flumazenil has been researched along with Alzheimer Disease in 19 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Propofol was administrated to the WT and AD Tg mice once a week for 8 or 12 weeks, respectively." | 1.40 | Chronic treatment with anesthetic propofol improves cognitive function and attenuates caspase activation in both aged and Alzheimer's disease transgenic mice. ( Dong, Y; Shao, H; Xia, W; Xie, Z; Yu, B; Zhang, Y, 2014) |
| "Neuronal loss in Alzheimer's disease, a better correlate of cognitive impairment than amyloid deposition, is currently gauged by the degree of regional atrophy." | 1.38 | Decreased carbon-11-flumazenil binding in early Alzheimer's disease. ( Arbizu, J; Marti-Climent, JM; Masdeu, JC; Pappatà, S; Pascual, B; Peñuelas, I; Prieto, E; Quincoces, G; Zarauza, R, 2012) |
| "Eight patients with probable Alzheimer's disease were studied." | 1.30 | Comparison of iodine-123-iomazenil SPECT and technetium-99m-HMPAO-SPECT in Alzheimer's disease. ( Fujita, M; Fukuchi, K; Hashikawa, K; Ishida, M; Kusuoka, H; Moriwaki, H; Nishimura, T; Oku, N; Seike, Y; Tanabe, H; Uehara, T, 1997) |
| "I-123 iomazenil SPECT in patients with Alzheimer's disease provided more sensitive information than Tc-99m HMPAO, allowing evaluation of brain perfusion and synaptic density." | 1.30 | Comparison between cortical distribution of I-123 iomazenil and Tc-99m HMPAO in patients with Alzheimer's disease using SPECT. ( Postiglione, A; Salvatore, M; Soricelli, A; Varrone, A, 1999) |
| "In patients with Alzheimer's disease, we determined the cerebral distribution of flumazenil tagged with carbon 11 ([11C]flumazenil), a ligand that binds to the gamma-aminobutyric acid A (GABAA) receptor complex, and the distribution of fludeoxyglucose tagged with fluorine 18 fludeoxyglucose F 18), a measure of local cerebral glucose metabolism." | 1.29 | Positron emission tomography measures of benzodiazepine binding in Alzheimer's disease. ( Foster, NL; Frey, KA; Koeppe, RA; Kuhl, DE; Meyer, M, 1995) |
| "In patients with Alzheimer's disease, the CBF (ratio to cerebellum) decreased significantly in the frontal cortex and the parietal cortex compared with the control values." | 1.29 | [Benzodiazepine receptor and cerebral blood flow in early Alzheimer's disease--SPECT study using 123I-iomazenil and 123I-IMP]. ( Kitamura, S; Komaba, Y; Komiyama, T; Koshi, Y; Mishina, M; Ohyama, M; Sakayori, O; Terashi, A; Tsuganesawa, T, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.26) | 18.7374 |
| 1990's | 12 (63.16) | 18.2507 |
| 2000's | 2 (10.53) | 29.6817 |
| 2010's | 4 (21.05) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shao, H | 1 |
| Zhang, Y | 1 |
| Dong, Y | 1 |
| Yu, B | 1 |
| Xia, W | 1 |
| Xie, Z | 1 |
| Pappatà, S | 2 |
| Varrone, A | 3 |
| Vicidomini, C | 1 |
| Milan, G | 1 |
| De Falco, C | 1 |
| Sansone, V | 1 |
| Iavarone, A | 1 |
| Comerci, M | 1 |
| Loré, E | 1 |
| Panico, MR | 1 |
| Quarantelli, M | 1 |
| Postiglione, A | 4 |
| Salvatore, M | 4 |
| Pascual, B | 1 |
| Prieto, E | 1 |
| Arbizu, J | 1 |
| Marti-Climent, JM | 1 |
| Peñuelas, I | 1 |
| Quincoces, G | 1 |
| Zarauza, R | 1 |
| Masdeu, JC | 1 |
| Hanyu, H | 1 |
| Kume, K | 1 |
| Sato, T | 1 |
| Hirao, K | 1 |
| Kanetaka, H | 1 |
| Sakurai, H | 1 |
| Iwamoto, T | 1 |
| Seike, Y | 2 |
| Hashikawa, K | 2 |
| Oku, N | 2 |
| Moriwaki, H | 2 |
| Yamamoto, H | 1 |
| Fukuchi, K | 2 |
| Watanabe, Y | 1 |
| Matsumoto, M | 1 |
| Hori, M | 1 |
| Nishimura, T | 2 |
| Meyer, M | 1 |
| Koeppe, RA | 1 |
| Frey, KA | 1 |
| Foster, NL | 1 |
| Kuhl, DE | 1 |
| Walsh, TJ | 1 |
| Soricelli, A | 2 |
| Grivet-Fojaja, MR | 1 |
| Mainenti, PP | 1 |
| Discepolo, A | 1 |
| Lassen, NA | 2 |
| Kitamura, S | 2 |
| Koshi, Y | 1 |
| Komiyama, T | 1 |
| Sakayori, O | 1 |
| Komaba, Y | 1 |
| Ohyama, M | 2 |
| Mishina, M | 2 |
| Tsuganesawa, T | 1 |
| Terashi, A | 1 |
| Onishi, Y | 1 |
| Yonekura, Y | 1 |
| Tanaka, F | 1 |
| Nishizawa, S | 1 |
| Okazawa, H | 1 |
| Ishizu, K | 1 |
| Fujita, T | 1 |
| Konishi, J | 1 |
| Mukai, T | 1 |
| Ott, BR | 1 |
| Thompson, JA | 1 |
| Whelihan, WM | 1 |
| Ishida, M | 1 |
| Fujita, M | 1 |
| Uehara, T | 1 |
| Tanabe, H | 1 |
| Kusuoka, H | 1 |
| Prohovnik, I | 1 |
| Senda, M | 1 |
| Ishiwata, K | 1 |
| Ishii, K | 1 |
| Toyama, H | 1 |
| Oda, K | 1 |
| Katayama, Y | 1 |
| Ihara, M | 1 |
| Fukuyama, H | 1 |
| Lee, T | 1 |
| Takao, S | 1 |
| Kohara, N | 1 |
| Shibasaki, H | 1 |
| Schubiger, PA | 1 |
| Hasler, PH | 1 |
| Beer-Wohlfahrt, H | 1 |
| Bekier, A | 1 |
| Oettli, R | 1 |
| Cordes, M | 1 |
| Ferstl, F | 1 |
| Deisenhammer, E | 1 |
| De Roo, M | 1 |
| Moser, E | 1 |
| Sedvall, G | 1 |
| Nybäck, H | 1 |
| Farde, L | 1 |
| Persson, A | 1 |
1 review available for flumazenil and Alzheimer Disease
| Article | Year |
|---|---|
Site-specific pharmacology for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Brain; Cerebral Cortex; Flumazenil; Hippocampus; Humans; Levodopa; Neuro | 1993 |
3 trials available for flumazenil and Alzheimer Disease
| Article | Year |
|---|---|
Evaluation of the use of a standard input function for compartment analysis of [123I]iomazenil data: factors influencing the quantitative results.
