flumazenil has been researched along with Aging in 19 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The influence of flumazenil on seizures induced by pentylenetetrazol (PTZ) was studied in rats aged 7, 12, 18, 25, and 90 days." | 3.68 | Anticonvulsant activity of flumazenil in rats during ontogenetic development. ( Kubová, H; Mares, P; Rathouská, J; Vorlícek, J, 1993) |
| " In 26% (elderly) and 23% (young), the absolute bioavailability of flumazenil was very similar." | 2.67 | Flumazenil kinetics in the elderly. ( Roncari, G; Timm, U; Weber, W; Zell, M; Zumbrunnen, R, 1993) |
| "Midazolam is an imidazobenzodiazepine with unique properties when compared with other benzodiazepines." | 2.37 | Midazolam: pharmacology and uses. ( Fragen, RJ; Greenblatt, DJ; Reves, JG; Vinik, HR, 1985) |
| "Propofol was administrated to the WT and AD Tg mice once a week for 8 or 12 weeks, respectively." | 1.40 | Chronic treatment with anesthetic propofol improves cognitive function and attenuates caspase activation in both aged and Alzheimer's disease transgenic mice. ( Dong, Y; Shao, H; Xia, W; Xie, Z; Yu, B; Zhang, Y, 2014) |
| "Because dystonia in mutant dtsz hamsters is transient and disappears after approximately 60-70 days of age, [3H]flumazenil binding was studied at the age of maximum severity of dystonia (30-40 days) and after disappearance of the disease, to examine which neurochemical changes were related to dystonia." | 1.29 | Regionally selective and age-dependent alterations in benzodiazepine receptor binding in the genetically dystonic hamster. ( Löscher, W; Möhler, H; Pratt, GD; Richter, A, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (21.05) | 18.7374 |
| 1990's | 8 (42.11) | 18.2507 |
| 2000's | 2 (10.53) | 29.6817 |
| 2010's | 4 (21.05) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Xu, NZ | 1 |
| Ernst, M | 1 |
| Treven, M | 1 |
| Cerne, R | 1 |
| Wakulchik, M | 1 |
| Li, X | 1 |
| Jones, TM | 1 |
| Gleason, SD | 1 |
| Morrow, D | 1 |
| Schkeryantz, JM | 1 |
| Rahman, MT | 1 |
| Li, G | 1 |
| Poe, MM | 1 |
| Cook, JM | 1 |
| Witkin, JM | 1 |
| Kessler, M | 1 |
| Mamach, M | 1 |
| Beutelmann, R | 1 |
| Lukacevic, M | 1 |
| Eilert, S | 1 |
| Bascuñana, P | 1 |
| Fasel, A | 1 |
| Bengel, FM | 1 |
| Bankstahl, JP | 1 |
| Ross, TL | 1 |
| Klump, GM | 1 |
| Berding, G | 1 |
| Shao, H | 1 |
| Zhang, Y | 1 |
| Dong, Y | 1 |
| Yu, B | 1 |
| Xia, W | 1 |
| Xie, Z | 1 |
| Hashimoto, T | 1 |
| Hatayama, Y | 1 |
| Nakamichi, K | 1 |
| Yoshida, N | 1 |
| Wills, TA | 1 |
| Knapp, DJ | 1 |
| Overstreet, DH | 1 |
| Breese, GR | 1 |
| Kato, H | 1 |
| Shimosegawa, E | 1 |
| Isohashi, K | 1 |
| Kimura, N | 1 |
| Kazui, H | 1 |
| Hatazawa, J | 1 |
| Gulinello, M | 1 |
| Smith, SS | 1 |
| Pratt, GD | 1 |
| Richter, A | 1 |
| Möhler, H | 1 |
| Löscher, W | 1 |
| Williamson, RE | 1 |
| Pritchett, DB | 1 |
| Roncari, G | 1 |
| Timm, U | 1 |
| Zell, M | 1 |
| Zumbrunnen, R | 1 |
| Weber, W | 1 |
| Rathouská, J | 1 |
| Kubová, H | 1 |
| Mares, P | 1 |
| Vorlícek, J | 1 |
| Travis, J | 1 |
| Otis, TS | 1 |
| Mody, I | 1 |
| Miller, LG | 1 |
| Lumpkin, M | 1 |
| Galpern, WR | 1 |
| Greenblatt, DJ | 2 |
| Shader, RI | 1 |
| Lal, H | 1 |
| Forster, MJ | 1 |
| Robbins, J | 1 |
| Ikeda, H | 1 |
| Insel, TR | 1 |
| Gelhard, RE | 1 |
| Miller, LP | 1 |
| Daval, JL | 1 |
| Deckert, J | 1 |
| Nakajima, T | 1 |
| Morgan, PF | 1 |
| Marangos, PJ | 1 |
| Reves, JG | 1 |
| Fragen, RJ | 1 |
| Vinik, HR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Premedication by Midazolam on Preoperative Anxiety for Emergency Surgery[NCT02213302] | Phase 4 | 59 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for flumazenil and Aging
| Article | Year |
|---|---|
Midazolam: pharmacology and uses.
