flucytosine has been researched along with Leukemia in 18 studies
Flucytosine: A fluorinated cytosine analog that is used as an antifungal agent.
flucytosine : An organofluorine compound that is cytosine that is substituted at position 5 by a fluorine. A prodrug for the antifungal 5-fluorouracil, it is used for the treatment of systemic fungal infections.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine if fluconazole is effective treatment for hepatosplenic candidiasis that has not resolved with amphotericin B and flucytosine treatment." | 7.68 | Hepatosplenic candidiasis: successful treatment with fluconazole. ( Bradley, SF; Kauffman, CA; Ross, SC; Weber, DR, 1991) |
| "We present six cases of fusariosis caused by Fusarium solani that were diagnosed over a three-year period in 166 adult patients undergoing chemotherapy for acute leukemia." | 4.77 | Diagnosis and successful treatment of fusariosis in the compromised host. ( Hoagland, M; Hood, AF; Jett-Goheen, M; Junkins, JM; Karp, JE; Merz, WG, 1988) |
| "To determine if fluconazole is effective treatment for hepatosplenic candidiasis that has not resolved with amphotericin B and flucytosine treatment." | 3.68 | Hepatosplenic candidiasis: successful treatment with fluconazole. ( Bradley, SF; Kauffman, CA; Ross, SC; Weber, DR, 1991) |
| "Over 80 percent of patients with invasive pulmonary aspergillosis (IPA) undergoing intensive antileukemic chemotherapy in a recent two-year period survived the pulmonary infection as a result of early diagnosis and aggressive therapy with high-dose amphotericin B and 5-fluorocytosine." | 3.67 | Invasive pulmonary aspergillosis in acute leukemia. The contribution of CT to early diagnosis and aggressive management. ( Burch, PA; Fishman, EK; Karp, JE; Kuhlman, JE; Siegelman, SS; Zerhouni, EA, 1987) |
| "Two different flucytosine (5-FC) treatment regimens, one by itself and the other in combination with fluconazole (FLCZ) were compared in chemotherapy against mycotic infections in 60 patients with hematological diseases." | 2.67 | [A comparative clinical study on flucytosine alone and in combination with fluconazole in hematological malignancies: a multicenter study using the envelope method]. ( Ariyoshi, H; Hamajima, N; Hotta, T; Kodera, Y; Murate, T; Naito, K; Naoe, T; Ogura, M; Saito, H; Tanaka, M, 1994) |
| " Liposomal Amphotericin B allowing higher dosage by lower toxicity appears effective as salvage treatment especially in aspergillosis which also responds to Itraconazole available as oral formulation so far." | 2.38 | Antifungal treatment strategy in leukemia patients. ( Büchner, T; Roos, N, 1992) |
| "Intestinal candidiasis is uncommon and poorly characterized." | 1.27 | Esophageal, gastric, and intestinal candidiasis. ( Bjorkman, DJ; Trier, JS, 1984) |
| "15 of 16 cases with septicemia at autopsy had terminal fever." | 1.26 | Causes of death in leukemia and lymphoma with modern treatment. ( Adolfsson, J; Lagerlöf, B; Lantz, B; Reizenstein, P, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (44.44) | 18.7374 |
| 1990's | 7 (38.89) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Park, GT | 1 |
| Heo, JR | 1 |
| Kim, SU | 1 |
| Choi, KC | 1 |
| Dong, XY | 1 |
| Wang, WQ | 1 |
| Zhao, Y | 1 |
| Li, XD | 1 |
| Fang, ZG | 1 |
| Lin, DJ | 1 |
| Xiao, RZ | 1 |
| Huang, RW | 1 |
| Pan, GJ | 1 |
| Liu, JJ | 1 |
| Kontoyiannis, DP | 1 |
| Trier, JS | 1 |
| Bjorkman, DJ | 1 |
| Lantz, B | 1 |
| Adolfsson, J | 1 |
| Lagerlöf, B | 1 |
| Reizenstein, P | 1 |
| Kurrle, E | 1 |
| Bhaduri, S | 1 |
| Krieger, D | 1 |
| Pflieger, H | 1 |
| Heimpel, H | 1 |
| Naito, K | 1 |
| Murate, T | 1 |
| Hotta, T | 1 |
| Saito, H | 1 |
| Hamajima, N | 1 |
| Naoe, T | 1 |
| Ogura, M | 1 |
| Ariyoshi, H | 1 |
| Tanaka, M | 1 |
| Kodera, Y | 1 |
| Wingard, JR | 1 |
| Merz, WG | 2 |
| Rinaldi, MG | 1 |
| Miller, CB | 1 |
| Karp, JE | 3 |
| Saral, R | 1 |
| Fouassier, M | 1 |
| Joly, D | 1 |
| Cambon, M | 1 |
| Peigue-Lafeuille, H | 1 |
| Condat, P | 1 |
| Myoken, Y | 2 |
| Sugata, T | 1 |
| Kyo, T | 1 |
| Fujihara, M | 1 |
| Mikami, Y | 1 |
| Sinclair, AJ | 1 |
| Rossof, AH | 1 |
| Coltman, CA | 1 |
| Krick, JA | 1 |
| Remington, JS | 1 |
| Büchner, T | 1 |
| Roos, N | 1 |
| Kauffman, CA | 1 |
| Bradley, SF | 1 |
| Ross, SC | 1 |
| Weber, DR | 1 |
| Wolf, HH | 1 |
| Scharf, RE | 1 |
| Arning, M | 1 |
| Schneider, W | 1 |
| Hoagland, M | 1 |
| Jett-Goheen, M | 1 |
| Junkins, JM | 1 |
| Hood, AF | 1 |
| Kuhlman, JE | 1 |
| Fishman, EK | 1 |
| Burch, PA | 1 |
| Zerhouni, EA | 1 |
| Siegelman, SS | 1 |
| Bodey, GP | 1 |
| Luna, M | 1 |
5 reviews available for flucytosine and Leukemia
| Article | Year |
|---|---|
Invasive mycoses: strategies for effective management.
Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Antifungal Agents; Antineoplastic Agents; Asparta | 2012 |
[Geotrichum capitatum infection in a neutropenic patient. Apropos of a case and review of the literature].
Topics: Acute Disease; Amphotericin B; Antifungal Agents; Antineoplastic Agents; Drug Combinations; Fatal Ou | 1998 |
Opportunistic invasive fungal infections in patients with leukaemia lymphoma.
Topics: Acute Disease; Adrenal Cortex Hormones; Amphotericin B; Aspergillosis; Blood Transfusion; Candidiasi | 1976 |
Antifungal treatment strategy in leukemia patients.
Topics: Amphotericin B; Antifungal Agents; Drug Therapy, Combination; Fluconazole; Flucytosine; Humans; Itra | 1992 |
Diagnosis and successful treatment of fusariosis in the compromised host.
Topics: Adult; Amphotericin B; Female; Flucytosine; Fusarium; Humans; Immune Tolerance; Leukemia; Leukemia, | 1988 |
2 trials available for flucytosine and Leukemia
| Article | Year |
|---|---|
Antimicrobial prophylaxis in acute leukaemia: prospective randomized study comparing two methods of selective decontamination.
Topics: Acute Disease; Adolescent; Adult; Aged; Aminoglycosides; Amphotericin B; Anti-Bacterial Agents; Bact | 1983 |
[A comparative clinical study on flucytosine alone and in combination with fluconazole in hematological malignancies: a multicenter study using the envelope method].
Topics: Adult; Aged; Aged, 80 and over; Drug Therapy, Combination; Female; Fluconazole; Flucytosine; Glucans | 1994 |
11 other studies available for flucytosine and Leukemia
| Article | Year |
|---|---|
The growth of K562 human leukemia cells was inhibited by therapeutic neural stem cells in cellular and xenograft mouse models.
Topics: Animals; Coculture Techniques; Cytosine Deaminase; Female; Flucytosine; Genetic Engineering; Genetic | 2018 |
Antibody-directed double suicide gene therapy targeting of MUC1- positive leukemia cells in vitro and in vivo.
Topics: Animals; Apoptosis; Cell Proliferation; Cytosine Deaminase; Disease Models, Animal; Flucytosine; Gan | 2013 |
Esophageal, gastric, and intestinal candidiasis.
Topics: Candidiasis; Deglutition Disorders; Diagnosis, Differential; Esophageal Diseases; Flucytosine; Human | 1984 |
Causes of death in leukemia and lymphoma with modern treatment.
Topics: Agranulocytosis; Bone Marrow; Escherichia coli; Female; Flucytosine; Heart Failure; Humans; Leukemia | 1980 |
Association of Torulopsis glabrata infections with fluconazole prophylaxis in neutropenic bone marrow transplant patients.
Topics: Amphotericin B; Bacterial Infections; Bone Marrow Transplantation; Candida; Candidiasis; Fluconazole | 1993 |
Antifungal susceptibility of Aspergillus species isolated from invasive oral infection in neutropenic patients with hematologic malignancies.
Topics: Adult; Aged; Amphotericin B; Antifungal Agents; Antineoplastic Agents; Aspergillosis; Aspergillus; D | 1999 |
Recognition and successful management in pulmonary aspergillosis in leukemia.
Topics: Adult; Aged; Amphotericin B; Aspergillosis; Female; Flucytosine; Humans; Leukemia; Lung Diseases, Fu | 1978 |
Hepatosplenic candidiasis: successful treatment with fluconazole.
Topics: Acute Disease; Adolescent; Adult; Amphotericin B; Candidiasis; Child; Child, Preschool; Fluconazole; | 1991 |
Preliminary results of treatment with itraconazole in patients with systemic fungal infections.
Topics: Acute Disease; Adult; Agranulocytosis; Antifungal Agents; Antineoplastic Agents; Drug Evaluation; Dr | 1990 |
Invasive pulmonary aspergillosis in acute leukemia. The contribution of CT to early diagnosis and aggressive management.
Topics: Acute Disease; Adult; Aged; Amphotericin B; Aspergillosis; Female; Flucytosine; Humans; Leukemia; Lu | 1987 |
Skin lesions associated with disseminated candidiasis.
Topics: Aged; Amphotericin B; Biopsy; Candida; Candidiasis; Candidiasis, Cutaneous; Child, Preschool; Female | 1974 |