flucytosine has been researched along with Neutropenia in 27 studies
Flucytosine: A fluorinated cytosine analog that is used as an antifungal agent.
flucytosine : An organofluorine compound that is cytosine that is substituted at position 5 by a fluorine. A prodrug for the antifungal 5-fluorouracil, it is used for the treatment of systemic fungal infections.
Neutropenia: A decrease in the number of NEUTROPHILS found in the blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amphotericin B deoxycholate (AmBd) is the recommended induction treatment for HIV-associated cryptococcal meningitis (CM)." | 9.20 | Toxicity of Amphotericin B Deoxycholate-Based Induction Therapy in Patients with HIV-Associated Cryptococcal Meningitis. ( Bicanic, T; Bottomley, C; Brouwer, AE; Harrison, TS; Hosseinipour, MC; Jackson, A; Jarvis, JN; Limmathurotsakul, D; Loyse, A; Meintjes, G; Muzoora, C; Phulusa, J; Taseera, K; van der Horst, C; White, NJ; Wilson, D; Wood, R, 2015) |
| "Due to an increasing number of leukemic patients with invasive gingival aspergillosis during neutropenia (neutrophils <500 cells/microl for >10 days), we evaluated the efficacy of oral itraconazole prophylaxis for preventing this invasive infection at our hospital." | 7.71 | Itraconazole prophylaxis for invasive gingival aspergillosis in neutropenic patients with acute leukemia. ( Fujihara, M; Kyo, T; Mikami, Y; Myoken, Y; Sugata, T, 2002) |
| " We used a neutropenic murine model of disseminated candidiasis to correlate the pharmacodynamic parameters (percentage of time above the MIC, area under the concentration-time curve [AUC]/MIC and peak level/MIC) for flucytosine (5-FC) in vivo with efficacy as measured by organism number in homogenized kidney cultures after 24 h of therapy." | 7.70 | In vivo characterization of the pharmacodynamics of flucytosine in a neutropenic murine disseminated candidiasis model. ( Andes, D; van Ogtrop, M, 2000) |
| "Amphotericin B deoxycholate (AmBd) is the recommended induction treatment for HIV-associated cryptococcal meningitis (CM)." | 5.20 | Toxicity of Amphotericin B Deoxycholate-Based Induction Therapy in Patients with HIV-Associated Cryptococcal Meningitis. ( Bicanic, T; Bottomley, C; Brouwer, AE; Harrison, TS; Hosseinipour, MC; Jackson, A; Jarvis, JN; Limmathurotsakul, D; Loyse, A; Meintjes, G; Muzoora, C; Phulusa, J; Taseera, K; van der Horst, C; White, NJ; Wilson, D; Wood, R, 2015) |
| " These events have lead to the development of new antifungal agents, and amphotericin B no longer is the standard therapy for a variety of invasive mycoses." | 4.80 | Therapy of invasive fungal infections. ( de Pauw, BE; Kullberg, BJ, 1999) |
| " The effect of neutropenia on the temporal profile of the burden of Candida albicans in untreated mice and those treated with amphotericin B was determined using a pharmacodynamic model of disseminated candidiasis." | 3.74 | Effect of neutropenia and treatment delay on the response to antifungal agents in experimental disseminated candidiasis. ( Denning, DW; Drusano, GL; Hope, WW; Louie, A; Moore, CB; Sharp, A; Walsh, TJ; Warn, PA, 2007) |
| "Due to an increasing number of leukemic patients with invasive gingival aspergillosis during neutropenia (neutrophils <500 cells/microl for >10 days), we evaluated the efficacy of oral itraconazole prophylaxis for preventing this invasive infection at our hospital." | 3.71 | Itraconazole prophylaxis for invasive gingival aspergillosis in neutropenic patients with acute leukemia. ( Fujihara, M; Kyo, T; Mikami, Y; Myoken, Y; Sugata, T, 2002) |
