flucytosine has been researched along with Experimental Neoplasms in 19 studies
Flucytosine: A fluorinated cytosine analog that is used as an antifungal agent.
flucytosine : An organofluorine compound that is cytosine that is substituted at position 5 by a fluorine. A prodrug for the antifungal 5-fluorouracil, it is used for the treatment of systemic fungal infections.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Immunohistochemistry of rat brain tumors inoculated with MSC-EGFP showed intratumoral distribution of MSC-EGFP." | 1.38 | Therapeutic effect of suicide gene-transferred mesenchymal stem cells in a rat model of glioma. ( Date, I; Hamada, H; Ichikawa, T; Inoue, S; Kambara, H; Kosaka, H; Kurozumi, K; Maruo, T; Nakamura, K, 2012) |
| "In a novel experimental brain metastases model, intravenously administered F3 cells migrated near lung cancer metastatic lesions, which were induced by the injection of lung cancer cells via the intracarotid artery." | 1.38 | Neural stem cell-based dual suicide gene delivery for metastatic brain tumors. ( Ito, M; Iwami, K; Kim, SU; Kinjo, S; Lee, HJ; Momota, H; Motomura, K; Natsume, A; Nishimira, Y; Ohka, F; Ohno, M; Wakabayashi, T; Wang, C, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.26) | 18.7374 |
| 1990's | 4 (21.05) | 18.2507 |
| 2000's | 8 (42.11) | 29.6817 |
| 2010's | 5 (26.32) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, SH | 1 |
| Sun, JM | 1 |
| Chen, BM | 1 |
| Lin, SC | 1 |
| Chang, HF | 1 |
| Collins, S | 1 |
| Chang, D | 1 |
| Wu, SF | 1 |
| Lu, YC | 1 |
| Wang, W | 1 |
| Chen, TC | 1 |
| Kasahara, N | 2 |
| Wang, HE | 1 |
| Tai, CK | 1 |
| Christie, C | 1 |
| Pomeroy, A | 1 |
| Nair, R | 1 |
| Berg, K | 1 |
| Hirschberg, H | 1 |
| Akbulut, H | 1 |
| Tang, Y | 1 |
| Akbulut, KG | 1 |
| Maynard, J | 2 |
| Deisseroth, A | 2 |
| Perez, OD | 1 |
| Logg, CR | 1 |
| Hiraoka, K | 1 |
| Diago, O | 1 |
| Burnett, R | 1 |
| Inagaki, A | 1 |
| Jolson, D | 1 |
| Amundson, K | 1 |
| Buckley, T | 1 |
| Lohse, D | 1 |
| Lin, A | 1 |
| Burrascano, C | 1 |
| Ibanez, C | 1 |
| Gruber, HE | 1 |
| Jolly, DJ | 1 |
| Kosaka, H | 1 |
| Ichikawa, T | 1 |
| Kurozumi, K | 1 |
| Kambara, H | 1 |
| Inoue, S | 1 |
| Maruo, T | 1 |
| Nakamura, K | 1 |
| Hamada, H | 1 |
| Date, I | 1 |
| Sun, X | 1 |
| Xing, L | 1 |
| Deng, X | 1 |
| Hsiao, HT | 1 |
| Manami, A | 1 |
| Koutcher, JA | 1 |
| Clifton Ling, C | 1 |
| Li, GC | 1 |
| Wang, C | 1 |
| Natsume, A | 1 |
| Lee, HJ | 1 |
| Motomura, K | 1 |
| Nishimira, Y | 1 |
| Ohno, M | 1 |
| Ito, M | 1 |
| Kinjo, S | 1 |
| Momota, H | 1 |
| Iwami, K | 1 |
| Ohka, F | 1 |
| Wakabayashi, T | 1 |
| Kim, SU | 1 |
| Zhang, Y | 1 |
| Wang, J | 1 |
| Zhou, H | 1 |
| Zhai, Y | 1 |
| Porosnicu, M | 1 |
| Mian, A | 1 |
| Barber, GN | 1 |
| Liu, Y | 1 |
| Ye, T | 1 |
| Sun, D | 1 |
| Dubois, L | 1 |
| Dresselaers, T | 1 |
| Landuyt, W | 1 |
| Paesmans, K | 1 |
| Mengesha, A | 1 |
| Wouters, BG | 1 |
| Van Hecke, P | 1 |
| Theys, J | 1 |
| Lambin, P | 1 |
| Erbs, P | 1 |
| Findeli, A | 1 |
| Kintz, J | 1 |
| Cordier, P | 1 |
| Hoffmann, C | 1 |
| Geist, M | 1 |
| Balloul, JM | 1 |
| Nishiyama, T | 1 |
| Kawamura, Y | 1 |
| Kawamoto, K | 1 |
| Matsumura, H | 1 |
| Yamamoto, N | 1 |
| Ito, T | 1 |
| Ohyama, A | 1 |
| Katsuragi, T | 1 |
| Sakai, T | 1 |
| Mullen, CA | 1 |
| Coale, MM | 1 |
| Lowe, R | 1 |
| Blaese, RM | 1 |
| Hanna, NN | 1 |
| Mauceri, HJ | 1 |
| Wayne, JD | 1 |
| Hallahan, DE | 1 |
| Kufe, DW | 1 |
| Weichselbaum, RR | 1 |
| Tiraby, M | 1 |
| Cazaux, C | 1 |
| Baron, M | 1 |
| Drocourt, D | 1 |
| Reynes, JP | 1 |
| Tiraby, G | 1 |
| Ju, DW | 1 |
| Wang, BM | 1 |
| Cao, X | 1 |
| Nakamura, H | 1 |
| Mullen, JT | 1 |
| Chandrasekhar, S | 1 |
| Pawlik, TM | 1 |
| Yoon, SS | 1 |
| Tanabe, KK | 1 |
| Zhang, S | 1 |
| Yuan, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase I, Open-label, Dose-escalating Study of the Safety or Percutaneous Intra-tumoral Injection of TG4023 (MVA-FCU1) Combined With Systemic Administration of 5-fluorocytosine in Patients With Primary or Secondary Hepatic Tumors.[NCT00978107] | Phase 1 | 16 participants (Actual) | Interventional | 2009-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
19 other studies available for flucytosine and Experimental Neoplasms
| Article | Year |
|---|---|
Efficient Prodrug Activator Gene Therapy by Retroviral Replicating Vectors Prolongs Survival in an Immune-Competent Intracerebral Glioma Model.
