flumazenil has been researched along with Alcohol Drinking in 26 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Alcohol Drinking: Behaviors associated with the ingesting of ALCOHOLIC BEVERAGES, including social drinking.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The benzodiazepine receptor antagonist flumazenil reduces anxiety-like behavior and sensitization of anxiety-like behavior in various models of ethanol withdrawal in rodents." | 7.74 | The amygdala regulates the antianxiety sensitization effect of flumazenil during repeated chronic ethanol or repeated stress. ( Angel, RA; Breese, GR; Knapp, DJ; Navarro, M; Overstreet, DH, 2007) |
| "The benzodiazepine receptor antagonist flumazenil reduces anxiety-like behavior and sensitization of anxiety-like behavior in various models of ethanol withdrawal in rodents." | 3.74 | The amygdala regulates the antianxiety sensitization effect of flumazenil during repeated chronic ethanol or repeated stress. ( Angel, RA; Breese, GR; Knapp, DJ; Navarro, M; Overstreet, DH, 2007) |
| "Improved treatment of alcohol dependence is a high priority, including defining subtypes that might respond differently." | 2.74 | Efficacy of a combination of flumazenil and gabapentin in the treatment of alcohol dependence: relationship to alcohol withdrawal symptoms. ( Anton, RF; Baros, AM; Latham, PK; Malcolm, R; Myrick, H; Randall, PK; Stewart, SH; Waid, R; Wright, TM, 2009) |
| "The aim of the study was to evaluate the genetic susceptibility of Roma to hazardous alcohol consumption compared to the Hungarian general population." | 1.46 | Distribution Characteristics and Combined Effect of Polymorphisms Affecting Alcohol Consumption Behaviour in the Hungarian General and Roma Populations. ( Ádány, R; Diószegi, J; Fiatal, S; Kósa, Z; McKee, M; Moravcsik-Kornyicki, Á; Sándor, J; Tóth, R, 2017) |
| "Most oral cancers are preventable; 75% of oral cancers are related to tobacco use, alcohol use, or use of both substances together." | 1.34 | [Model program for screening oral cancers in the Roma population]. ( Bánóczy, J; Csépe, P; Döbrossy, L; Dombi, C; Forrai, J; Gyenes, M, 2007) |
| "When flumazenil was given alone, both doses reduced ETOH self-administration at 60 min; although the magnitude of the antagonism was comparable to that of Ro15-4513 only with the highest does of flumazenil (16." | 1.29 | Ethanol self-administration in freely feeding and drinking rats: effects of Ro15-4513 alone, and in combination with Ro15-1788 (flumazenil). ( Hughes, RW; June, HL; Lewis, MJ; Spurlock, HL, 1994) |
| "Saccharin intake was either not altered by RO19-4603 or showed increases during the initial 15 min intervals and the total 4 h sessions on days 1 and 2." | 1.29 | Effects of the benzodiazepine inverse agonist RO19-4603 alone and in combination with the benzodiazepine receptor antagonists flumazenil, ZK 93426 and CGS 8216, on ethanol intake in alcohol-preferring (P) rats. ( Cason, CR; Cox, R; Duemler, SE; Greene, TL; Hite, ML; June, HL; Li, TK; Lumeng, L; Mellon-Burke, J; Murphy, JM; Torres, L; Williams, JA, 1996) |
| "0 mg/kg), and Ro15-4513 in combination with Ro15-1788 on the time course of ETOH self-administration." | 1.28 | Ethanol self-administration in deprived rats: effects of Ro15-4513 alone, and in combination with flumazenil (Ro15-1788). ( Colker, RE; Domangue, KR; Hicks, LH; June, HL; June, PL; Lewis, MJ; Perry, LE, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (19.23) | 18.2507 |
| 2000's | 12 (46.15) | 29.6817 |
| 2010's | 8 (30.77) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Wills, TA | 1 |
| Knapp, DJ | 6 |
| Overstreet, DH | 6 |
| Breese, GR | 6 |
| Anton, RF | 3 |
| Myrick, H | 3 |
| Baros, AM | 2 |
| Latham, PK | 2 |
| Randall, PK | 3 |
| Wright, TM | 2 |
| Stewart, SH | 1 |
| Waid, R | 1 |
