is a specific benzodiazepine antagonist which can prevent or abolish selectively at the receptor level all centrally mediated effects of benzodiazepines."2.37Pharmacokinetics and clinical use of flumazenil (Ro 15-1788). ( Kanto, J; Klotz, U, 1988)
" The addition of flumazenil showed no significant difference to atipamezole alone, but subcutaneous administration of atipamezole alone was not sufficient in the dosage used to show an advantage compared to non-reversed cats."1.34Partial antagonization of midazolam-medetomidine-ketamine in cats--atipamezole versus combined atipamezole and flumazenil. ( Baumgartner, C; Ebner, J; Erhardt, W; Henke, J; Wehr, U, 2007)
"The treatment with flumazenil completely abolished the decrease in the metabolite (P < 0."1.33Flumazenil-induced improvement of the central dopaminergic system in rats with acute hepatic failure. ( Adachi, N; Arai, T; Liu, K; Yano, M, 2005)
"Flumazenil was used most frequently after anaesthesia and in the initial management of intentional drug overdose."1.28Flumazenil: a twelve-month survey of use in a New Zealand public hospital. ( Galletly, DC; Turley, A; Ure, R, 1990)
" The drug was administered intramuscularly in ten dogs at a dosage of 10 mg/kg bwt of tiletamine and 10 mg/kg bwt of zolazepam and tested for its effects on hemodynamics, respiration, and the antagonistic effect of flumazenil."1.28[Anesthesia in dogs with the combination preparation Tilest 500]. ( Hess, L, 1991)

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-199015 (34.09)18.7374
1990's18 (40.91)18.2507
2000's5 (11.36)29.6817
2010's3 (6.82)24.3611
2020's3 (6.82)2.80

Authors

AuthorsStudies
Kiyama, S1
Masui, K1
Li, C1
Yan, J1
Tang, D1
Zhu, J1
Huang, C1
Sun, Y1
Hu, R1
Wang, H1
Fu, C1
Chen, Y1
Jiang, H1
Sandiego, CM1
Jin, X1
Mulnix, T1
Fowles, K1
Labaree, D1
Ropchan, J1
Huang, Y1
Cosgrove, K1
Castner, SA1
Williams, GV1
Wells, L1
Rabiner, EA1
Carson, RE1
Heldwein, CG1
Silva, Lde L1
Gai, EZ1
Roman, C1
Parodi, TV1
Bürger, ME1
Baldisserotto, B1
Flores, ÉM1
Heinzmann, BM1
Ueoka, N2
Hikasa, Y2
Salmi, E1
Kaisti, KK1
Metsähonkala, L1
Oikonen, V1
Aalto, S1
Någren, K1
Hinkka, S1
Hietala, J1
Korpi, ER1
Scheinin, H1
Yano, M1
Adachi, N1
Liu, K1
Arai, T1
Vesal, N1
Zare, P1
Ebner, J1
Wehr, U1
Baumgartner, C1
Erhardt, W1
Henke, J1
Doenicke, A1
Suttmann, H1
Kapp, W1
Kugler, J1
Ebentheuer, H1
Soubrie, P1
Blas, C1
Ferron, A1
Glowinski, J1
Donnelly, M1
Browne, J1
Fitzpatrick, G1
Shapira, Y1
Eilig, I1
Bar-Lavy, Y1
Fan, SZ1
Liu, CC1
Yu, HY1
Chao, CC1
Lin, SM1
Hoffman, EJ1
Warren, EW1
Koht, A1
Moss, JI1
Spelman, LH1
Summer, PW1
Karesh, WB1
Stoskopf, MK1
Ghoneim, MM1
Larson, JS1
Lunn, JJ1
Gross, ME1
Tranquilli, WJ1
Thurmon, JC1
Benson, GJ1
Olson, WA1
Baktai, G1
Székely, E1
Márialigeti, T1
Kovács, L1
Ilkiw, JE1
Grande, LM1
Guerra-Narducci, P1
Arpino, I1
Stefanelli, A1
Roscetti, A1
Dordoni, PL1
Cannelli, G1
Camaioni, D1
Deacon, RM1
Budhram, P1
Thomson, TA1
Gardner, CR1
Galletly, DC1
Ure, R1
Turley, A1
Hess, L1
Collins, S1
Carter, JA1
Camu, F1
Lebrault, C1
Costes, H1
Guirimand, F1
Chauvin, M1
Duvaldestin, P1
Barakat, T1
Lechat, JP1
Laurent, P1
Fletcher, D1
Clergue, F1
Viars, P1
Bougeois, B1
Servin, F1
Farinotti, R1
Desmonts, JM1
Geller, E1
Schiff, B1
Halpern, P1
Speiser, Z1
Cohen, S1
Albertson, TE1
Joy, RM1
Marty, J1
Joyon, D1
Baehrendtz, S1
Höjer, J1
Breimer, LT1
Hennis, PJ1
Bovill, JG1
Spierdijk, J1
Roald, OK1
Steen, PA1
Milde, JH1
Michenfelder, JD1
Klotz, U1
Kanto, J1
Kretz, FJ1
Peisdersky, B1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of Neurotoxic Effect of Sevoflurane-Based Anaesthesia Guided by Significant Short-Term Olfactory Identification Impairment in Old Age[NCT03726580]600 participants (Actual)Observational [Patient Registry]2017-03-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

