Page last updated: 2024-10-27

flumazenil and Aggression

flumazenil has been researched along with Aggression in 41 studies

Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.

Aggression: Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.

Research Excerpts

ExcerptRelevanceReference
" The benzodiazepine antagonist flumazenil has reduced, increased or not affected hostility and aggression in animal and human studies."9.14Reduction of aggression during benzodiazepine withdrawal: effects of flumazenil. ( Borg, S; Hiltunen, AJ; Saxon, L, 2010)
"The beta-carboline FG 7142 decreases conspecific aggression in male hooded rats."7.67beta-Carboline FG 7142-reduced aggression in male rats: reversed by the benzodiazepine receptor antagonist, Ro15-1788. ( Beck, CH; Cooper, SJ, 1986)
"The effects of intraperitoneal administrations of the deoxycorticosterone metabolite, 5 alpha-pregnane-, 21 diol-20-one (3 alpha, 5 alpha-tetrahydrodeoxycorticosterone; alpha-THDOC) on the responses to aggression and defeat-induced analgesia were examined in subordinate intruder male mice in "resident-intruder" pairings."7.67Inhibitory influences of the adrenal steroid, 3 alpha, 5 alpha-tetrahydrodeoxycorticosterone [correction of tetrahydroxycorticosterone] on aggression and defeat-induced analgesia in mice. ( Kavaliers, M, 1988)
" The benzodiazepine antagonist flumazenil has reduced, increased or not affected hostility and aggression in animal and human studies."5.14Reduction of aggression during benzodiazepine withdrawal: effects of flumazenil. ( Borg, S; Hiltunen, AJ; Saxon, L, 2010)
" Predatory aggression (mouse killing) was facilitated by chlordiazepoxide (CDP) when tested in naive female rats, but CDP was unable to induce muricide in non-killing rats with extensive experience with mice."3.67Modulatory actions of benzodiazepine receptor ligands on agonistic behaviour. ( Mos, J; Olivier, B; van der Poel, AM, 1987)
"The influence of Ro 15-1788 and bicuculline on the action of GABA-positive drugs (muscimol), GABA cethyl ester, piracetam and depakine and benzodiazepine tranquilizers (diazepam, phenazepam) on motivated aggression has been studied."3.67[Antagonism of RO 15-1788 with benzodiazepines in the effect on motivated aggression and the action of analgesics]. ( Molodavkin, GM; Ostrovskaia, RU, 1985)
"The effects of a benzodiazepine receptor agonist (diazepam), antagonist (Ro 15-1788), and an "active" antagonist [inverse agonist] (3-carboethoxy-beta-carboline) were examined in an isolation-induced model of aggression."3.67Benzodiazepine-receptor mediated inhibition of isolation-induced aggression in mice. ( Paul, SM; Reed, GF; Skolnick, P, 1985)
"The beta-carboline FG 7142 decreases conspecific aggression in male hooded rats."3.67beta-Carboline FG 7142-reduced aggression in male rats: reversed by the benzodiazepine receptor antagonist, Ro15-1788. ( Beck, CH; Cooper, SJ, 1986)
"The effects of intraperitoneal administrations of the deoxycorticosterone metabolite, 5 alpha-pregnane-, 21 diol-20-one (3 alpha, 5 alpha-tetrahydrodeoxycorticosterone; alpha-THDOC) on the responses to aggression and defeat-induced analgesia were examined in subordinate intruder male mice in "resident-intruder" pairings."3.67Inhibitory influences of the adrenal steroid, 3 alpha, 5 alpha-tetrahydrodeoxycorticosterone [correction of tetrahydroxycorticosterone] on aggression and defeat-induced analgesia in mice. ( Kavaliers, M, 1988)
"Sedation and restlessness in all patients were controlled by midazolam administered intravenously by the attending anaesthesiologist; these parameters were later objectively confirmed by recorded actigrams."2.41The midazolam-induced paradox phenomenon is reversible by flumazenil. Epidemiology, patient characteristics and review of the literature. ( Flaishon, R; Ogorek, D; Szold, O; Weinbroum, AA, 2001)
"Bilateral intraocular pressures were monitored before and after the first 7 ECTs and intermittently after ECT for 10 months of maintenance ECT."1.40Stability of intraocular pressure after retinal reattachment surgery during electroconvulsive therapy for intractable self-injury in a 12-year-old autistic boy. ( Reti, IM; Wachtel, LE; Ying, H, 2014)
"Oral treatment with abecarnil (0."1.29Pharmacological characterization of the novel anxiolytic beta-carboline abecarnil in rodents and primates. ( Akai, T; Kuno, S; Mizuta, E; Nakada, Y; Ozawa, M; Sugimachi, K; Yabuuchi, F; Yamaguchi, M, 1994)
"Unlike apomorphine, Ro 15-1788 reversed catalepsy induced by haloperidol (0."1.27[Effect of an imidazobenzodiazepine (RO 15-1788) on aggressive behavior in mice]. ( Allikmets, LKh; Maĭmets, MO; Nurk, AM; Riago, LK; Vasar, EE, 1984)
"Brotizolam has a pharmacologic spectrum of action similar to clinically useful benzodiazepines, while the closely related derivatives WE 973 and WE 1008 appear to lack hypnotic action."1.27Pharmacological and neurochemical properties of 1,4-diazepines with two annelated heterocycles ('hetrazepines'). ( Böke-Kuhn, K; Danneberg, PB; Hommer, D; Kuhn, FJ; Lehr, E; Paul, SM; Skolnick, P; Weber, KH, 1985)

