flucytosine has been researched along with Colorectal Neoplasms in 26 studies
Flucytosine: A fluorinated cytosine analog that is used as an antifungal agent.
flucytosine : An organofluorine compound that is cytosine that is substituted at position 5 by a fluorine. A prodrug for the antifungal 5-fluorouracil, it is used for the treatment of systemic fungal infections.
Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Colorectal cancer is a leading cause of cancer mortality in Western countries." | 2.41 | Gene therapy for colorectal cancer: therapeutic potential. ( Chen, MJ; Chung-Faye, GA; Kerr, DJ; Searle, PF; Young, LS, 2001) |
| "5-FC treatment of peritoneal carcinomatosis generated in syngeneic BDIX rats by CD-expressing DHD/K12 cells led to a complete and prolonged response and to prolonged survival." | 1.31 | Cytosine deaminase suicide gene therapy for peritoneal carcinomatosis. ( Bentires-Alj, M; Bours, V; Fillet, G; Gielen, J; Hellin, AC; Lechanteur, C; Lopez, M; Merville, MP; Princen, F, 2000) |
| " We previously used an adenoviral vector under control of the cytomegalovirus promoter (AdCMVCD) encoding the CD gene in combination with 5-FC and a single fraction of radiation exposure to enhance cytotoxicity to human cholangiocarcinoma cells in vitro and in vivo." | 1.31 | Fractionated radiation therapy in combination with adenoviral delivery of the cytosine deaminase gene and 5-fluorocytosine enhances cytotoxic and antitumor effects in human colorectal and cholangiocarcinoma models. ( Buchsbaum, DJ; Curiel, DT; Gebert, J; Grizzle, WE; Haack, K; Mayo, MS; Pederson, LC; Stackhouse, MA; Vickers, SM, 2000) |
| "To study the effect of X-ray on gene transfer and the antitumoral effect of X-ray combined with suicide gene therapy on colorectal carcinoma cells." | 1.31 | [X-ray combined with cytosine deaminase suicide gene therapy enhances killing of colorectal carcinoma cells in vitro]. ( An, P; Cai, H; Chen, G; Guo, W; Li, S; Yu, B, 2002) |
| "These results suggest that (1) intrahepatic cancer responds to 5FC when cells express yCD; (2) the luciferin-luciferase system permits non-invasive real time imaging of viable intrahepatic cancer; and (3) this system can be used to carry out gene therapy experiments using yCD adenovirus." | 1.31 | The potential of 5-fluorocytosine/cytosine deaminase enzyme prodrug gene therapy in an intrahepatic colon cancer model. ( Dornfeld, KJ; Kievit, E; Lawrence, TS; Nyati, MK; Rehemtulla, A; Ross, BD; Rynkiewicz, SD; Symon, Z, 2002) |
| " These results indicate that effective and safe in vivo gene therapy for advanced CRC may be feasible by transferring the CD gene controlled by the CEA promoter followed by 5-FC treatment." | 1.30 | Effective and safe gene therapy for colorectal carcinoma using the cytosine deaminase gene directed by the carcinoembryonic antigen promoter. ( Cao, G; Cui, L; Fukui, H; Gao, J; Kikukawa, M; Kuriyama, S; Nakatani, T; Pan, X; Qi, Z; Tsujinoue, H; Zhang, X, 1999) |