8 reviews available for flumazenil and Anesthesia

ArticleYear
[Flumazenil].
    Harefuah, 1995, Jun-15, Volume: 128, Issue:12

    Topics: Anesthesia; Flumazenil; GABA Modulators; Humans

1995
Flumazenil: a benzodiazepine antagonist.
    Clinical pharmacy, 1993, Volume: 12, Issue:9

    Topics: Anesthesia; Benzodiazepines; Drug Interactions; Drug Overdose; Flumazenil; Hepatic Encephalopathy; H

1993
Comparing drugs for short-term sedation.
    Contemporary internal medicine, 1994, Volume: 6, Issue:12

    Topics: Anesthesia; Benzodiazepines; Conscious Sedation; Diazepam; Flumazenil; Humans; Lorazepam; Midazolam;

1994
Other potentially useful new injectable anesthetic agents.
    The Veterinary clinics of North America. Small animal practice, 1992, Volume: 22, Issue:2

    Topics: Anesthesia; Anesthetics; Animals; Cats; Dogs; Flumazenil; Midazolam; Propofol

1992
Experience of Anexate in anesthesiology.
    Acta anaesthesiologica Belgica, 1989, Volume: 40, Issue:1

    Topics: Adjuvants, Anesthesia; Anesthesia; Benzodiazepines; Flumazenil; Humans; Time Factors

1989
Haemodynamic responses following reversal of benzodiazepine-induced anaesthesia or sedation with flumazenil.
    European journal of anaesthesiology. Supplement, 1988, Volume: 2

    Topics: Anesthesia; Benzodiazepines; Double-Blind Method; Flumazenil; Hemodynamics; Humans; Receptors, GABA-

1988
Flumazenil in self-induced benzodiazepine poisoning.
    European journal of anaesthesiology. Supplement, 1988, Volume: 2

    Topics: Anesthesia; Benzodiazepines; Emergencies; Flumazenil; Humans; Receptors, GABA-A

1988
Pharmacokinetics and clinical use of flumazenil (Ro 15-1788).
    Clinical pharmacokinetics, 1988, Volume: 14, Issue:1

    Topics: Anesthesia; Benzodiazepines; Diazepam; Flumazenil; Humans; Injections, Intravenous; Poisoning

1988

Trials

7 trials available for flumazenil and Anesthesia

ArticleYear
Clinical evaluation of intranasal benzodiazepines, alpha-agonists and their antagonists in canaries.
    Veterinary anaesthesia and analgesia, 2006, Volume: 33, Issue:3