Topics: Adolescent; Adult; Aged; Algorithms; Alzheimer Disease; Brain; Cerebrovascular Disorders; Epilepsy; | 2004 |
Cognitive effects of flumazenil in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cognition; Flumazenil; GABA Modulators; Humans; Male; No | 1996 |
Evaluation of a multicentre study with Iomazenil--a benzodiazepine receptor ligand.
Topics: Adult; Alzheimer Disease; Brain Chemistry; Epilepsies, Partial; Evaluation Studies as Topic; Female; | 1991 |
15 other studies available for flumazenil and Alzheimer Disease
| Article | Year |
|---|---|
Chronic treatment with anesthetic propofol improves cognitive function and attenuates caspase activation in both aged and Alzheimer's disease transgenic mice.
Topics: Aging; Alzheimer Disease; Amyloidogenic Proteins; Animals; Brain; Caspases; Cell Line, Tumor; Cognit | 2014 |
SPECT imaging of GABA(A)/benzodiazepine receptors and cerebral perfusion in mild cognitive impairment.
Topics: Aged; Alzheimer Disease; Case-Control Studies; Cerebrovascular Circulation; Cognition Disorders; Fem | 2010 |
Decreased carbon-11-flumazenil binding in early Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Carbon Radioisotopes; Female; Flumazenil; Humans; | 2012 |
Regional differences in cortical benzodiazepine receptors of Alzheimer, vascular, and mixed dementia patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Brain Mapping; Cerebral Cortex; Cerebrovascu | 2012 |
Positron emission tomography measures of benzodiazepine binding in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Benzodiazepines; Brain; Cerebrovascular Circulation; Deoxyglucose; Female; | 1995 |
Reduced cortical distribution volume of iodine-123 iomazenil in Alzheimer's disease as a measure of loss of synapses.
Topics: Alzheimer Disease; Case-Control Studies; Cerebral Cortex; Female; Flumazenil; Humans; Iodine Radiois | 1996 |
[Benzodiazepine receptor and cerebral blood flow in early Alzheimer's disease--SPECT study using 123I-iomazenil and 123I-IMP].
Topics: Aged; Alzheimer Disease; Amphetamines; Brain; Cerebrovascular Circulation; Female; Flumazenil; Human | 1996 |
Delayed image of iodine-123 iomazenil as a relative map of benzodiazepine receptor binding: the optimal scan time.
Topics: Alzheimer Disease; Brain; Case-Control Studies; Cerebral Infarction; Computer Simulation; Dementia, | 1996 |
Comparison of iodine-123-iomazenil SPECT and technetium-99m-HMPAO-SPECT in Alzheimer's disease.
Topics: Alzheimer Disease; Brain; Female; Flumazenil; Humans; Image Processing, Computer-Assisted; Iodine Ra | 1997 |
123I-iomazenil as a clinical tool for studying neuronal loss.
Topics: Alzheimer Disease; Cerebral Cortex; Flumazenil; Humans; Iodine Radioisotopes; Male; Middle Aged; Rec | 1997 |
Iodine-123-iomazenil SPECT in Alzheimer's disease.
Topics: Alzheimer Disease; Flumazenil; Humans; Iodine Radioisotopes; Radiopharmaceuticals; Sensitivity and S | 1998 |
Comparison between cortical distribution of I-123 iomazenil and Tc-99m HMPAO in patients with Alzheimer's disease using SPECT.
Topics: Alzheimer Disease; Brain; Female; Flumazenil; Humans; Iodine Radioisotopes; Male; Middle Aged; Techn | 1999 |
Preserved benzodiazepine receptors in Alzheimer's disease measured with C-11 flumazenil PET and I-123 iomazenil SPECT in comparison with CBF.
Topics: Aged; Alzheimer Disease; Carbon Radioisotopes; Case-Control Studies; Cerebrovascular Circulation; Ev | 1999 |
Delayed synaptic dysfunction of association cortices in carbon monoxide intoxication.
Topics: Alzheimer Disease; Antidotes; Carbon Monoxide Poisoning; Carbon Radioisotopes; Cerebral Cortex; Flum | 2001 |
Neurotransmitter receptor imaging in Alzheimer's disease.
Topics: Alzheimer Disease; Brain; Carbon Radioisotopes; Deoxyglucose; Flumazenil; Humans; Raclopride; Recept | 1987 |