Topics: Adult; Aged; Aging; Ambulatory Surgical Procedures; Anesthetics; Animals; Benzodiazepines; Benzodiaz | 1985 |
1 trial available for flumazenil and Aging
| Article | Year |
|---|---|
Flumazenil kinetics in the elderly.
Topics: Administration, Oral; Adult; Aged; Aging; Biological Availability; Female; Flumazenil; Humans; Injec | 1993 |
17 other studies available for flumazenil and Aging
| Article | Year |
|---|---|
Negative allosteric modulation of alpha 5-containing GABA
Topics: Aging; Allosteric Regulation; Animals; Antidepressive Agents; Benzodiazepines; Depressive Disorder; | 2018 |
GABA
Topics: Age Factors; Aging; Animals; Autoradiography; Brain; Brain Mapping; Flumazenil; Fluorine Radioisotop | 2020 |
Chronic treatment with anesthetic propofol improves cognitive function and attenuates caspase activation in both aged and Alzheimer's disease transgenic mice.
Topics: Aging; Alzheimer Disease; Amyloidogenic Proteins; Animals; Brain; Caspases; Cell Line, Tumor; Cognit | 2014 |
Procognitive effect of AC-3933 in aged mice, and synergistic effect of combination with donepezil in scopolamine-treated mice.
Topics: Aging; Animals; Donepezil; Drug Synergism; Flumazenil; GABA-A Receptor Agonists; Indans; Male; Maze | 2014 |
Sensitization, duration, and pharmacological blockade of anxiety-like behavior following repeated ethanol withdrawal in adolescent and adult rats.
Topics: Aging; Alcohol Drinking; Animals; Anxiety; Buspirone; Central Nervous System Depressants; Ethanol; F | 2009 |
Distribution of cortical benzodiazepine receptor binding in right-handed healthy humans: a voxel-based statistical analysis of iodine 123 iomazenil SPECT with partial volume correction.
Topics: Adult; Aged; Aged, 80 and over; Aging; Brain; Female; Flumazenil; Functional Laterality; Humans; Ima | 2012 |
Anxiogenic effects of neurosteroid exposure: sex differences and altered GABAA receptor pharmacology in adult rats.
Topics: Acoustic Stimulation; Aging; Animals; Anti-Anxiety Agents; Anxiety; Exploratory Behavior; Female; Fl | 2003 |
Regionally selective and age-dependent alterations in benzodiazepine receptor binding in the genetically dystonic hamster.
Topics: Aging; Animals; Binding Sites; Brain; Cerebellum; Corpus Striatum; Cricetinae; Disease Models, Anima | 1995 |
Levels of benzodiazepine receptor subtypes and GABAA receptor alpha-subunit mRNA do not correlate during development.
Topics: Aging; Animals; Animals, Newborn; Anti-Anxiety Agents; Binding, Competitive; Cerebellum; Flumazenil; | 1994 |
Anticonvulsant activity of flumazenil in rats during ontogenetic development.
Topics: Aging; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; Female; F | 1993 |
Biologists visit New Orleans (under an assumed name)
Topics: Aging; Animals; Colonic Neoplasms; Flumazenil; Genes, DCC; Humans; Memory; Rats; Societies, Scientif | 1993 |
Modulation of decay kinetics and frequency of GABAA receptor-mediated spontaneous inhibitory postsynaptic currents in hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Anesthetics, Local; Animal | 1992 |
Modification of gamma-aminobutyric acidA receptor binding and function by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline in vitro and in vivo: effects of aging.
Topics: Aging; Animals; Benzodiazepines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; | 1991 |
Flumazenil improves active avoidance performance in aging NZB/BlNJ and C57BL/6NNia mice.
Topics: Aging; Animals; Avoidance Learning; Flumazenil; Mice; Mice, Inbred C57BL; Receptors, GABA-A; Species | 1990 |
Benzodiazepines and the mammalian retina. III. Postnatal development.
Topics: Action Potentials; Aging; Animals; Cats; Flumazenil; Flurazepam; Photic Stimulation; Receptors, GABA | 1989 |
Rat pup isolation distress and the brain benzodiazepine receptor.
Topics: Aging; Animals; Animals, Newborn; Arousal; Brain; Brain Mapping; Flumazenil; Rats; Rats, Inbred Stra | 1989 |
Regional ontogenetic profile of central and peripheral benzodiazepine receptors in the guinea pig brain.
Topics: Aging; Animals; Benzodiazepinones; Brain; Flumazenil; Guinea Pigs; Receptors, GABA-A | 1988 |