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-199018 (43.90)18.7374
1990's12 (29.27)18.2507
2000's7 (17.07)29.6817
2010's4 (9.76)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wachtel, LE1
Reti, IM1
Ying, H1
Saxon, L1
Borg, S1
Hiltunen, AJ1
Fachinelli, C1
Ison, M1
Rodríguez Echandía, EL1
Uhlírová, L1
Sustková-Fiserová, M1
Krsiak, M1
Tcheremissine, OV1
Lane, SD1
Lieving, LM1
Rhoades, HM1
Nouvion, S1
Cherek, DR1
Mizoule, J1
Rataud, J1
Uzan, A1
Mazadier, M1
Daniel, M1
Gauthier, A1
Ollat, C1
Gueremy, C1
Renault, C1
Dubroeucq, MC1
Vasar, EE1
Maĭmets, MO1
Riago, LK1
Nurk, AM1
Allikmets, LKh1
Allikmets, LH1
Rägo, LK1
Rodgers, RJ3
Waters, AJ2
Weerts, EM3
Tornatzky, W2
Miczek, KA4
Vivian, JA1
Ozawa, M1
Nakada, Y1
Sugimachi, K1
Yabuuchi, F1
Akai, T1
Mizuta, E1
Kuno, S1
Yamaguchi, M1
Auta, J1
Romeo, E1
Kozikowski, A1
Ma, D1
Costa, E1
Guidotti, A1
Miachon, S1
Cespuglio, R1
Massanari, M1
Novitsky, J1
Reinstein, LJ1
Adamec, RE2
Weinbroum, AA1
Szold, O1
Ogorek, D1
Flaishon, R1
Sakaue, M1
Ago, Y1
Murakami, C1
Sowa, C1
Sakamoto, Y1
Koyama, Y1
Baba, A1
Matsuda, T1
Miller, LG1
Hood, KE1
Belzung, C1
Cabib, S1
Fabiani, L1
Tolentino, P1
Puglisi-Allegra, S1
Nagatani, T2
Yamamoto, T2
Takao, K2
Hashimoto, S1
Kasahara, K1
Sugihara, T2
Ueki, S2
van der Bijl, P1
Roelofse, JA1
Mos, J2
Olivier, B2
van der Poel, AM1
Kavaliers, M3
Innes, DG1
Ostrovskaia, RU1
Molodavkin, GM1
Weber, KH1
Kuhn, FJ1
Böke-Kuhn, K1
Lehr, E1
Danneberg, PB1
Hommer, D1
Paul, SM2
Skolnick, P2
Reed, GF1
Sethi, BB1
Trivedi, JK1
Kumar, P1
Gulati, A1
Agarwal, AK1
Sethi, N1
File, SE1
Pellow, S1
Beck, CH1
Cooper, SJ1
Hirst, M1
Randall, JI1
Kolarcik, P1
Madarasova Geckova, A1
Reijneveld, SA1
van Dijk, JP1
Kteily, N1
Hodson, G1
Bruneau, E1
Rex-Kiss, B1
Szabó, S1

Reviews

4 reviews available for flumazenil and Aggression

ArticleYear
The midazolam-induced paradox phenomenon is reversible by flumazenil. Epidemiology, patient characteristics and review of the literature.
    European journal of anaesthesiology, 2001, Volume: 18, Issue:12