| " Tumor xenografts composed of CD-expressing cells can selectively generate tumor levels of > 400 microM 5FUra when the host mouse is dosed with nontoxic levels of 5FCyt." | 1.29 | Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase. ( Austin, EA; Davis, ST; Good, SS; Huber, BE; Richards, CA, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (34.62) | 18.2507 |
| 2000's | 14 (53.85) | 29.6817 |
| 2010's | 3 (11.54) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kazlauskas, A | 1 |
| Darinskas, A | 1 |
| Meškys, R | 1 |
| Tamašauskas, A | 1 |
| Urbonavičius, J | 1 |
| Huang, ZJ | 1 |
| Feng, QZ | 1 |
| You, J | 1 |
| Xu, L | 1 |
| Luo, WY | 1 |
| Yi, WC | 1 |
| Zeng, YY | 1 |
| Luo, Q | 1 |
| Park, GT | 1 |
| Kim, SU | 1 |
| Choi, KC | 1 |
| Chen, HJ | 1 |
| Huang, ZH | 1 |
| Wu, AG | 1 |
| Yu, JL | 1 |
| Su, GQ | 1 |
| Hiraoka, K | 1 |
| Kimura, T | 1 |
| Logg, CR | 1 |
| Tai, CK | 1 |
| Haga, K | 1 |
| Lawson, GW | 1 |
| Kasahara, N | 1 |
| Bertin, S | 1 |
| Neves, S | 1 |
| Gavelli, A | 1 |
| Baqué, P | 1 |
| Brossette, N | 1 |
| Simões, S | 1 |
| Pedroso de Lima, MC | 1 |
| Pierrefite-Carle, V | 2 |
| Fogar, P | 1 |
| Navaglia, F | 1 |
| Basso, D | 1 |
| Greco, E | 1 |
| Zambon, CF | 1 |
| Fadi, E | 1 |
| Falda, A | 1 |
| Stranges, A | 1 |
| Vannozzi, F | 1 |
| Danesi, R | 1 |
| Pedrazzoli, S | 1 |
| Plebani, M | 1 |
| Negroni, L | 1 |
| Samson, M | 1 |
| Guigonis, JM | 1 |
| Rossi, B | 1 |
| Baudoin, C | 1 |
| Chaszczewska-Markowska, M | 1 |
| Stebelska, K | 1 |
| Sikorski, A | 1 |
| Madej, J | 1 |
| Opolski, A | 1 |
| Ugorski, M | 1 |
| Foloppe, J | 1 |
| Kintz, J | 1 |
| Futin, N | 1 |
| Findeli, A | 1 |
| Cordier, P | 1 |
| Schlesinger, Y | 1 |
| Hoffmann, C | 1 |
| Tosch, C | 1 |
| Balloul, JM | 1 |
| Erbs, P | 1 |
| Zamboni, S | 1 |
| Mallano, A | 1 |
| Flego, M | 1 |
| Ascione, A | 1 |
| Dupuis, ML | 1 |
| Gellini, M | 1 |
| Barca, S | 1 |
| Cianfriglia, M | 1 |
| Trinh, QT | 1 |
| Austin, EA | 4 |
| Murray, DM | 1 |
| Knick, VC | 2 |
| Huber, BE | 4 |
| Richards, CA | 2 |
| Davis, ST | 1 |
| Good, SS | 2 |
| Tibbels, S | 1 |
| Rowley, S | 1 |
| Lindauer, M | 1 |
| Gebert, JF | 1 |
| Haberkorn, U | 1 |
| Oberdorfer, F | 1 |
| Moebius, U | 1 |
| Herfarth, C | 1 |
| Schackert, HK | 1 |
| Gabel, M | 1 |
| Kim, JH | 2 |
| Kolozsvary, A | 1 |
| Khil, M | 1 |
| Freytag, S | 1 |
| Khil, MS | 1 |
| Mullen, CA | 1 |
| Kim, SH | 1 |
| Freytag, SO | 1 |
| Szary, J | 1 |
| Missol, E | 1 |
| Szala, S | 1 |
| Cao, G | 1 |
| Kuriyama, S | 1 |
| Gao, J | 1 |
| Kikukawa, M | 1 |
| Cui, L | 1 |
| Nakatani, T | 1 |
| Zhang, X | 1 |
| Tsujinoue, H | 1 |
| Pan, X | 1 |
| Fukui, H | 1 |
| Qi, Z | 1 |
| Bentires-Alj, M | 1 |
| Hellin, AC | 1 |
| Lechanteur, C | 1 |
| Princen, F | 1 |
| Lopez, M | 1 |
| Fillet, G | 1 |
| Gielen, J | 1 |
| Merville, MP | 1 |
| Bours, V | 1 |
| Stackhouse, MA | 1 |
| Pederson, LC | 1 |
| Grizzle, WE | 1 |
| Curiel, DT | 1 |
| Gebert, J | 1 |
| Haack, K | 1 |
| Vickers, SM | 1 |
| Mayo, MS | 1 |
| Buchsbaum, DJ | 1 |
| Chen, MJ | 1 |
| Chung-Faye, GA | 1 |
| Searle, PF | 1 |
| Young, LS | 1 |
| Kerr, DJ | 1 |
| Shen, LZ | 1 |
| Wu, WX | 1 |
| Xu, DH | 1 |
| Zheng, ZC | 1 |
| Liu, XY | 1 |
| Ding, Q | 1 |
| Hua, YB | 1 |
