flumazenil has been researched along with Amnesia in 23 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Amnesia: Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMNESIA, ANTEROGRADE). This condition may be of organic or psychologic origin. Organic forms of amnesia are usually associated with dysfunction of the DIENCEPHALON or HIPPOCAMPUS. (From Adams et al., Principles of Neurology, 6th ed, pp426-7)
| Excerpt | Relevance | Reference |
|---|---|---|
| "01 mg kg-1 on the amnesia and sedation caused by midazolam 2 mg and 5 mg i." | 9.06 | Effect of flumazenil on midazolam-induced amnesia. ( Clarke, RS; McKay, AC; McKinney, MS, 1990) |
| "Alprazolam produced anterograde as well as retrograde amnesia in mice assessed using elevated plus-maze." | 7.70 | Possible mechanism of alprazolam-induced amnesia in mice. ( Sharma, A; Singh, M; Singh, N, 1998) |
| "Anterograde amnesia, possibly accompanied by acute brain syndrome, is a potential side-effect of certain benzodiazepines, particularly triazolam." | 7.68 | Anterograde amnesia in triazolam overdose despite flumazenil treatment: a case report. ( Deng, JF; Hung, DZ; Tsai, WJ, 1992) |
| "The effects of N-(2,6-dimethyl-phenyl)-2-(2-oxo-1-pyrrolidinyl) acetamide (DM-9384), a new pyrrolidone derivative, were investigated on ethanol- and chlordiazepoxide (CDP)-induced amnesia animal model using the passive avoidance task in comparison with aniracetam, another pyrrolidone derivative." | 7.68 | Effects of DM-9384, a pyrrolidone derivative, on alcohol- and chlordiazepoxide-induced amnesia in mice. ( Kameyama, T; Nabeshima, T; Tohyama, K, 1990) |
| "01 mg kg-1 on the amnesia and sedation caused by midazolam 2 mg and 5 mg i." | 5.06 | Effect of flumazenil on midazolam-induced amnesia. ( Clarke, RS; McKay, AC; McKinney, MS, 1990) |
| "Alprazolam produced anterograde as well as retrograde amnesia in mice assessed using elevated plus-maze." | 3.70 | Possible mechanism of alprazolam-induced amnesia in mice. ( Sharma, A; Singh, M; Singh, N, 1998) |
| "Anterograde amnesia, possibly accompanied by acute brain syndrome, is a potential side-effect of certain benzodiazepines, particularly triazolam." | 3.68 | Anterograde amnesia in triazolam overdose despite flumazenil treatment: a case report. ( Deng, JF; Hung, DZ; Tsai, WJ, 1992) |
| "The effects of N-(2,6-dimethyl-phenyl)-2-(2-oxo-1-pyrrolidinyl) acetamide (DM-9384), a new pyrrolidone derivative, were investigated on ethanol- and chlordiazepoxide (CDP)-induced amnesia animal model using the passive avoidance task in comparison with aniracetam, another pyrrolidone derivative." | 3.68 | Effects of DM-9384, a pyrrolidone derivative, on alcohol- and chlordiazepoxide-induced amnesia in mice. ( Kameyama, T; Nabeshima, T; Tohyama, K, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (30.43) | 18.7374 |
| 1990's | 13 (56.52) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (8.70) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Cappelli, A | 1 |
| Anzini, M | 1 |
| Castriconi, F | 1 |
| Grisci, G | 1 |
| Paolino, M | 1 |
| Braile, C | 1 |
| Valenti, S | 1 |
| Giuliani, G | 1 |
| Vomero, S | 1 |
| Di Capua, A | 1 |
| Betti, L | 1 |
| Giannaccini, G | 1 |
| Lucacchini, A | 1 |
| Ghelardini, C | 1 |