| " We used a neutropenic murine model of disseminated candidiasis to correlate the pharmacodynamic parameters (percentage of time above the MIC, area under the concentration-time curve [AUC]/MIC and peak level/MIC) for flucytosine (5-FC) in vivo with efficacy as measured by organism number in homogenized kidney cultures after 24 h of therapy." | 3.70 | In vivo characterization of the pharmacodynamics of flucytosine in a neutropenic murine disseminated candidiasis model. ( Andes, D; van Ogtrop, M, 2000) |
| "Fungal infections are life-threatening complications in patients with prolonged neutropenia." | 2.41 | Standard antifungal therapy in neutropenic patients. ( Aoun, M, 2000) |
| "Fungal infections have emerged as a major complication of marrow transplantation in children." | 2.39 | Evolving concepts of prevention and treatment of invasive fungal infections in pediatric bone marrow transplant recipients. ( Chanock, SJ; Walsh, TJ, 1996) |
| "Treatment with amphotericin B(AMPH-B) and flucytosine(5-FC) was initiated as diagnosis of cryptococcus meningitis." | 1.37 | Disseminated cryptococcosis in a non-Hodgkin's lymphoma patient with late-onset neutropenia following rituximab-CHOP chemotherapy: a case report and literature review. ( Ainoda, Y; Fujita, T; Hirai, Y; Mori, N; Motoji, T; Shiseki, M; Shoji, T; Teramura, M; Totsuka, K; Yoshinaga, K, 2011) |
| " Long-term use of fluconazole may explain the outcome of the resistant stipple phenotype." | 1.31 | Phenotypic variation and antifungal susceptibility patterns of Candida albicans strains isolated from neutropenic patients. ( Akgün, Y; Anğ, O; Erturan, Z; Kiraz, N, 2000) |
| "Flucytosine was added to AmB-IL in 12 patients (mean duration 10." | 1.29 | Efficacy and tolerance of an amphotericin B lipid (Intralipid) emulsion in the treatment of candidaemia in neutropenic patients. ( Bonnin, A; Bonnotte, B; Caillot, D; Casasnovas, O; Chavanet, P; Entezam, F; Guy, H; Lopez, J; Reny, G; Solary, E, 1993) |
| "Candidiasis was established by intravenously administering Candida albicans or Candida tropicalis (1-2 x 10(5) colony-forming units) and resulted in hepatic and splenic lesions that mimicked those associated with hepatosplenic candidiasis in humans." | 1.27 | Evaluation of single-drug and combination antifungal therapy in an experimental model of candidiasis in rabbits with prolonged neutropenia. ( Bacher, J; O'Leary, T; Pizzo, PA; Thaler, M, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (14.81) | 18.7374 |
| 1990's | 12 (44.44) | 18.2507 |
| 2000's | 8 (29.63) | 29.6817 |
| 2010's | 3 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chittick, P | 1 |
| Palavecino, EL | 1 |
| Delashmitt, B | 1 |
| Evans, J | 1 |
| Peacock, JE | 1 |
| Bicanic, T | 1 |
| Bottomley, C | 1 |
| Loyse, A | 1 |
| Brouwer, AE | 1 |
| Muzoora, C | 1 |
| Taseera, K | 1 |
| Jackson, A | 1 |
| Phulusa, J | 1 |
| Hosseinipour, MC | 1 |
| van der Horst, C | 1 |
| Limmathurotsakul, D | 1 |
| White, NJ | 1 |
| Wilson, D | 1 |
| Wood, R | 1 |
| Meintjes, G | 1 |
| Harrison, TS | 1 |
| Jarvis, JN | 1 |
| Hirai, Y | 1 |
| Ainoda, Y | 1 |
| Shoji, T | 1 |
| Fujita, T | 1 |
| Yoshinaga, K | 1 |
| Shiseki, M | 1 |
| Mori, N | 1 |
| Teramura, M | 1 |
| Totsuka, K | 1 |
| Motoji, T | 1 |
| Zarogoulidis, P | 1 |
| Chatzaki, E | 1 |
| Hohenforst-Schmidt, W | 1 |
| Goldberg, EP | 1 |
| Galaktidou, G | 1 |
| Kontakiotis, T | 1 |
| Karamanos, N | 1 |
| Zarogoulidis, K | 1 |
| Vermes, A | 1 |
| Kuijper, EJ | 1 |
| Guchelaar, HJ | 1 |
| Dankert, J | 1 |
| Hope, WW | 1 |
| Drusano, GL | 1 |
| Moore, CB | 1 |
| Sharp, A | 1 |
| Louie, A | 1 |
| Walsh, TJ | 3 |
| Denning, DW | 1 |
| Warn, PA | 1 |
| Björkholm, M | 1 |
