flucytosine has been researched along with Glioblastoma with Sarcomatous Component in 5 studies
Flucytosine: A fluorinated cytosine analog that is used as an antifungal agent.
flucytosine : An organofluorine compound that is cytosine that is substituted at position 5 by a fluorine. A prodrug for the antifungal 5-fluorouracil, it is used for the treatment of systemic fungal infections.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The presence of transfected cytosine deaminase and thymidine kinase genes in 9L gliosarcoma cells reduced cell survival, both in vitro and in vivo, following treatment with the relevant prodrugs; the effects of the two components appeared to be synergistic and related mechanistically to the enhancement of ganciclovir phosphorylation by thymidine kinase following 5-fluorouracil treatment." | 3.70 | Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies. ( Aghi, M; Breakefield, XO; Chiocca, EA; Chou, TC; Kramm, CM, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dong, Y | 1 |
| Wen, P | 1 |
| Manome, Y | 1 |
| Parr, M | 1 |
| Hirshowitz, A | 1 |
| Chen, L | 1 |
| Hirschowitz, EA | 1 |
| Crystal, R | 1 |
| Weichselbaum, R | 1 |
| Kufe, DW | 1 |
| Fine, HA | 1 |
| Rogulski, KR | 2 |
| Kim, JH | 2 |
| Kim, SH | 1 |
| Freytag, SO | 2 |
| Aghi, M | 1 |
| Kramm, CM | 1 |
| Chou, TC | 1 |
| Breakefield, XO | 1 |
| Chiocca, EA | 1 |
| Zhang, K | 1 |
| Kolozsvary, A | 1 |
| Liao, WC | 1 |
| Chang, WS | 1 |
| Wu, FY | 1 |
5 other studies available for flucytosine and Glioblastoma with Sarcomatous Component
| Article | Year |
|---|---|
In vivo replication-deficient adenovirus vector-mediated transduction of the cytosine deaminase gene sensitizes glioma cells to 5-fluorocytosine.
Topics: Adenoviruses, Human; Animals; Cell Division; Cell Line, Transformed; Cytosine Deaminase; Defective V | 1996 |
Glioma cells transduced with an Escherichia coli CD/HSV-1 TK fusion gene exhibit enhanced metabolic suicide and radiosensitivity.
Topics: Blotting, Western; Bromodeoxyuridine; Cytosine; Cytosine Deaminase; Deoxyuridine; Enzyme Inhibitors; | 1997 |
Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Cytosine Deaminase; Flucytos | 1998 |
Pronounced antitumor effects and tumor radiosensitization of double suicide gene therapy.
Topics: Animals; Combined Modality Therapy; Flucytosine; Ganciclovir; Genetic Therapy; Gliosarcoma; Herpesvi | 1997 |
Re: Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Antiviral | 1999 |