flumazenil has been researched along with Acute Disease in 26 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Acute Disease: Disease having a short and relatively severe course.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the beneficial and harmful effects of flumazenil versus placebo or no intervention for people with cirrhosis and hepatic encephalopathy." | 8.95 | Flumazenil versus placebo or no intervention for people with cirrhosis and hepatic encephalopathy. ( Andersen, ML; Gluud, LL; Goh, ET; Morgan, MY, 2017) |
| "The anticonvulsive efficacy of flumazenil, a specific antagonist of the ligands of the benzodiazepine receptor, was studied in the experimental seizures induced by electrical stimulation of corpus Amygdaloideum and Cornu Ammonis dorsale of the hippocampus in rabbits." | 7.68 | Anticonvulsive efficacy of flumazenil in the electroinduced seizures in the rabbit. ( Bo, P; Dallocchio, C; Savoldi, F; Turrini, R, 1991) |
| "In animal studies as well as in a few cases in humans, the benzodiazepine antagonist flumazenil has been shown to reverse hepatic encephalopathy." | 7.68 | [Treatment of acute hepatic encephalopathy with flumazenil]. ( Bassoul, B; de La Coussaye, JE; Eledjam, JJ; Saissi, G; Viel, E, 1990) |
| "The effect of flumazenil, a benzodiazepine antagonist, on hepatic encephalopathy was studied in rabbits with acute hepatic failure induced by a two-stage liver devascularization procedure." | 7.68 | Flumazenil does not improve hepatic encephalopathy associated with acute ischemic liver failure in the rabbit. ( de Knegt, RJ; Mechelse, K; Schalm, SW; Terpstra, OT; van der Rijt, CC, 1990) |
| "The effects of the benzodiazepine antagonist flumazenil were studied in 20 episodes of hepatic encephalopathy (HE) in 17 patients with acute (n = 9) or chronic (n = 8) liver failure who had not responded to conventional therapy." | 7.67 | Improvement of hepatic encephalopathy treated with flumazenil. ( Ferenci, P; Gangl, A; Grimm, G; Katzenschlager, R; Laggner, AN; Lenz, K; Madl, C; Schneeweiss, B, 1988) |
| "Flumazenil was not found to induce significant changes in the clinical status or in maps of the cerebral activity of patients with chronic encephalopathy." | 5.28 | [Evaluation of the therapeutic effect of flumazenil in hepatic encephalopathy using cerebral cartography]. ( Bello Mimbrera, G; de la Torre Fernández, JM; de la Torre Gutiérrez, S; García de León, M; Montero Vázquez, J; Torres Salcines, J, 1989) |
| "To evaluate the beneficial and harmful effects of flumazenil versus placebo or no intervention for people with cirrhosis and hepatic encephalopathy." | 4.95 | Flumazenil versus placebo or no intervention for people with cirrhosis and hepatic encephalopathy. ( Andersen, ML; Gluud, LL; Goh, ET; Morgan, MY, 2017) |
| "Flumazenil had a significant beneficial effect on short-term improvement of hepatic encephalopathy in patients with cirrhosis and a highly favourable prognosis." | 4.82 | Benzodiazepine receptor antagonists for hepatic encephalopathy. ( Als-Nielsen, B; Gluud, C; Gluud, LL, 2004) |
| "Flumazenil had no significant effect on recovery or survival from hepatic encephalopathy." | 4.81 | Benzodiazepine receptor antagonists for acute and chronic hepatic encephalopathy. ( Als-Nielsen, B; Gluud, C; Kjaergard, LL, 2001) |