| Wingard, JR | 1 |
| Merz, WG | 1 |
| Rinaldi, MG | 1 |
| Miller, CB | 1 |
| Karp, JE | 1 |
| Saral, R | 1 |
| Caillot, D | 1 |
| Casasnovas, O | 1 |
| Solary, E | 1 |
| Chavanet, P | 1 |
| Bonnotte, B | 1 |
| Reny, G | 1 |
| Entezam, F | 1 |
| Lopez, J | 1 |
| Bonnin, A | 1 |
| Guy, H | 1 |
| Lyman, CA | 1 |
| Chanock, SJ | 1 |
| Myoken, Y | 4 |
| Sugata, T | 3 |
| Kyo, T | 3 |
| Fujihara, M | 3 |
| Mikami, Y | 3 |
| Graybill, JR | 1 |
| Fouassier, M | 1 |
| Joly, D | 1 |
| Cambon, M | 1 |
| Peigue-Lafeuille, H | 1 |
| Condat, P | 1 |
| Kullberg, BJ | 1 |
| de Pauw, BE | 2 |
| Andes, D | 1 |
| van Ogtrop, M | 1 |
| Silling, G | 1 |
| Fegeler, W | 1 |
| Roos, N | 1 |
| Essink, M | 1 |
| Büchner, T | 1 |
| Kiraz, N | 1 |
| Anğ, O | 1 |
| Akgün, Y | 1 |
| Erturan, Z | 1 |
| Aoun, M | 1 |
| André, MH | 1 |
| Lortholary, O | 1 |
| Krick, JA | 1 |
| Remington, JS | 1 |
| van't Wout, JW | 1 |
| Novakova, I | 1 |
| Verhagen, CA | 1 |
| Fibbe, WE | 1 |
| van der Meer, JW | 1 |
| Thaler, M | 1 |
| Bacher, J | 1 |
| O'Leary, T | 1 |
| Pizzo, PA | 1 |
| Muramoto, T | 1 |
| Ohi, T | 1 |
| Nishimura, K | 1 |
| Hughes, CE | 1 |
| Peterson, LR | 1 |
| Beggs, WH | 1 |
| Gerding, DN | 1 |
8 reviews available for flucytosine and Neutropenia
| Article | Year |
|---|---|
Management of malignant pleural effusion by suicide gene therapy in advanced stage lung cancer: a case series and literature review.
Topics: Adenoviridae; Aged; Anemia; Animals; Antimetabolites, Antineoplastic; Bystander Effect; Carcinoma, N | 2012 |
Chemoprophylaxis of fungal infections in neutropenic patients.
Topics: Antifungal Agents; Flucytosine; Humans; Imidazoles; Mycoses; Neutropenia; Polyenes; Triazoles | 1994 |
New antifungal compounds and strategies for treatment of invasive fungal infections in patients with neoplastic diseases.
Topics: Amphotericin B; Antifungal Agents; Azoles; Flucytosine; Humans; Immunocompromised Host; Mycoses; Neo | 1995 |
Evolving concepts of prevention and treatment of invasive fungal infections in pediatric bone marrow transplant recipients.
Topics: Amphotericin B; Antifungal Agents; Bone Marrow Transplantation; Child; Clinical Trials as Topic; Flu | 1996 |
[Geotrichum capitatum infection in a neutropenic patient. Apropos of a case and review of the literature].
Topics: Acute Disease; Amphotericin B; Antifungal Agents; Antineoplastic Agents; Drug Combinations; Fatal Ou | 1998 |
Therapy of invasive fungal infections.
Topics: Amphotericin B; Antifungal Agents; Catheterization, Central Venous; Contraindications; Drug Therapy, | 1999 |
Standard antifungal therapy in neutropenic patients.
Topics: Amphotericin B; Antifungal Agents; Fever; Flucytosine; Humans; Mycoses; Neutropenia | 2000 |
Opportunistic invasive fungal infections in patients with leukaemia lymphoma.
Topics: Acute Disease; Adrenal Cortex Hormones; Amphotericin B; Aspergillosis; Blood Transfusion; Candidiasi | 1976 |
3 trials available for flucytosine and Neutropenia
| Article | Year |
|---|---|
Toxicity of Amphotericin B Deoxycholate-Based Induction Therapy in Patients with HIV-Associated Cryptococcal Meningitis.
Topics: Adult; Amphotericin B; Anemia; Antifungal Agents; Blood Cell Count; Coinfection; Creatinine; Cryptoc | 2015 |
Early empiric antifungal therapy of infections in neutropenic patients comparing fluconazole with amphotericin B/flucytosine.
Topics: Adolescent; Adult; Aged; Amphotericin B; Antifungal Agents; Drug Therapy, Combination; Female; Fluco | 1999 |
The efficacy of itraconazole against systemic fungal infections in neutropenic patients: a randomised comparative study with amphotericin B.
