flumazenil has been researched along with Amnesia-Memory Loss in 23 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
| Excerpt | Relevance | Reference |
|---|---|---|
| "01 mg kg-1 on the amnesia and sedation caused by midazolam 2 mg and 5 mg i." | 9.06 | Effect of flumazenil on midazolam-induced amnesia. ( Clarke, RS; McKay, AC; McKinney, MS, 1990) |
| "Alprazolam produced anterograde as well as retrograde amnesia in mice assessed using elevated plus-maze." | 7.70 | Possible mechanism of alprazolam-induced amnesia in mice. ( Sharma, A; Singh, M; Singh, N, 1998) |
| "Anterograde amnesia, possibly accompanied by acute brain syndrome, is a potential side-effect of certain benzodiazepines, particularly triazolam." | 7.68 | Anterograde amnesia in triazolam overdose despite flumazenil treatment: a case report. ( Deng, JF; Hung, DZ; Tsai, WJ, 1992) |
| "The effects of N-(2,6-dimethyl-phenyl)-2-(2-oxo-1-pyrrolidinyl) acetamide (DM-9384), a new pyrrolidone derivative, were investigated on ethanol- and chlordiazepoxide (CDP)-induced amnesia animal model using the passive avoidance task in comparison with aniracetam, another pyrrolidone derivative." | 7.68 | Effects of DM-9384, a pyrrolidone derivative, on alcohol- and chlordiazepoxide-induced amnesia in mice. ( Kameyama, T; Nabeshima, T; Tohyama, K, 1990) |
| "01 mg kg-1 on the amnesia and sedation caused by midazolam 2 mg and 5 mg i." | 5.06 | Effect of flumazenil on midazolam-induced amnesia. ( Clarke, RS; McKay, AC; McKinney, MS, 1990) |
| "Alprazolam produced anterograde as well as retrograde amnesia in mice assessed using elevated plus-maze." | 3.70 | Possible mechanism of alprazolam-induced amnesia in mice. ( Sharma, A; Singh, M; Singh, N, 1998) |
| "Anterograde amnesia, possibly accompanied by acute brain syndrome, is a potential side-effect of certain benzodiazepines, particularly triazolam." | 3.68 | Anterograde amnesia in triazolam overdose despite flumazenil treatment: a case report. ( Deng, JF; Hung, DZ; Tsai, WJ, 1992) |
| "The effects of N-(2,6-dimethyl-phenyl)-2-(2-oxo-1-pyrrolidinyl) acetamide (DM-9384), a new pyrrolidone derivative, were investigated on ethanol- and chlordiazepoxide (CDP)-induced amnesia animal model using the passive avoidance task in comparison with aniracetam, another pyrrolidone derivative." | 3.68 | Effects of DM-9384, a pyrrolidone derivative, on alcohol- and chlordiazepoxide-induced amnesia in mice. ( Kameyama, T; Nabeshima, T; Tohyama, K, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (30.43) | 18.7374 |
| 1990's | 13 (56.52) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (8.70) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Cappelli, A | 1 |
| Anzini, M | 1 |
| Castriconi, F | 1 |
| Grisci, G | 1 |
| Paolino, M | 1 |
| Braile, C | 1 |
| Valenti, S | 1 |
| Giuliani, G | 1 |
| Vomero, S | 1 |
| Di Capua, A | 1 |
| Betti, L | 1 |
| Giannaccini, G | 1 |
| Lucacchini, A | 1 |
| Ghelardini, C | 1 |
| Di Cesare Mannelli, L | 1 |
| Frosini, M | 1 |
| Ricci, L | 1 |
| Giorgi, G | 1 |
| Mascia, MP | 1 |
| Biggio, G | 1 |
| Sehara, Y | 1 |
| Ando, Y | 1 |
| Minezumi, T | 1 |
