flumazenil has been researched along with Alcoholism in 23 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The benzodiazepine receptor antagonist flumazenil reduces anxiety-like behavior and sensitization of anxiety-like behavior in various models of ethanol withdrawal in rodents." | 7.74 | The amygdala regulates the antianxiety sensitization effect of flumazenil during repeated chronic ethanol or repeated stress. ( Angel, RA; Breese, GR; Knapp, DJ; Navarro, M; Overstreet, DH, 2007) |
| "Disulfiram is an aldehyde dehydrogenase inhibitor that is widely used as an adjunctive agent in the treatment of patients with severe chronic alcoholism." | 7.69 | Effects of disulfiram on positron emission tomography and neuropsychological studies in severe chronic alcoholism. ( Adams, KM; Gilman, S; Heumann, M; Hill, E; Johnson-Greene, D; Junck, L; Kluin, KJ; Koeppe, RA; Martorello, S, 1996) |
| "The benzodiazepine receptor antagonist flumazenil reduces anxiety-like behavior and sensitization of anxiety-like behavior in various models of ethanol withdrawal in rodents." | 3.74 | The amygdala regulates the antianxiety sensitization effect of flumazenil during repeated chronic ethanol or repeated stress. ( Angel, RA; Breese, GR; Knapp, DJ; Navarro, M; Overstreet, DH, 2007) |
| "Disulfiram is an aldehyde dehydrogenase inhibitor that is widely used as an adjunctive agent in the treatment of patients with severe chronic alcoholism." | 3.69 | Effects of disulfiram on positron emission tomography and neuropsychological studies in severe chronic alcoholism. ( Adams, KM; Gilman, S; Heumann, M; Hill, E; Johnson-Greene, D; Junck, L; Kluin, KJ; Koeppe, RA; Martorello, S, 1996) |
| " Flumazenil was efficient for leading out from coma in 86% of cases with poisoning only by benzodiazepines and 13% of cases with mixed intoxications mainly containing benzodiazepines and alcohol or carbamazepine." | 3.69 | [Suicidal poisoning with benzodiazepines]. ( Chodorowski, Z; Sein Anand, J, 1997) |
| "Improved treatment of alcohol dependence is a high priority, including defining subtypes that might respond differently." | 2.74 | Efficacy of a combination of flumazenil and gabapentin in the treatment of alcohol dependence: relationship to alcohol withdrawal symptoms. ( Anton, RF; Baros, AM; Latham, PK; Malcolm, R; Myrick, H; Randall, PK; Stewart, SH; Waid, R; Wright, TM, 2009) |
| "Abstinent male alcohol dependent subjects underwent [11C]flumazenil PET to measure occupancy of BDZ receptors by midazolam whilst recording its pharmacodynamic effects on behavioural and physiological measures." | 2.71 | GABA-benzodiazepine receptor function in alcohol dependence: a combined 11C-flumazenil PET and pharmacodynamic study. ( Brooks, DJ; Cunningham, VJ; Feeney, A; Lingford-Hughes, AR; Nutt, DJ; Stevenson, B; Wilson, SJ, 2005) |
| "He was treated for hepatic encephalopathy with complete recovery and resolution of the neurologic findings." | 2.46 | Reversible hepatic decerebration: a case report and review of the literature. ( Antoun, SA; Delgado, F; Saad, D; Ta, H; Wehbe, E, 2010) |
