flumazenil has been researched along with Abdominal Epilepsy in 37 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
| Excerpt | Relevance | Reference |
|---|---|---|
| "When flumazenil (3 mg) was administered immediately after intravenous diazepam (10 mg), the reduction in interictal epileptic activity was not significantly different from that produced by diazepam alone." | 2.67 | The effect of intravenous flumazenil on interictal electroencephalographic epileptic activity: results of a placebo-controlled study. ( Hart, YM; Meinardi, H; Nutt, DJ; Sander, JW; Shorvon, SD, 1991) |
| "Most PET receptor studies in idiopathic generalized epilepsy conducted to date include only small numbers of patients and should be interpreted with caution." | 2.42 | Flumazenil positron emission tomography and other ligands for functional imaging. ( Hammers, A, 2004) |
| "We observed an early-onset partial epilepsy syndrome with seizure semiology strongly suggestive of temporal lobe epilepsy (TLE), with mild intellectual deficit co-occurring in a large proportion of the patients." | 1.35 | Partial epilepsy syndrome in a Gypsy family linked to 5q31.3-q32. ( Angelicheva, D; Azmanov, DN; Bojinova, V; Brown, M; Carter, K; Guergueltcheva, V; Jablensky, A; Kalaydjieva, L; Kaneva, R; Mihaylova, V; Morar, B; Radionova, M; Sander, JW; Smith, SJ; Stevens, JM; Tournev, I; Zlatareva, D, 2009) |
| "Fourteen patients had unilateral frontal lobe epilepsy, five occipital lobe epilepsy (OLE), six parietal lobe epilepsy (PLE) and 19 neocortical epilepsy that was not clearly lobar." | 1.32 | Grey and white matter flumazenil binding in neocortical epilepsy with normal MRI. A PET study of 44 patients. ( Brooks, DJ; Duncan, JS; Hammers, A; Hurlemann, R; Koepp, MJ; Richardson, MP, 2003) |
| "Flumazenil, 1 mg, was injected intravenously in 67 patients undergoing presurgical monitoring for epilepsy surgery, 49 of whom had been treated with benzodiazepines (BZDs) before flumazenil was given." | 1.31 | Induction of partial epileptic seizures by flumazenil. ( Elger, CE; Schulze-Bonhage, A, 2000) |
| "Flumazenil binding was decreased in some MCDs with increased grey matter volume and increased in some adjacent or overlying areas of normal-appearing cortex, suggesting functional abnormalities beyond MRI- detectable structural changes." | 1.31 | Central benzodiazepine receptors in malformations of cortical development: A quantitative study. ( Brooks, DJ; Cunningham, VJ; Duncan, JS; Hammers, A; Koepp, MJ; Labbé, C; Richardson, MP, 2001) |
| "Seventeen patients with unilateral partial epilepsy were subjected to 99mTc-hexamethylpropylene amine oxime (HMPAO) SPECT, and early and delayed IMZ SPECT." | 1.30 | Asymmetries of benzodiazepine receptor binding potential in the inferior medial temporal lobe and cerebellum detected with 123I-iomazenil SPECT in comparison with 99mTc-HMPAO SPECT in patients with partial epilepsy. ( Ichikawa, A; Kuji, I; Sumiya, H; Tonami, N; Tsuji, S, 1998) |
