flumazenil has been researched along with Aggression in 41 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Aggression: Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The benzodiazepine antagonist flumazenil has reduced, increased or not affected hostility and aggression in animal and human studies." | 9.14 | Reduction of aggression during benzodiazepine withdrawal: effects of flumazenil. ( Borg, S; Hiltunen, AJ; Saxon, L, 2010) |
| "The beta-carboline FG 7142 decreases conspecific aggression in male hooded rats." | 7.67 | beta-Carboline FG 7142-reduced aggression in male rats: reversed by the benzodiazepine receptor antagonist, Ro15-1788. ( Beck, CH; Cooper, SJ, 1986) |
| "The effects of intraperitoneal administrations of the deoxycorticosterone metabolite, 5 alpha-pregnane-, 21 diol-20-one (3 alpha, 5 alpha-tetrahydrodeoxycorticosterone; alpha-THDOC) on the responses to aggression and defeat-induced analgesia were examined in subordinate intruder male mice in "resident-intruder" pairings." | 7.67 | Inhibitory influences of the adrenal steroid, 3 alpha, 5 alpha-tetrahydrodeoxycorticosterone [correction of tetrahydroxycorticosterone] on aggression and defeat-induced analgesia in mice. ( Kavaliers, M, 1988) |
| " The benzodiazepine antagonist flumazenil has reduced, increased or not affected hostility and aggression in animal and human studies." | 5.14 | Reduction of aggression during benzodiazepine withdrawal: effects of flumazenil. ( Borg, S; Hiltunen, AJ; Saxon, L, 2010) |
| " Predatory aggression (mouse killing) was facilitated by chlordiazepoxide (CDP) when tested in naive female rats, but CDP was unable to induce muricide in non-killing rats with extensive experience with mice." | 3.67 | Modulatory actions of benzodiazepine receptor ligands on agonistic behaviour. ( Mos, J; Olivier, B; van der Poel, AM, 1987) |
| "The influence of Ro 15-1788 and bicuculline on the action of GABA-positive drugs (muscimol), GABA cethyl ester, piracetam and depakine and benzodiazepine tranquilizers (diazepam, phenazepam) on motivated aggression has been studied." | 3.67 | [Antagonism of RO 15-1788 with benzodiazepines in the effect on motivated aggression and the action of analgesics]. ( Molodavkin, GM; Ostrovskaia, RU, 1985) |
| "The effects of a benzodiazepine receptor agonist (diazepam), antagonist (Ro 15-1788), and an "active" antagonist [inverse agonist] (3-carboethoxy-beta-carboline) were examined in an isolation-induced model of aggression." | 3.67 | Benzodiazepine-receptor mediated inhibition of isolation-induced aggression in mice. ( Paul, SM; Reed, GF; Skolnick, P, 1985) |
| "The beta-carboline FG 7142 decreases conspecific aggression in male hooded rats." | 3.67 | beta-Carboline FG 7142-reduced aggression in male rats: reversed by the benzodiazepine receptor antagonist, Ro15-1788. ( Beck, CH; Cooper, SJ, 1986) |
| "The effects of intraperitoneal administrations of the deoxycorticosterone metabolite, 5 alpha-pregnane-, 21 diol-20-one (3 alpha, 5 alpha-tetrahydrodeoxycorticosterone; alpha-THDOC) on the responses to aggression and defeat-induced analgesia were examined in subordinate intruder male mice in "resident-intruder" pairings." | 3.67 | Inhibitory influences of the adrenal steroid, 3 alpha, 5 alpha-tetrahydrodeoxycorticosterone [correction of tetrahydroxycorticosterone] on aggression and defeat-induced analgesia in mice. ( Kavaliers, M, 1988) |
