flumazenil has been researched along with Absence Status in 13 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report on a 33-year-old female suffering from frequent complex-partial seizures who developed a non-convulsive status epilepticus after one week of antiepileptic therapy with valproate (VPA) which had been added to a basic medication with barbexaclone (BBC) in rapidly increasing dosage." | 7.68 | Temporary abolition of seizure activity by flumazenil in a case of valproate-induced non-convulsive status epilepticus. ( Steinhoff, BJ; Stodieck, SR, 1993) |
| "Positron emission tomography (PET) was used to investigate, in the living baboon, the in vivo modulation of [11C]Ro 15-1788 binding to benzodiazepine receptors in brain and the changes with ligands acting at the supramolecular complex during status epilepticus induced by pentylenetetrazole." | 7.67 | Status epilepticus induced by pentylenetetrazole modulates in vivo [11C]Ro 15-1788 binding to benzodiazepine receptors. Effects of ligands acting at the supramolecular receptor complex. ( Brouillet, E; Chavoix, C; De la Sayette, V; Fournier, D; Fukuda, H; Guibert, B; Hantraye, P; Mazière, M; Naquet, R, 1988) |
| "Three cases of seizure recurrence after flumazenil use in this context are reported, and the pharmacology is discussed." | 5.33 | Danger of flumazenil use in pediatric status epilepticus. ( Brierley, J, 2006) |
| "The objective of this investigation was to characterize quantitatively the time-dependent changes in midazolam (MDL) efficacy in the silent period after induction of status epilepticus (SE) in rats." | 3.74 | Decreased Efficacy of GABAA-receptor modulation by midazolam in the kainate model of temporal lobe epilepsy. ( Danhof, M; Gunput, RA; Liefaard, LC; Voskuyl, RA, 2007) |
| "To report a fatal case of refractory status epilepticus precipitated by flumazenil use in a mixed benzodiazepine-tricyclic antidepressant overdose." | 3.69 | Fatal seizures after flumazenil administration in a patient with mixed overdose. ( DiSalvo, RP; Haverkos, GP; Imhoff, TE, 1994) |
| "We report on a 33-year-old female suffering from frequent complex-partial seizures who developed a non-convulsive status epilepticus after one week of antiepileptic therapy with valproate (VPA) which had been added to a basic medication with barbexaclone (BBC) in rapidly increasing dosage." | 3.68 | Temporary abolition of seizure activity by flumazenil in a case of valproate-induced non-convulsive status epilepticus. ( Steinhoff, BJ; Stodieck, SR, 1993) |
| "Positron emission tomography (PET) was used to investigate, in the living baboon, the in vivo modulation of [11C]Ro 15-1788 binding to benzodiazepine receptors in brain and the changes with ligands acting at the supramolecular complex during status epilepticus induced by pentylenetetrazole." | 3.67 | Status epilepticus induced by pentylenetetrazole modulates in vivo [11C]Ro 15-1788 binding to benzodiazepine receptors. Effects of ligands acting at the supramolecular receptor complex. ( Brouillet, E; Chavoix, C; De la Sayette, V; Fournier, D; Fukuda, H; Guibert, B; Hantraye, P; Mazière, M; Naquet, R, 1988) |
| "Stupor is defined as a deep sleep or behaviourally similar unresponsiveness from which the subject can be aroused only by vigorous repeated stimuli." | 1.35 | Idiopathic recurrent stupor mimicking status epilepticus. ( Agrawal, S; Asthana, V; Goel, D; Sharma, JP, 2008) |
| "Three cases of seizure recurrence after flumazenil use in this context are reported, and the pharmacology is discussed." | 1.33 | Danger of flumazenil use in pediatric status epilepticus. ( Brierley, J, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 5 (38.46) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Horino, A | 1 |
| Kawawaki, H | 1 |
| Fukuoka, M | 1 |
| Tsuji, H | 1 |
| Hattori, Y | 1 |
| Inoue, T | 1 |
| Nukui, M | 1 |