| "All patients had partial epilepsy and normal magnetic resonance imaging (MRI) of the brain." | 1.29 | Cortical benzodiazepine receptor changes are related to frequency of partial seizures: a positron emission tomography study. ( Savic, I; Svanborg, E; Thorell, JO, 1996) |
| "A patient with focal epilepsy due to a localized abnormality in cortical differentiation is presented who showed a marked focal decrease in Bz receptor binding and a normal 99mTc-HMPAO SPECT." | 1.28 | [Cortical dysplasia as an epileptogenic focus: reduced binding of 123I-iomezanil with barely perceptible 99mTc-HMPAO SPECT]. ( Bartenstein, P; Lehmenkühler, C; Schuierer, G; Sciuk, J, 1992) |
| "Ten patients with partial epilepsy and five healthy controls had positron emission tomography (PET) of the brain after intravenous administration of the 11C-labelled benzodiazepine (BZ) receptor ligand 'Ro-15 1788'." | 1.27 | In-vivo demonstration of reduced benzodiazepine receptor binding in human epileptic foci. ( Pauli, S; Persson, A; Roland, P; Savic, I; Sedvall, G; Widén, L, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (5.41) | 18.7374 |
| 1990's | 19 (51.35) | 18.2507 |
| 2000's | 14 (37.84) | 29.6817 |
| 2010's | 2 (5.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ikemoto, S | 1 |
| Hamano, SI | 1 |
| Hirata, Y | 1 |
| Matsuura, R | 1 |
| Kikuchi, K | 1 |
| Komoto, D | 1 |
| Iida, K | 1 |
| Higaki, T | 1 |
| Kaichi, Y | 1 |
| Takauchi, K | 1 |
| Arihiro, K | 1 |
| Kakita, A | 1 |
| Hirokawa, Y | 1 |
| Awai, K | 1 |
| Juhász, C | 2 |
| Asano, E | 1 |
| Shah, A | 2 |
| Chugani, DC | 2 |
| Batista, CE | 1 |
| Muzik, O | 2 |
| Sood, S | 1 |
| Chugani, HT | 2 |
| Goethals, I | 1 |
| Van de Wiele, C | 1 |
| Boon, P | 1 |
| Dierckx, R | 1 |
| Hammers, A | 3 |
| Koepp, MJ | 5 |
| Richardson, MP | 4 |
| Hurlemann, R | 1 |
| Brooks, DJ | 4 |
| Duncan, JS | 5 |
| Ryvlin, P | 3 |
| Mauguière, F | 3 |
| Bouvard, S | 2 |
| Costes, N | 1 |
| Bonnefoi, F | 1 |
| Lavenne, F | 1 |
| Delforge, J | 1 |
| Morimoto, K | 1 |
| Tamagami, H | 1 |
| Matsuda, K | 1 |
| Hirashima, Y | 1 |
| Morimoto, M | 1 |
| Nishimura, A | 1 |
| Osamura, T | 1 |
| Sugimoto, T | 1 |
| Kuki, I | 1 |
| Kawawaki, H | 1 |
| Oba, S | 1 |
| Okazaki, S | 1 |
| Ikeda, H | 1 |
| Tomiwa, K | 1 |
| Bartenstein, P | 2 |
| Koepp, M | 1 |
| Venz, S | 2 |
| Cordes, M | 4 |
| Straub, HB | 1 |
| Hierholzer, J | 2 |
| Schröder, R | 1 |
| Richter, W | 2 |
| Schmitz, B | 3 |
| Meencke, H | 1 |
| Felix, R | 2 |
| Siekmann, R | 1 |
| Keske, U | 1 |
| Eichstädt, H | 2 |
| Verhoeff, NP | 1 |
| Busemann Sokole, E | 1 |
| Hengst, D | 1 |
| Stubbs, JB | 1 |
| van Royen, EA | 1 |
| Savic, I | 3 |
| Svanborg, E | 1 |
| Thorell, JO | 2 |
| Fish, DR | 1 |
| Mielke, R | 1 |
| Weber-Luxenburger, G | 1 |
| Kessler, J | 1 |
| Szelies, B | 1 |
| Heiss, WD | 1 |
| Decoo, D | 1 |
| Destée, A | 1 |
| Bo, P | 1 |
| Soragna, D | 1 |
| Marchioni, E | 1 |
| Albergati, A | 1 |
| Candeloro, E | 1 |
| Savoldi, F | 1 |
| Kuji, I | 1 |
| Sumiya, H | 1 |
| Tsuji, S | 1 |
| Ichikawa, A | 1 |
| Tonami, N | 1 |
| Le Bars, D | 1 |