| Malcolm, R | 1 |
| Schacht, JP | 2 |
| Waid, LR | 1 |
| Li, X | 1 |
| Henderson, S | 1 |
| Moy, SS | 1 |
| Besheer, J | 1 |
| Lepoutre, V | 1 |
| Mole, B | 1 |
| Hodge, CW | 1 |
| Angel, RA | 1 |
| Navarro, M | 1 |
| Uzbay, IT | 1 |
| Akarsu, ES | 1 |
| Kayaalp, SO | 1 |
| Weinberg, AD | 1 |
| Pals, JK | 1 |
| Marinelli, FC | 1 |
| Thibault, GE | 1 |
| June, HL | 3 |
| Hughes, RW | 1 |
| Spurlock, HL | 1 |
| Lewis, MJ | 2 |
| Greene, TL | 1 |
| Murphy, JM | 1 |
| Hite, ML | 1 |
| Williams, JA | 1 |
| Cason, CR | 1 |
| Mellon-Burke, J | 1 |
| Cox, R | 1 |
| Duemler, SE | 1 |
| Torres, L | 1 |
| Lumeng, L | 1 |
| Li, TK | 1 |
| Colker, RE | 1 |
| Domangue, KR | 1 |
| Perry, LE | 1 |
| Hicks, LH | 1 |
| June, PL | 1 |
| Kurshed, AAM | 1 |
| Vincze, F | 1 |
| Pikó, P | 1 |
| Kósa, Z | 3 |
| Sándor, J | 3 |
| Ádány, R | 3 |
| Diószegi, J | 2 |
| Babinská, I | 2 |
| Halánová, M | 1 |
| Kalinová, Z | 1 |
| Čechová, L | 1 |
| Čisláková, L | 1 |
| Madarasová Gecková, A | 1 |
| Hubáček, JA | 1 |
| Šedová, L | 1 |
| Olišarová, V | 1 |
| Adámková, V | 1 |
| Adámek, V | 1 |
| Tóthová, V | 1 |
| Sárváry, A | 2 |
| Jávorné, RE | 1 |
| Gyulai, A | 1 |
| Takács, P | 1 |
| Németh, Á | 1 |
| Halmai, R | 1 |
| Gecková, AM | 1 |
| Jarcuska, P | 1 |
| Pella, D | 1 |
| Mareková, M | 1 |
| Stefková, G | 1 |
| Veselská, ZD | 1 |
| Sudzinova, A | 1 |
| Rosenberger, J | 1 |
| Stewart, RE | 1 |
| van Dijk, JP | 1 |
| Reijneveld, SA | 1 |
| Fiatal, S | 1 |
| Tóth, R | 1 |
| Moravcsik-Kornyicki, Á | 1 |
| McKee, M | 1 |
| Jung, H | 1 |
| Matei, DB | 1 |
| Hecser, L | 1 |
| Kanapeckiene, V | 1 |
| Valinteliene, R | 1 |
| Berzanskyte, A | 1 |
| Kevalas, R | 1 |
| Supranowicz, P | 1 |
| Csépe, P | 1 |
| Bánóczy, J | 1 |
| Dombi, C | 1 |
| Forrai, J | 1 |
| Gyenes, M | 1 |
| Döbrossy, L | 1 |
| Dejmek, J | 1 |
| Ginter, E | 1 |
| Solanský, I | 1 |
| Podrazilová, K | 1 |
| Stávková, Z | 1 |
| Benes, I | 1 |
| Srám, RJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double Blind Evaluation of Flumazenil and Gabapentin for the Treatment of Alcohol Withdrawal and Relapse Prevention[NCT00262639] | Phase 2/Phase 3 | 60 participants (Actual) | Interventional | 2005-12-31 | Completed | ||
| Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics[NCT03220776] | Phase 2 | 54 participants (Actual) | Interventional | 2017-08-07 | Completed | ||
| Neurocognitive and Neurobehavioral Mechanisms of Change Following Psychological[NCT03842670] | 140 participants (Anticipated) | Interventional | 2018-11-14 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
percent days abstinent during treatment (NCT00262639)
Timeframe: Weeks 1 to 6
| Intervention | percent days (Mean) |
|---|---|
| Low CIWA Flumazenil/Gabapentin | 70.8 |
| Low CIWAar Placebo | 86.1 |
| High CIWAar Placebo | 75.9 |
| High CIWAar Flumazenil/Gabapentin | 95.9 |
percent of subjects completely abstinent during the six week medication study study (NCT00262639)
Timeframe: 6 week trial
| Intervention | percent of participants (Number) |
|---|---|
| Low CIWA Flumazenil/Gabapentin | 44 |
| Low CIWAar Placebo | 19 |
| High CIWAar Placebo | 33 |
| High CIWAar Flumazenil/Gabapentin | 71 |
Concentrations of GABA+, referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy (i.e., MEGA-PRESS). (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 3.90 |
| Gabapentin | 3.93 |
| Placebo Oral Tablet | 3.73 |
Concentrations of Glx (i.e., glutamate + glutamine), referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy. (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 21.59 |
| Gabapentin | 21.69 |
| Placebo Oral Tablet | 22.25 |
3 trials available for flumazenil and Alcohol Drinking
| Article | Year |
|---|---|
Efficacy of a combination of flumazenil and gabapentin in the treatment of alcohol dependence: relationship to alcohol withdrawal symptoms.