    Topics: Aged; Aggression; Anesthesia, Epidural; Anesthesia, Spinal; Anti-Anxiety Agents; Female; Flumazenil;

2001
Disinhibitory reactions to benzodiazepines: a review.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1991, Volume: 49, Issue:5

    Topics: Aggression; Animals; Benzodiazepines; Flumazenil; Humans

1991
Benzodiazepines and their antagonists: a pharmacoethological analysis with particular reference to effects on "aggression".
    Neuroscience and biobehavioral reviews, 1985,Spring, Volume: 9, Issue:1

    Topics: Aggression; Agonistic Behavior; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Ben

1985
Intrinsic actions of the benzodiazepine receptor antagonist Ro 15-1788.
    Psychopharmacology, 1986, Volume: 88, Issue:1

    Topics: Aggression; Animals; Anticonvulsants; Anxiety; Avoidance Learning; Benzodiazepinones; Body Temperatu

1986

Trials

2 trials available for flumazenil and Aggression

ArticleYear
Reduction of aggression during benzodiazepine withdrawal: effects of flumazenil.
    Pharmacology, biochemistry, and behavior, 2010, Volume: 96, Issue:2

    Topics: Adult; Aggression; Benzodiazepines; Dose-Response Relationship, Drug; Female; Flumazenil; Hostility;

2010
Individual differences in aggressive responding to intravenous flumazenil administration in adult male parolees.
    Journal of psychopharmacology (Oxford, England), 2005, Volume: 19, Issue:6

    Topics: Adult; Aggression; Child; Conduct Disorder; Dose-Response Relationship, Drug; Double-Blind Method; F

2005

Other Studies

35 other studies available for flumazenil and Aggression

ArticleYear
Stability of intraocular pressure after retinal reattachment surgery during electroconvulsive therapy for intractable self-injury in a 12-year-old autistic boy.
    The journal of ECT, 2014, Volume: 30, Issue:1

    Topics: Aggression; Anticonvulsants; Antipsychotic Agents; Autistic Disorder; Child; Electroconvulsive Thera

2014
Effects of diazepam and flumazenil on food competition behavior in high- and low-aggression pigeons.
    Pharmacology, biochemistry, and behavior, 2003, Volume: 74, Issue:3

    Topics: Aggression; Animals; Columbidae; Competitive Behavior; Diazepam; Feeding Behavior; Female; Flumazeni

2003
Behavioral effects of flumazenil in the social conflict test in mice.
    Psychopharmacology, 2004, Volume: 171, Issue:3

    Topics: Aggression; Animals; Conflict, Psychological; Flumazenil; Male; Mice; Mice, Inbred ICR; Motor Activi

2004
Pharmacological evidence that PK 8165 behaves as a partial agonist of brain type benzodiazepine receptors.
    Archives internationales de pharmacodynamie et de therapie, 1984, Volume: 271, Issue:2

    Topics: Aggression; Animals; Anticonvulsants; Benzodiazepinones; Conflict, Psychological; Diazepam; Drinking

1984
[Effect of an imidazobenzodiazepine (RO 15-1788) on aggressive behavior in mice].
    Biulleten' eksperimental'noi biologii i meditsiny, 1984, Volume: 98, Issue:10

    Topics: Aggression; Animals; Apomorphine; Benzodiazepinones; Brain; Catalepsy; Dose-Response Relationship, D

1984
The action of benzodiazepine antagonist Ro 15-1788 on the effects of GABA-ergic drugs.
    Naunyn-Schmiedeberg's archives of pharmacology, 1983, Volume: 324, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Aggression; Animals; Baclofen; Benzodiazepines; Benzodiazepinones; B

1983
Effects of the benzodiazepine antagonist Ro 15-1788 on social and agonistic behaviour in male albino mice.
    Physiology & behavior, 1984, Volume: 33, Issue:3

    Topics: Aggression; Agonistic Behavior; Animals; Benzodiazepinones; Flumazenil; Humans; Male; Mice; Rats; So

1984
"Anxiolytic" and "anxiogenic" benzodiazepines and beta-carbolines: effects on aggressive and social behavior in rats and squirrel monkeys.
    Psychopharmacology, 1993, Volume: 110, Issue:4

    Topics: Aggression; Animals; Anti-Anxiety Agents; Anxiety; Azides; Benzodiazepines; Carbolines; Dose-Respons

1993
Prevention of the pro-aggressive effects of alcohol in rats and squirrel monkeys by benzodiazepine receptor antagonists.
    Psychopharmacology, 1993, Volume: 111, Issue:2

