flucytosine has been researched along with Liver Neoplasms in 29 studies
Flucytosine: A fluorinated cytosine analog that is used as an antifungal agent.
flucytosine : An organofluorine compound that is cytosine that is substituted at position 5 by a fluorine. A prodrug for the antifungal 5-fluorouracil, it is used for the treatment of systemic fungal infections.
Liver Neoplasms: Tumors or cancer of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the antitumor effects of cytosine deaminase (CD) gene in combination with prodrug flucytosine (Flu, 5-fluorocytosine) on human hepatocellular carcinoma." | 7.70 | Gene therapy for human hepatocellular carcinoma with cytosine deaminase gene and prodrug flucytosine. ( Gao, HZ; Gu, B; Liang, YQ; Lü, HZ; Wan, YL; Wang, JX; Wu, DZ, 1999) |
| " Although it has been shown in several in vitro studies that the bacterial cytosine deaminase (CD) gene/5-fluorocytosine (5-FC) system is superior to the herpes simplex virus thymidine kinase (HSV-TK) gene/ganciclovir (GCV) system, we examined here which suicide gene system was more promising in vivo for the treatment of hepatocellular carcinoma (HCC)." | 3.70 | Comparison of gene therapy with the herpes simplex virus thymidine kinase gene and the bacterial cytosine deaminase gene for the treatment of hepatocellular carcinoma. ( Akahane, T; Fukui, H; Kojima, H; Kuriyama, S; Mitoro, A; Nakatani, T; Okamoto, S; Toyokawa, Y; Tsujinoue, H; Yamazaki, M, 1999) |
| "To investigate the antitumor effects of cytosine deaminase (CD) gene in combination with prodrug flucytosine (Flu, 5-fluorocytosine) on human hepatocellular carcinoma." | 3.70 | Gene therapy for human hepatocellular carcinoma with cytosine deaminase gene and prodrug flucytosine. ( Gao, HZ; Gu, B; Liang, YQ; Lü, HZ; Wan, YL; Wang, JX; Wu, DZ, 1999) |
| "Treatment of Hep3B, human liver cancer cells, with the prodrug 5-fluorocytosine (5-FC) in the presence of HB1." | 1.38 | Synergistic effects of genetically engineered stem cells expressing cytosine deaminase and interferon-β via their tumor tropism to selectively target human hepatocarcinoma cells. ( Choi, KC; Hwang, KA; Jeung, EB; Kang, NH; Kim, HC; Kim, SU; Yi, BR, 2012) |
| "Orthotopic colon cancer models were developed." | 1.32 | Improvement of carcinoembryonic antigen-specific prodrug gene therapy for experimental colon cancer. ( Iwahashi, M; Matsuura, I; Nakamori, M; Nakamura, M; Ojima, T; Ueda, K; Yamaue, H, 2003) |
| "In mice bearing liver cancer, (60)Co-irradiated MM45T." | 1.31 | [Combined gene therapy for murine liver cancer with interleukin-18 and cytosine deaminase genes]. ( Chen, S; Sun, W; Tang, Y; Tang, Z; Wei, D, 2001) |