    Topics: Administration, Intranasal; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthesia; Ani

2006
Lack of effect of flumazenil on the reversal of propofol anaesthesia.
    Acta anaesthesiologica Scandinavica, 1995, Volume: 39, Issue:3

    Topics: Adult; Anesthesia; Double-Blind Method; Drug Interactions; Female; Flumazenil; Humans; Propofol

1995
Use of midazolam ('Dormicum') and flumazenil ('Anexate') in paediatric bronchology.
    Current medical research and opinion, 1992, Volume: 12, Issue:9

    Topics: Anesthesia; Atropine; Bronchoscopy; Child, Preschool; Chronic Disease; Drug Administration Schedule;

1992
Haemodynamic responses following reversal of benzodiazepine-induced anaesthesia or sedation with flumazenil.
    European journal of anaesthesiology. Supplement, 1988, Volume: 2

    Topics: Anesthesia; Benzodiazepines; Double-Blind Method; Flumazenil; Hemodynamics; Humans; Receptors, GABA-

1988
Flumazenil in self-induced benzodiazepine poisoning.
    European journal of anaesthesiology. Supplement, 1988, Volume: 2

    Topics: Anesthesia; Benzodiazepines; Emergencies; Flumazenil; Humans; Receptors, GABA-A

1988
The efficacy of flumazenil versus physostigmine after midazolam-alfentanil anaesthesia in man.
    European journal of anaesthesiology. Supplement, 1988, Volume: 2

    Topics: Adult; Alfentanil; Anesthesia; Anesthesia Recovery Period; Double-Blind Method; Female; Fentanyl; Fl

1988
[The effectiveness of the benzodiazepine antagonist Ro 15-1788 after the induction of anesthesia with midazolam].
    Der Anaesthesist, 1988, Volume: 37, Issue:1

    Topics: Adult; Anesthesia; Anesthesia Recovery Period; Double-Blind Method; Drug Evaluation; Female; Flumaze

1988

Other Studies

31 other studies available for flumazenil and Anesthesia

ArticleYear
Re-sedation after a large dose of flumazenil.
    Journal of anesthesia, 2023, Volume: 37, Issue:1

    Topics: Anesthesia; Benzodiazepines; Flumazenil; Midazolam

2023
Reply to "Re-sedation after a large dose of flumazenil".
    Journal of anesthesia, 2023, Volume: 37, Issue:1

    Topics: Anesthesia; Flumazenil; Midazolam

2023
GluN2A-selective positive allosteric modulator-nalmefene-flumazenil reverses ketamine-fentanyl-dexmedetomidine-induced anesthesia and analgesia in rats.
    Scientific reports, 2020, 03-24, Volume: 10, Issue:1

    Topics: Adjuvants, Anesthesia; Allosteric Regulation; Analgesia; Anesthesia; Animals; Delayed Emergence from

2020
Awake nonhuman primate brain PET imaging with minimal head restraint: evaluation of GABAA-benzodiazepine binding with 11C-flumazenil in awake and anesthetized animals.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2013, Volume: 54, Issue:11

    Topics: Anesthesia; Animals; Benzodiazepines; Brain; Carbon Radioisotopes; Female; Flumazenil; gamma-Aminobu

2013
S-(+)-Linalool from Lippia alba: sedative and anesthetic for silver catfish (Rhamdia quelen).
    Veterinary anaesthesia and analgesia, 2014, Volume: 41, Issue:6

    Topics: Acyclic Monoterpenes; Anesthesia; Anesthetics; Animals; Catfishes; Central Nervous System; Diazepam;

2014
Effects in cats of atipamezole, flumazenil and 4-aminopyridine on stress-related neurohormonal and metabolic responses induced by medetomidine, midazolam and ketamine.
    Journal of feline medicine and surgery, 2015, Volume: 17, Issue:8