| De Lamérie, G | 1 |
| Grégoire, MC | 1 |
| Kahane, P | 1 |
| Froment, JC | 1 |
| Koutroumanidis, M | 1 |
| Binnie, CD | 1 |
| Panayiotopoulos, CP | 1 |
| Schulze-Bonhage, A | 1 |
| Elger, CE | 1 |
| Shah, J | 1 |
| Watson, C | 1 |
| Canady, A | 1 |
| Labbé, C | 1 |
| Cunningham, VJ | 1 |
| Lehmenkühler, C | 1 |
| Sciuk, J | 1 |
| Schuierer, G | 1 |
| Olsen, RW | 1 |
| Bureau, M | 1 |
| Houser, CR | 1 |
| Delgado-Escueta, AV | 1 |
| Richards, JG | 1 |
| Möhler, H | 1 |
| Hart, YM | 1 |
| Meinardi, H | 1 |
| Sander, JW | 2 |
| Nutt, DJ | 1 |
| Shorvon, SD | 1 |
| Schubiger, PA | 2 |
| Hasler, PH | 2 |
| Beer-Wohlfahrt, H | 1 |
| Bekier, A | 1 |
| Oettli, R | 1 |
| Ferstl, F | 1 |
| Deisenhammer, E | 1 |
| De Roo, M | 1 |
| Moser, E | 1 |
| Ferstl, FJ | 1 |
| Cordes, I | 1 |
| Henkes, H | 1 |
| Christe, W | 1 |
| Barzen, G | 1 |
| Persson, A | 1 |
| Roland, P | 1 |
| Pauli, S | 1 |
| Sedvall, G | 1 |
| Widén, L | 1 |
| Angelicheva, D | 1 |
| Tournev, I | 1 |
| Guergueltcheva, V | 1 |
| Mihaylova, V | 1 |
| Azmanov, DN | 1 |
| Morar, B | 1 |
| Radionova, M | 1 |
| Smith, SJ | 1 |
| Zlatareva, D | 1 |
| Stevens, JM | 1 |
| Kaneva, R | 1 |
| Bojinova, V | 1 |
| Carter, K | 1 |
| Brown, M | 1 |
| Jablensky, A | 1 |
| Kalaydjieva, L | 1 |
| Kardos, M | 1 |
| Nagy, I | 1 |
| Schultz, K | 1 |
| Kiss, I | 1 |
| Gastonyi, V | 1 |
7 reviews available for flumazenil and Abdominal Epilepsy
| Article | Year |
|---|---|
Is central benzodiazepine receptor imaging useful for the identification of epileptogenic foci in localization-related epilepsies?
Topics: Brain; Epilepsies, Partial; Flumazenil; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Humans; Iodi | 2003 |
Flumazenil positron emission tomography and other ligands for functional imaging.
Topics: Brain; Epilepsies, Partial; Epilepsy, Generalized; Flumazenil; GABA Modulators; Humans; Ligands; Neu | 2004 |
[Functional neuroimaging in adults].
Topics: Adult; Anterior Temporal Lobectomy; Anticonvulsants; Carbon Radioisotopes; Combined Modality Therapy | 2004 |
[Benzodiazepine receptor imaging with positron emission tomography and single photon emission tomography].
Topics: Brain; Brain Damage, Chronic; Brain Mapping; Cerebral Cortex; Epilepsies, Partial; Epilepsy, Tempora | 1995 |
PET studies in epilepsy.
Topics: Brain; Carbon Radioisotopes; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Fentanyl; Flumaze | 1997 |
Positron emission tomography in partial epilepsies: the clinical point of view.
Topics: Brain; Carbon Radioisotopes; Cerebrovascular Circulation; Electroencephalography; Epilepsies, Partia | 1998 |
PET: central benzodiazepine neuroreceptor mapping in localization-related epilepsies.
Topics: Cerebral Cortex; Epilepsies, Partial; Flumazenil; GABA Modulators; Hippocampus; Humans; Receptors, G | 2000 |
5 trials available for flumazenil and Abdominal Epilepsy
| Article | Year |
|---|---|
[Preoperative evaluation of drug resistant focal epilepsies with 123I-iomazenil SPECT. Comparison with vidio/EEG monitoring and postoperative results].
