Page last updated: 2024-10-27

flumazenil and Amnesia

flumazenil has been researched along with Amnesia in 23 studies

Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.

Amnesia: Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMNESIA, ANTEROGRADE). This condition may be of organic or psychologic origin. Organic forms of amnesia are usually associated with dysfunction of the DIENCEPHALON or HIPPOCAMPUS. (From Adams et al., Principles of Neurology, 6th ed, pp426-7)

Research Excerpts

ExcerptRelevanceReference
"01 mg kg-1 on the amnesia and sedation caused by midazolam 2 mg and 5 mg i."9.06Effect of flumazenil on midazolam-induced amnesia. ( Clarke, RS; McKay, AC; McKinney, MS, 1990)
"Alprazolam produced anterograde as well as retrograde amnesia in mice assessed using elevated plus-maze."7.70Possible mechanism of alprazolam-induced amnesia in mice. ( Sharma, A; Singh, M; Singh, N, 1998)
"Anterograde amnesia, possibly accompanied by acute brain syndrome, is a potential side-effect of certain benzodiazepines, particularly triazolam."7.68Anterograde amnesia in triazolam overdose despite flumazenil treatment: a case report. ( Deng, JF; Hung, DZ; Tsai, WJ, 1992)
"The effects of N-(2,6-dimethyl-phenyl)-2-(2-oxo-1-pyrrolidinyl) acetamide (DM-9384), a new pyrrolidone derivative, were investigated on ethanol- and chlordiazepoxide (CDP)-induced amnesia animal model using the passive avoidance task in comparison with aniracetam, another pyrrolidone derivative."7.68Effects of DM-9384, a pyrrolidone derivative, on alcohol- and chlordiazepoxide-induced amnesia in mice. ( Kameyama, T; Nabeshima, T; Tohyama, K, 1990)
"01 mg kg-1 on the amnesia and sedation caused by midazolam 2 mg and 5 mg i."5.06Effect of flumazenil on midazolam-induced amnesia. ( Clarke, RS; McKay, AC; McKinney, MS, 1990)
"Alprazolam produced anterograde as well as retrograde amnesia in mice assessed using elevated plus-maze."3.70Possible mechanism of alprazolam-induced amnesia in mice. ( Sharma, A; Singh, M; Singh, N, 1998)
"Anterograde amnesia, possibly accompanied by acute brain syndrome, is a potential side-effect of certain benzodiazepines, particularly triazolam."3.68Anterograde amnesia in triazolam overdose despite flumazenil treatment: a case report. ( Deng, JF; Hung, DZ; Tsai, WJ, 1992)
"The effects of N-(2,6-dimethyl-phenyl)-2-(2-oxo-1-pyrrolidinyl) acetamide (DM-9384), a new pyrrolidone derivative, were investigated on ethanol- and chlordiazepoxide (CDP)-induced amnesia animal model using the passive avoidance task in comparison with aniracetam, another pyrrolidone derivative."3.68Effects of DM-9384, a pyrrolidone derivative, on alcohol- and chlordiazepoxide-induced amnesia in mice. ( Kameyama, T; Nabeshima, T; Tohyama, K, 1990)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19907 (30.43)18.7374
1990's13 (56.52)18.2507
2000's0 (0.00)29.6817
2010's2 (8.70)24.3611
2020's1 (4.35)2.80