    Topics: 4-Aminopyridine; Anesthesia; Anesthetics, Combined; Animals; Arousal; Cats; Dose-Response Relationsh

2015
Sevoflurane and propofol increase 11C-flumazenil binding to gamma-aminobutyric acidA receptors in humans.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:5

    Topics: Adult; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Blood Gas Analysis; Brain; Car

2004
Flumazenil-induced improvement of the central dopaminergic system in rats with acute hepatic failure.
    Journal of neurosurgical anesthesiology, 2005, Volume: 17, Issue:2

    Topics: Ammonia; Anesthesia; Animals; Biogenic Monoamines; Brain Chemistry; Central Nervous System; Dopamine

2005
Antagonistic effects of atipamezole, flumazenil and 4-aminopyridine against anaesthesia with medetomidine, midazolam and ketamine combination in cats.
    Journal of feline medicine and surgery, 2008, Volume: 10, Issue:1

    Topics: 4-Aminopyridine; Anesthesia; Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Intraven

2008
Partial antagonization of midazolam-medetomidine-ketamine in cats--atipamezole versus combined atipamezole and flumazenil.
    Journal of veterinary medicine. A, Physiology, pathology, clinical medicine, 2007, Volume: 54, Issue:9

    Topics: Adrenergic alpha-Antagonists; Anesthesia; Anesthetics, Combined; Anesthetics, Dissociative; Anesthet

2007
[The action of the benzodiazepine antagonist Ro 15-1788].
    Der Anaesthesist, 1984, Volume: 33, Issue:8

    Topics: Anesthesia; Animals; Anti-Anxiety Agents; Benzodiazepinones; Brain; Electroencephalography; Flumazen

1984
Chlordiazepoxide reduces in vivo serotonin release in the basal ganglia of encéphale isolé but not anesthetized cats: evidence for a dorsal raphe site of action.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 226, Issue:2

    Topics: Anesthesia; Animals; Basal Ganglia; Benzodiazepinones; Brain Stem; Cats; Chlordiazepoxide; Decerebra

1983
Anaesthesia for thyroplasty.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1995, Volume: 42, Issue:9

    Topics: Anesthesia; Flumazenil; Humans; Larynx; Midazolam; Vocal Cord Paralysis

1995
Does midazolam cause retrograde amnesia, and can flumazenil reverse that amnesia?
    Anesthesia and analgesia, 1997, Volume: 85, Issue:1

    Topics: Amnesia, Retrograde; Anesthesia; Anesthetics, Intravenous; Anti-Anxiety Agents; Benzodiazepines; Flu

1997
Tiletamine-zolazepam anesthesia in North American river otters (Lutra canadensis) and its partial antagonism with flumazenil.
    Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 1997, Volume: 28, Issue:4

    Topics: Anesthesia; Anesthetics, Dissociative; Animals; Antidotes; Body Temperature; Female; Flumazenil; Hea

1997
Transient global amnesia: a cause for postanesthetic memory disorder.
    Anesthesia and analgesia, 1998, Volume: 87, Issue:4

    Topics: Amnesia; Anesthesia; Flumazenil; Humans

1998
Yohimbine/flumazenil antagonism of hemodynamic alterations induced by a combination of midazolam, xylazine, and butorphanol in dogs.
    Journal of the American Veterinary Medical Association, 1992, Dec-15, Volume: 201, Issue:12

    Topics: Anesthesia; Anesthetics; Animals; Blood Pressure; Butorphanol; Cardiac Output; Dogs; Female; Flumaze

1992
[Use of flumazenil in anesthesia. Personal experience].
    Minerva anestesiologica, 1991, Volume: 57, Issue:6

    Topics: Anesthesia; Anti-Anxiety Agents; Flumazenil; Humans

1991
[Pure benzodiazepine anesthesia: psychometric evaluation of the recovery state obtained with flumazenil (anexate)].
    Minerva anestesiologica, 1991, Volume: 57, Issue:9