| "Men with alcohol dependence (n = 27) and a matched healthy comparison group (n = 15)." | 1.33 | Cortical gamma-aminobutyric acid type A-benzodiazepine receptors in recovery from alcohol dependence: relationship to features of alcohol dependence and cigarette smoking. ( Baldwin, R; Frohlich, E; Gottschalk, C; Gueorguieva, R; Innis, RB; Jatlow, P; Krystal, JH; O'Malley, S; Perry, E; Petrakis, IL; Ruff, E; Seibyl, JP; Staley, JK; van Dyck, CH; Verhoeff, NP; Weinzimmer, D, 2005) |
| "Although alcohol dependence in women is an increasing problem, little is known about the effects of alcohol on the female brain." | 1.31 | Levels of gamma-aminobutyric acid-benzodiazepine receptors in abstinent, alcohol-dependent women: preliminary findings from an 123I-iomazenil single photon emission tomography study. ( Acton, PD; Boddington, SJ; Costa, DC; Ell, PJ; Gacinovic, S; Kerwin, RW; Lingford-Hughes, AR; Marshall, EJ; Pilowsky, LS, 2000) |
| "[11C]Flumazenil binding was quantified by applying a saturation procedure with two PET experiments, the first with high (400-3400 Ci/mmol) and the second with low (approximately 1 Ci/mmol) specific radioactivity." | 1.29 | PET analysis of [11C]flumazenil binding to benzodiazepine receptors in chronic alcohol-dependent men and healthy controls. ( Farde, L; Halldin, C; Hindmarsh, T; Litton, JE; Neiman, J; Pauli, S; Sedvall, G, 1993) |
| "Flumazenil treatment of ethanol-dependent mice 14 hr before isolation of brain membrane vesicles partially reversed the augmentation of Ro15-4513 inhibition of muscimol-stimulated 36Cl- uptake in vitro." | 1.28 | Reversal of alcohol dependence and tolerance by a single administration of flumazenil. ( Buck, KJ; Harris, RA; Heim, H, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.70) | 18.7374 |
| 1990's | 7 (30.43) | 18.2507 |
| 2000's | 6 (26.09) | 29.6817 |
| 2010's | 7 (30.43) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Yin, W | 1 |
| Majumder, S | 1 |
| Clayton, T | 1 |
| Petrou, S | 1 |
| VanLinn, ML | 1 |
| Namjoshi, OA | 1 |
| Ma, C | 1 |
| Cromer, BA | 1 |
| Roth, BL | 1 |
| Platt, DM | 1 |
| Cook, JM | 1 |
| Lucyk, S | 1 |
| von Schweinitz, BA | 1 |
| Hoffman, RS | 1 |
| Moore, PW | 1 |
| Hieger, MA | 1 |
| Donovan, JW | 1 |
| Wehbe, E | 1 |
| Saad, D | 1 |
| Delgado, F | 1 |
| Ta, H | 1 |
| Antoun, SA | 1 |
| Anton, RF | 3 |
| Myrick, H | 3 |
| Baros, AM | 2 |
| Latham, PK | 2 |
| Randall, PK | 3 |
| Wright, TM | 2 |
| Stewart, SH | 1 |
| Waid, R | 1 |
| Malcolm, R | 1 |
| Schacht, JP | 2 |
| Waid, LR | 1 |
| Li, X | 1 |
| Henderson, S | 1 |
| Lingford-Hughes, AR | 2 |
| Wilson, SJ | 1 |
| Cunningham, VJ | 1 |
| Feeney, A | 1 |
| Stevenson, B | 1 |
| Brooks, DJ | 1 |
| Nutt, DJ | 1 |
| Staley, JK | 1 |
| Gottschalk, C | 1 |
| Petrakis, IL | 2 |
| Gueorguieva, R | 1 |
| O'Malley, S | 1 |
| Baldwin, R | 1 |
| Jatlow, P | 1 |
| Verhoeff, NP | 1 |
| Perry, E | 1 |
| Weinzimmer, D | 1 |
| Frohlich, E | 1 |
| Ruff, E | 1 |
| van Dyck, CH | 1 |
| Seibyl, JP | 2 |
| Innis, RB | 2 |
| Krystal, JH | 2 |
| Knapp, DJ | 1 |
| Overstreet, DH | 1 |
| Angel, RA | 1 |
| Navarro, M | 1 |
| Breese, GR | 1 |
| Farde, L | 2 |
| Pauli, S | 2 |
| Litton, JE | 2 |
| Halldin, C | 2 |
| Neiman, J | 2 |
| Sedvall, G | 2 |
| Hindmarsh, T | 1 |
| Gilman, S | 1 |
| Adams, KM | 1 |