| "The anticonvulsive efficacy of flumazenil, a specific antagonist of the ligands of the benzodiazepine receptor, was studied in the experimental seizures induced by electrical stimulation of corpus Amygdaloideum and Cornu Ammonis dorsale of the hippocampus in rabbits." | 3.68 | Anticonvulsive efficacy of flumazenil in the electroinduced seizures in the rabbit. ( Bo, P; Dallocchio, C; Savoldi, F; Turrini, R, 1991) |
| "In animal studies as well as in a few cases in humans, the benzodiazepine antagonist flumazenil has been shown to reverse hepatic encephalopathy." | 3.68 | [Treatment of acute hepatic encephalopathy with flumazenil]. ( Bassoul, B; de La Coussaye, JE; Eledjam, JJ; Saissi, G; Viel, E, 1990) |
| "The effect of flumazenil, a benzodiazepine antagonist, on hepatic encephalopathy was studied in rabbits with acute hepatic failure induced by a two-stage liver devascularization procedure." | 3.68 | Flumazenil does not improve hepatic encephalopathy associated with acute ischemic liver failure in the rabbit. ( de Knegt, RJ; Mechelse, K; Schalm, SW; Terpstra, OT; van der Rijt, CC, 1990) |
| "The effects of the benzodiazepine antagonist flumazenil were studied in 20 episodes of hepatic encephalopathy (HE) in 17 patients with acute (n = 9) or chronic (n = 8) liver failure who had not responded to conventional therapy." | 3.67 | Improvement of hepatic encephalopathy treated with flumazenil. ( Ferenci, P; Gangl, A; Grimm, G; Katzenschlager, R; Laggner, AN; Lenz, K; Madl, C; Schneeweiss, B, 1988) |
| "Further threatening complications of opiate abuse include rhabdomyolysis, noncardiogenic pulmonary edema, and both peripheral and central nervous lesions." | 2.38 | [Drug emergencies]. ( Monotti, R, 1993) |
| "Flumazenil was studied on cocaine intoxicated rats for its preventive effect on seizure, death and loss of righting reflex." | 1.29 | [The effect of flumazenil administration on acute cocaine intoxication of rats]. ( Hirakawa, K; Nihira, M; Uekusa, K; Uki, F, 1994) |
| "Flumazenil was injected intravenously first in a regimen of 0." | 1.28 | [Flumazenil as an emergency management of patients with acute mental disorder]. ( Chern, TL; Deng, JF; Hu, SC; Lee, CH, 1992) |
| "Flumazenil was not found to induce significant changes in the clinical status or in maps of the cerebral activity of patients with chronic encephalopathy." | 1.28 | [Evaluation of the therapeutic effect of flumazenil in hepatic encephalopathy using cerebral cartography]. ( Bello Mimbrera, G; de la Torre Fernández, JM; de la Torre Gutiérrez, S; García de León, M; Montero Vázquez, J; Torres Salcines, J, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (19.23) | 18.7374 |
| 1990's | 13 (50.00) | 18.2507 |
| 2000's | 5 (19.23) | 29.6817 |
| 2010's | 3 (11.54) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goh, ET | 1 |
| Andersen, ML | 1 |
| Morgan, MY | 1 |
| Gluud, LL | 2 |
| Iseki, K | 1 |
| Ikeda, A | 1 |
| Kihara, T | 1 |
| Kawamoto, Y | 1 |
| Mezaki, T | 1 |
| Hanakawa, T | 1 |
| Hashikawa, K | 1 |
| Fukuyama, H | 1 |
| Shibasaki, H | 1 |
| Rojas, S | 1 |
| Martín, A | 1 |
| Pareto, D | 1 |
| Herance, JR | 1 |
| Abad, S | 1 |
| Ruíz, A | 1 |
| Flotats, N | 1 |
| Gispert, JD | 1 |
| Llop, J | 1 |
| Gómez-Vallejo, V | 1 |
| Planas, AM | 1 |
| Rudolf, J | 1 |
| Sobesky, J | 1 |
| Ghaemi, M | 1 |
| Heiss, WD | 1 |
| Als-Nielsen, B | 2 |
| Gluud, C | 2 |
| Matsuda, H | 1 |
| Tsuji, S | 1 |