| Di Cesare Mannelli, L | 1 |
| Frosini, M | 1 |
| Ricci, L | 1 |
| Giorgi, G | 1 |
| Mascia, MP | 1 |
| Biggio, G | 1 |
| Sehara, Y | 1 |
| Ando, Y | 1 |
| Minezumi, T | 1 |
| Funayama, N | 1 |
| Kawai, K | 1 |
| Sawada, M | 1 |
| Rinehart, JB | 1 |
| Baker, B | 1 |
| Raphael, D | 1 |
| Thiébot, MH | 1 |
| Childs, M | 1 |
| Soubrié, P | 1 |
| Simon, P | 1 |
| Martin, JR | 1 |
| Schoch, P | 1 |
| Jenck, F | 1 |
| Moreau, JL | 1 |
| Haefely, WE | 1 |
| Hommer, D | 1 |
| Weingartner, H | 1 |
| Breier, A | 1 |
| Singh, N | 1 |
| Sharma, A | 1 |
| Singh, M | 1 |
| Ghoneim, MM | 1 |
| File, SE | 1 |
| Hung, DZ | 1 |
| Tsai, WJ | 1 |
| Deng, JF | 1 |
| Ilyutchenok, RY | 1 |
| Loskutova, LV | 1 |
| Finkelberg, AL | 1 |
| Dubrovina, NI | 1 |
| Prather, PL | 1 |
| Forster, MJ | 1 |
| Lal, H | 1 |
| Curran, HV | 1 |
| Birch, B | 1 |
| Colpaert, FC | 1 |
| Ochs, MW | 1 |
| Tucker, MR | 1 |
| Owsley, TG | 1 |
| Anderson, JA | 1 |
| Nabeshima, T | 2 |
| Tohyama, K | 2 |
| Kameyama, T | 2 |
| McKay, AC | 1 |
| McKinney, MS | 1 |
| Clarke, RS | 1 |
| Dorow, R | 1 |
| Berenberg, D | 1 |
| Duka, T | 1 |
| Sauerbrey, N | 1 |
| Ricou, B | 1 |
| Forster, A | 1 |
| Brückner, A | 1 |
| Chastonay, P | 1 |
| Gemperle, M | 1 |
| Kirkegaard, L | 1 |
| Knudsen, L | 1 |
| Jensen, S | 1 |
| Kruse, A | 1 |
| Sage, DJ | 1 |
| Close, A | 1 |
| Boas, RA | 1 |
| Dodgson, MS | 1 |
| Skeie, B | 1 |
| Emhjellen, S | 1 |
| Wickstrøm, E | 1 |
| Steen, PA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Neurocognitive Functioning Following The PROMETA® Treatment Protocol In Subjects With Alcohol Dependence[NCT00570388] | 120 participants (Anticipated) | Interventional | 2007-03-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 trials available for flumazenil and Amnesia
| Article | Year |
|---|---|
Dissociation of benzodiazepine-induced amnesia from sedation by flumazenil pretreatment.
Topics: Adult; Amnesia; Attention; Cross-Over Studies; Diazepam; Double-Blind Method; Flumazenil; Humans; Hy | 1993 |
Differentiating the sedative, psychomotor and amnesic effects of benzodiazepines: a study with midazolam and the benzodiazepine antagonist, flumazenil.
Topics: Adult; Amnesia; Anti-Anxiety Agents; Cognition; Double-Blind Method; Emotions; Female; Flicker Fusio | 1991 |
The effectiveness of flumazenil in reversing the sedation and amnesia produced by intravenous midazolam.
Topics: Amnesia; Anesthesia, Dental; Anesthesia, General; Double-Blind Method; Female; Flumazenil; Humans; M | 1990 |
Effect of flumazenil on midazolam-induced amnesia.
Topics: Adult; Amnesia; Dose-Response Relationship, Drug; Flicker Fusion; Flumazenil; Humans; Memory; Midazo | 1990 |
Amnestic effects of lormetazepam and their reversal by the benzodiazepine antagonist Ro 15-1788.
Topics: Adult; Amnesia; Anti-Anxiety Agents; Benzodiazepines; Cognition; Emotions; Female; Flumazenil; Human | 1987 |
Clinical evaluation of a specific benzodiazepine antagonist (RO 15-1788). Studies in elderly patients after regional anaesthesia under benzodiazepine sedation.
Topics: Aged; Amnesia; Anesthesia Recovery Period; Anesthesia, Conduction; Benzodiazepines; Drug Evaluation; | 1986 |
Benzodiazepine antagonist Ro 15-1788. Antagonism of diazepam sedation in outpatients undergoing gastroscopy.