| Yao, K | 1 |
| Chen, G | 1 |
| Li, S | 1 |
| Yu, B | 1 |
| An, P | 1 |
| Cai, H | 1 |
| Guo, W | 1 |
| Nyati, MK | 1 |
| Symon, Z | 1 |
| Kievit, E | 1 |
| Dornfeld, KJ | 1 |
| Rynkiewicz, SD | 1 |
| Ross, BD | 1 |
| Rehemtulla, A | 1 |
| Lawrence, TS | 1 |
1 review available for flucytosine and Colorectal Neoplasms
| Article | Year |
|---|---|
Gene therapy for colorectal cancer: therapeutic potential.
Topics: Adenoviridae; Antigen Presentation; Aziridines; Carcinoembryonic Antigen; Clinical Trials as Topic; | 2001 |
25 other studies available for flucytosine and Colorectal Neoplasms
| Article | Year |
|---|---|
Isocytosine deaminase Vcz as a novel tool for the prodrug cancer therapy.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Brain Neoplasms; Caco-2 Cells; Cell Line, | 2019 |
[Cytosine deaminase and thymidine kinase double suicide gene system driven by carcinoembryonic antigen promoter for the treatment of colorectal carcinoma xenograft in nude mice].
Topics: Animals; Carcinoembryonic Antigen; Colorectal Neoplasms; Cytosine Deaminase; Flucytosine; Ganciclovi | 2013 |
Anti-proliferative Effect of Engineered Neural Stem Cells Expressing Cytosine Deaminase and Interferon-β against Lymph Node-Derived Metastatic Colorectal Adenocarcinoma in Cellular and Xenograft Mouse Models.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell- and Tissue-Based Therapy; Colore | 2017 |
[Targeted killing of colorectal tumor cells by lentiviral constructs containing CD/TK suicide genes and KDR promoter].
Topics: Antimetabolites; Apoptosis; Cell Line; Cell Line, Tumor; Colorectal Neoplasms; Cytosine Deaminase; F | 2007 |
Therapeutic efficacy of replication-competent retrovirus vector-mediated suicide gene therapy in a multifocal colorectal cancer metastasis model.
Topics: Animals; Colorectal Neoplasms; Cytosine Deaminase; Disease Models, Animal; Female; Flucytosine; Fluo | 2007 |
Cellular and molecular events associated with the antitumor response induced by the cytosine deaminase/5-fluorocytosine suicide gene therapy system in a rat liver metastasis model.
Topics: Animals; Antimetabolites; Apoptosis; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Colorec | 2007 |
Suicide gene therapy with the yeast fusion gene cytosine deaminase/uracil phosphoribosyltransferase is not enough for pancreatic cancer.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Biotransformation; Cell Line, Tumor; Colorectal Neo | 2007 |
Treatment of colon cancer cells using the cytosine deaminase/5-fluorocytosine suicide system induces apoptosis, modulation of the proteome, and Hsp90beta phosphorylation.
Topics: Adenocarcinoma; Amino Acid Sequence; Animals; Annexin A5; Apoptosis; Biomarkers, Tumor; Blotting, We | 2007 |
Liposomal formulation of 5-fluorocytosine in suicide gene therapy with cytosine deaminase--for colorectal cancer.
Topics: Animals; Cell Line, Tumor; Colorectal Neoplasms; Cytosine Deaminase; Flucytosine; Genes, Transgenic, | 2008 |
Targeted delivery of a suicide gene to human colorectal tumors by a conditionally replicating vaccinia virus.
