flumazenil has been researched along with Amyotrophic Lateral Sclerosis in 6 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We used the benzodiazepine GABA(A) marker [(11)C] flumazenil to study cerebral dysfunction in amyotrophic lateral sclerosis (ALS) with PET." | 3.70 | Extramotor involvement in ALS: PET studies with the GABA(A) ligand [(11)C]flumazenil. ( Al-Chalabi, A; Brooks, DJ; Leigh, PN; Lloyd, CM; Richardson, MP, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caioli, S | 1 |
| Pieri, M | 1 |
| Antonini, A | 1 |
| Guglielmotti, A | 1 |
| Severini, C | 1 |
| Zona, C | 1 |
| Turner, MR | 3 |
| Hammers, A | 3 |
| Al-Chalabi, A | 3 |
| Shaw, CE | 2 |
| Andersen, PM | 2 |
| Brooks, DJ | 4 |
| Leigh, PN | 4 |
| Osei-Lah, AD | 1 |
| Mills, KR | 1 |
| Wicks, P | 1 |
| Abrahams, S | 1 |
| Goldstein, LH | 1 |
| Gredal, O | 1 |
| Pakkenberg, B | 1 |
| Nielsen, M | 1 |
| Lloyd, CM | 1 |
| Richardson, MP | 1 |
6 other studies available for flumazenil and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Monocyte Chemoattractant Protein-1 upregulates GABA-induced current: evidence of modified GABAA subunit composition in cortical neurons from the G93A mouse model of Amyotrophic Lateral Sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cells, Cultured; Cerebral Cortex; Chemokine CCL2; Disease Mo | 2013 |
Distinct cerebral lesions in sporadic and 'D90A' SOD1 ALS: studies with [11C]flumazenil PET.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Carbon Radioisotopes; Cerebral Cortex; Disease Progressi | 2005 |
Abnormal cortical excitability in sporadic but not homozygous D90A SOD1 ALS.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Case-Control Studies; Cerebral Cortex; Disease Progressi | 2005 |
Neuronal loss associated with cognitive performance in amyotrophic lateral sclerosis: an (11C)-flumazenil PET study.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Carbon Radioisotopes; Cognition Disorders; Female; Fluma | 2008 |
Muscarinic, N-methyl-D-aspartate (NMDA) and benzodiazepine receptor binding sites in cortical membranes from amyotrophic lateral sclerosis patients.
Topics: Aged; Amyotrophic Lateral Sclerosis; Binding Sites; Brain Chemistry; Dizocilpine Maleate; Excitatory | 1996 |
Extramotor involvement in ALS: PET studies with the GABA(A) ligand [(11)C]flumazenil.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Benzodiazepines; Brain Mapping; Carbon Radioisotopes; Ce | 2000 |