| Kuki, I | 1 |
| Okazaki, S | 1 |
| Tomiwa, K | 1 |
| Hirose, S | 1 |
| Asthana, V | 1 |
| Agrawal, S | 1 |
| Goel, D | 1 |
| Sharma, JP | 1 |
| Kuroda, H | 1 |
| Ogasawara, K | 1 |
| Aso, K | 1 |
| Beppu, T | 1 |
| Kobayashi, M | 1 |
| Chida, K | 1 |
| Ogawa, A | 1 |
| Leroy, C | 1 |
| Poisbeau, P | 1 |
| Keller, AF | 1 |
| Nehlig, A | 1 |
| Brierley, J | 1 |
| Liefaard, LC | 1 |
| Gunput, RA | 1 |
| Danhof, M | 1 |
| Voskuyl, RA | 1 |
| Amemiya, S | 1 |
| Hamamoto, M | 1 |
| Mishina, M | 1 |
| Ueda, M | 1 |
| Kumagai, T | 1 |
| Nishiyama, Y | 1 |
| Katayama, Y | 1 |
| Haverkos, GP | 1 |
| DiSalvo, RP | 1 |
| Imhoff, TE | 1 |
| Buchanan, N | 1 |
| Steinhoff, BJ | 1 |
| Stodieck, SR | 1 |
| Chavoix, C | 2 |
| Brouillet, E | 2 |
| Hantraye, P | 2 |
| de la Sayette, V | 2 |
| Kunimoto, M | 1 |
| Varastet, M | 1 |
| Guibert, B | 2 |
| Dodd, RH | 1 |
| Fournier, D | 2 |
| Naquet, R | 2 |
| O'Connor, HJ | 1 |
| Fukuda, H | 1 |
| Mazière, M | 1 |
13 other studies available for flumazenil and Absence Status
| Article | Year |
|---|---|
A case of succinic semialdehyde dehydrogenase deficiency with status epilepticus and rapid regression.
Topics: Amino Acid Metabolism, Inborn Errors; Atrophy; Brain; Developmental Disabilities; Diffusion Magnetic | 2016 |
Idiopathic recurrent stupor mimicking status epilepticus.
Topics: Diagnosis, Differential; Electroencephalography; Flumazenil; GABA Modulators; Humans; Male; Middle A | 2008 |
Spontaneous recovery of reduced cortical central benzodiazepine receptor binding potential on I-123 Iomazenil SPECT in a patient with status epilepticus.
Topics: Adult; Cerebral Cortex; Female; Flumazenil; Humans; Receptors, GABA-A; Remission, Spontaneous; Statu | 2010 |
Pharmacological plasticity of GABA(A) receptors at dentate gyrus synapses in a rat model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Diazepam; Disease Models, Animal; Electric Conductivity; Ep | 2004 |
Danger of flumazenil use in pediatric status epilepticus.
Topics: Benzodiazepines; Child, Preschool; Female; Flumazenil; Humans; Infant; Male; Recurrence; Respiratory | 2006 |
Decreased Efficacy of GABAA-receptor modulation by midazolam in the kainate model of temporal lobe epilepsy.
Topics: Animals; Autoradiography; Beta Rhythm; Disease Models, Animal; Electroencephalography; Epilepsy, Tem | 2007 |
Short-term plasticity of central benzodiazepine receptors in status epilepticus: case report.
Topics: Aged; Biomarkers; Brain; Brain Mapping; Down-Regulation; Female; Flumazenil; gamma-Aminobutyric Acid | 2008 |
Fatal seizures after flumazenil administration in a patient with mixed overdose.
Topics: Acute Kidney Injury; Adult; Antidepressive Agents, Tricyclic; Benzodiazepines; Charcoal; Drug Overdo | 1994 |
Temporary abolition of seizure activity by flumazenil.
Topics: Flumazenil; Humans; Status Epilepticus; Valproic Acid | 1994 |
Temporary abolition of seizure activity by flumazenil in a case of valproate-induced non-convulsive status epilepticus.
Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Electroencephalography; Evoked Potentials; Female | 1993 |
In vivo interactions of pentylenetetrazole with benzodiazepine receptors: lack of direct correlation between benzodiazepine receptor occupancy and convulsant potency of this drug.
Topics: Animals; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Electroencephalography; Flum | 1992 |
Status epilepticus following administration of flumazenil after endoscopy.
Topics: Adult; Endoscopy, Gastrointestinal; Female; Flumazenil; Humans; Status Epilepticus | 1991 |
Status epilepticus induced by pentylenetetrazole modulates in vivo [11C]Ro 15-1788 binding to benzodiazepine receptors. Effects of ligands acting at the supramolecular receptor complex.
Topics: Animals; Binding, Competitive; Brain; Flumazenil; Male; Papio; Pentylenetetrazole; Receptors, GABA-A | 1988 |