| "In a hepatic metastasis model, mice treated with an intravenous administration of both AdCD (2 x 10(8) pfu) and an intermediate dose of AdmIL-2 (1 x 10(6) pfu) demonstrated the most significant reduction of metastatic foci and the longest survival following a 5-FC administration." | 1.31 | Dose of adenoviral vectors expressing interleukin-2 plays an important role in combined gene therapy with cytosine deaminase/5-fluorocytosine: preclinical consideration. ( Hamada, H; Iwahashi, M; Nakamori, M; Terasawa, H; Tsunoda, T; Ueda, K; Yamaue, H, 2002) |
| "These results suggest that (1) intrahepatic cancer responds to 5FC when cells express yCD; (2) the luciferin-luciferase system permits non-invasive real time imaging of viable intrahepatic cancer; and (3) this system can be used to carry out gene therapy experiments using yCD adenovirus." | 1.31 | The potential of 5-fluorocytosine/cytosine deaminase enzyme prodrug gene therapy in an intrahepatic colon cancer model. ( Dornfeld, KJ; Kievit, E; Lawrence, TS; Nyati, MK; Rehemtulla, A; Ross, BD; Rynkiewicz, SD; Symon, Z, 2002) |
| "After transfecting three human hepatoma cell lines and one non-hepatoma cell line with LX2." | 1.30 | [Experimental studies in vitro on the alpha-fetoprotein-specific promoter mediated target gene therapy of hepatocellular carcinoma]. ( Fang, F; Liu, D; Lu, C; Pan, G; Quan, S, 1999) |
| "The growth of the human colon cancer cells was quantified by dot blot analysis of genomic DNA extracted from tumor-bearing liver, hybridized with a human-specific Alu probe." | 1.29 | Regional delivery of an adenovirus vector containing the Escherichia coli cytosine deaminase gene to provide local activation of 5-fluorocytosine to suppress the growth of colon carcinoma metastatic to liver. ( Crystal, RG; Hirschowitz, EA; Ohwada, A, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (27.59) | 18.2507 |
| 2000's | 15 (51.72) | 29.6817 |
| 2010's | 5 (17.24) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Kurosaki, H | 1 |
| Nakatake, M | 1 |
| Sakamoto, T | 1 |
| Kuwano, N | 1 |
| Yamane, M | 1 |
| Ishii, K | 1 |
| Fujiwara, Y | 1 |
| Nakamura, T | 2 |
| Yang, XP | 1 |
| Liu, L | 1 |
| Wang, P | 1 |
| Ma, SL | 1 |
| Husseini, F | 1 |
| Delord, JP | 1 |
| Fournel-Federico, C | 1 |
| Guitton, J | 1 |
| Erbs, P | 2 |
| Homerin, M | 1 |
| Halluard, C | 1 |
| Jemming, C | 1 |
| Orange, C | 1 |
| Limacher, JM | 1 |
| Kurtz, JE | 1 |
| Warmann, SW | 1 |
| Armeanu, S | 2 |
| Heigoldt, H | 1 |
| Ruck, P | 1 |
| Vonthein, R | 2 |
| Heitmann, H | 1 |
| Seitz, G | 1 |
| Lemken, ML | 2 |
| Bitzer, M | 2 |
| Fuchs, J | 1 |
| Lauer, UM | 2 |
| Sia, KC | 1 |
| Huynh, H | 1 |
| Chinnasamy, N | 1 |
| Hui, KM | 1 |
| Lam, PY | 1 |
| Torimura, T | 1 |
| Ueno, T | 1 |
| Taniguchi, E | 1 |
| Masuda, H | 1 |
| Iwamoto, H | 1 |
| Inoue, K | 1 |
| Hashimoto, O | 1 |
| Abe, M | 1 |
| Koga, H | 1 |
| Barresi, V | 1 |
| Nakashima, E | 1 |
| Yano, H | 1 |
| Sata, M | 1 |
| Yi, BR | 1 |
| Hwang, KA | 1 |
| Kang, NH | 1 |
| Kim, SU | 1 |
| Jeung, EB | 1 |
| Kim, HC | 1 |
| Choi, KC | 1 |
| Lin-Lee, YC | 1 |
| Nakamura, S | 1 |