| Funayama, N | 1 |
| Kawai, K | 1 |
| Sawada, M | 1 |
| Rinehart, JB | 1 |
| Baker, B | 1 |
| Raphael, D | 1 |
| Thiébot, MH | 1 |
| Childs, M | 1 |
| Soubrié, P | 1 |
| Simon, P | 1 |
| Martin, JR | 1 |
| Schoch, P | 1 |
| Jenck, F | 1 |
| Moreau, JL | 1 |
| Haefely, WE | 1 |
| Hommer, D | 1 |
| Weingartner, H | 1 |
| Breier, A | 1 |
| Singh, N | 1 |
| Sharma, A | 1 |
| Singh, M | 1 |
| Ghoneim, MM | 1 |
| File, SE | 1 |
| Hung, DZ | 1 |
| Tsai, WJ | 1 |
| Deng, JF | 1 |
| Ilyutchenok, RY | 1 |
| Loskutova, LV | 1 |
| Finkelberg, AL | 1 |
| Dubrovina, NI | 1 |
| Prather, PL | 1 |
| Forster, MJ | 1 |
| Lal, H | 1 |
| Curran, HV | 1 |
| Birch, B | 1 |
| Colpaert, FC | 1 |
| Ochs, MW | 1 |
| Tucker, MR | 1 |
| Owsley, TG | 1 |
| Anderson, JA | 1 |
| Nabeshima, T | 2 |
| Tohyama, K | 2 |
| Kameyama, T | 2 |
| McKay, AC | 1 |
| McKinney, MS | 1 |
| Clarke, RS | 1 |
| Dorow, R | 1 |
| Berenberg, D | 1 |
| Duka, T | 1 |
| Sauerbrey, N | 1 |
| Ricou, B | 1 |
| Forster, A | 1 |
| Brückner, A | 1 |
| Chastonay, P | 1 |
| Gemperle, M | 1 |
| Kirkegaard, L | 1 |
| Knudsen, L | 1 |
| Jensen, S | 1 |
| Kruse, A | 1 |
| Sage, DJ | 1 |
| Close, A | 1 |
| Boas, RA | 1 |
| Dodgson, MS | 1 |
| Skeie, B | 1 |
| Emhjellen, S | 1 |
| Wickstrøm, E | 1 |
| Steen, PA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Neurocognitive Functioning Following The PROMETA® Treatment Protocol In Subjects With Alcohol Dependence[NCT00570388] | 120 participants (Anticipated) | Interventional | 2007-03-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 trials available for flumazenil and Amnesia-Memory Loss
| Article | Year |
|---|---|
Dissociation of benzodiazepine-induced amnesia from sedation by flumazenil pretreatment.
Topics: Adult; Amnesia; Attention; Cross-Over Studies; Diazepam; Double-Blind Method; Flumazenil; Humans; Hy | 1993 |
Differentiating the sedative, psychomotor and amnesic effects of benzodiazepines: a study with midazolam and the benzodiazepine antagonist, flumazenil.
Topics: Adult; Amnesia; Anti-Anxiety Agents; Cognition; Double-Blind Method; Emotions; Female; Flicker Fusio | 1991 |
The effectiveness of flumazenil in reversing the sedation and amnesia produced by intravenous midazolam.
Topics: Amnesia; Anesthesia, Dental; Anesthesia, General; Double-Blind Method; Female; Flumazenil; Humans; M | 1990 |
Effect of flumazenil on midazolam-induced amnesia.
Topics: Adult; Amnesia; Dose-Response Relationship, Drug; Flicker Fusion; Flumazenil; Humans; Memory; Midazo | 1990 |
Amnestic effects of lormetazepam and their reversal by the benzodiazepine antagonist Ro 15-1788.
Topics: Adult; Amnesia; Anti-Anxiety Agents; Benzodiazepines; Cognition; Emotions; Female; Flumazenil; Human | 1987 |
Clinical evaluation of a specific benzodiazepine antagonist (RO 15-1788). Studies in elderly patients after regional anaesthesia under benzodiazepine sedation.
Topics: Aged; Amnesia; Anesthesia Recovery Period; Anesthesia, Conduction; Benzodiazepines; Drug Evaluation; | 1986 |
Benzodiazepine antagonist Ro 15-1788. Antagonism of diazepam sedation in outpatients undergoing gastroscopy.
