flufenamic acid has been researched along with Bone Loss, Osteoclastic in 7 studies
Flufenamic Acid: An anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorders and administered by mouth and topically. (From Martindale, The Extra Pharmacopoeia, 30th ed, p16)
flufenamic acid : An aromatic amino acid consisting of anthranilic acid carrying an N-(trifluoromethyl)phenyl substituent. An analgesic and anti-inflammatory, it is used in rheumatic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Levels of PGB (presumed to arise from PGE) in synovial fluids are elevated in the majority of a group of patients with inflammatory rheumatic diseases, as compared to similar patients treated with aspirin and indomethacin and patients with osteoarthritis." | 3.65 | Prostaglandins in the rheumatic diseases. ( Levine, L; McGuire, MB; Robinson, DR, 1975) |
| "Postmenopausal osteoporosis is one of the most common types of osteoporosis resulting from estrogen deficiency in elderly women." | 1.56 | Flufenamic acid inhibits osteoclast formation and bone resorption and act against estrogen-dependent bone loss in mice. ( Huo, S; Li, H; Nie, B; Qu, X; Tang, H; Yue, B; Zhang, S, 2020) |
| "Patients with advanced breast cancer may develop acute, severe hypercalcemia when treated with estrogens or antiestrogens." | 1.27 | Estrogens and antiestrogens stimulate release of bone resorbing activity by cultured human breast cancer cells. ( Eilon, G; Mundy, GR; Saez, S; Valentin-Opran, A, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (85.71) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, S | 1 |
| Huo, S | 1 |
| Li, H | 1 |
| Tang, H | 1 |
| Nie, B | 1 |
| Qu, X | 1 |
| Yue, B | 1 |
| Rodan, SB | 1 |
| Rodan, GA | 1 |
| Simmons, HA | 1 |
| Walenga, RW | 1 |
| Feinstein, MB | 1 |
| Raisz, LG | 1 |
| Yoneda, T | 1 |
| Mundy, GR | 2 |
| Robinson, DR | 1 |
| McGuire, MB | 1 |
| Levine, L | 1 |
| Lorenzo, JA | 2 |
| Sousa, S | 1 |
| Sousa, SL | 1 |
| Centrella, M | 1 |
| Valentin-Opran, A | 1 |
| Eilon, G | 1 |
| Saez, S | 1 |
7 other studies available for flufenamic acid and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Flufenamic acid inhibits osteoclast formation and bone resorption and act against estrogen-dependent bone loss in mice.
Topics: Animals; Anti-Inflammatory Agents; Bone Density; Bone Resorption; Cell Differentiation; Disease Mode | 2020 |
Bone resorptive factor produced by osteosarcoma cells with osteoblastic features is PGE2.
Topics: Animals; Bone Neoplasms; Bone Resorption; Cell Line; Chromatography, Thin Layer; Culture Media; Dino | 1981 |
Prostaglandins are necessary for osteoclast-activating factor production by activated peripheral blood leukocytes.
Topics: Bone Resorption; Cyclooxygenase Inhibitors; Flufenamic Acid; Humans; Indomethacin; Leukocytes; Lymph | 1979 |
Prostaglandins in the rheumatic diseases.
Topics: Arthritis, Rheumatoid; Aspirin; Bone Resorption; Cell Line; Colchicine; Cyclic AMP; Flufenamic Acid; | 1975 |
Phorbol esters stimulate bone resorption in fetal rat long-bone cultures by mechanisms independent of prostaglandin synthesis.
Topics: Animals; Aphidicolin; Bone and Bones; Bone Resorption; Calcium; Diterpenes; DNA Replication; Epiderm | 1988 |
Interleukin-1 in combination with transforming growth factor-alpha produces enhanced bone resorption in vitro.
Topics: Animals; Bone and Bones; Bone Resorption; Cell Line; Cells, Cultured; DNA; Epidermal Growth Factor; | 1988 |
Estrogens and antiestrogens stimulate release of bone resorbing activity by cultured human breast cancer cells.
Topics: Biological Products; Bone Resorption; Breast Neoplasms; Cells, Cultured; Cytokines; Dinoprostone; Es | 1985 |