flufenamic acid and Acute Liver Injury, Drug-Induced studies

flufenamic acid and Acute Liver Injury, Drug-Induced

Flufenamic Acid: An anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorders and administered by mouth and topically. (From Martindale, The Extra Pharmacopoeia, 30th ed, p16)
flufenamic acid : An aromatic amino acid consisting of anthranilic acid carrying an N-(trifluoromethyl)phenyl substituent. An analgesic and anti-inflammatory, it is used in rheumatic disorders.

Research Excerpts

Excerpt	Relevance	Reference
" An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems."	1.36	Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010)

Research

Studies (4)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (25.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (75.00)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

1 (25.00)

18.7374

1990's

0 (0.00)

18.2507

2000's

0 (0.00)

29.6817

2010's

3 (75.00)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
Fourches, D	1
Barnes, JC	1
Day, NC	1
Bradley, P	1
Reed, JZ	1
Tropsha, A	1
Greene, N	1
Fisk, L	1
Naven, RT	1
Note, RR	1
Patel, ML	1
Pelletier, DJ	1
Ekins, S	1
Williams, AJ	1
Xu, JJ	1
Masheter, HC	1
Hardy, SM	1

Studies

Fourches, D

Barnes, JC

Day, NC

Bradley, P

Reed, JZ

Tropsha, A

Greene, N

Fisk, L

Naven, RT

Note, RR

Patel, ML

Pelletier, DJ

Ekins, S

Williams, AJ

Xu, JJ

Masheter, HC

Hardy, SM

Other Studies

4 other studies available for flufenamic acid and Acute Liver Injury, Drug-Induced

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship;	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Serum-enzymes and drug toxicity. Lancet (London, England), 1970, May-02, Volume: 1, Issue:7653 Topics: Alanine Transaminase; Alcohol Oxidoreductases; Alkaline Phosphatase; Aspartate Aminotransferases; Ch	1970

Article

Year

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chemical research in toxicology, 2010, Volume: 23, Issue:1

Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI

2010

Developing structure-activity relationships for the prediction of hepatotoxicity.

Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship;

2010

A predictive ligand-based Bayesian model for human drug-induced liver injury.

Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010

Serum-enzymes and drug toxicity.

Lancet (London, England), 1970, May-02, Volume: 1, Issue:7653

Topics: Alanine Transaminase; Alcohol Oxidoreductases; Alkaline Phosphatase; Aspartate Aminotransferases; Ch

1970