Topics: Adolescent; Adult; Brain; Child; Electroencephalography; Epilepsies, Partial; Female; Flumazenil; Fo | 1994 |
11C-flumazenil PET in neocortical epilepsy.
Topics: Adolescent; Adult; Brain Mapping; Carbon Isotopes; Epilepsies, Partial; Epilepsy, Frontal Lobe; Fema | 1998 |
The effect of intravenous flumazenil on interictal electroencephalographic epileptic activity: results of a placebo-controlled study.
Topics: Adult; Anticonvulsants; Brain; Diazepam; Dose-Response Relationship, Drug; Drug Therapy, Combination | 1991 |
Evaluation of a multicentre study with Iomazenil--a benzodiazepine receptor ligand.
Topics: Adult; Alzheimer Disease; Brain Chemistry; Epilepsies, Partial; Evaluation Studies as Topic; Female; | 1991 |
123-I-iomazenil-SPECT in patients with focal epilepsies--a comparative study with 99mTc-HMPAO-SPECT, CT and MR.
Topics: Adult; Epilepsies, Partial; Female; Flumazenil; Humans; Iodine Radioisotopes; Magnetic Resonance Ima | 1991 |
25 other studies available for flumazenil and Abdominal Epilepsy
| Article | Year |
|---|---|
Maturational Changes of Gamma-Aminobutyric Acid A Receptors Measured With Benzodiazepine Binding of Iodine 123 Iomazenil Single-Photon Emission Computed Tomography.
Topics: Adolescent; Brain; Brain Mapping; Child; Child, Preschool; Epilepsies, Partial; Female; Flumazenil; | 2018 |
Diagnostic Performance of Positron Emission Tomography for the Presurgical Evaluation of Patients with Non-lesional Intractable Partial Epilepsy: Comparison among 18F-FDG, 11C-Flumazenil, and 11C-Flumazenil Binding Potential Imaging Using Statistical Imag
Topics: Adolescent; Adult; Brain; Brain Mapping; Brain Waves; Carbon Radioisotopes; Case-Control Studies; Da | 2015 |
Focal decreases of cortical GABAA receptor binding remote from the primary seizure focus: what do they indicate?
Topics: Adolescent; Carbon Radioisotopes; Cerebral Cortex; Child; Child, Preschool; Dominance, Cerebral; Ele | 2009 |
Grey and white matter flumazenil binding in neocortical epilepsy with normal MRI. A PET study of 44 patients.
Topics: Adolescent; Adult; Artifacts; Epilepsies, Partial; Epilepsy, Frontal Lobe; False Negative Reactions; | 2003 |
Seizure-related short-term plasticity of benzodiazepine receptors in partial epilepsy: a [11C]flumazenil-PET study.
Topics: Adolescent; Adult; Carbon Radioisotopes; Drug Resistance; Electroencephalography; Epilepsies, Partia | 2005 |
Central-type benzodiazepine receptors and epileptogenesis: basic mechanisms and clinical validity.
Topics: Adult; Amygdala; Animals; Autoradiography; Cerebral Cortex; Dentate Gyrus; Disease Models, Animal; E | 2005 |
Alternative psychosis and dysgraphia accompanied by forced normalization in a girl with occipital lobe epilepsy.
Topics: Agraphia; Anticonvulsants; Carbamazepine; Child; Electroencephalography; Epilepsies, Partial; Female | 2008 |
[123I iomazenil SPECT and identification of the epileptogenic tubers in patients with tuberous sclerosis].
Topics: Adolescent; Adult; Cerebral Cortex; Child; Child, Preschool; Epilepsies, Partial; Female; Flumazenil | 2008 |
[123I-iomazenil- and 99mTc-HMPAO in the diagnosis of focal epilepsies: a comparison of untreated and treated patients].
Topics: Adolescent; Adult; Epilepsies, Partial; Female; Flumazenil; Humans; Iodine Radioisotopes; Male; Midd | 1994 |
Dosimetry of iodine-123 iomazenil in humans.