    Topics: Aggression; Animals; Carbolines; Dominance-Subordination; Dose-Response Relationship, Drug; Drug Int

1993
Diazepam and gepirone selectively attenuate either 20-32 or 32-64 kHz ultrasonic vocalizations during aggressive encounters.
    Psychopharmacology, 1993, Volume: 112, Issue:1

    Topics: Aggression; Animals; Anti-Anxiety Agents; Depression, Chemical; Diazepam; Dose-Response Relationship

1993
Pharmacological characterization of the novel anxiolytic beta-carboline abecarnil in rodents and primates.
    Japanese journal of pharmacology, 1994, Volume: 64, Issue:3

    Topics: Aggression; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Binding, Competitive; C

1994
Participation of mitochondrial diazepam binding inhibitor receptors in the anticonflict, antineophobic and anticonvulsant action of 2-aryl-3-indoleacetamide and imidazopyridine derivatives.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:2

    Topics: Aggression; Allosteric Regulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal;

1993
Prevention of ACTH- and adrenalectomy-induced muricidal behavior: by benzodiazepinic ligands.
    Peptides, 1997, Volume: 18, Issue:2

    Topics: Adrenalectomy; Adrenocorticotropic Hormone; Aggression; Animals; Benzodiazepinones; Clonazepam; Flum

1997
Paradoxical reactions in children associated with midazolam use during endoscopy.
    Clinical pediatrics, 1997, Volume: 36, Issue:12

    Topics: Adjuvants, Anesthesia; Adolescent; Adolescent Behavior; Aggression; Akathisia, Drug-Induced; Anti-An

1997
Evidence that long-lasting potentiation in limbic circuits mediating defensive behaviour in the right hemisphere underlies pharmacological stressor (FG-7142) induced lasting increases in anxiety-like behaviour: role of benzodiazepine receptors.
    Journal of psychopharmacology (Oxford, England), 2000, Volume: 14, Issue:4

    Topics: Aggression; Animals; Anxiety; Behavior, Animal; Carbolines; Catheterization; Cats; Flumazenil; Funct

2000
Evidence that long-lasting potentiation of amygdala efferents in the right hemisphere underlies pharmacological stressor (FG-7142) induced lasting increases in anxiety-like behaviour: role of GABA tone in initiation of brain and behavioural changes.
    Journal of psychopharmacology (Oxford, England), 2000, Volume: 14, Issue:4

    Topics: Aggression; Amygdala; Animals; Anticonvulsants; Anxiety; Behavior, Animal; Brain Chemistry; Carbolin

2000
Involvement of benzodiazepine binding sites in an antiaggressive effect by 5-HT(1A) receptor activation in isolated mice.
    European journal of pharmacology, 2001, Dec-07, Volume: 432, Issue:2-3

    Topics: Aggression; Animals; Behavior, Animal; Binding Sites; Diazepam; Dioxanes; Dioxoles; Dose-Response Re

2001
Increased GABAA-dependent chloride uptake in mice selectively bred for low aggressive behavior.
    Psychopharmacology, 1992, Volume: 108, Issue:1-2

    Topics: Aggression; Animals; Chlorides; Flumazenil; gamma-Aminobutyric Acid; Genetics, Behavioral; Male; Mic

1992
LY 171555-induced hyperdefensiveness in the mouse does not implicate benzodiazepine receptors.
    Psychopharmacology, 1991, Volume: 103, Issue:4

    Topics: Aggression; Animals; Behavior, Animal; Carbolines; Chlordiazepoxide; Convulsants; Dopamine Agents; D

1991
Pharmacological profile of a potential anxiolytic: AP159, a new benzothieno-pyridine derivative.
    Psychopharmacology, 1991, Volume: 104, Issue:4

    Topics: Aggression; Animals; Anti-Anxiety Agents; Avoidance Learning; Conflict, Psychological; Drinking Beha

1991
beta-CCM inhibits muricide induced by olfactory bulbectomy in rats.
    Japanese journal of pharmacology, 1990, Volume: 52, Issue:3

    Topics: Aggression; Animals; Brain; Carbolines; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Inje

1990
Modulatory actions of benzodiazepine receptor ligands on agonistic behaviour.
    Physiology & behavior, 1987, Volume: 41, Issue:3

    Topics: Aggression; Agonistic Behavior; Animals; Behavior, Animal; Carbolines; Chlordiazepoxide; Female; Flu