| Kuji, I | 1 |
| Shiba, K | 1 |
| Hisada, K | 1 |
| Mori, H | 1 |
| Uki, F | 1 |
| Nihira, M | 1 |
| Hirakawa, K | 1 |
| Uekusa, K | 1 |
| Monotti, R | 1 |
| Kamijo, Y | 1 |
| Masuda, T | 1 |
| Nishikawa, T | 1 |
| Tsuruta, H | 1 |
| Ohwada, T | 1 |
| D'Alessandro, G | 1 |
| Corso, G | 1 |
| Bottacchi, E | 1 |
| Kjaergard, LL | 1 |
| Chern, TL | 1 |
| Deng, JF | 1 |
| Hu, SC | 1 |
| Lee, CH | 1 |
| Bo, P | 1 |
| Dallocchio, C | 1 |
| Turrini, R | 1 |
| Savoldi, F | 1 |
| del Busto Prado, F | 1 |
| Alvarez García, A | 1 |
| Ibarra Peláez, A | 1 |
| Menéndez Fernándéz, J | 1 |
| Barraca de Ramos, R | 1 |
| Alonso Calo, L | 1 |
| Munné, P | 1 |
| Nogué, S | 1 |
| Millá, J | 1 |
| Frenkel, AL | 1 |
| Hermant, JL | 1 |
| Blaise, M | 1 |
| Volter, F | 1 |
| Pourriat, JL | 1 |
| Stolarek, IH | 1 |
| Ford, MJ | 1 |
| Viel, E | 1 |
| de La Coussaye, JE | 1 |
| Bassoul, B | 1 |
| Saissi, G | 1 |
| Eledjam, JJ | 1 |
| van der Rijt, CC | 1 |
| de Knegt, RJ | 1 |
| Schalm, SW | 1 |
| Terpstra, OT | 1 |
| Mechelse, K | 1 |
| Bello Mimbrera, G | 1 |
| García de León, M | 1 |
| de la Torre Gutiérrez, S | 1 |
| Montero Vázquez, J | 1 |
| Torres Salcines, J | 1 |
| de la Torre Fernández, JM | 1 |
| Leykin, Y | 1 |
| Halpern, P | 1 |
| Silbiger, A | 1 |
| Sorkin, P | 1 |
| Niv, D | 1 |
| Rudick, V | 1 |
| Geller, E | 1 |
| Grimm, G | 1 |
| Ferenci, P | 1 |
| Katzenschlager, R | 1 |
| Madl, C | 1 |
| Schneeweiss, B | 1 |
| Laggner, AN | 1 |
| Lenz, K | 1 |
| Gangl, A | 1 |
| Feldman, R | 1 |
| Szajewski, J | 1 |
| Neill, SJ | 1 |
| Jones, CH | 1 |
| Lakhanpaul, M | 1 |
| Roland, DT | 1 |
| Thompson, MJ | 1 |
| Wetzel, RC | 1 |
| Dean, JM | 1 |
| Rogers, MC | 1 |
| Catalán Muñoz, M | 1 |
| Carrasco Sánchez, P | 1 |
| Gentles, MG | 1 |
| García Botia, J | 1 |
| Gómez Calzado, A | 1 |
| Bonilla Abascal, G | 1 |
| González Hachero, J | 1 |
5 reviews available for flumazenil and Acute Disease
| Article | Year |
|---|---|
Flumazenil versus placebo or no intervention for people with cirrhosis and hepatic encephalopathy.
Topics: Acute Disease; Antidotes; Cause of Death; Chronic Disease; Flumazenil; GABA Modulators; GABA-A Recep | 2017 |
Benzodiazepine receptor antagonists for hepatic encephalopathy.
Topics: Acute Disease; Antidotes; Chronic Disease; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; | 2004 |
[Drug emergencies].
Topics: Acute Disease; Cocaine; Combined Modality Therapy; Critical Care; Drug Overdose; Flumazenil; Humans; | 1993 |
Benzodiazepine receptor antagonists for acute and chronic hepatic encephalopathy.
Topics: Acute Disease; Antidotes; Chronic Disease; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; | 2001 |
[Methemoglobinemia, acidemia and diarrhea induced by hypersensitivity to cow's milk proteins].
Topics: Acidosis; Acute Disease; Diarrhea, Infantile; Female; Humans; Infant, Newborn; Methemoglobinemia; Mi | 1996 |
1 trial available for flumazenil and Acute Disease
| Article | Year |
|---|---|
Cardiovascular response and stress reaction to flumazenil injection in patients under infusion with midazolam.
Topics: Acute Disease; Adolescent; Adult; Aged; Antidotes; Conscious Sedation; Consciousness; Drug Monitorin | 2000 |
20 other studies available for flumazenil and Acute Disease
| Article | Year |
|---|---|
Impairment of the cortical GABAergic inhibitory system in catatonic stupor: a case report with neuroimaging.
