flucytosine has been researched along with Ovarian Neoplasms in 14 studies
Flucytosine: A fluorinated cytosine analog that is used as an antifungal agent.
flucytosine : An organofluorine compound that is cytosine that is substituted at position 5 by a fluorine. A prodrug for the antifungal 5-fluorouracil, it is used for the treatment of systemic fungal infections.
Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment of human epithelial ovarian cancer cell line (SKOV-3, an ovarian adenocarcinoma derived from the ascites of an ovarian cancer patient) with the prodrugs 5-fluorocytosine (5-FC) or camptothecin-11 (CPT-11) in the presence of HB1." | 1.36 | Influence of the prodrugs 5-fluorocytosine and CPT-11 on ovarian cancer cells using genetically engineered stem cells: tumor-tropic potential and inhibition of ovarian cancer cell growth. ( Choi, KC; Jeung, EB; Kim, KY; Kim, SU; Leung, PC, 2010) |
| "The Ovcar-5 and Skov-3 ovarian cancer cell lines exposed to the Ad-Lp-CD adenoviral vector were much more sensitive to the prodrug 5-fluorocytosine (5FC), which is converted from the 5FC prodrug into the toxic chemical 5-fluorouracil, than was the CCD minimal deviation fibroblast cell line after exposure to the same vector." | 1.31 | The use of the L-plastin promoter for adenoviral-mediated, tumor-specific gene expression in ovarian and bladder cancer cell lines. ( Crystal, R; Deisseroth, A; Fujii, T; Kacinski, B; Leavitt, J; Peng, XY; Pizzorno, G; Rutherford, T; Sapi, E; Schwartz, P; Won, JH; Zelterman, D, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 8 (57.14) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Isoda, L | 1 |
| Sonoda-Fukuda, E | 1 |
| Fujino, H | 1 |
| Takarada, T | 1 |
| Hasegawa, K | 1 |
| Kasahara, N | 1 |
| Kubo, S | 1 |
| Hartkopf, AD | 1 |
| Bossow, S | 1 |
| Lampe, J | 1 |
| Zimmermann, M | 1 |
| Taran, FA | 1 |
| Wallwiener, D | 1 |
| Fehm, T | 1 |
| Bitzer, M | 1 |
| Lauer, UM | 1 |
| Jiang, J | 1 |
| Wei, D | 1 |
| Sun, L | 1 |
| Wang, Y | 1 |
| Wu, X | 1 |
| Li, Y | 1 |
| Fang, Z | 1 |
| Shang, H | 1 |
| Wei, Z | 1 |
| Kim, KY | 1 |
| Kim, SU | 1 |
| Leung, PC | 1 |
| Jeung, EB | 1 |
| Choi, KC | 1 |
| Sher, YP | 1 |
| Chang, CM | 1 |
| Juo, CG | 1 |
| Chen, CT | 1 |
| Hsu, JL | 1 |
| Lin, CY | 1 |
| Han, Z | 1 |
| Shiah, SG | 1 |
| Hung, MC | 1 |
| Yao, Y | 1 |
| Peng, Z | 1 |
| Wang, H | 2 |
| Li, Q | 1 |
| Liu, S | 1 |
| Akbulut, H | 1 |
| Zhang, L | 1 |
| Tang, Y | 1 |
| Deisseroth, A | 2 |
| Chung, I | 1 |
| Deisseroth, AB | 1 |
| Kong, BH | 1 |
| Song, Y | 1 |
| Ma, DX | 1 |
| Qu, X | 1 |
| Jiang, S | 1 |
| Cai, LQ | 1 |
| Li, M | 1 |
| Lu, S | 1 |
| Wang, HB | 1 |
| Wang, ZH | 1 |
| Wang, Z | 1 |
| Cai, L | 1 |
| Chalikonda, S | 1 |
| Kivlen, MH | 1 |
| O'Malley, ME | 1 |
| Eric Dong, XD | 1 |
| McCart, JA | 1 |
| Gorry, MC | 1 |
| Yin, XY | 1 |
| Brown, CK | 1 |
| Zeh, HJ | 1 |
| Guo, ZS | 1 |
| Bartlett, DL | 1 |
| Xie, Y | 1 |
| Gilbert, JD | 1 |
| Kim, JH | 1 |
| Freytag, SO | 1 |
| Peng, XY | 1 |
| Won, JH | 1 |
| Rutherford, T | 1 |
| Fujii, T | 1 |
| Zelterman, D | 1 |
| Pizzorno, G | 1 |
| Sapi, E | 1 |
| Leavitt, J | 1 |
| Kacinski, B | 1 |
| Crystal, R | 1 |
| Schwartz, P | 1 |
14 other studies available for flucytosine and Ovarian Neoplasms
| Article | Year |
|---|---|
Therapeutic Efficacy of Prodrug Activator Gene Therapy Using Retroviral Replicating Vectors for Human Ovarian Cancer.