Authors

AuthorsStudies
Cappelli, A1
Anzini, M1
Castriconi, F1
Grisci, G1
Paolino, M1
Braile, C1
Valenti, S1
Giuliani, G1
Vomero, S1
Di Capua, A1
Betti, L1
Giannaccini, G1
Lucacchini, A1
Ghelardini, C1
Di Cesare Mannelli, L1
Frosini, M1
Ricci, L1
Giorgi, G1
Mascia, MP1
Biggio, G1
Sehara, Y1
Ando, Y1
Minezumi, T1
Funayama, N1
Kawai, K1
Sawada, M1
Rinehart, JB1
Baker, B1
Raphael, D1
Thiébot, MH1
Childs, M1
Soubrié, P1
Simon, P1
Martin, JR1
Schoch, P1
Jenck, F1
Moreau, JL1
Haefely, WE1
Hommer, D1
Weingartner, H1
Breier, A1
Singh, N1
Sharma, A1
Singh, M1
Ghoneim, MM1
File, SE1
Hung, DZ1
Tsai, WJ1
Deng, JF1
Ilyutchenok, RY1
Loskutova, LV1
Finkelberg, AL1
Dubrovina, NI1
Prather, PL1
Forster, MJ1
Lal, H1
Curran, HV1
Birch, B1
Colpaert, FC1
Ochs, MW1
Tucker, MR1
Owsley, TG1
Anderson, JA1
Nabeshima, T2
Tohyama, K2
Kameyama, T2
McKay, AC1
McKinney, MS1
Clarke, RS1
Dorow, R1
Berenberg, D1
Duka, T1
Sauerbrey, N1
Ricou, B1
Forster, A1
Brückner, A1
Chastonay, P1
Gemperle, M1
Kirkegaard, L1
Knudsen, L1
Jensen, S1
Kruse, A1
Sage, DJ1
Close, A1
Boas, RA1
Dodgson, MS1
Skeie, B1
Emhjellen, S1
Wickstrøm, E1
Steen, PA1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Neurocognitive Functioning Following The PROMETA® Treatment Protocol In Subjects With Alcohol Dependence[NCT00570388]120 participants (Anticipated)Interventional2007-03-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

9 trials available for flumazenil and Amnesia

ArticleYear
Dissociation of benzodiazepine-induced amnesia from sedation by flumazenil pretreatment.
    Psychopharmacology, 1993, Volume: 112, Issue:4

    Topics: Adult; Amnesia; Attention; Cross-Over Studies; Diazepam; Double-Blind Method; Flumazenil; Humans; Hy

1993
Differentiating the sedative, psychomotor and amnesic effects of benzodiazepines: a study with midazolam and the benzodiazepine antagonist, flumazenil.
    Psychopharmacology, 1991, Volume: 103, Issue:4

    Topics: Adult; Amnesia; Anti-Anxiety Agents; Cognition; Double-Blind Method; Emotions; Female; Flicker Fusio

1991
The effectiveness of flumazenil in reversing the sedation and amnesia produced by intravenous midazolam.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1990, Volume: 48, Issue:3

    Topics: Amnesia; Anesthesia, Dental; Anesthesia, General; Double-Blind Method; Female; Flumazenil; Humans; M

1990
Effect of flumazenil on midazolam-induced amnesia.
    British journal of anaesthesia, 1990, Volume: 65, Issue:2

    Topics: Adult; Amnesia; Dose-Response Relationship, Drug; Flicker Fusion; Flumazenil; Humans; Memory; Midazo

1990
Amnestic effects of lormetazepam and their reversal by the benzodiazepine antagonist Ro 15-1788.
    Psychopharmacology, 1987, Volume: 93, Issue:4

    Topics: Adult; Amnesia; Anti-Anxiety Agents; Benzodiazepines; Cognition; Emotions; Female; Flumazenil; Human

1987
Clinical evaluation of a specific benzodiazepine antagonist (RO 15-1788). Studies in elderly patients after regional anaesthesia under benzodiazepine sedation.
    British journal of anaesthesia, 1986, Volume: 58, Issue:9

    Topics: Aged; Amnesia; Anesthesia Recovery Period; Anesthesia, Conduction; Benzodiazepines; Drug Evaluation;

1986
Benzodiazepine antagonist Ro 15-1788. Antagonism of diazepam sedation in outpatients undergoing gastroscopy.
    Anaesthesia, 1986, Volume: 41, Issue:12

    Topics: Adolescent; Adult; Aged; Amnesia; Clinical Trials as Topic; Diazepam; Double-Blind Method; Female; F

1986
Reversal of midazolam sedation with anexate.
    British journal of anaesthesia, 1987, Volume: 59, Issue:4

    Topics: Aged; Amnesia; Anesthesia Recovery Period; Anesthesia, Spinal; Flumazenil; Hemodynamics; Humans; Mal

1987
Antagonism of diazepam-induced sedative effects by Ro15-1788 in patients after surgery under lumbar epidural block. A double-blind placebo-controlled investigation of efficacy and safety.
    Acta anaesthesiologica Scandinavica, 1987, Volume: 31, Issue:7

    Topics: Adult; Aged; Amnesia; Anesthesia, Epidural; Clinical Trials as Topic; Diazepam; Double-Blind Method;