| Gandhi, V | 1 |
| Curley, SA | 1 |
| Stüber, D | 1 |
| Burkot, TR | 1 |
| Kuo, MT | 1 |
| Zhang, M | 1 |
| Li, S | 1 |
| Nyati, MK | 2 |
| DeRemer, S | 1 |
| Parsels, J | 1 |
| Rehemtulla, A | 2 |
| Ensminger, WD | 1 |
| Lawrence, TS | 2 |
| Quan, S | 1 |
| Pan, G | 1 |
| Lu, C | 1 |
| Liu, D | 1 |
| Fang, F | 1 |
| Ueda, K | 2 |
| Iwahashi, M | 2 |
| Nakamori, M | 2 |
| Nakamura, M | 1 |
| Matsuura, I | 1 |
| Ojima, T | 1 |
| Yamaue, H | 2 |
| Gavelli, A | 5 |
| Baqué, P | 5 |
| Brossettej, N | 1 |
| Bourgeon, A | 5 |
| Staccini, P | 5 |
| Rossi, B | 5 |
| Pierrefite-Carle, V | 5 |
| Yanagie, H | 1 |
| Eriguchi, M | 1 |
| Graepler, F | 1 |
| Wybranietz, WA | 1 |
| Schmidt, U | 1 |
| Smirnow, I | 1 |
| Gross, CD | 1 |
| Spiegel, M | 1 |
| Schenk, A | 1 |
| Graf, H | 1 |
| Lauer, UA | 1 |
| Gregor, M | 1 |
| Foloppe, J | 1 |
| Kintz, J | 1 |
| Futin, N | 1 |
| Findeli, A | 1 |
| Cordier, P | 1 |
| Schlesinger, Y | 1 |
| Hoffmann, C | 1 |
| Tosch, C | 1 |
| Balloul, JM | 1 |
| Ohwada, A | 2 |
| Hirschowitz, EA | 1 |
| Crystal, RG | 3 |
| Hirschowitz, E | 1 |
| Lieberman, M | 1 |
| Daly, J | 1 |
| Kazam, E | 1 |
| Henschke, C | 1 |
| Yankelevitz, D | 1 |
| Kemeny, N | 1 |
| Silverstein, R | 1 |
| Russi, T | 1 |
| Mastrangeli, A | 1 |
| Sanders, A | 1 |
| Cooke, J | 1 |
| Harvey, BG | 1 |
| Topf, N | 1 |
| Worgall, S | 1 |
| Hackett, NR | 1 |
| Gnant, MF | 1 |
| Puhlmann, M | 1 |
| Alexander, HR | 1 |
| Bartlett, DL | 1 |
| Kuriyama, S | 1 |
| Mitoro, A | 1 |
| Yamazaki, M | 1 |
| Tsujinoue, H | 1 |
| Nakatani, T | 1 |
| Akahane, T | 1 |
| Toyokawa, Y | 1 |
| Kojima, H | 1 |
| Okamoto, S | 1 |
| Fukui, H | 1 |
| Mala, M | 2 |
| Chazal, M | 2 |
| Gugenheim, J | 2 |
| Milano, G | 2 |
| Lü, HZ | 1 |
| Wu, DZ | 1 |
| Wan, YL | 1 |
| Gu, B | 1 |
| Gao, HZ | 1 |
| Liang, YQ | 1 |
| Wang, JX | 1 |
| Brossette, N | 3 |
| Benchimol, D | 3 |
| Saint-Paul, MC | 1 |
| Huguet, C | 1 |
| Humphreys, MJ | 1 |
| Ghaneh, P | 1 |
| Greenhalf, W | 1 |
| Campbell, F | 1 |
| Clayton, TM | 1 |
| Everett, P | 1 |
| Huber, BE | 1 |
| Richards, CA | 1 |
| Ford, MJ | 1 |
| Neoptolemos, JP | 1 |
| Sun, W | 1 |
| Tang, Z | 1 |
| Wei, D | 1 |
| Tang, Y | 1 |
| Chen, S | 1 |
| Saint Paul, MC | 1 |
| Tsunoda, T | 1 |
| Terasawa, H | 1 |
| Hamada, H | 1 |
| Symon, Z | 1 |
| Kievit, E | 1 |
| Dornfeld, KJ | 1 |
| Rynkiewicz, SD | 1 |
| Ross, BD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase I, Open-label, Dose-escalating Study of the Safety or Percutaneous Intra-tumoral Injection of TG4023 (MVA-FCU1) Combined With Systemic Administration of 5-fluorocytosine in Patients With Primary or Secondary Hepatic Tumors.[NCT00978107] | Phase 1 | 16 participants (Actual) | Interventional | 2009-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for flucytosine and Liver Neoplasms
| Article | Year |
|---|---|
[Gene therapy for liver metastasis of colon cancer].