Topics: Amphotericin B; Aspergillosis; Aspergillus fumigatus; Candidiasis; Drug Therapy, Combination; Female | 1991 |
16 other studies available for flucytosine and Neutropenia
| Article | Year |
|---|---|
Case of fatal Blastoschizomyces capitatus infection occurring in a patient receiving empiric micafungin therapy.
Topics: Aged; Antifungal Agents; Echinocandins; Fatal Outcome; Geotrichosis; Geotrichum; Humans; Lipopeptide | 2009 |
Disseminated cryptococcosis in a non-Hodgkin's lymphoma patient with late-onset neutropenia following rituximab-CHOP chemotherapy: a case report and literature review.
Topics: Aged; Amphotericin B; Antibodies, Monoclonal, Murine-Derived; Antifungal Agents; Antineoplastic Comb | 2011 |
An in vitro study on the active conversion of flucytosine to fluorouracil by microorganisms in the human intestinal microflora.
Topics: Antifungal Agents; Child; Dose-Response Relationship, Drug; Escherichia coli; Feces; Female; Flucyto | 2003 |
Effect of neutropenia and treatment delay on the response to antifungal agents in experimental disseminated candidiasis.
Topics: Amphotericin B; Animals; Antifungal Agents; Candida albicans; Candidiasis; Disease Models, Animal; D | 2007 |
Association of Torulopsis glabrata infections with fluconazole prophylaxis in neutropenic bone marrow transplant patients.
Topics: Amphotericin B; Bacterial Infections; Bone Marrow Transplantation; Candida; Candidiasis; Fluconazole | 1993 |
Efficacy and tolerance of an amphotericin B lipid (Intralipid) emulsion in the treatment of candidaemia in neutropenic patients.
Topics: Adult; Aged; Amphotericin B; Candida; Candidiasis; Fat Emulsions, Intravenous; Female; Flucytosine; | 1993 |
Early surgical management of invasive gingival aspergillosis in a neutropenic patient with leukemia: a case report.
Topics: Adult; Amphotericin B; Antifungal Agents; Aspergillosis; Female; Fluconazole; Flucytosine; Gingival | 1997 |
Can we agree on the treatment of candidiasis?
Topics: Antifungal Agents; Candidiasis; Drug Resistance, Microbial; Drug Therapy, Combination; Fluconazole; | 1997 |
Antifungal susceptibility of Aspergillus species isolated from invasive oral infection in neutropenic patients with hematologic malignancies.
Topics: Adult; Aged; Amphotericin B; Antifungal Agents; Antineoplastic Agents; Aspergillosis; Aspergillus; D | 1999 |
In vivo characterization of the pharmacodynamics of flucytosine in a neutropenic murine disseminated candidiasis model.
Topics: Alkylating Agents; Animals; Antifungal Agents; Area Under Curve; Candida albicans; Candidiasis; Colo | 2000 |
Phenotypic variation and antifungal susceptibility patterns of Candida albicans strains isolated from neutropenic patients.
Topics: Amphotericin B; Antifungal Agents; Candida albicans; Candidiasis; Digestive System; Fluconazole; Flu | 2000 |
[Visceral mycotic infections. In clinical practice].
Topics: Amphotericin B; Antifungal Agents; Candidiasis; Cryptococcosis; Fluconazole; Flucytosine; Histoplasm | 2001 |
Itraconazole prophylaxis for invasive gingival aspergillosis in neutropenic patients with acute leukemia.
Topics: Administration, Oral; Amphotericin B; Antifungal Agents; Aspergillosis; Candidiasis, Oral; Capsules; | 2002 |
Evaluation of single-drug and combination antifungal therapy in an experimental model of candidiasis in rabbits with prolonged neutropenia.
Topics: Agranulocytosis; Amphotericin B; Animals; Antifungal Agents; Candidiasis; Cytarabine; Drug Evaluatio | 1988 |
[Case of autoimmune hemolytic anemia complicated by cryptococcal meningitis during therapy of neutropenia].
Topics: Agranulocytosis; Amphotericin B; Anemia, Hemolytic, Autoimmune; Cryptococcosis; Female; Flucytosine; | 1988 |
Ketoconazole and flucytosine alone and in combination against Candida spp. in a neutropenic site in rabbits.
Topics: Animals; Candida; Candida albicans; Candidiasis; Drug Synergism; Drug Therapy, Combination; Flucytos | 1986 |