1987

Other Studies

14 other studies available for flumazenil and Amnesia

ArticleYear
Design, Synthesis, and Biological Evaluation of Imidazo[1,5-a]quinoline as Highly Potent Ligands of Central Benzodiazepine Receptors.
    Journal of medicinal chemistry, 2016, Apr-14, Volume: 59, Issue:7

    Topics: Amnesia; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Binding Sites; Brain; Catt

2016
[123I]Iomazenil SPECT Detects a Reversible Lesion of the Left Medial Temporal Lobe in a Case of Global Autobiographical Amnesia.
    Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology, 2021, 03-03, Volume: 34, Issue:1

    Topics: Amnesia; Female; Flumazenil; Humans; Iodine Radioisotopes; Magnetic Resonance Imaging; Middle Aged;

2021
Postoperative global amnesia reversed with flumazenil.
    The neurologist, 2012, Volume: 18, Issue:4

    Topics: Amnesia; Analgesics; Anesthesia, General; Cholangiopancreatography, Endoscopic Retrograde; Desfluran

2012
Diazepam-induced release of behavior in an extinction procedure: its reversal by Ro 15-1788.
    European journal of pharmacology, 1983, Mar-18, Volume: 88, Issue:1

    Topics: Amnesia; Animals; Behavior, Animal; Benzodiazepinones; Diazepam; Drinking; Extinction, Psychological

1983
Pharmacological characterization of benzodiazepine receptor ligands with intrinsic efficacies ranging from high to zero.
    Psychopharmacology, 1993, Volume: 111, Issue:4

    Topics: Acoustic Stimulation; Amnesia; Animals; Anticonvulsants; Conditioning, Operant; Eating; Female; Flum

1993
Possible mechanism of alprazolam-induced amnesia in mice.
    Pharmacology, 1998, Volume: 56, Issue:1

    Topics: Alprazolam; Amnesia; Animals; Azepines; Drug Evaluation, Preclinical; Female; Flumazenil; GABA Agoni

1998
Transient global amnesia: a cause for postanesthetic memory disorder.
    Anesthesia and analgesia, 1998, Volume: 87, Issue:4

    Topics: Amnesia; Anesthesia; Flumazenil; Humans

1998
Benzodiazepines and memory.
    Clinical neuropharmacology, 1992, Volume: 15 Suppl 1 Pt A

    Topics: Amnesia; Anti-Anxiety Agents; Attention; Flumazenil; Humans; Memory

1992
Anterograde amnesia in triazolam overdose despite flumazenil treatment: a case report.
    Human & experimental toxicology, 1992, Volume: 11, Issue:4

    Topics: Adolescent; Amnesia; Drug Overdose; Flumazenil; Humans; Male; Suicide, Attempted; Triazolam

1992
Neurochemical mechanisms of memory control.
    Acta physiologica Hungarica, 1992, Volume: 79, Issue:4

    Topics: Amnesia; Animals; Bicuculline; Brain; Cats; Dopamine; Evoked Potentials; Flumazenil; GABA-A Receptor

1992
Learning and memory-enhancing effects of Ro 15-4513: a comparison with flumazenil.
    Neuropharmacology, 1992, Volume: 31, Issue:3

    Topics: Amnesia; Animals; Avoidance Learning; Azides; Benzodiazepines; Discrimination Learning; Flumazenil;

1992
Amnesic trace locked into the benzodiazepine state of memory.
    Psychopharmacology, 1990, Volume: 102, Issue:1

    Topics: Amnesia; Animals; Anti-Anxiety Agents; Chlordiazepoxide; Conditioning, Operant; Conflict, Psychologi

1990
Effects of DM-9384, a pyrrolidone derivative, on alcohol- and chlordiazepoxide-induced amnesia in mice.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 36, Issue:2

    Topics: Amnesia; Animals; Avoidance Learning; Bicuculline; Central Nervous System Agents; Chlordiazepoxide;

1990
Reversal of alcohol-induced amnesia by the benzodiazepine inverse agonist Ro 15-4513.
    European journal of pharmacology, 1988, Oct-18, Volume: 155, Issue:3

    Topics: Amnesia; Animals; Avoidance Learning; Azides; Benzodiazepines; Carbolines; Dose-Response Relationshi

1988