| Johnson-Greene, D | 1 |
| Koeppe, RA | 1 |
| Junck, L | 1 |
| Kluin, KJ | 1 |
| Martorello, S | 1 |
| Heumann, M | 1 |
| Hill, E | 1 |
| Chodorowski, Z | 1 |
| Sein Anand, J | 1 |
| Abi-Dargham, A | 1 |
| Anjilvel, S | 1 |
| Scanley, BE | 1 |
| Zoghbi, S | 1 |
| Baldwin, RM | 1 |
| Rajeevan, N | 1 |
| Ellis, S | 1 |
| Charney, DS | 1 |
| Laruelle, M | 1 |
| Acton, PD | 1 |
| Gacinovic, S | 1 |
| Boddington, SJ | 1 |
| Costa, DC | 1 |
| Pilowsky, LS | 1 |
| Ell, PJ | 1 |
| Marshall, EJ | 1 |
| Kerwin, RW | 1 |
| Buck, KJ | 1 |
| Heim, H | 1 |
| Harris, RA | 1 |
| López Soriano, F | 1 |
| García Basterrechea, JM | 1 |
| Hallal Hachem, H | 1 |
| Alguacil García, GF | 1 |
| Mhatre, M | 1 |
| Ticku, MK | 1 |
| Chan, AW | 1 |
| Kurshed, AAM | 1 |
| Vincze, F | 2 |
| Pikó, P | 1 |
| Kósa, Z | 1 |
| Sándor, J | 2 |
| Ádány, R | 2 |
| Diószegi, J | 1 |
| Nagy, A | 1 |
| Földvári, A | 1 |
| Szabó, E | 1 |
| Csenteri, O | 1 |
| Sipos, V | 1 |
| Kovács, N | 1 |
| Pálinkás, A | 1 |
| Papp, M | 1 |
| Fürjes, G | 1 |
| Ekuklu, G | 1 |
| Deveci, S | 1 |
| Eskiocak, M | 1 |
| Berberoglu, U | 1 |
| Saltik, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double Blind Evaluation of Flumazenil and Gabapentin for the Treatment of Alcohol Withdrawal and Relapse Prevention[NCT00262639] | Phase 2/Phase 3 | 60 participants (Actual) | Interventional | 2005-12-31 | Completed | ||
| Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics[NCT03220776] | Phase 2 | 54 participants (Actual) | Interventional | 2017-08-07 | Completed | ||
| Neurocognitive and Neurobehavioral Mechanisms of Change Following Psychological[NCT03842670] | 140 participants (Anticipated) | Interventional | 2018-11-14 | Active, not recruiting | |||
| Characterization of [11C]Flumazenil to Image GABA Transmission in Healthy Adult Subjects and Subjects With Alcohol Dependence[NCT01904487] | Phase 1 | 11 participants (Actual) | Interventional | 2011-04-19 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
percent days abstinent during treatment (NCT00262639)
Timeframe: Weeks 1 to 6
| Intervention | percent days (Mean) |
|---|---|
| Low CIWA Flumazenil/Gabapentin | 70.8 |
| Low CIWAar Placebo | 86.1 |
| High CIWAar Placebo | 75.9 |
| High CIWAar Flumazenil/Gabapentin | 95.9 |
percent of subjects completely abstinent during the six week medication study study (NCT00262639)
Timeframe: 6 week trial
| Intervention | percent of participants (Number) |
|---|---|
| Low CIWA Flumazenil/Gabapentin | 44 |
| Low CIWAar Placebo | 19 |
| High CIWAar Placebo | 33 |
| High CIWAar Flumazenil/Gabapentin | 71 |
Concentrations of GABA+, referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy (i.e., MEGA-PRESS). (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 3.90 |
| Gabapentin | 3.93 |
| Placebo Oral Tablet | 3.73 |
Concentrations of Glx (i.e., glutamate + glutamine), referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy. (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 21.59 |
| Gabapentin | 21.69 |
| Placebo Oral Tablet | 22.25 |
1 review available for flumazenil and Alcoholism
| Article | Year |
|---|---|
Reversible hepatic decerebration: a case report and review of the literature.