Topics: Acute Disease; Adult; Catatonia; Cerebral Cortex; Diazepam; Electroencephalography; Encephalitis; Fl | 2009 |
Positron emission tomography with 11C-flumazenil in the rat shows preservation of binding sites during the acute phase after 2 h-transient focal ischemia.
Topics: Acute Disease; Animals; Binding Sites; Brain Ischemia; Disease Models, Animal; Flumazenil; Male; Ner | 2011 |
The correlation between cerebral glucose metabolism and benzodiazepine receptor density in the acute vegetative state.
Topics: Acute Disease; Aged; Binding Sites; Brain; Carbon Radioisotopes; Control Groups; Female; Flumazenil; | 2002 |
Dual-tracer autoradiography using 125I-iomazenil and 99Tcm-HMPAO in experimental brain ischaemia.
Topics: Acute Disease; Animals; Autoradiography; Brain; Brain Ischemia; Chronic Disease; Flumazenil; Functio | 1995 |
[The effect of flumazenil administration on acute cocaine intoxication of rats].
Topics: Acute Disease; Animals; Cocaine; Diazepam; Flumazenil; Male; Poisoning; Rats; Rats, Wistar | 1994 |
Could flumazenil reverse neurological deficits in acute cerebral ischemia?
Topics: Acute Disease; Brain Ischemia; Carotid Artery Thrombosis; Carotid Artery, Internal; Cerebral Angiogr | 1999 |
[Flumazenil as an emergency management of patients with acute mental disorder].
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Emergencies; Female; Flumazenil; Humans; Male; Middle | 1992 |
Anticonvulsive efficacy of flumazenil in the electroinduced seizures in the rabbit.
Topics: Acute Disease; Amygdala; Animals; Anticonvulsants; Electric Stimulation; Electroencephalography; Flu | 1991 |
[Significance of flumazenil in acute benzodiazepine poisoning].
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Alcoholic Intoxication; Anti-Anxiety Agen | 1990 |
[The usefulness of flumazenil in benzodiazepine poisoning].
Topics: Acute Disease; Adult; Aged; Anti-Anxiety Agents; Drug Evaluation; Female; Flumazenil; Glasgow Coma S | 1990 |
[The quantitative electroencephalogram in a case of acute hepatic encephalopathy treated with flumazenil].
Topics: Acute Disease; Electroencephalography; Female; Flumazenil; Hepatic Encephalopathy; Humans | 1991 |
Acute dystonia induced by midazolam and abolished by flumazenil.
Topics: Acute Disease; Adolescent; Dystonia; Flumazenil; Humans; Male; Midazolam | 1990 |
[Treatment of acute hepatic encephalopathy with flumazenil].
Topics: Acute Disease; Flumazenil; Glasgow Coma Scale; Hepatic Encephalopathy; Humans; Liver Cirrhosis, Alco | 1990 |
Flumazenil does not improve hepatic encephalopathy associated with acute ischemic liver failure in the rabbit.
Topics: Acute Disease; Animals; Dose-Response Relationship, Drug; Electroencephalography; Flumazenil; Hepati | 1990 |
[Evaluation of the therapeutic effect of flumazenil in hepatic encephalopathy using cerebral cartography].
Topics: Acute Disease; Aged; Brain Mapping; Chronic Disease; Drug Evaluation; Female; Flumazenil; Hepatic En | 1989 |
Acute poisoning treated in the intensive care unit: a case series.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Critical Care; Female; Flumazenil; Humans | 1989 |
Improvement of hepatic encephalopathy treated with flumazenil.
Topics: Acute Disease; Adolescent; Adult; Aged; Brain; Child; Chronic Disease; Evoked Potentials, Somatosens | 1988 |
[Flumazepil (Anexate) in the treatment of acute benzodiazepine poisoning. Preliminary report].
Topics: Acute Disease; Adolescent; Adult; Anti-Anxiety Agents; Female; Flumazenil; Humans; Infusion Pumps; I | 1988 |
Parent's information seeking in acute childhood illness: what helps and what hinders decision making?
Topics: Acute Disease; Adult; Asia; Child, Preschool; Decision Making; Female; Focus Groups; Grounded Theory | 2015 |
Gypsies and acute medical intervention.
Topics: Acute Disease; Culture; Ethnicity; Female; Humans; Infant; Intensive Care Units, Neonatal; Male; Mar | 1983 |