| "Sedation and restlessness in all patients were controlled by midazolam administered intravenously by the attending anaesthesiologist; these parameters were later objectively confirmed by recorded actigrams." | 2.41 | The midazolam-induced paradox phenomenon is reversible by flumazenil. Epidemiology, patient characteristics and review of the literature. ( Flaishon, R; Ogorek, D; Szold, O; Weinbroum, AA, 2001) |
| "Bilateral intraocular pressures were monitored before and after the first 7 ECTs and intermittently after ECT for 10 months of maintenance ECT." | 1.40 | Stability of intraocular pressure after retinal reattachment surgery during electroconvulsive therapy for intractable self-injury in a 12-year-old autistic boy. ( Reti, IM; Wachtel, LE; Ying, H, 2014) |
| "Oral treatment with abecarnil (0." | 1.29 | Pharmacological characterization of the novel anxiolytic beta-carboline abecarnil in rodents and primates. ( Akai, T; Kuno, S; Mizuta, E; Nakada, Y; Ozawa, M; Sugimachi, K; Yabuuchi, F; Yamaguchi, M, 1994) |
| "Unlike apomorphine, Ro 15-1788 reversed catalepsy induced by haloperidol (0." | 1.27 | [Effect of an imidazobenzodiazepine (RO 15-1788) on aggressive behavior in mice]. ( Allikmets, LKh; Maĭmets, MO; Nurk, AM; Riago, LK; Vasar, EE, 1984) |
| "Brotizolam has a pharmacologic spectrum of action similar to clinically useful benzodiazepines, while the closely related derivatives WE 973 and WE 1008 appear to lack hypnotic action." | 1.27 | Pharmacological and neurochemical properties of 1,4-diazepines with two annelated heterocycles ('hetrazepines'). ( Böke-Kuhn, K; Danneberg, PB; Hommer, D; Kuhn, FJ; Lehr, E; Paul, SM; Skolnick, P; Weber, KH, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (43.90) | 18.7374 |
| 1990's | 12 (29.27) | 18.2507 |
| 2000's | 7 (17.07) | 29.6817 |
| 2010's | 4 (9.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wachtel, LE | 1 |
| Reti, IM | 1 |
| Ying, H | 1 |
| Saxon, L | 1 |
| Borg, S | 1 |
| Hiltunen, AJ | 1 |
| Fachinelli, C | 1 |
| Ison, M | 1 |
| Rodríguez Echandía, EL | 1 |
| Uhlírová, L | 1 |
| Sustková-Fiserová, M | 1 |
| Krsiak, M | 1 |
| Tcheremissine, OV | 1 |
| Lane, SD | 1 |
| Lieving, LM | 1 |
| Rhoades, HM | 1 |
| Nouvion, S | 1 |
| Cherek, DR | 1 |
| Mizoule, J | 1 |
| Rataud, J | 1 |
| Uzan, A | 1 |
| Mazadier, M | 1 |
| Daniel, M | 1 |
| Gauthier, A | 1 |
| Ollat, C | 1 |
| Gueremy, C | 1 |
| Renault, C | 1 |
| Dubroeucq, MC | 1 |
| Vasar, EE | 1 |
| Maĭmets, MO | 1 |
| Riago, LK | 1 |
| Nurk, AM | 1 |
| Allikmets, LKh | 1 |
| Allikmets, LH | 1 |
| Rägo, LK | 1 |
| Rodgers, RJ | 3 |
| Waters, AJ | 2 |
| Weerts, EM | 3 |
| Tornatzky, W | 2 |
| Miczek, KA | 4 |
| Vivian, JA | 1 |
| Ozawa, M | 1 |
| Nakada, Y | 1 |
| Sugimachi, K | 1 |
| Yabuuchi, F | 1 |
| Akai, T | 1 |
| Mizuta, E | 1 |
| Kuno, S | 1 |
| Yamaguchi, M | 1 |
| Auta, J | 1 |
| Romeo, E | 1 |
| Kozikowski, A | 1 |
| Ma, D | 1 |
| Costa, E | 1 |
| Guidotti, A | 1 |
| Miachon, S | 1 |
| Cespuglio, R | 1 |
| Massanari, M | 1 |
| Novitsky, J | 1 |
| Reinstein, LJ | 1 |
| Adamec, RE | 2 |
| Weinbroum, AA | 1 |
| Szold, O | 1 |
| Ogorek, D | 1 |
| Flaishon, R | 1 |
| Sakaue, M | 1 |
| Ago, Y | 1 |
| Murakami, C | 1 |
| Sowa, C | 1 |
| Sakamoto, Y | 1 |
| Koyama, Y | 1 |