Topics: Adult; Epilepsies, Partial; Flumazenil; Humans; Iodine Radioisotopes; Male; Middle Aged; Radiometry; | 1993 |
Cortical benzodiazepine receptor changes are related to frequency of partial seizures: a positron emission tomography study.
Topics: Adult; Carbon Radioisotopes; Cerebral Cortex; Electroencephalography; Epilepsies, Partial; Female; F | 1996 |
Benzodiazepine receptors in focal epilepsy with cortical dysgenesis: an 11C-flumazenil PET study.
Topics: Adult; Aged; Carbon Radioisotopes; Cerebral Cortex; Epilepsies, Partial; Female; Flumazenil; gamma-A | 1996 |
Localized cerebellar reductions in benzodiazepine receptor density in human partial epilepsy.
Topics: Adult; Cerebellum; Deoxyglucose; Epilepsies, Partial; Epilepsy, Frontal Lobe; Epilepsy, Temporal Lob | 1996 |
Widespread functional deficits in perception-related networks demonstrated by PET in a case with simple visual seizures.
Topics: Adult; Carbon Radioisotopes; Deoxyglucose; Electroencephalography; Epilepsies, Partial; Female; Flum | 1997 |
The effects of flumazenil on focal, electroinduced after-discharge in rabbits.
Topics: Amygdala; Animals; Anticonvulsants; Benzodiazepines; Brain; Electric Stimulation; Electroencephalogr | 1998 |
Asymmetries of benzodiazepine receptor binding potential in the inferior medial temporal lobe and cerebellum detected with 123I-iomazenil SPECT in comparison with 99mTc-HMPAO SPECT in patients with partial epilepsy.
Topics: Adult; Cerebellum; Epilepsies, Partial; Female; Flumazenil; Humans; Iodine Radioisotopes; Male; Midd | 1998 |
Clinical utility of flumazenil-PET versus [18F]fluorodeoxyglucose-PET and MRI in refractory partial epilepsy. A prospective study in 100 patients.
Topics: Brain; Electroencephalography; Epilepsies, Partial; Epilepsy, Frontal Lobe; Epilepsy, Temporal Lobe; | 1998 |
Induction of partial epileptic seizures by flumazenil.
Topics: Anticonvulsants; Benzodiazepines; Electrodes, Implanted; Electroencephalography; Epilepsies, Partial | 2000 |
Relationship of flumazenil and glucose PET abnormalities to neocortical epilepsy surgery outcome.
Topics: Adolescent; Adult; Brain Mapping; Child; Child, Preschool; Electroencephalography; Epilepsies, Parti | 2001 |
Central benzodiazepine receptors in malformations of cortical development: A quantitative study.
Topics: Adolescent; Adult; Carbon Radioisotopes; Central Nervous System; Cerebral Cortex; Child; Child, Pres | 2001 |
[Cortical dysplasia as an epileptogenic focus: reduced binding of 123I-iomezanil with barely perceptible 99mTc-HMPAO SPECT].
Topics: Cerebral Cortex; Epilepsies, Partial; Female; Flumazenil; Humans; Iodine Radioisotopes; Middle Aged; | 1992 |
GABA/benzodiazepine receptors in human focal epilepsy.
Topics: Amygdala; Autoradiography; Brain Mapping; Dominance, Cerebral; Electroencephalography; Epilepsies, P | 1992 |
In-vivo demonstration of reduced benzodiazepine receptor binding in human epileptic foci.
Topics: Adult; Analysis of Variance; Carbon Radioisotopes; Cerebral Cortex; Epilepsies, Partial; Female; Flu | 1988 |
Partial epilepsy syndrome in a Gypsy family linked to 5q31.3-q32.
Topics: Adolescent; Adult; Child; Chromosomes, Human, Pair 5; Electroencephalography; Epilepsies, Partial; E | 2009 |
[Congenital type I antithrombin III deficiency with serious complications in a 7-year-old girl].
Topics: Acenocoumarol; Antithrombin III Deficiency; Ataxia; Blood Coagulation Disorders; Child; Epilepsies, | 1989 |