    Topics: Anesthesia; Anti-Anxiety Agents; Female; Flumazenil; Humans; Middle Aged; Psychological Tests; Wakef

1991
Differential interactions of Ro 15-4513 with benzodiazepines, ethanol and pentobarbital.
    European journal of pharmacology, 1990, May-16, Volume: 180, Issue:2-3

    Topics: Anesthesia; Animals; Anti-Anxiety Agents; Azides; Behavior, Animal; Benzodiazepines; Diazepam; Drug

1990
Flumazenil: a twelve-month survey of use in a New Zealand public hospital.
    Anaesthesia and intensive care, 1990, Volume: 18, Issue:2

    Topics: Adult; Anesthesia; Anti-Anxiety Agents; Dose-Response Relationship, Drug; Drug Utilization; Female;

1990
[Anesthesia in dogs with the combination preparation Tilest 500].
    Tierarztliche Praxis, 1991, Volume: 19, Issue:1

    Topics: Analgesia; Anesthesia; Animals; Arrhythmias, Cardiac; Blood Pressure; Coronary Disease; Dog Diseases

1991
Resedation after bolus administration of midazolam to an infant and its reversal by flumazenil.
    Anaesthesia, 1991, Volume: 46, Issue:6

    Topics: Anesthesia; Flumazenil; Hematoma, Subdural; Humans; Infant; Male; Midazolam

1991
Midazolam and flumazenil--the agonist-antagonist concept for sedation and anaesthesia. Proceedings of an international symposium. Sardinia, April 1989.
    Acta anaesthesiologica Scandinavica. Supplementum, 1990, Volume: 92

    Topics: Anesthesia; Flumazenil; Humans; Midazolam

1990
Papers presented at the international symposium on "Sedation in intensive care medicine and flumazenil". Brussels, December 3, 1988.
    Acta anaesthesiologica Belgica, 1989, Volume: 40, Issue:1

    Topics: Anesthesia; Animals; Critical Care; Flumazenil; Humans

1989
[Antagonism of the effects of midazolam by flumazenil on the consumption of oxygen by the body].
    Annales francaises d'anesthesie et de reanimation, 1989, Volume: 8 Suppl

    Topics: Anesthesia; Flumazenil; Humans; Lorazepam; Midazolam; Oxygen Consumption; Postoperative Period; Prea

1989
[Respiratory effect of flumazenil after anesthesia with midazolam].
    Annales francaises d'anesthesie et de reanimation, 1989, Volume: 8 Suppl

    Topics: Adult; Anesthesia; Flumazenil; Humans; Male; Midazolam; Respiration; Respiratory Function Tests; Spi

1989
[The effects of flumazenil given for resuscitation from midazolam anesthesia in patients over 80 years of age].
    Annales francaises d'anesthesie et de reanimation, 1989, Volume: 8 Suppl

    Topics: Aged; Aged, 80 and over; Anesthesia; Flumazenil; Humans; Midazolam; Postoperative Period

1989
A benzodiazepine receptor antagonist improves emergence of mice from halothane anaesthesia.
    Neuropharmacology, 1989, Volume: 28, Issue:3

    Topics: Anesthesia; Animals; Flumazenil; Halothane; Male; Mice; Mice, Inbred ICR; Motor Activity; Postural B

1989
Modification of evoked hippocampal dentate inhibition by diazepam and three antagonists in urethane-anesthetized rats.
    Experimental neurology, 1989, Volume: 106, Issue:2

    Topics: Anesthesia; Animals; Diazepam; Evoked Potentials; Flumazenil; gamma-Aminobutyric Acid; Hippocampus;

1989
Reversal of the cerebral effects of diazepam in the dog by the benzodiazepine antagonist Ro15-1788.
    Acta anaesthesiologica Scandinavica, 1986, Volume: 30, Issue:4

    Topics: Anesthesia; Animals; Benzodiazepinones; Brain; Cerebrovascular Circulation; Diazepam; Dogs; Electroe

1986