| Baba, A | 1 |
| Matsuda, T | 1 |
| Miller, LG | 1 |
| Hood, KE | 1 |
| Belzung, C | 1 |
| Cabib, S | 1 |
| Fabiani, L | 1 |
| Tolentino, P | 1 |
| Puglisi-Allegra, S | 1 |
| Nagatani, T | 2 |
| Yamamoto, T | 2 |
| Takao, K | 2 |
| Hashimoto, S | 1 |
| Kasahara, K | 1 |
| Sugihara, T | 2 |
| Ueki, S | 2 |
| van der Bijl, P | 1 |
| Roelofse, JA | 1 |
| Mos, J | 2 |
| Olivier, B | 2 |
| van der Poel, AM | 1 |
| Kavaliers, M | 3 |
| Innes, DG | 1 |
| Ostrovskaia, RU | 1 |
| Molodavkin, GM | 1 |
| Weber, KH | 1 |
| Kuhn, FJ | 1 |
| Böke-Kuhn, K | 1 |
| Lehr, E | 1 |
| Danneberg, PB | 1 |
| Hommer, D | 1 |
| Paul, SM | 2 |
| Skolnick, P | 2 |
| Reed, GF | 1 |
| Sethi, BB | 1 |
| Trivedi, JK | 1 |
| Kumar, P | 1 |
| Gulati, A | 1 |
| Agarwal, AK | 1 |
| Sethi, N | 1 |
| File, SE | 1 |
| Pellow, S | 1 |
| Beck, CH | 1 |
| Cooper, SJ | 1 |
| Hirst, M | 1 |
| Randall, JI | 1 |
| Kolarcik, P | 1 |
| Madarasova Geckova, A | 1 |
| Reijneveld, SA | 1 |
| van Dijk, JP | 1 |
| Kteily, N | 1 |
| Hodson, G | 1 |
| Bruneau, E | 1 |
| Rex-Kiss, B | 1 |
| Szabó, S | 1 |
4 reviews available for flumazenil and Aggression
| Article | Year |
|---|---|
The midazolam-induced paradox phenomenon is reversible by flumazenil. Epidemiology, patient characteristics and review of the literature.
Topics: Aged; Aggression; Anesthesia, Epidural; Anesthesia, Spinal; Anti-Anxiety Agents; Female; Flumazenil; | 2001 |
Disinhibitory reactions to benzodiazepines: a review.
Topics: Aggression; Animals; Benzodiazepines; Flumazenil; Humans | 1991 |
Benzodiazepines and their antagonists: a pharmacoethological analysis with particular reference to effects on "aggression".
Topics: Aggression; Agonistic Behavior; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Ben | 1985 |
Intrinsic actions of the benzodiazepine receptor antagonist Ro 15-1788.
Topics: Aggression; Animals; Anticonvulsants; Anxiety; Avoidance Learning; Benzodiazepinones; Body Temperatu | 1986 |
2 trials available for flumazenil and Aggression
| Article | Year |
|---|---|
Reduction of aggression during benzodiazepine withdrawal: effects of flumazenil.
Topics: Adult; Aggression; Benzodiazepines; Dose-Response Relationship, Drug; Female; Flumazenil; Hostility; | 2010 |
Individual differences in aggressive responding to intravenous flumazenil administration in adult male parolees.
Topics: Adult; Aggression; Child; Conduct Disorder; Dose-Response Relationship, Drug; Double-Blind Method; F | 2005 |
35 other studies available for flumazenil and Aggression
| Article | Year |
|---|---|
Stability of intraocular pressure after retinal reattachment surgery during electroconvulsive therapy for intractable self-injury in a 12-year-old autistic boy.
Topics: Aggression; Anticonvulsants; Antipsychotic Agents; Autistic Disorder; Child; Electroconvulsive Thera | 2014 |
Effects of diazepam and flumazenil on food competition behavior in high- and low-aggression pigeons.
Topics: Aggression; Animals; Columbidae; Competitive Behavior; Diazepam; Feeding Behavior; Female; Flumazeni | 2003 |
Behavioral effects of flumazenil in the social conflict test in mice.
Topics: Aggression; Animals; Conflict, Psychological; Flumazenil; Male; Mice; Mice, Inbred ICR; Motor Activi | 2004 |
Pharmacological evidence that PK 8165 behaves as a partial agonist of brain type benzodiazepine receptors.