Topics: Animals; Cell Line, Tumor; Cytosine Deaminase; Female; Flucytosine; Genetic Therapy; Genetic Vectors | 2023 |
Enhanced killing of ovarian carcinoma using oncolytic measles vaccine virus armed with a yeast cytosine deaminase and uracil phosphoribosyltransferase.
Topics: Cell Line, Tumor; Cytosine Deaminase; Female; Flucytosine; Genetic Therapy; Humans; Measles Vaccine; | 2013 |
A preliminary study on the construction of double suicide gene delivery vectors by mesenchymal stem cells and the in vitro inhibitory effects on SKOV3 cells.
Topics: Adenoviridae; Antimetabolites; Base Sequence; Cell Proliferation; Coculture Techniques; Cytosine Dea | 2014 |
Influence of the prodrugs 5-fluorocytosine and CPT-11 on ovarian cancer cells using genetically engineered stem cells: tumor-tropic potential and inhibition of ovarian cancer cell growth.
Topics: Animals; Antimetabolites; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line; Cell Line, Tum | 2010 |
Targeted endostatin-cytosine deaminase fusion gene therapy plus 5-fluorocytosine suppresses ovarian tumor growth.
Topics: Animals; Cell Line, Tumor; Cytosine Deaminase; Endostatins; Female; Flucytosine; Gene Fusion; Geneti | 2013 |
[Anticancer effects of cytosine deaminase gene/5-fluorocytosine therapies to ovarian cancer in vivo].
Topics: Adenoviridae; Animals; Antimetabolites; Cytosine Deaminase; Female; Flucytosine; Genetic Therapy; Hu | 2002 |
Cytotoxic effect of replication-competent adenoviral vectors carrying L-plastin promoter regulated E1A and cytosine deaminase genes in cancers of the breast, ovary and colon.
Topics: Adenoviridae; Adenovirus E1A Proteins; Animals; Breast Neoplasms; Cell Death; Colonic Neoplasms; Cyt | 2003 |
Recombinant adenoviral vector containing tumor-specific L-plastin promoter fused to cytosine deaminase gene as a transcription unit: generation and functional test.
Topics: Adenoviridae; Artificial Gene Fusion; Cell Line, Tumor; Chromatography, High Pressure Liquid; Cytosi | 2004 |
[In vitro treatment of ovarian cancer cells with cytosine deaminase-thymidine kinase fusion disuicide gene therapy system under the control of human telomerase reverse transcriptase gene promoter].
Topics: Cystadenocarcinoma, Serous; Cytosine Deaminase; DNA-Binding Proteins; Female; Flucytosine; Ganciclov | 2004 |
[Killing effect of adenovirus mediated fusion gene cytosine and deaminase uracil phosphoribosyl transferase directed by glutathione S-transferase P1 promoter on cisplatin-resistant ovarian cancer cells in vitro].
Topics: Adenoviruses, Human; Antineoplastic Agents; Cisplatin; Cytosine Deaminase; Drug Resistance, Neoplasm | 2004 |
Gene therapy of adenovirus mediated CD ::upp/5-FC directed by GSTP1 promoter in cisplatin-resistant ovarian cancer.
Topics: Adenoviruses, Human; Animals; Antineoplastic Agents; Artificial Gene Fusion; Cell Growth Processes; | 2005 |
Oncolytic virotherapy for ovarian carcinomatosis using a replication-selective vaccinia virus armed with a yeast cytosine deaminase gene.
Topics: Animals; Antimetabolites; Carcinoma; Cell Line, Tumor; Combined Modality Therapy; Cytosine Deaminase | 2008 |
Efficacy of adenovirus-mediated CD/5-FC and HSV-1 thymidine kinase/ganciclovir suicide gene therapies concomitant with p53 gene therapy.
Topics: Adenoviridae; Animals; Antiviral Agents; Cytosine Deaminase; Female; Flucytosine; Ganciclovir; Genes | 1999 |
The use of the L-plastin promoter for adenoviral-mediated, tumor-specific gene expression in ovarian and bladder cancer cell lines.
Topics: Adenoviridae; Animals; Cytomegalovirus; Cytosine Deaminase; Female; Flucytosine; Fluorouracil; Gene | 2001 |