1987
Male scent-induced analgesia in the deer mouse, Peromyscus maniculatus: involvement of benzodiazepine systems.
    Physiology & behavior, 1988, Volume: 42, Issue:2

    Topics: Aggression; Analgesia; Animals; Diazepam; Female; Flumazenil; Male; Naloxone; Nociceptors; Peromyscu

1988
[Antagonism of RO 15-1788 with benzodiazepines in the effect on motivated aggression and the action of analgesics].
    Biulleten' eksperimental'noi biologii i meditsiny, 1985, Volume: 99, Issue:4

    Topics: Aggression; Analgesics; Animals; Anti-Anxiety Agents; Benzodiazepinones; Bicuculline; Electric Stimu

1985
Pharmacological and neurochemical properties of 1,4-diazepines with two annelated heterocycles ('hetrazepines').
    European journal of pharmacology, 1985, Feb-12, Volume: 109, Issue:1

    Topics: Action Potentials; Aggression; Animals; Anticonvulsants; Azepines; Behavior, Animal; Benzodiazepinon

1985
Benzodiazepine-receptor mediated inhibition of isolation-induced aggression in mice.
    Pharmacology, biochemistry, and behavior, 1985, Volume: 23, Issue:1

    Topics: Aggression; Animals; Benzodiazepinones; Carbolines; Diazepam; Flumazenil; Humans; Indoles; Male; Mic

1985
Antianxiety effect of cannabis: involvement of central benzodiazepine receptors.
    Biological psychiatry, 1986, Volume: 21, Issue:1

    Topics: Adult; Aggression; Animals; Anxiety; Benzodiazepinones; Cannabinoids; Diazepam; Dronabinol; Electros

1986
beta-Carboline FG 7142-reduced aggression in male rats: reversed by the benzodiazepine receptor antagonist, Ro15-1788.
    Pharmacology, biochemistry, and behavior, 1986, Volume: 24, Issue:6

    Topics: Aggression; Analysis of Variance; Animals; Avoidance Learning; Benzodiazepinones; Carbolines; Chlord

1986
An octadecaneuropeptide (ODN) derived from diazepam binding inhibitor increases aggressive interactions in mice.
    Brain research, 1986, Sep-24, Volume: 383, Issue:1-2

    Topics: Aggression; Animals; Diazepam Binding Inhibitor; Flumazenil; Injections, Intraventricular; Male; Mic

1986
RO 15-1788 does not influence postpartum aggression in lactating female rats.
    Psychopharmacology, 1986, Volume: 90, Issue:2

    Topics: Aggression; Animals; Female; Flumazenil; Lactation; Male; Motor Activity; Postpartum Period; Pregnan

1986
Social conflict analgesia: inhibition of early non-opioid component by diazepam or flumazepil fails to affect appearance of late opioid component.
    Brain research bulletin, 1987, Volume: 19, Issue:1

    Topics: Aggression; Animals; Appetitive Behavior; Conflict, Psychological; Diazepam; Endorphins; Flumazenil;

1987
Inhibitory influences of the adrenal steroid, 3 alpha, 5 alpha-tetrahydrodeoxycorticosterone [correction of tetrahydroxycorticosterone] on aggression and defeat-induced analgesia in mice.
    Psychopharmacology, 1988, Volume: 95, Issue:4

    Topics: Aggression; Analgesia; Animals; Desoxycorticosterone; Flumazenil; Injections, Intraperitoneal; Male;

1988
Delinquent and Aggressive Behavior and Social Desirability Among Roma and Non-Roma Adolescents in Slovakia: A Cross-Sectional Study.
    Journal of interpersonal violence, 2016, Volume: 31, Issue:4

    Topics: Adolescent; Adolescent Behavior; Aggression; Cross-Sectional Studies; Female; Hostility; Humans; Juv

2016
They see us as less than human: Metadehumanization predicts intergroup conflict via reciprocal dehumanization.
    Journal of personality and social psychology, 2016, Volume: 110, Issue:3

    Topics: Adult; Aggression; Arabs; Dehumanization; Female; Group Processes; Humans; Hungary; Islam; Israel; M

2016
[ABO blood group investigations on prisoners (author's transl)].
    Zeitschrift fur Rechtsmedizin. Journal of legal medicine, 1981, Volume: 86, Issue:4

    Topics: ABO Blood-Group System; Aggression; Antisocial Personality Disorder; Humans; Phenotype; Prisoners; R

1981