Topics: Administration, Oral; Adult; Alcohol Drinking; Alcoholism; Amines; Cyclohexanecarboxylic Acids; Doub | 2009 |
Efficacy of a combination of flumazenil and gabapentin in the treatment of alcohol dependence: relationship to alcohol withdrawal symptoms.
Topics: Administration, Oral; Adult; Alcohol Drinking; Alcoholism; Amines; Cyclohexanecarboxylic Acids; Doub | 2009 |
Efficacy of a combination of flumazenil and gabapentin in the treatment of alcohol dependence: relationship to alcohol withdrawal symptoms.
Topics: Administration, Oral; Adult; Alcohol Drinking; Alcoholism; Amines; Cyclohexanecarboxylic Acids; Doub | 2009 |
Efficacy of a combination of flumazenil and gabapentin in the treatment of alcohol dependence: relationship to alcohol withdrawal symptoms.
Topics: Administration, Oral; Adult; Alcohol Drinking; Alcoholism; Amines; Cyclohexanecarboxylic Acids; Doub | 2009 |
Neurocognitive performance, alcohol withdrawal, and effects of a combination of flumazenil and gabapentin in alcohol dependence.
Topics: Adult; Alcohol Drinking; Alcoholism; Amines; Cognition; Cyclohexanecarboxylic Acids; Drug Therapy, C | 2011 |
Neurocognitive performance, alcohol withdrawal, and effects of a combination of flumazenil and gabapentin in alcohol dependence.
Topics: Adult; Alcohol Drinking; Alcoholism; Amines; Cognition; Cyclohexanecarboxylic Acids; Drug Therapy, C | 2011 |
Neurocognitive performance, alcohol withdrawal, and effects of a combination of flumazenil and gabapentin in alcohol dependence.
Topics: Adult; Alcohol Drinking; Alcoholism; Amines; Cognition; Cyclohexanecarboxylic Acids; Drug Therapy, C | 2011 |
Neurocognitive performance, alcohol withdrawal, and effects of a combination of flumazenil and gabapentin in alcohol dependence.
Topics: Adult; Alcohol Drinking; Alcoholism; Amines; Cognition; Cyclohexanecarboxylic Acids; Drug Therapy, C | 2011 |
Effects of a GABA-ergic medication combination and initial alcohol withdrawal severity on cue-elicited brain activation among treatment-seeking alcoholics.
Topics: Adult; Alcohol Drinking; Alcoholism; Amines; Brain; Cues; Cyclohexanecarboxylic Acids; Drug Therapy, | 2013 |
23 other studies available for flumazenil and Alcohol Drinking
| Article | Year |
|---|---|
Sensitization, duration, and pharmacological blockade of anxiety-like behavior following repeated ethanol withdrawal in adolescent and adult rats.
Topics: Aging; Alcohol Drinking; Animals; Anxiety; Buspirone; Central Nervous System Depressants; Ethanol; F | 2009 |
SB242084, flumazenil, and CRA1000 block ethanol withdrawal-induced anxiety in rats.
Topics: Alcohol Drinking; Aminopyridines; Animals; Anxiety; Ethanol; Flumazenil; Indoles; Male; Pyridines; P | 2004 |
Pharmacological modulation of repeated ethanol withdrawal-induced anxiety-like behavior differs in alcohol-preferring P and Sprague-Dawley rats.
Topics: Alcohol Drinking; Animals; Anxiety; Ethanol; Flumazenil; Indoles; Interpersonal Relations; Male; Pyr | 2005 |
GABAA receptor regulation of voluntary ethanol drinking requires PKCepsilon.
Topics: Alcohol Drinking; Animals; Diazepam; Flumazenil; GABA Agonists; GABA Modulators; Hypnotics and Sedat | 2006 |
Baclofen blocks expression and sensitization of anxiety-like behavior in an animal model of repeated stress and ethanol withdrawal.
Topics: Alcohol Drinking; Animals; Anxiety; Baclofen; Body Weight; Central Nervous System Depressants; Diet; | 2007 |
Drug challenges reveal differences in mediation of stress facilitation of voluntary alcohol drinking and withdrawal-induced anxiety in alcohol-preferring P rats.