Topics: Alcoholism; Decerebrate State; Flumazenil; Hepatic Encephalopathy; Humans; Liver Cirrhosis, Alcoholi | 2010 |
4 trials available for flumazenil and Alcoholism
| Article | Year |
|---|---|
Efficacy of a combination of flumazenil and gabapentin in the treatment of alcohol dependence: relationship to alcohol withdrawal symptoms.
Topics: Administration, Oral; Adult; Alcohol Drinking; Alcoholism; Amines; Cyclohexanecarboxylic Acids; Doub | 2009 |
Efficacy of a combination of flumazenil and gabapentin in the treatment of alcohol dependence: relationship to alcohol withdrawal symptoms.
Topics: Administration, Oral; Adult; Alcohol Drinking; Alcoholism; Amines; Cyclohexanecarboxylic Acids; Doub | 2009 |
Efficacy of a combination of flumazenil and gabapentin in the treatment of alcohol dependence: relationship to alcohol withdrawal symptoms.
Topics: Administration, Oral; Adult; Alcohol Drinking; Alcoholism; Amines; Cyclohexanecarboxylic Acids; Doub | 2009 |
Efficacy of a combination of flumazenil and gabapentin in the treatment of alcohol dependence: relationship to alcohol withdrawal symptoms.
Topics: Administration, Oral; Adult; Alcohol Drinking; Alcoholism; Amines; Cyclohexanecarboxylic Acids; Doub | 2009 |
Neurocognitive performance, alcohol withdrawal, and effects of a combination of flumazenil and gabapentin in alcohol dependence.
Topics: Adult; Alcohol Drinking; Alcoholism; Amines; Cognition; Cyclohexanecarboxylic Acids; Drug Therapy, C | 2011 |
Neurocognitive performance, alcohol withdrawal, and effects of a combination of flumazenil and gabapentin in alcohol dependence.
Topics: Adult; Alcohol Drinking; Alcoholism; Amines; Cognition; Cyclohexanecarboxylic Acids; Drug Therapy, C | 2011 |
Neurocognitive performance, alcohol withdrawal, and effects of a combination of flumazenil and gabapentin in alcohol dependence.
Topics: Adult; Alcohol Drinking; Alcoholism; Amines; Cognition; Cyclohexanecarboxylic Acids; Drug Therapy, C | 2011 |
Neurocognitive performance, alcohol withdrawal, and effects of a combination of flumazenil and gabapentin in alcohol dependence.
Topics: Adult; Alcohol Drinking; Alcoholism; Amines; Cognition; Cyclohexanecarboxylic Acids; Drug Therapy, C | 2011 |
Effects of a GABA-ergic medication combination and initial alcohol withdrawal severity on cue-elicited brain activation among treatment-seeking alcoholics.
Topics: Adult; Alcohol Drinking; Alcoholism; Amines; Brain; Cues; Cyclohexanecarboxylic Acids; Drug Therapy, | 2013 |
GABA-benzodiazepine receptor function in alcohol dependence: a combined 11C-flumazenil PET and pharmacodynamic study.
Topics: Adult; Alcoholism; Analysis of Variance; Blood Pressure; Brain; Case-Control Studies; Competitive Bi | 2005 |
18 other studies available for flumazenil and Alcoholism
| Article | Year |
|---|---|
Design, synthesis, and subtype selectivity of 3,6-disubstituted β-carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents for treatment of alcohol abuse.
Topics: Alcoholism; Animals; Benzodiazepines; Binding Sites; Carbolines; Cell Line; Computer Simulation; GAB | 2010 |
In response to: safety and efficacy of flumazenil for reversal of iatrogenic benzodiazepine-associated delirium toxicity during treatment of alcohol withdrawal, a retrospective review at one center.
Topics: Alcoholism; Antidotes; Benzodiazepines; Delirium; Flumazenil; Humans; Retrospective Studies; Substan | 2014 |
The toxicologist and delirium: flumazenil as a diagnostic and therapeutic tool for delirium during the course of alcohol withdrawal.