Topics: Adenoviridae; Adenoviruses, Human; Clinical Trials as Topic; Colonic Neoplasms; Cytosine Deaminase; | 2005 |
2 trials available for flucytosine and Liver Neoplasms
| Article | Year |
|---|---|
Vectorized gene therapy of liver tumors: proof-of-concept of TG4023 (MVA-FCU1) in combination with flucytosine.
Topics: Adult; Aged; Aged, 80 and over; Combined Modality Therapy; Cytosine Deaminase; Female; Flucytosine; | 2017 |
Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine.
Topics: Adenoviridae; Administration, Oral; Adolescent; Adult; Antimetabolites; Colonic Neoplasms; Cytosine | 1997 |
26 other studies available for flucytosine and Liver Neoplasms
| Article | Year |
|---|---|
Anti-Tumor Effects of MAPK-Dependent Tumor-Selective Oncolytic Vaccinia Virus Armed with CD/UPRT against Pancreatic Ductal Adenocarcinoma in Mice.
Topics: Animals; Apoptosis; Carcinoma, Pancreatic Ductal; Cell Proliferation; Combined Modality Therapy; Cyt | 2021 |
Human Sulfatase-1 Improves the Effectiveness of Cytosine Deaminase Suicide Gene Therapy with 5-Fluorocytosine Treatment on Hepatocellular Carcinoma Cell Line HepG2 In Vitro and In Vivo.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Cytosine Deaminase | 2015 |
Adenovirus-mediated cytosine deaminase/5-fluorocytosine suicide gene therapy of human hepatoblastoma in vitro.
Topics: Adenoviridae; Antineoplastic Agents; Cell Line, Tumor; Cytosine Deaminase; Flucytosine; Fluorescent | 2009 |
Suicidal gene therapy in the effective control of primary human hepatocellular carcinoma as monitored by noninvasive bioimaging.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytosine Deaminase; Flucytosine; Foot-and-Mout | 2012 |
Interaction of endothelial progenitor cells expressing cytosine deaminase in tumor tissues and 5-fluorocytosine administration suppresses growth of 5-fluorouracil-sensitive liver cancer in mice.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cytosine Deaminase; Endothelial Cel | 2012 |
Synergistic effects of genetically engineered stem cells expressing cytosine deaminase and interferon-β via their tumor tropism to selectively target human hepatocarcinoma cells.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Migration Assays; | 2012 |
Prolonged stability and sustained prodrug cell killing activity using receptor-mediated delivery of malarial circumsporozoite-cytosine deaminase fusion protein into liver cancer cells.
Topics: Antimalarials; Cytosine Deaminase; DNA; Electrophoresis, Polyacrylamide Gel; Flucytosine; Humans; Li | 2002 |
Regional delivery and selective expression of a high-activity yeast cytosine deaminase in an intrahepatic colon cancer model.
Topics: Adenoviridae; Animals; Antimetabolites, Antineoplastic; Carcinoembryonic Antigen; Colonic Neoplasms; | 2003 |
[Experimental studies in vitro on the alpha-fetoprotein-specific promoter mediated target gene therapy of hepatocellular carcinoma].
Topics: alpha-Fetoproteins; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Division; Cytosine Deamin | 1999 |
Improvement of carcinoembryonic antigen-specific prodrug gene therapy for experimental colon cancer.
Topics: Adenoviridae; Antimetabolites, Antineoplastic; Carcinoembryonic Antigen; Colonic Neoplasms; Cytosine | 2003 |
Per os administration of 5-fluorocytosine is effective in the regression of CD-expressing liver metastases in rats.
Topics: Administration, Oral; Animals; Antimetabolites; Cancer Vaccines; Cell Line, Tumor; Cytosine Deaminas | 2004 |
Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cytosine Deaminase; Disease Models, Anim | 2005 |
Targeted delivery of a suicide gene to human colorectal tumors by a conditionally replicating vaccinia virus.