Topics: Adolescent; Adult; Aged; Amnesia; Clinical Trials as Topic; Diazepam; Double-Blind Method; Female; F | 1986 |
Reversal of midazolam sedation with anexate.
Topics: Aged; Amnesia; Anesthesia Recovery Period; Anesthesia, Spinal; Flumazenil; Hemodynamics; Humans; Mal | 1987 |
Antagonism of diazepam-induced sedative effects by Ro15-1788 in patients after surgery under lumbar epidural block. A double-blind placebo-controlled investigation of efficacy and safety.
Topics: Adult; Aged; Amnesia; Anesthesia, Epidural; Clinical Trials as Topic; Diazepam; Double-Blind Method; | 1987 |
14 other studies available for flumazenil and Amnesia-Memory Loss
| Article | Year |
|---|---|
Design, Synthesis, and Biological Evaluation of Imidazo[1,5-a]quinoline as Highly Potent Ligands of Central Benzodiazepine Receptors.
Topics: Amnesia; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Binding Sites; Brain; Catt | 2016 |
[123I]Iomazenil SPECT Detects a Reversible Lesion of the Left Medial Temporal Lobe in a Case of Global Autobiographical Amnesia.
Topics: Amnesia; Female; Flumazenil; Humans; Iodine Radioisotopes; Magnetic Resonance Imaging; Middle Aged; | 2021 |
Postoperative global amnesia reversed with flumazenil.
Topics: Amnesia; Analgesics; Anesthesia, General; Cholangiopancreatography, Endoscopic Retrograde; Desfluran | 2012 |
Diazepam-induced release of behavior in an extinction procedure: its reversal by Ro 15-1788.
Topics: Amnesia; Animals; Behavior, Animal; Benzodiazepinones; Diazepam; Drinking; Extinction, Psychological | 1983 |
Pharmacological characterization of benzodiazepine receptor ligands with intrinsic efficacies ranging from high to zero.
Topics: Acoustic Stimulation; Amnesia; Animals; Anticonvulsants; Conditioning, Operant; Eating; Female; Flum | 1993 |
Possible mechanism of alprazolam-induced amnesia in mice.
Topics: Alprazolam; Amnesia; Animals; Azepines; Drug Evaluation, Preclinical; Female; Flumazenil; GABA Agoni | 1998 |
Transient global amnesia: a cause for postanesthetic memory disorder.
Topics: Amnesia; Anesthesia; Flumazenil; Humans | 1998 |
Benzodiazepines and memory.
Topics: Amnesia; Anti-Anxiety Agents; Attention; Flumazenil; Humans; Memory | 1992 |
Anterograde amnesia in triazolam overdose despite flumazenil treatment: a case report.
Topics: Adolescent; Amnesia; Drug Overdose; Flumazenil; Humans; Male; Suicide, Attempted; Triazolam | 1992 |
Neurochemical mechanisms of memory control.
Topics: Amnesia; Animals; Bicuculline; Brain; Cats; Dopamine; Evoked Potentials; Flumazenil; GABA-A Receptor | 1992 |
Learning and memory-enhancing effects of Ro 15-4513: a comparison with flumazenil.
Topics: Amnesia; Animals; Avoidance Learning; Azides; Benzodiazepines; Discrimination Learning; Flumazenil; | 1992 |
Amnesic trace locked into the benzodiazepine state of memory.
Topics: Amnesia; Animals; Anti-Anxiety Agents; Chlordiazepoxide; Conditioning, Operant; Conflict, Psychologi | 1990 |
Effects of DM-9384, a pyrrolidone derivative, on alcohol- and chlordiazepoxide-induced amnesia in mice.
Topics: Amnesia; Animals; Avoidance Learning; Bicuculline; Central Nervous System Agents; Chlordiazepoxide; | 1990 |
Reversal of alcohol-induced amnesia by the benzodiazepine inverse agonist Ro 15-4513.
Topics: Amnesia; Animals; Avoidance Learning; Azides; Benzodiazepines; Carbolines; Dose-Response Relationshi | 1988 |