Topics: Alcoholism; Benzodiazepines; Delirium; Flumazenil; Humans; Substance Withdrawal Syndrome | 2014 |
Cortical gamma-aminobutyric acid type A-benzodiazepine receptors in recovery from alcohol dependence: relationship to features of alcohol dependence and cigarette smoking.
Topics: Adult; Alcoholism; Cerebral Cortex; Comorbidity; Ethanol; Flumazenil; Humans; Iodine Radioisotopes; | 2005 |
The amygdala regulates the antianxiety sensitization effect of flumazenil during repeated chronic ethanol or repeated stress.
Topics: Alcohol Drinking; Alcoholism; Amygdala; Animals; Anxiety; Behavior, Animal; Body Weight; Disease Mod | 2007 |
PET-determination of benzodiazepine receptor binding in studies on alcoholism.
Topics: Adult; Alcoholism; Brain; Carbon Radioisotopes; Cerebellum; Cerebral Cortex; Flumazenil; Humans; Mal | 1994 |
PET analysis of [11C]flumazenil binding to benzodiazepine receptors in chronic alcohol-dependent men and healthy controls.
Topics: Adult; Alcoholism; Brain; Carbon Radioisotopes; Flumazenil; Humans; Kinetics; Magnetic Resonance Ima | 1993 |
Effects of disulfiram on positron emission tomography and neuropsychological studies in severe chronic alcoholism.
Topics: Adult; Aged; Alcohol Deterrents; Alcoholism; Blood Glucose; Brain; Deoxyglucose; Disulfiram; Energy | 1996 |
[Suicidal poisoning with benzodiazepines].
Topics: Adolescent; Adult; Aged; Alcoholism; Benzodiazepines; Carbamazepine; Coma; Ethanol; Female; Flumazen | 1997 |
Alterations of benzodiazepine receptors in type II alcoholic subjects measured with SPECT and [123I]iomazenil.
Topics: Adult; Alcoholism; Brain; Cerebellum; Cerebral Cortex; Flumazenil; Frontal Lobe; Gyrus Cinguli; Huma | 1998 |
Levels of gamma-aminobutyric acid-benzodiazepine receptors in abstinent, alcohol-dependent women: preliminary findings from an 123I-iomazenil single photon emission tomography study.
Topics: Adult; Alcoholism; Brain; Brain Chemistry; Cerebellum; Female; Flumazenil; Humans; Male; Middle Aged | 2000 |
Reversal of alcohol dependence and tolerance by a single administration of flumazenil.
Topics: Alcoholism; Animals; Ataxia; Behavior, Animal; Brain; Carbolines; Chlorides; Drug Administration Sch | 1991 |
[Can flumazenil counteract the central effects of alcohol?].
Topics: Adult; Alcoholism; Ethanol; Female; Flumazenil; Humans; Male | 1990 |
Chronic ethanol treatment selectively increases the binding of inverse agonists for benzodiazepine binding sites in cultured spinal cord neurons.
Topics: Alcoholism; Animals; Azides; Benzodiazepines; Cells, Cultured; Female; Flumazenil; Flunitrazepam; Ma | 1989 |
Ethanol and chlordiazepoxide cross-dependence.
Topics: Alcoholism; Animals; Chlordiazepoxide; Flumazenil; Male; Mice; Mice, Inbred C57BL; Substance Withdra | 1987 |
Taste Preference-Related Genetic Polymorphisms Modify Alcohol Consumption Behavior of the Hungarian General and Roma Populations.
Topics: Alcohol Drinking; Alcoholism; Humans; Hungary; Polymorphism, Genetic; Roma; Taste | 2023 |
Delivery of cardio-metabolic preventive services to Hungarian Roma of different socio-economic strata.
Topics: Adult; Alcoholism; Blood Glucose; Cholesterol; Cross-Sectional Studies; Delivery of Health Care; Edu | 2017 |
Alcoholism prevalence and some related factors in Edirne, Turkey.
Topics: Adolescent; Adult; Alcoholism; Female; Humans; Male; Middle Aged; Prevalence; Risk Factors; Roma; Tu | 2004 |