Topics: Animals; Antineoplastic Agents; Colorectal Neoplasms; Cytosine Deaminase; Flucytosine; Gene Targetin | 2008 |
Regional delivery of an adenovirus vector containing the Escherichia coli cytosine deaminase gene to provide local activation of 5-fluorocytosine to suppress the growth of colon carcinoma metastatic to liver.
Topics: Animals; Antineoplastic Agents; Blotting, Northern; Cell Division; Colonic Neoplasms; Cytosine Deami | 1996 |
Regional 'pro-drug' gene therapy: intravenous administration of an adenoviral vector expressing the E. coli cytosine deaminase gene and systemic administration of 5-fluorocytosine suppresses growth of hepatic metastasis of colon carcinoma.
Topics: Adenoviridae; Animals; Antimetabolites; Colonic Neoplasms; Cytosine Deaminase; Escherichia coli; Flu | 1998 |
Systemic administration of a recombinant vaccinia virus expressing the cytosine deaminase gene and subsequent treatment with 5-fluorocytosine leads to tumor-specific gene expression and prolongation of survival in mice.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Colonic Neoplasms; Cytosine Deaminase; Fem | 1999 |
Comparison of gene therapy with the herpes simplex virus thymidine kinase gene and the bacterial cytosine deaminase gene for the treatment of hepatocellular carcinoma.
Topics: Animals; Antifungal Agents; Antiviral Agents; Carcinoma, Hepatocellular; Cytosine Deaminase; Escheri | 1999 |
Cytosine deaminase/5-fluorocytosine-based vaccination against liver tumors: evidence of distant bystander effect.
Topics: Animals; Antifungal Agents; Antimetabolites; Antineoplastic Agents; Cancer Vaccines; Colonic Neoplas | 1999 |
Gene therapy for human hepatocellular carcinoma with cytosine deaminase gene and prodrug flucytosine.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cytosine Deaminase; Female; Flucytosine; | 1999 |
Re: Cytosine deaminase/5-fluorocytosine-based vaccination against liver tumors: evidence of distant bystander effect.
Topics: Animals; Antimetabolites, Antineoplastic; Cancer Vaccines; Colonic Neoplasms; Cytosine Deaminase; Di | 2000 |
[Vaccination by suicide gene therapy against a model of hepatic metastasis from colon cancer in the rat].
Topics: Animals; Antimetabolites; Colonic Neoplasms; Cytosine Deaminase; Disease Models, Animal; Flucytosine | 2000 |
Hepatic intra-arterial delivery of a retroviral vector expressing the cytosine deaminase gene, controlled by the CEA promoter and intraperitoneal treatment with 5-fluorocytosine suppresses growth of colorectal liver metastases.
Topics: Animals; Antimetabolites; Carcinoembryonic Antigen; Carcinoma; Colonic Neoplasms; Cytosine Deaminase | 2001 |
[Combined gene therapy for murine liver cancer with interleukin-18 and cytosine deaminase genes].
Topics: Animals; Carcinoma, Hepatocellular; Combined Modality Therapy; Cytosine Deaminase; Disease Models, A | 2001 |
Subcutaneous or intrahepatic injection of suicide gene modified tumour cells induces a systemic antitumour response in a metastatic model of colon carcinoma in rats.
Topics: Animals; Antimetabolites, Antineoplastic; Bystander Effect; Colonic Neoplasms; Cytosine Deaminase; D | 2002 |
Dose of adenoviral vectors expressing interleukin-2 plays an important role in combined gene therapy with cytosine deaminase/5-fluorocytosine: preclinical consideration.
Topics: Adenoviridae; Animals; Antimetabolites; Combined Modality Therapy; Cytosine Deaminase; Escherichia c | 2002 |
The potential of 5-fluorocytosine/cytosine deaminase enzyme prodrug gene therapy in an intrahepatic colon cancer model.
Topics: Adenoviridae; Animals; Colorectal Neoplasms; Cytosine Deaminase; Flucytosine; Genetic Therapy; Genet | 2002 |