Topics: Alcohol Drinking; Aminopyridines; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Benzodiaz | 2007 |
The amygdala regulates the antianxiety sensitization effect of flumazenil during repeated chronic ethanol or repeated stress.
Topics: Alcohol Drinking; Alcoholism; Amygdala; Animals; Anxiety; Behavior, Animal; Body Weight; Disease Mod | 2007 |
Effects of flumazenil on ethanol withdrawal syndrome in rats.
Topics: Alcohol Drinking; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Ethanol; Flumazenil; | 1995 |
Oxazepam overdose associated with ethanol ingestion: treatment with a benzodiazepine antagonist.
Topics: Alcohol Drinking; Benzodiazepines; Drug Interactions; Drug Overdose; Flumazenil; Humans; Male; Middl | 1994 |
Ethanol self-administration in freely feeding and drinking rats: effects of Ro15-4513 alone, and in combination with Ro15-1788 (flumazenil).
Topics: Alcohol Drinking; Animals; Azides; Benzodiazepines; Conditioning, Operant; Dose-Response Relationshi | 1994 |
Effects of the benzodiazepine inverse agonist RO19-4603 alone and in combination with the benzodiazepine receptor antagonists flumazenil, ZK 93426 and CGS 8216, on ethanol intake in alcohol-preferring (P) rats.
Topics: Alcohol Drinking; Animals; Azepines; Benzodiazepines; Dose-Response Relationship, Drug; Drinking; Dr | 1996 |
Ethanol self-administration in deprived rats: effects of Ro15-4513 alone, and in combination with flumazenil (Ro15-1788).
Topics: Alcohol Drinking; Animals; Azides; Benzodiazepines; Brain; Flumazenil; Male; Motivation; Rats; Rats, | 1992 |
Taste Preference-Related Genetic Polymorphisms Modify Alcohol Consumption Behavior of the Hungarian General and Roma Populations.
Topics: Alcohol Drinking; Alcoholism; Humans; Hungary; Polymorphism, Genetic; Roma; Taste | 2023 |
Prevalence of Chlamydia trachomatis Infection and Its Association with Sexual Behaviour and Alcohol Use in the Population Living in Separated and Segregated Roma Settlements in Eastern Slovakia.
Topics: Adult; Alcohol Drinking; Chlamydia Infections; Chlamydia trachomatis; Cross-Sectional Studies; Femal | 2017 |
Distribution of ADH1B genotypes predisposed to enhanced alcohol consumption in the Czech Roma/Gypsy population.
Topics: Alcohol Dehydrogenase; Alcohol Drinking; Czech Republic; Genetic Predisposition to Disease; Genotype | 2018 |
Socioeconomic status, health related behaviour, and self-rated health of children living in Roma settlements in Hungary.
Topics: Adolescent; Alcohol Drinking; Child; Cross-Sectional Studies; Female; Health Behavior; Health Status | 2019 |
Does the population living in Roma settlements differ in physical activity, smoking and alcohol consumption from the majority population in Slovakia?
Topics: Adolescent; Adult; Alcohol Drinking; Cross-Sectional Studies; Female; Health Behavior; Health Survey | 2014 |
Does poorer self-rated health mediate the effect of Roma ethnicity on mortality in patients with coronary artery disease after coronaro-angiography?
Topics: Adult; Age Factors; Aged; Alcohol Drinking; Angiography; Body Mass Index; Coronary Artery Disease; F | 2016 |
Distribution Characteristics and Combined Effect of Polymorphisms Affecting Alcohol Consumption Behaviour in the Hungarian General and Roma Populations.
Topics: Adult; Alcohol Drinking; Female; Genetic Predisposition to Disease; Humans; Hungary; Male; Middle Ag | 2017 |
Biostatistical study of suicide features in Mures County (Romania).
Topics: Adult; Age Distribution; Aged; Alcohol Drinking; Asphyxia; Drowning; Female; Forensic Medicine; Huma | 2009 |
Health of Roma children in Vilnius and Ventspils.
Topics: Adolescent; Age Factors; Alcohol Drinking; Chi-Square Distribution; Child; Chronic Disease; Emotions | 2009 |
[Model program for screening oral cancers in the Roma population].
Topics: Adult; Aged; Alcohol Drinking; Early Diagnosis; Evidence-Based Medicine; Female; Humans; Hungary; Ma | 2007 |
Vitamin C, E and A levels in maternal and fetal blood for Czech and Gypsy ethnic groups in the Czech Republic.
Topics: Alcohol Drinking; Ascorbic Acid; Ascorbic Acid Deficiency; Czech Republic; Diet; Dietary Supplements | 2002 |