Topics: Aggression; Animals; Anticonvulsants; Benzodiazepinones; Conflict, Psychological; Diazepam; Drinking | 1984 |
[Effect of an imidazobenzodiazepine (RO 15-1788) on aggressive behavior in mice].
Topics: Aggression; Animals; Apomorphine; Benzodiazepinones; Brain; Catalepsy; Dose-Response Relationship, D | 1984 |
The action of benzodiazepine antagonist Ro 15-1788 on the effects of GABA-ergic drugs.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aggression; Animals; Baclofen; Benzodiazepines; Benzodiazepinones; B | 1983 |
Effects of the benzodiazepine antagonist Ro 15-1788 on social and agonistic behaviour in male albino mice.
Topics: Aggression; Agonistic Behavior; Animals; Benzodiazepinones; Flumazenil; Humans; Male; Mice; Rats; So | 1984 |
"Anxiolytic" and "anxiogenic" benzodiazepines and beta-carbolines: effects on aggressive and social behavior in rats and squirrel monkeys.
Topics: Aggression; Animals; Anti-Anxiety Agents; Anxiety; Azides; Benzodiazepines; Carbolines; Dose-Respons | 1993 |
Prevention of the pro-aggressive effects of alcohol in rats and squirrel monkeys by benzodiazepine receptor antagonists.
Topics: Aggression; Animals; Carbolines; Dominance-Subordination; Dose-Response Relationship, Drug; Drug Int | 1993 |
Diazepam and gepirone selectively attenuate either 20-32 or 32-64 kHz ultrasonic vocalizations during aggressive encounters.
Topics: Aggression; Animals; Anti-Anxiety Agents; Depression, Chemical; Diazepam; Dose-Response Relationship | 1993 |
Pharmacological characterization of the novel anxiolytic beta-carboline abecarnil in rodents and primates.
Topics: Aggression; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Binding, Competitive; C | 1994 |
Participation of mitochondrial diazepam binding inhibitor receptors in the anticonflict, antineophobic and anticonvulsant action of 2-aryl-3-indoleacetamide and imidazopyridine derivatives.
Topics: Aggression; Allosteric Regulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; | 1993 |
Prevention of ACTH- and adrenalectomy-induced muricidal behavior: by benzodiazepinic ligands.
Topics: Adrenalectomy; Adrenocorticotropic Hormone; Aggression; Animals; Benzodiazepinones; Clonazepam; Flum | 1997 |
Paradoxical reactions in children associated with midazolam use during endoscopy.
Topics: Adjuvants, Anesthesia; Adolescent; Adolescent Behavior; Aggression; Akathisia, Drug-Induced; Anti-An | 1997 |
Evidence that long-lasting potentiation in limbic circuits mediating defensive behaviour in the right hemisphere underlies pharmacological stressor (FG-7142) induced lasting increases in anxiety-like behaviour: role of benzodiazepine receptors.
Topics: Aggression; Animals; Anxiety; Behavior, Animal; Carbolines; Catheterization; Cats; Flumazenil; Funct | 2000 |
Evidence that long-lasting potentiation of amygdala efferents in the right hemisphere underlies pharmacological stressor (FG-7142) induced lasting increases in anxiety-like behaviour: role of GABA tone in initiation of brain and behavioural changes.
Topics: Aggression; Amygdala; Animals; Anticonvulsants; Anxiety; Behavior, Animal; Brain Chemistry; Carbolin | 2000 |
Involvement of benzodiazepine binding sites in an antiaggressive effect by 5-HT(1A) receptor activation in isolated mice.
Topics: Aggression; Animals; Behavior, Animal; Binding Sites; Diazepam; Dioxanes; Dioxoles; Dose-Response Re | 2001 |
Increased GABAA-dependent chloride uptake in mice selectively bred for low aggressive behavior.
Topics: Aggression; Animals; Chlorides; Flumazenil; gamma-Aminobutyric Acid; Genetics, Behavioral; Male; Mic | 1992 |
LY 171555-induced hyperdefensiveness in the mouse does not implicate benzodiazepine receptors.