Topics: Adolescent; Adult; Aged; Amnesia; Clinical Trials as Topic; Diazepam; Double-Blind Method; Female; F | 1986 |
Reversal of midazolam sedation with anexate.
Topics: Aged; Amnesia; Anesthesia Recovery Period; Anesthesia, Spinal; Flumazenil; Hemodynamics; Humans; Mal | 1987 |
Antagonism of diazepam-induced sedative effects by Ro15-1788 in patients after surgery under lumbar epidural block. A double-blind placebo-controlled investigation of efficacy and safety.
Topics: Adult; Aged; Amnesia; Anesthesia, Epidural; Clinical Trials as Topic; Diazepam; Double-Blind Method; | 1987 |
14 other studies available for flumazenil and Amnesia
| Article | Year |
|---|---|
Design, Synthesis, and Biological Evaluation of Imidazo[1,5-a]quinoline as Highly Potent Ligands of Central Benzodiazepine Receptors.
Topics: Amnesia; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Binding Sites; Brain; Catt | 2016 |
[123I]Iomazenil SPECT Detects a Reversible Lesion of the Left Medial Temporal Lobe in a Case of Global Autobiographical Amnesia.
Topics: Amnesia; Female; Flumazenil; Humans; Iodine Radioisotopes; Magnetic Resonance Imaging; Middle Aged; | 2021 |
Postoperative global amnesia reversed with flumazenil.
Topics: Amnesia; Analgesics; Anesthesia, General; Cholangiopancreatography, Endoscopic Retrograde; Desfluran | 2012 |
Diazepam-induced release of behavior in an extinction procedure: its reversal by Ro 15-1788.
Topics: Amnesia; Animals; Behavior, Animal; Benzodiazepinones; Diazepam; Drinking; Extinction, Psychological | 1983 |
Pharmacological characterization of benzodiazepine receptor ligands with intrinsic efficacies ranging from high to zero.
Topics: Acoustic Stimulation; Amnesia; Animals; Anticonvulsants; Conditioning, Operant; Eating; Female; Flum | 1993 |
Possible mechanism of alprazolam-induced amnesia in mice.
Topics: Alprazolam; Amnesia; Animals; Azepines; Drug Evaluation, Preclinical; Female; Flumazenil; GABA Agoni | 1998 |
Transient global amnesia: a cause for postanesthetic memory disorder.
Topics: Amnesia; Anesthesia; Flumazenil; Humans | 1998 |
Benzodiazepines and memory.
Topics: Amnesia; Anti-Anxiety Agents; Attention; Flumazenil; Humans; Memory | 1992 |
Anterograde amnesia in triazolam overdose despite flumazenil treatment: a case report.
Topics: Adolescent; Amnesia; Drug Overdose; Flumazenil; Humans; Male; Suicide, Attempted; Triazolam | 1992 |
Neurochemical mechanisms of memory control.
Topics: Amnesia; Animals; Bicuculline; Brain; Cats; Dopamine; Evoked Potentials; Flumazenil; GABA-A Receptor | 1992 |
Learning and memory-enhancing effects of Ro 15-4513: a comparison with flumazenil.
Topics: Amnesia; Animals; Avoidance Learning; Azides; Benzodiazepines; Discrimination Learning; Flumazenil; | 1992 |
Amnesic trace locked into the benzodiazepine state of memory.
Topics: Amnesia; Animals; Anti-Anxiety Agents; Chlordiazepoxide; Conditioning, Operant; Conflict, Psychologi | 1990 |
Effects of DM-9384, a pyrrolidone derivative, on alcohol- and chlordiazepoxide-induced amnesia in mice.
Topics: Amnesia; Animals; Avoidance Learning; Bicuculline; Central Nervous System Agents; Chlordiazepoxide; | 1990 |
Reversal of alcohol-induced amnesia by the benzodiazepine inverse agonist Ro 15-4513.
Topics: Amnesia; Animals; Avoidance Learning; Azides; Benzodiazepines; Carbolines; Dose-Response Relationshi | 1988 |