Topics: Animals; Antineoplastic Agents; Colorectal Neoplasms; Cytosine Deaminase; Flucytosine; Gene Targetin | 2008 |
Genetic construction, expression, and characterization of a single chain anti-CEA antibody fused to cytosine deaminase from yeast.
Topics: Amino Acid Sequence; Antibodies, Monoclonal; Apoptosis; Blotting, Western; Carcinoembryonic Antigen; | 2008 |
Enzyme/prodrug gene therapy: comparison of cytosine deaminase/5-fluorocytosine versus thymidine kinase/ganciclovir enzyme/prodrug systems in a human colorectal carcinoma cell line.
Topics: Animals; Antimetabolites, Antineoplastic; Base Sequence; Colorectal Neoplasms; Cytosine Deaminase; D | 1995 |
Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase.
Topics: Animals; Biotransformation; Cell Division; Cell Survival; Chromatography, High Pressure Liquid; Colo | 1994 |
In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase.
Topics: Animals; Cell Division; Colorectal Neoplasms; Cytosine Deaminase; Female; Flucytosine; Fluorouracil; | 1993 |
A first step in the development of gene therapy for colorectal carcinoma: cloning, sequencing, and expression of Escherichia coli cytosine deaminase.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; Colorectal Neoplasms; Cytosine Deam | 1993 |
Cytosine deaminase gene as a potential tool for the genetic therapy of colorectal cancer.
Topics: Base Sequence; Cell Death; Cloning, Molecular; Colorectal Neoplasms; Cytosine Deaminase; Escherichia | 1996 |
Selective in vivo radiosensitization by 5-fluorocytosine of human colorectal carcinoma cells transduced with the E. coli cytosine deaminase (CD) gene.
Topics: Animals; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Combined Modality Therapy; Cytosine | 1998 |
Radiosensitization by 5-fluorocytosine of human colorectal carcinoma cells in culture transduced with cytosine deaminase gene.
Topics: Cell Survival; Colorectal Neoplasms; Combined Modality Therapy; Cytosine Deaminase; Flucytosine; Gen | 1996 |
Characteristics of cytosine deaminase-5-fluorocytosine system. Enhancement of radiation cytotoxicity and bystander effect.
Topics: Animals; Bovine papillomavirus 1; Cell Division; Cell Survival; Coculture Techniques; Colorectal Neo | 1998 |
Effective and safe gene therapy for colorectal carcinoma using the cytosine deaminase gene directed by the carcinoembryonic antigen promoter.
Topics: Animals; Antimetabolites; Bone Marrow Cells; Carcinoembryonic Antigen; Colorectal Neoplasms; Cytosin | 1999 |
Cytosine deaminase suicide gene therapy for peritoneal carcinomatosis.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Carcinoma; Colorectal Neoplasms; Cytosine Deami | 2000 |
Fractionated radiation therapy in combination with adenoviral delivery of the cytosine deaminase gene and 5-fluorocytosine enhances cytotoxic and antitumor effects in human colorectal and cholangiocarcinoma models.
Topics: Adenoviridae; Animals; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Survival; Cholangiocarcin | 2000 |
Specific CEA-producing colorectal carcinoma cell killing with recombinant adenoviral vector containing cytosine deaminase gene.
Topics: Adenoviridae; Animals; Antimetabolites; Bystander Effect; Carcinoembryonic Antigen; Cell Line; Color | 2002 |
[X-ray combined with cytosine deaminase suicide gene therapy enhances killing of colorectal carcinoma cells in vitro].
Topics: Antimetabolites; Cell Survival; Colorectal Neoplasms; Cytosine Deaminase; Drug Interactions; Flucyto | 2002 |
The potential of 5-fluorocytosine/cytosine deaminase enzyme prodrug gene therapy in an intrahepatic colon cancer model.
Topics: Adenoviridae; Animals; Colorectal Neoplasms; Cytosine Deaminase; Flucytosine; Genetic Therapy; Genet | 2002 |