Topics: Aggression; Animals; Behavior, Animal; Carbolines; Chlordiazepoxide; Convulsants; Dopamine Agents; D | 1991 |
Pharmacological profile of a potential anxiolytic: AP159, a new benzothieno-pyridine derivative.
Topics: Aggression; Animals; Anti-Anxiety Agents; Avoidance Learning; Conflict, Psychological; Drinking Beha | 1991 |
beta-CCM inhibits muricide induced by olfactory bulbectomy in rats.
Topics: Aggression; Animals; Brain; Carbolines; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Inje | 1990 |
Modulatory actions of benzodiazepine receptor ligands on agonistic behaviour.
Topics: Aggression; Agonistic Behavior; Animals; Behavior, Animal; Carbolines; Chlordiazepoxide; Female; Flu | 1987 |
Male scent-induced analgesia in the deer mouse, Peromyscus maniculatus: involvement of benzodiazepine systems.
Topics: Aggression; Analgesia; Animals; Diazepam; Female; Flumazenil; Male; Naloxone; Nociceptors; Peromyscu | 1988 |
[Antagonism of RO 15-1788 with benzodiazepines in the effect on motivated aggression and the action of analgesics].
Topics: Aggression; Analgesics; Animals; Anti-Anxiety Agents; Benzodiazepinones; Bicuculline; Electric Stimu | 1985 |
Pharmacological and neurochemical properties of 1,4-diazepines with two annelated heterocycles ('hetrazepines').
Topics: Action Potentials; Aggression; Animals; Anticonvulsants; Azepines; Behavior, Animal; Benzodiazepinon | 1985 |
Benzodiazepine-receptor mediated inhibition of isolation-induced aggression in mice.
Topics: Aggression; Animals; Benzodiazepinones; Carbolines; Diazepam; Flumazenil; Humans; Indoles; Male; Mic | 1985 |
Antianxiety effect of cannabis: involvement of central benzodiazepine receptors.
Topics: Adult; Aggression; Animals; Anxiety; Benzodiazepinones; Cannabinoids; Diazepam; Dronabinol; Electros | 1986 |
beta-Carboline FG 7142-reduced aggression in male rats: reversed by the benzodiazepine receptor antagonist, Ro15-1788.
Topics: Aggression; Analysis of Variance; Animals; Avoidance Learning; Benzodiazepinones; Carbolines; Chlord | 1986 |
An octadecaneuropeptide (ODN) derived from diazepam binding inhibitor increases aggressive interactions in mice.
Topics: Aggression; Animals; Diazepam Binding Inhibitor; Flumazenil; Injections, Intraventricular; Male; Mic | 1986 |
RO 15-1788 does not influence postpartum aggression in lactating female rats.
Topics: Aggression; Animals; Female; Flumazenil; Lactation; Male; Motor Activity; Postpartum Period; Pregnan | 1986 |
Social conflict analgesia: inhibition of early non-opioid component by diazepam or flumazepil fails to affect appearance of late opioid component.
Topics: Aggression; Animals; Appetitive Behavior; Conflict, Psychological; Diazepam; Endorphins; Flumazenil; | 1987 |
Inhibitory influences of the adrenal steroid, 3 alpha, 5 alpha-tetrahydrodeoxycorticosterone [correction of tetrahydroxycorticosterone] on aggression and defeat-induced analgesia in mice.
Topics: Aggression; Analgesia; Animals; Desoxycorticosterone; Flumazenil; Injections, Intraperitoneal; Male; | 1988 |
Delinquent and Aggressive Behavior and Social Desirability Among Roma and Non-Roma Adolescents in Slovakia: A Cross-Sectional Study.
Topics: Adolescent; Adolescent Behavior; Aggression; Cross-Sectional Studies; Female; Hostility; Humans; Juv | 2016 |
They see us as less than human: Metadehumanization predicts intergroup conflict via reciprocal dehumanization.
Topics: Adult; Aggression; Arabs; Dehumanization; Female; Group Processes; Humans; Hungary; Islam; Israel; M | 2016 |
[ABO blood group investigations on prisoners (author's transl)].
Topics: ABO Blood-Group System; Aggression; Antisocial Personality Disorder; Humans; Phenotype; Prisoners; R | 1981 |