Topics: Animals; Aziridines; Brain Neoplasms; Cell Line, Tumor; Cytosine Deaminase; Escherichia coli Protein | 2020 |
Photodynamic therapy enhances the efficacy of gene-directed enzyme prodrug therapy.
Topics: Cell Line, Tumor; Combined Modality Therapy; Cytosine Deaminase; Drug Synergism; Enzyme Therapy; Flu | 2017 |
Chemotherapy targeted to cancer tissue potentiates antigen-specific immune response induced by vaccine for in vivo antigen loading and activation of dendritic cells.
Topics: Adenoviridae; Animals; Antigens, Neoplasm; Antineoplastic Agents; Base Sequence; Cancer Vaccines; De | 2008 |
Design and selection of Toca 511 for clinical use: modified retroviral replicating vector with improved stability and gene expression.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cytosine Deaminase; Flucytosine; Fluorouracil; Fun | 2012 |
Therapeutic effect of suicide gene-transferred mesenchymal stem cells in a rat model of glioma.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Coculture Techniques; Cytosine Deaminase; | 2012 |
Hypoxia targeted bifunctional suicide gene expression enhances radiotherapy in vitro and in vivo.
Topics: Animals; Blotting, Western; Cell Hypoxia; Cell Line, Tumor; Colony-Forming Units Assay; Cytosine Dea | 2012 |
Neural stem cell-based dual suicide gene delivery for metastatic brain tumors.
Topics: Administration, Intravenous; Animals; Antineoplastic Agents; Brain Neoplasms; Bystander Effect; Caro | 2012 |
[Study on the in vivo killing activity of YCD/5-FC gene therapy system on K562B cells].
Topics: Animals; Cytosine Deaminase; Flucytosine; Genetic Therapy; Humans; K562 Cells; Male; Mice; Mice, SCI | 2002 |
The oncolytic effect of recombinant vesicular stomatitis virus is enhanced by expression of the fusion cytosine deaminase/uracil phosphoribosyltransferase suicide gene.
Topics: Animals; Cell Line, Tumor; Cytosine Deaminase; Escherichia coli; Flucytosine; Fluorouracil; Genetic | 2003 |
Tumor-specific therapeutic effect induced by an oncolytic adenoviral vector containing heat shock protein 70 and prodrug activation genes.
Topics: Adenoviridae; Adenovirus E1A Proteins; Animals; Antimetabolites; Cell Line, Tumor; Combined Modality | 2006 |
Efficacy of gene therapy-delivered cytosine deaminase is determined by enzymatic activity but not expression.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Chromatography, Thin Layer; Cytosine Deaminase; F | 2007 |
Modified vaccinia virus Ankara as a vector for suicide gene therapy.
Topics: Adenoviridae; Animals; Antimetabolites; Cell Line, Tumor; Chick Embryo; Cytosine Deaminase; Flucytos | 2008 |
[Antineoplastic effect of 5-fluorocytosine and cytosine deaminase on brain tumor (author's transl)].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cytosine; Cytosine Deaminase; Drug Therapy, Combina | 1982 |
Tumors expressing the cytosine deaminase suicide gene can be eliminated in vivo with 5-fluorocytosine and induce protective immunity to wild type tumor.
Topics: Animals; Bacterial Proteins; Cytosine Deaminase; Drug Screening Assays, Antitumor; Flucytosine; Gene | 1994 |
Virally directed cytosine deaminase/5-fluorocytosine gene therapy enhances radiation response in human cancer xenografts.
Topics: Adenoviruses, Human; Animals; Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Combined Mo | 1997 |
Concomitant expression of E. coli cytosine deaminase and uracil phosphoribosyltransferase improves the cytotoxicity of 5-fluorocytosine.
Topics: Animals; Antimetabolites, Antineoplastic; Artificial Gene Fusion; Cytosine Deaminase; Drug Resistanc | 1998 |
Adenovirus-mediated combined suicide gene and interleukin-2 gene therapy for the treatment of established tumor and induction of antitumor immunity.
Topics: Adenoviridae; Animals; Antimetabolites; Cytosine Deaminase; Escherichia coli; Female; Flucytosine; G | 1998 |
Multimodality therapy with a replication-conditional herpes simplex virus 1 mutant that expresses yeast cytosine deaminase for intratumoral conversion of 5-fluorocytosine to 5-fluorouracil.
Topics: Animals; Chlorocebus aethiops; Combined Modality Therapy; Cytosine Deaminase; Flucytosine; Fluoroura | 2001 |
[Experimental study on human pancreatic carcinoma treated by cytosine deaminase gene therapy].
Topics: Adenocarcinoma; Adenoviruses, Human; Animals; Antimetabolites, Antineoplastic; Carcinoembryonic Anti | 2000 |